| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Yun Wang, Yan-Yan Wei, Jing Huang, Wei Wang, Nobuaiki Tamamaki, Yun-Qing Li, Sheng-Xi W. Expression patterns of 5-HT receptor subtypes 1A and 2A on GABAergic neurons within the spinal dorsal horn of GAD67-GFP knock-in mice. Journal of chemical neuroanatomy. vol 38. issue 1. 2009-09-18. PMID:19409978. |
the present result showed that 5-ht(1a) receptor subtype mrna was present on about half of gfp-positive gabaergic interneurons in the spinal dorsal horn, which suggests a role of 5-ht(1a) receptor in gaba-mediated modulation of nociception at the spinal cord level. |
2009-09-18 |
2023-08-12 |
mouse |
| Ya-Yun Wang, Yan-Yan Wei, Jing Huang, Wei Wang, Nobuaiki Tamamaki, Yun-Qing Li, Sheng-Xi W. Expression patterns of 5-HT receptor subtypes 1A and 2A on GABAergic neurons within the spinal dorsal horn of GAD67-GFP knock-in mice. Journal of chemical neuroanatomy. vol 38. issue 1. 2009-09-18. PMID:19409978. |
however, it is unexpected that just a very limited sub-population of the total gabaergic interneurons express 5-ht(2a) receptor mrna or proteins in the spinal dorsal horn, which suggests that the 5-ht(2a) receptor subtype may not be important for spinal gabaergic effects in nociceptive modulation. |
2009-09-18 |
2023-08-12 |
mouse |
| Tasuku Akiyama, Austin W Merrill, Karen Zanotto, Mirela Iodi Carstens, E Carsten. Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19293390. |
the par-2 agonist and 5-ht produced overlapping distributions of fos-like immunoreactivity in the superficial dorsal horn. |
2009-06-23 |
2023-08-12 |
mouse |
| Tasuku Akiyama, Austin W Merrill, Karen Zanotto, Mirela Iodi Carstens, E Carsten. Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19293390. |
these results indicate that par-2 and par-4 agonists, histamine, and 5-ht elicit itch-related scratching and activate superficial dorsal horn neurons that may participate in scratch reflex and ascending itch signaling pathways. |
2009-06-23 |
2023-08-12 |
mouse |
| Tasuku Akiyama, Austin W Merrill, Mirela Iodi Carstens, E Carsten. Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 20. 2009-06-08. PMID:19458238. |
activation of superficial dorsal horn neurons in the mouse by a par-2 agonist and 5-ht: potential role in itch. |
2009-06-08 |
2023-08-12 |
mouse |
| Tasuku Akiyama, Austin W Merrill, Mirela Iodi Carstens, E Carsten. Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 20. 2009-06-08. PMID:19458238. |
small id microinjections of sligrl-nh(2) or 5-ht identified responsive single units in the superficial dorsal horn of mice anesthetized with pentobarbital. |
2009-06-08 |
2023-08-12 |
mouse |
| Tasuku Akiyama, Austin W Merrill, Mirela Iodi Carstens, E Carsten. Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 20. 2009-06-08. PMID:19458238. |
the prolonged responses of superficial dorsal horn neurons to sligrl-nh(2) and 5-ht suggest a role in signaling itch. |
2009-06-08 |
2023-08-12 |
mouse |
| Alex Brenchat, Luz Romero, Mónica García, Marta Pujol, Javier Burgueño, Antoni Torrens, Michel Hamon, José Manuel Baeyens, Helmut Buschmann, Daniel Zamanillo, José Miguel Vel. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. vol 141. issue 3. 2009-04-28. PMID:19118950. |
for this purpose, the effects of relevant ligands (5-ht(7) receptor agonists: as-19, msd-5a, e-55888; 5-ht(7) receptor antagonists: sb-258719, sb-269970; 5-ht(1a) receptor agonist: f-13640; 5-ht(1a) receptor antagonist: way-100635) were assessed on capsaicin-induced mechanical hypersensitivity, a pain behavior involving hypersensitivity of dorsal horn neurons (central sensitization). |
2009-04-28 |
2023-08-12 |
mouse |
| Ya-Yun Wang, Pascal Legendre, Jing Huang, Wen Wang, Sheng-Xi Wu, Yun-Qing L. The effect of serotonin on GABA synthesis in cultured rat spinal dorsal horn neurons. Journal of chemical neuroanatomy. vol 36. issue 3-4. 2009-02-06. PMID:18672053. |
the effect of serotonin on gaba synthesis in cultured rat spinal dorsal horn neurons. |
2009-02-06 |
2023-08-12 |
rat |
| Ya-Yun Wang, Pascal Legendre, Jing Huang, Wen Wang, Sheng-Xi Wu, Yun-Qing L. The effect of serotonin on GABA synthesis in cultured rat spinal dorsal horn neurons. Journal of chemical neuroanatomy. vol 36. issue 3-4. 2009-02-06. PMID:18672053. |
the spinal dorsal horn (sdh) is the first step in the integration of primary nociceptive information, which is controlled by the descending serotonin (5-ht) system as well as the principal inhibitory neurotransmitter gamma-aminobutyric acid (gaba). |
2009-02-06 |
2023-08-12 |
rat |
| Jing Huang, Ya-Yun Wang, Wei Wang, Yun-Qing Li, Nobuaki Tamamaki, Sheng-Xi W. 5-HT(3A) receptor subunit is expressed in a subpopulation of GABAergic and enkephalinergic neurons in the mouse dorsal spinal cord. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18586398. |
to gain insight into the cellular mechanism of 5-ht(3) receptors, we examined their expression in gabaergic and enkephalinergic (enkergic) neurons in the spinal dorsal horn (sdh) using single-cell reverse transcription-polymerase chain reaction (rt-pcr). |
2008-11-05 |
2023-08-12 |
mouse |
| Wahida Rahman, Rie Suzuki, Stephen P Hunt, Anthony H Dickenso. Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones. Neuropharmacology. vol 54. issue 8. 2008-08-25. PMID:18462764. |
loss of these nk(1)+ve neurones attenuates excitability of deep dorsal horn neurones due to a disruption of both intrinsic spinal circuits and a spino-bulbo-spinal loop, which activates a descending excitatory drive, mediated through spinal 5ht(3) receptors. |
2008-08-25 |
2023-08-12 |
Not clear |
| Christine Gerin, Jean-Rene Teilhac, Kristin Smith, Alain Priva. Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18400395. |
motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord. |
2008-08-13 |
2023-08-12 |
rat |
| Christine Gerin, Jean-Rene Teilhac, Kristin Smith, Alain Priva. Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18400395. |
literature highlights that serotonergic descending pathways are implicated in somatosensory functions in the spinal cord and that serotonin (5-ht) in the dorsal horn might play a role in motor function through proprioceptive feedback. |
2008-08-13 |
2023-08-12 |
rat |
| Christine Gerin, Jean-Rene Teilhac, Kristin Smith, Alain Priva. Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18400395. |
we hypothesized that 5-ht release in dorsal horn might represent an important factor in the completion of locomotion by facilitation of the spinocerebellar tract and/or by modulation of spinal reflex pathways. |
2008-08-13 |
2023-08-12 |
rat |
| Christine Gerin, Jean-Rene Teilhac, Kristin Smith, Alain Priva. Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18400395. |
our results show a significant 41% increase of 5-ht release within the dorsal horn during the exercise. |
2008-08-13 |
2023-08-12 |
rat |
| Christine Gerin, Jean-Rene Teilhac, Kristin Smith, Alain Priva. Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18400395. |
the present study demonstrates that dorsal horn 5-ht release might modulate locomotion. |
2008-08-13 |
2023-08-12 |
rat |
| Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Masaki Takashina, Satoshi Hagihira, Masahiko Shibata, Koichi Ueda, Takashi Mashim. Serotonin2C receptor mRNA editing in neuropathic pain model. Neuroscience research. vol 60. issue 2. 2008-04-18. PMID:18045717. |
our results might be evidence of a functional adaptation mechanism in which increased expression of 5ht2c mrna isoforms that encode receptors more sensitive to serotonin works to activate brainstem-spinal descending 5ht systems to, in effect, suppress transmission of nociceptive signals from primary afferent neurons to the spinal dorsal horn. |
2008-04-18 |
2023-08-12 |
Not clear |
| Till Manzke, Stefan Preusse, Swen Hülsmann, Diethelm W Richte. Developmental changes of serotonin 4(a) receptor expression in the rat pre-Bötzinger complex. The Journal of comparative neurology. vol 506. issue 5. 2008-03-04. PMID:18076058. |
in all developmental stages, 5-ht(4(a)) and mu-opioid receptors were strongly coexpressed in neurons of the pre-bötc, whereas 5-ht(4(a))r expression was absent in neurons within the dorsal horn. |
2008-03-04 |
2023-08-12 |
rat |
| Kumiko Mukaida, Tsutomu Shichino, Kazuhiko Fukud. Nitrous oxide increases serotonin release in the rat spinal cord. Journal of anesthesia. vol 21. issue 3. 2007-10-25. PMID:17680202. |
we measured the extracellular level of serotonin by using in vivo microdialysis in the dorsal horn of the spinal cord in rats. |
2007-10-25 |
2023-08-12 |
rat |