| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Caton, Enrique L M Ochoa, Francisco J Barrante. The role of nicotinic cholinergic neurotransmission in delusional thinking. NPJ schizophrenia. vol 6. issue 1. 2021-02-20. PMID:32532978. |
here we review the role of cholinergic neurotransmission in delusions, with a focus on nicotinic receptors, which are known to play a part in some illnesses where these symptoms appear, including delirium, schizophrenia spectrum disorders, bipolar disorder, parkinson, huntington, and alzheimer diseases. |
2021-02-20 |
2023-08-13 |
Not clear |
| Roxanna Korologou-Linden, Genevieve M Leyden, Caroline L Relton, Rebecca C Richmond, Tom G Richardso. Multi-omics analyses of cognitive traits and psychiatric disorders highlights brain-dependent mechanisms. Human molecular genetics. 2021-01-22. PMID:33481009. |
we have applied the principles of mendelian randomization (mr) to investigate whether brain-derived gene expression (n = 1194) may be responsible for mediating the effect of genetic variants on eight cognitive and psychological outcomes (attention deficit hyperactivity disorder (adhd), alzheimer's disease, bipolar disorder, depression, intelligence, insomnia, neuroticism and schizophrenia). |
2021-01-22 |
2023-08-13 |
Not clear |
| Silvia Alemany, Marta Ribasés, Natàlia Vilor-Tejedor, Mariona Bustamante, Cristina Sánchez-Mora, Rosa Bosch, Vanesa Richarte, Bru Cormand, Miguel Casas, Josep A Ramos-Quiroga, Jordi Sunye. New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168. issue 6. 2020-09-30. PMID:26174813. |
the most relevant associated snp was located in the sorcs2 gene (p = 3.65e-07), previously associated with bipolar disorder (bp), alzheimer disease (ad), and brain structure in elderly individuals. |
2020-09-30 |
2023-08-13 |
Not clear |
| Akanksha Mishra, Sonu Singh, Shubha Shukl. Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson's disease. Journal of experimental neuroscience. vol 12. 2020-09-30. PMID:29899667. |
dopamine receptors are g protein-coupled receptors involved in the regulation of motor activity and several neurological disorders such as schizophrenia, bipolar disorder, parkinson's disease (pd), alzheimer's disease, and attention-deficit/hyperactivity disorder. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zsuzsanna Szepesi, Oscar Manouchehrian, Sara Bachiller, Tomas Deierbor. Bidirectional Microglia-Neuron Communication in Health and Disease. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30319362. |
we summarize the current state of knowledge of physiological role and function of microglia during brain development and in the mature brain and further highlight microglial contribution to brain pathologies such as alzheimer's and parkinson's disease, brain ischemia, traumatic brain injury, brain tumor as well as neuropsychiatric diseases (depression, bipolar disorder, and schizophrenia). |
2020-09-30 |
2023-08-13 |
Not clear |
| Błażej Misiak, Laura Ricceri, Maria M Sąsiade. Transposable Elements and Their Epigenetic Regulation in Mental Disorders: Current Evidence in the Field. Frontiers in genetics. vol 10. 2020-09-30. PMID:31293617. |
therefore, aberrant epigenetic regulation and expression of tes emerged as a potential mechanism underlying the development of various mental disorders, including autism spectrum disorders (asd), schizophrenia, bipolar disorder, major depression, and alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
human |
| Elisa Dalla Vecchia, Vincenzo Di Donato, Andrew M J Young, Filippo Del Bene, William H J Norto. Reelin Signaling Controls the Preference for Social Novelty in Zebrafish. Frontiers in behavioral neuroscience. vol 13. 2020-09-30. PMID:31607872. |
genetic studies of human patients have demonstrated association between the reln locus and autism spectrum disorder, schizophrenia, bipolar disorder, and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
human |
| Rao Muralikrishna Adibhatla, J F Hatche. Role of Lipids in Brain Injury and Diseases. Future lipidology. vol 2. issue 4. 2020-09-29. PMID:18176634. |
this review attempts to provide an overview of the lipid imbalances associated with neurological disorders (alzheimer's, parkinson's; niemann-pick; multiple sclerosis, huntington, amyotrophic lateral sclerosis, schizophrenia, bipolar disorders and epilepsy) and cns injury (stroke, traumatic brain injury; and spinal cord injury) and a few provocative thoughts. |
2020-09-29 |
2023-08-12 |
Not clear |
| Suji Ham, Tae K Kim, Heeok Hong, Yong S Kim, Ya-Ping Tang, Heh-In I. Big Data Analysis of Genes Associated With Neuropsychiatric Disorders in an Alzheimer's Disease Animal Model. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:29962931. |
here, we explore the comprehensive changes in gene expression of genes that are associated with bipolar disorder, schizophrenia, and major depression disorder through the microarray of an alzheimer's disease animal model, the forebrain specific psen double knockout mouse. |
2020-09-29 |
2023-08-13 |
mouse |
| Hans-Gert Bernstein, Gerburg Keilhoff, Henrik Dobrowolny, Paul C Guest, Johann Steine. Perineuronal oligodendrocytes in health and disease: the journey so far. Reviews in the neurosciences. vol 31. issue 1. 2020-07-24. PMID:31323013. |
we also highlighted the occurrences in which perineuronal oligodendroglia are altered, such as in experimental demyelination, multiple sclerosis, cerebral ischemia, epilepsy, alzheimer's disease, schizophrenia, major depression, and bipolar disorder. |
2020-07-24 |
2023-08-13 |
Not clear |
| Marco Calabrò, Laura Mandelli, Concetta Crisafulli, Stefano Porcelli, Diego Albani, Antonis Politis, George N Papadimitriou, Marco Di Nicola, Luigi Janiri, Roberto Colombo, Giovanni Martinotti, Antonello Bellomo, Eduard Vieta, Stefano Bonassi, Alessandra Frustaci, Giuseppe Ducci, Stefano Landi, Stefania Boccia, Alessandro Serrett. Psychiatric disorders and SLC6A4 gene variants: possible effects on alcohol dependence and alzheimer's disease. Molecular biology reports. vol 47. issue 1. 2020-06-03. PMID:31595439. |
slc6a4 variants, namely 5httlpr, stin2, rs2066713, rs25531, rs4251417, rs6354 and rs7224199 were investigated in 4 independent cohorts of subjects with specific psychiatric disorders, including alcohol dependence disorder (alc), alzheimer disease (alz), schizophrenia (scz) and bipolar disorder (bpd). |
2020-06-03 |
2023-08-13 |
human |
| Mahboubeh S Noori, Pooja M Bhatt, Maria C Courreges, Davoud Ghazanfari, Chaz Cuckler, Crina M Orac, Mark C McMills, Frank L Schwartz, Sudhir P Deosarkar, Stephen C Bergmeier, Kelly D McCall, Douglas J Goet. Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3. American journal of physiology. Cell physiology. vol 317. issue 6. 2020-04-07. PMID:31553649. |
not surprisingly, elevated gsk-3 activity has been implicated in a host of diseases including pathological inflammation, diabetes, cancer, arthritis, asthma, bipolar disorder, and alzheimer's. |
2020-04-07 |
2023-08-13 |
human |
| Katharina Schmidt, Bilal Bari, Martina Ralle, Clorissa Washington-Hughes, Abigael Muchenditsi, Evan Maxey, Svetlana Lutsenk. Localization of the Locus Coeruleus in the Mouse Brain. Journal of visualized experiments : JoVE. issue 145. 2020-01-31. PMID:30907876. |
structural or functional abnormalities of lc impact several brain regions including cortex, hippocampus, and cerebellum and may contribute to depression, bipolar disorder, anxiety, as well as parkinson disease and alzheimer disease. |
2020-01-31 |
2023-08-13 |
mouse |
| L Holper, D Ben-Shachar, J J Man. Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 5. 2019-12-18. PMID:29855563. |
complex i (nadh dehydrogenase, ndu) and complex iv (cytochrome-c-oxidase, cox) of the mitochondrial electron transport chain have been implicated in the pathophysiology of major psychiatric disorders, such as major depressive disorder (mdd), bipolar disorder (bd), and schizophrenia (sz), as well as in neurodegenerative disorders, such as alzheimer disease (ad) and parkinson disease (pd). |
2019-12-18 |
2023-08-13 |
Not clear |
| Lawrence Fourgeaud, Curt Dvorak, Malika Faouzi, John Starkus, Sunil Sahdeo, Qi Wang, Brian Lord, Heather Coate, Natalie Taylor, Yingbo He, Ning Qin, Alan Wickenden, Nicholas Carruthers, Timothy W Lovenberg, Reinhold Penner, Anindya Bhattachary. Pharmacology of JNJ-28583113: A novel TRPM2 antagonist. European journal of pharmacology. vol 853. 2019-09-03. PMID:30965058. |
trpm2 signaling has been linked to the pathophysiology of cns disorders such as neuropathic pain, bipolar disorder and alzheimer's disease. |
2019-09-03 |
2023-08-13 |
Not clear |
| Kaiyi Zhu, Tai-Hsien Ou Yang, Vincent Dorie, Tian Zheng, Dimitris Anastassio. Meta-analysis of expression and methylation signatures indicates a stress-related epigenetic mechanism in multiple neuropsychiatric disorders. Translational psychiatry. vol 9. issue 1. 2019-06-12. PMID:30670680. |
to investigate such commonality, we applied an unsupervised computational approach identifying several consensus co-expression and co-methylation signatures from a data cohort of postmortem prefrontal cortex (pfc) samples from individuals with six different neuropsychiatric disorders-schizophrenia, bipolar disorder, major depression, alcoholism, alzheimer's and parkinson's-as well as healthy controls. |
2019-06-12 |
2023-08-13 |
Not clear |
| Johannes Hebebrand, Triinu Peters, Dick Schijven, Moritz Hebebrand, Corinna Grasemann, Thomas W Winkler, Iris M Heid, Jochen Antel, Manuel Föcker, Lisa Tegeler, Lena Brauner, Roger A H Adan, Jurjen J Luykx, Christoph U Correll, Inke R König, Anke Hinney, Lars Libud. The role of genetic variation of human metabolism for BMI, mental traits and mental disorders. Molecular metabolism. vol 12. 2019-04-11. PMID:29673576. |
these 516 snps (216 independent loci) were looked-up in genome-wide association studies for association with body mass index (bmi) and the mental traits/disorders educational attainment, neuroticism, schizophrenia, well-being, anxiety, depressive symptoms, major depressive disorder, autism-spectrum disorder, attention-deficit/hyperactivity disorder, alzheimer's disease, bipolar disorder, aggressive behavior, and internalizing problems. |
2019-04-11 |
2023-08-13 |
human |
| M Xu, S L Wang, L Zhu, P Y Wu, W B Dai, K P Rakes. Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review. European journal of medicinal chemistry. vol 164. 2019-03-06. PMID:30616053. |
inhibition of gsk-3 may be useful in curing various diseases such as alzheimer's disease, type ii diabetes, mood disorders, cancers, chronic inflammatory agents, stroke, bipolar disorders and so on, but the approach poses significant challenges. |
2019-03-06 |
2023-08-13 |
Not clear |
| Natasha A M Jackson, Angelina M Flores, Elizabeth D Eldon, Lisa S Kli. Disruption of G3 (Bethesda, Md.). vol 8. issue 9. 2018-12-12. PMID:29991509. |
alterations of inositol metabolism have been implicated in human reproductive issues, the therapeutic effects of drugs used to treat epilepsy and bipolar disorder, spinal cord defects, and diseases including diabetes and alzheimer's. |
2018-12-12 |
2023-08-13 |
human |
| Julie A Morgan, Gaurav Singhal, Frances Corrigan, Emily J Jaehne, Magdalene C Jawahar, Bernhard T Baun. TNF signalling via the TNF receptors mediates the effects of exercise on cognition-like behaviours. Behavioural brain research. vol 353. 2018-11-26. PMID:29969604. |
altered tnf levels are associated with cognitive impairment in depression, schizophrenia, bipolar disorder, and alzheimer's disease (ad). |
2018-11-26 |
2023-08-13 |
Not clear |