| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariana Dias Castela de Carvalho, Joelma Freire De Mesquit. Structural modeling and in silico analysis of human superoxide dismutase 2. PloS one. vol 8. issue 6. 2014-01-21. PMID:23785434. |
polymorphisms in sod2 have been associated with the development of neurodegenerative diseases, such as alzheimer's and parkinson's disease, as well as psychiatric disorders, such as schizophrenia, depression and bipolar disorder. |
2014-01-21 |
2023-08-12 |
human |
| Michael Berk, Gin S Malhi, Laura J Gray, Olivia M Dea. The promise of N-acetylcysteine in neuropsychiatry. Trends in pharmacological sciences. vol 34. issue 3. 2013-09-20. PMID:23369637. |
this review summarises the areas where the mechanisms of action of nac overlap with known pathophysiological elements, and offers a précis of current literature regarding the use of nac in disorders including cocaine, cannabis, and smoking addictions, alzheimer's and parkinson's diseases, autism, compulsive and grooming disorders, schizophrenia, depression, and bipolar disorder. |
2013-09-20 |
2023-08-12 |
Not clear |
| Mary Ann Raghanti, Tiffini Conley, Jessica Sudduth, Joseph M Erwin, Cheryl D Stimpson, Patrick R Hof, Chet C Sherwoo. Neuropeptide Y-immunoreactive neurons in the cerebral cortex of humans and other haplorrhine primates. American journal of primatology. vol 75. issue 5. 2013-09-18. PMID:23042407. |
npy has been implicated in learning and memory and the density of npy-expressing cortical neurons and axons is reduced in depression, bipolar disorder, schizophrenia, and alzheimer's disease. |
2013-09-18 |
2023-08-12 |
monkey |
| C J Carte. Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders. Journal of pathogens. vol 2013. 2013-03-28. PMID:23533776. |
susceptibility genes for multiple sclerosis, alzheimer's disease, schizophrenia, bipolar disorder, depression, childhood obesity, parkinson's disease, attention deficit hyperactivity disorder (p from 8.01e - 05 (adhd) to 1.22e - 71) (multiple sclerosis), and autism (p = 0.013), but not anorexia or chronic fatigue are highly enriched in the human arm of this interactome and 18 (adhd) to 33% (ms) of the susceptibility genes relate to it. |
2013-03-28 |
2023-08-12 |
human |
| J S Rao, V L Keleshian, S Klein, S I Rapopor. Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Translational psychiatry. vol 2. 2013-03-14. PMID:22760556. |
epigenetic modifications in frontal cortex from alzheimer's disease and bipolar disorder patients. |
2013-03-14 |
2023-08-12 |
Not clear |
| George Bartzoki. Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22306524. |
similarly, psychotropic treatments ranging from lithium and antipsychotics to serotonin reuptake inhibitors (ssris) and acetylcholinesterase inhibitors have been shown to be efficacious in a wide spectrum of psychiatric disorders ranging from autism, schizophrenia (sz), depression, and bipolar disorder (bd) to alzheimer's disease (ad). |
2012-12-20 |
2023-08-12 |
human |
| A Besga, M Termenon, M Graña, J Echeveste, J M Pérez, A Gonzalez-Pint. Discovering Alzheimer's disease and bipolar disorder white matter effects building computer aided diagnostic systems on brain diffusion tensor imaging features. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22617636. |
the aim of this study is to look for differential effects in white matter (wm) of bipolar disorder (bd) and alzheimer's disease (ad) patients. |
2012-10-04 |
2023-08-12 |
human |
| Patrick F Sullivan, Mark J Daly, Michael O'Donova. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nature reviews. Genetics. vol 13. issue 8. 2012-09-25. PMID:22777127. |
in this review, we discuss the genetics of nine cardinal psychiatric disorders (namely, alzheimer's disease, attention-deficit hyperactivity disorder, alcohol dependence, anorexia nervosa, autism spectrum disorder, bipolar disorder, major depressive disorder, nicotine dependence and schizophrenia). |
2012-09-25 |
2023-08-12 |
Not clear |
| Hiroyasu Akatsu, Akira Hori, Takayuki Yamamoto, Mari Yoshida, Maya Mimuro, Yoshio Hashizume, Ikuo Tooyama, Eric M Yezdime. Transition metal abnormalities in progressive dementias. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 25. issue 2. 2012-07-23. PMID:22080191. |
abnormal distributions of transition metals inside the brain are potential diagnostic markers for several central nervous system diseases, including alzheimer's disease (ad), parkinson's disease, dementia with lewy bodies (dlb), bipolar disorders and depression. |
2012-07-23 |
2023-08-12 |
Not clear |
| Changsu Han, Dong Suk Shim, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pa. Association of chronic divalproex sodium use and brain atrophy in Alzheimer's disease. Expert review of neurotherapeutics. vol 12. issue 2. 2012-06-22. PMID:22288670. |
divalproex sodium has been widely use for the treatment of bipolar disorder, behavioral control in schizophrenia, seizure and agitation in alzheimer's disease. |
2012-06-22 |
2023-08-12 |
Not clear |
| Xue-Qiu Jian, Ke-Sheng Wang, Tie-Jian Wu, Joel J Hillhouse, Jerald E Mullersma. Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies. Journal of abnormal child psychology. vol 39. issue 6. 2011-10-28. PMID:21611732. |
especially, the two genes (adam10 and camk2a) have been reported to be associated with alzheimer's disease, bipolar disorder and depression. |
2011-10-28 |
2023-08-12 |
Not clear |
| Antonio Lucio Teixeira, Izabela Guimarães Barbosa, Breno Satler Diniz, Arthur Kumme. Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function. Biomarkers in medicine. vol 4. issue 6. 2011-04-11. PMID:21133708. |
recent studies have consistently reported altered levels of bdnf in the circulation (i.e., serum or plasma) of patients with major depression, bipolar disorder, alzheimer's disease, huntington's disease and parkinson's disease. |
2011-04-11 |
2023-08-12 |
Not clear |
| Anthony P Popkie, Leigh C Zeidner, Ashley M Albrecht, Anthony D'Ippolito, Sigrid Eckardt, David E Newsom, Joanna Groden, Bradley W Doble, Bruce Aronow, K John McLaughlin, Peter White, Christopher J Phie. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. The Journal of biological chemistry. vol 285. issue 53. 2011-02-09. PMID:21047779. |
underscoring their biological significance, altered gsk-3 activity has been implicated in diabetes, alzheimer disease, schizophrenia, and bipolar disorder. |
2011-02-09 |
2023-08-12 |
mouse |
| Albert Eugene Pekary, Schetema A Stevens, James D Blood, Albert Satti. Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor. Peptides. vol 31. issue 6. 2010-08-17. PMID:20338209. |
thyrotropin-releasing hormone (trh) is an endogenous antidepressant-like neuropeptide that reduces the expression of glycogen synthase kinase-3beta (gsk-3beta), an enzyme that hyperphosphorylates tau and is implicated in bipolar disorder, diabetes and alzheimer's disease. |
2010-08-17 |
2023-08-12 |
rat |
| Arnab Datta, Jung Eun Park, Xin Li, Huoming Zhang, Zhi Shan Ho, Klaus Heese, Sai Kiang Lim, James P Tam, Siu Kwan Sz. Phenotyping of an in vitro model of ischemic penumbra by iTRAQ-based shotgun quantitative proteomics. Journal of proteome research. vol 9. issue 1. 2010-03-30. PMID:19916522. |
additionally, many proteins (for instance, park7 and vap-a) involved in the chronic neurological disorders (such as alzheimer's disease, parkinson's disease or bipolar disorder) were also regulated in this model of acute neuronal injury. |
2010-03-30 |
2023-08-12 |
rat |
| Mohammad A Khanfar, Bilal Abu Asal, Mudit Mudit, Amal Kaddoumi, Khalid A El Saye. The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. Bioorganic & medicinal chemistry. vol 17. issue 16. 2009-10-27. PMID:19616957. |
the gsk-3beta inhibitory activity of pmhs entitles them to be potential leads for the treatment of cancer, alzheimer's disease, bipolar disorders, stroke, different tau pathologies, and type-2 diabetes. |
2009-10-27 |
2023-08-12 |
mouse |
| R Tabarés-Seisdedos, J L R Rubenstei. Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer. Molecular psychiatry. vol 14. issue 6. 2009-08-28. PMID:19204725. |
molecular genetics and developmental studies have identified 21 genes in this region (adra1a, arhgef10, chrna2, chrna6, chrnb3, dkk4, dpysl2, egr3, fgf17, fgf20, fgfr1, fzd3, ldl, nat2, nef3, nrg1, pcm1, plat, ppp3cc, sfrp1 and vmat1/slc18a1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (parkinson's and alzheimer's disease) and cancer. |
2009-08-28 |
2023-08-12 |
mouse |
| George R Uhl, Tomas Drgon, Catherine Johnson, Chuan-Yun Li, Carlo Contoreggi, Judith Hess, Daniel Naiman, Qing-Rong Li. Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. Annals of the New York Academy of Sciences. vol 1141. 2008-12-12. PMID:18991966. |
here, we review (a) evidence that supports polygenic models with (at least) modest heterogeneity for the genetic architectures of addiction and several related phenotypes; (b) technical and ethical aspects of importance for understanding gwa data, including genotyping in individual samples versus dna pools, analytic approaches, power estimation, and ethical issues in genotyping individuals with illegal behaviors; (c) the samples and the data that shape our current understanding of the molecular genetics of individual differences in vulnerability to substance dependence and related phenotypes; (d) overlaps between gwa data sets for dependence on different substances; and (e) overlaps between gwa data for addictions versus other heritable, brain-based phenotypes that include bipolar disorder, cognitive ability, frontal lobe brain volume, the ability to successfully quit smoking, neuroticism, and alzheimer's disease. |
2008-12-12 |
2023-08-12 |
human |
| Nils Bros. Altered complexin expression in psychiatric and neurological disorders: cause or consequence? Molecules and cells. vol 25. issue 1. 2008-06-11. PMID:18319609. |
genetic elimination of complexins from mammalian neurons causes a strong reduction in evoked neurotransmitter release, and altered complexin expression levels with consequent deficits in synaptic transmission were suggested to contribute to the etiology or pathogenesis of schizophrenia, huntington's disease, depression, bipolar disorder, parkinson's disease, alzheimer's disease, traumatic brain injury, wernicke's encephalopathy, and fetal alcohol syndrome. |
2008-06-11 |
2023-08-12 |
Not clear |
| Megan E Kozisek, David Middlemas, David B Bylun. Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies. Pharmacology & therapeutics. vol 117. issue 1. 2008-03-11. PMID:17949819. |
clinical studies demonstrate an association between bdnf levels and several disorders, including depression, epilepsy, bipolar disorder, parkinson's and alzheimer's diseases. |
2008-03-11 |
2023-08-12 |
Not clear |