| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Fei, Xin Wang, Songsong Chen, Qiangqiang Zhou, Chao Zhang, Ying Li, Lihong Sun, Licai Zhan. Role of the RVM in Descending Pain Regulation Originating from the Cerebrospinal Fluid-Contacting Nucleus. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:26961890. |
a significant downregulation of 5-ht-labeled neurons and tryptophan hydroxylase 2 (tph2) as the marker of 5-ht cells in the rvm, and 5-ht expression in spinal dorsal horn in both normal and chronic constriction injury (cci) rats after i.c.v. |
2017-03-03 |
2023-08-13 |
rat |
| Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. |
moreover, it has been shown that 5-ht released in the dorsal horn of the spinal cord by stimulation of the periaqueductal gray causes activation of inhibitory interneurons, resulting in inhibition of spinal neurons. |
2016-10-05 |
2023-08-13 |
mouse |
| Toshiharu Tazawa, Yoshinori Kamiya, Ayako Kobayashi, Kensuke Saeki, Masahito Takiguchi, Yusuke Nakahashi, Hironobu Shinbori, Kengo Funakoshi, Takahisa Got. Spinal cord stimulation modulates supraspinal centers of the descending antinociceptive system in rats with unilateral spinal nerve injury. Molecular pain. vol 11. 2016-03-08. PMID:26104415. |
we also investigated immunohistochemical changes in the drn and locus coeruleus (lc), regarded as the adrenergic center of the das, and expression changes of synthetic enzymes of 5-ht [tryptophan hydroxylase (tph)] and norepinephrine [dopamine β-hydroxylase (dβh)] in the spinal dorsal horn. |
2016-03-08 |
2023-08-13 |
rat |
| Hajime Hoshino, Hideaki Obata, Shigeru Sait. Antihyperalgesic effect of duloxetine and amitriptyline in rats after peripheral nerve injury: Influence of descending noradrenergic plasticity. Neuroscience letters. vol 602. 2015-10-28. PMID:26135544. |
in vivo microdialysis in the lumbar spinal dorsal horn revealed that na and 5-ht concentrations increased after intraperitoneal administration of duloxetine and amitriptyline (10 mg/kg, respectively). |
2015-10-28 |
2023-08-13 |
rat |
| Raffaele Nardone, Yvonne Höller, Aljoscha Thomschewski, Peter Höller, Piergiorgio Lochner, Stefan Golaszewski, Francesco Brigo, Eugen Trink. Serotonergic transmission after spinal cord injury. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 2. 2015-09-25. PMID:24866695. |
there are functional relevant connections between the descending serotonergic system from the rostral ventromedial medulla in the brainstem, the 5-ht receptors in the spinal dorsal horn, and the descending pain facilitation after tissue and nerve injury. |
2015-09-25 |
2023-08-13 |
Not clear |
| Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Hideaki Obata, Shigeru Saito, Woong Mo Ki. The antiallodynic effect of intrathecal tianeptine is exerted by increased serotonin and norepinephrine in the spinal dorsal horn. Neuroscience letters. vol 583. 2015-06-05. PMID:25233863. |
the antiallodynic effect of intrathecal tianeptine is exerted by increased serotonin and norepinephrine in the spinal dorsal horn. |
2015-06-05 |
2023-08-13 |
rat |
| Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Hideaki Obata, Shigeru Saito, Woong Mo Ki. The antiallodynic effect of intrathecal tianeptine is exerted by increased serotonin and norepinephrine in the spinal dorsal horn. Neuroscience letters. vol 583. 2015-06-05. PMID:25233863. |
additionally microdialysis studies were performed to measure the extracellular levels of serotonin (5-ht) and norepinephrine (ne) in the spinal dorsal horn following tianeptine administration. |
2015-06-05 |
2023-08-13 |
rat |
| Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Hideaki Obata, Shigeru Saito, Woong Mo Ki. The antiallodynic effect of intrathecal tianeptine is exerted by increased serotonin and norepinephrine in the spinal dorsal horn. Neuroscience letters. vol 583. 2015-06-05. PMID:25233863. |
microdialysis studies revealed that tianeptine increased the levels of 5-ht and ne in the spinal dorsal horn. |
2015-06-05 |
2023-08-13 |
rat |
| Orie Tomoyose, Daisuke Kodama, Hideki Ono, Mitsuo Tanab. Presynaptic inhibitory effects of fluvoxamine, a selective serotonin reuptake inhibitor, on nociceptive excitatory synaptic transmission in spinal superficial dorsal horn neurons of adult mice. Journal of pharmacological sciences. vol 126. issue 2. 2015-05-12. PMID:25252797. |
presynaptic inhibitory effects of fluvoxamine, a selective serotonin reuptake inhibitor, on nociceptive excitatory synaptic transmission in spinal superficial dorsal horn neurons of adult mice. |
2015-05-12 |
2023-08-13 |
mouse |
| Antonio Rodríguez-Gaztelumendi, María Luisa Rojo, Angel Pazos, Alvaro Día. An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. Experimental brain research. vol 232. issue 6. 2015-01-26. PMID:24584836. |
autoradiographic studies demonstrated down-regulation of 5-ht transporters ([(3)h]citalopram binding) and decreased functionality of 5-ht1a receptors (8-oh-dpat-stimulated [(35)s]gtpγs binding) in the dorsal horn of the lumbar spinal cord in ob rats. |
2015-01-26 |
2023-08-12 |
rat |
| Jing Cao, Tong Wu, Li-Cai Zhan. [Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 30. issue 3. 2015-01-15. PMID:25244785. |
[targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-ht and c-fos in spinal dorsal horn of rats]. |
2015-01-15 |
2023-08-13 |
rat |
| Jing Cao, Tong Wu, Li-Cai Zhan. [Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 30. issue 3. 2015-01-15. PMID:25244785. |
the changes of pain threshold and expression of 5-hydroxytryptamine(5-ht) and c-fos in spinal dorsal horn of rats were observed after targetedly damaged the cerebraspinal fluid-contacting nucleus (csf-contacting nucleus) to provide experimental evidence for the mechanism of regulating pain csf-contacting nucleus involved in. |
2015-01-15 |
2023-08-13 |
rat |
| He Liu, Wei-Wei Yan, Xiao-Xing Lu, Xiu-Li Zhang, Jing-Qiu Wei, Xiao-Yu Wang, Tiao Wang, Tong Wu, Jing Cao, Cui-Jie Shao, Fang Zhou, Hong-Xing Zhang, Peng Zhang, Ting Zang, Xian-Fu Lu, Jun-Li Cao, Hai-Lei Ding, Li-Cai Zhan. Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission. Experimental neurology. vol 261. 2014-12-17. PMID:25108066. |
cb-sap induced significant downregulation of 5-ht in the spinal dorsal horn, and intrathecal injection of 5-ht significantly reversed hypersensitivity in responses to acute nociceptive stimulation in the cb-sap-treated rats. |
2014-12-17 |
2023-08-13 |
rat |
| Yong-Hai Sun, Hong-Shi Li, Chao Zhu, Wei Hu, Jing Yang, Guo-Li Zhao, Gui-Jun Lu, Sheng-Xi Wu, Yu-Lin Don. The analgesia effect of duloxetine on post-operative pain via intrathecal or intraperitoneal administration. Neuroscience letters. vol 568. 2014-12-09. PMID:24686187. |
microdialysis study revealed that 5-ht and na concentrations at the spinal dorsal horn were increased, peaking at 30min after i.p. |
2014-12-09 |
2023-08-12 |
rat |
| Wei Guo, Kan Miyoshi, Ronald Dubner, Ming Gu, Man Li, Jian Liu, Jiale Yang, Shiping Zou, Ke Ren, Koichi Noguchi, Feng We. Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade. Molecular pain. vol 10. 2014-10-17. PMID:24913307. |
it has been recently recognized that the descending serotonin (5-ht) system from the rostral ventromedial medulla (rvm) in the brainstem and the 5-ht3 receptor subtype in the spinal dorsal horn are involved in enhanced descending pain facilitation after tissue and nerve injury. |
2014-10-17 |
2023-08-13 |
Not clear |
| K Nishida, K Takechi, T Akiyama, M I Carstens, E Carsten. Scratching inhibits serotonin-evoked responses of rat dorsal horn neurons in a site- and state-dependent manner. Neuroscience. vol 250. 2014-04-04. PMID:23867770. |
we recorded from rat lumbar dorsal horn neurons responsive to intradermal (id) microinjection of serotonin (5-hydroxytryptamine, 5-ht). |
2014-04-04 |
2023-08-12 |
rat |
| Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Toshihiro Sekizawa, Shuichiro Kakimoto, Mina Tsukamoto, Tomoya Oe, Ryugo Enomoto, Nozomu Hamakawa, Nobuya Matsuok. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover. The Journal of pharmacology and experimental therapeutics. vol 348. issue 3. 2014-04-02. PMID:24338505. |
as1069562 significantly elevated extracellular 5-ht and ne levels in the rat spinal dorsal horn, although its 5-ht and ne reuptake inhibition was much weaker than that of duloxetine in vitro. |
2014-04-02 |
2023-08-12 |
rat |
| In-Sun Choi, Jin-Hwa Cho, Il-Sung Jan. 5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport. vol 24. issue 8. 2013-11-14. PMID:23629688. |
5-hydroxytryptamine 1a receptors inhibit glutamate release in rat medullary dorsal horn neurons. |
2013-11-14 |
2023-08-12 |
rat |
| In-Sun Choi, Jin-Hwa Cho, Il-Sung Jan. 5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport. vol 24. issue 8. 2013-11-14. PMID:23629688. |
we examined 5-hydroxytryptamine 1a (5-ht1a) receptor-mediated modulation of glutamatergic transmission in rat medullary dorsal horn neurons using a conventional whole-cell patch clamp technique. |
2013-11-14 |
2023-08-12 |
rat |
| Masamichi Okubo, Alberto Castro, Wei Guo, Shiping Zou, Ke Ren, Feng Wei, Asaf Keller, Ronald Dubne. Transition to persistent orofacial pain after nerve injury involves supraspinal serotonin mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 12. 2013-05-28. PMID:23516281. |
the centralization of the secondary hyperalgesia involved descending 5-ht drive from the rostral ventromedial medulla and the contribution of 5-ht3 receptors in the trigeminal nucleus caudalis (vc), the homolog of the spinal dorsal horn. |
2013-05-28 |
2023-08-12 |
rat |