| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiu R Lowe, Xiaochen Lu, Francesco Marchetti, Andrew J Wyrobe. The expression of Troponin T1 gene is induced by ketamine in adult mouse brain. Brain research. vol 1174. 2008-03-10. PMID:17850769. |
the glutamatergic system has been implicated in neuropsychiatric disorders, such as schizophrenia, bipolar disorder and alzheimer's disease, which also have a high prevalence of metabolic syndrome. |
2008-03-10 |
2023-08-12 |
mouse |
| Nigus Dessalew, Dhilon S Patel, Prasad V Bharata. 3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3beta inhibitors. Journal of molecular graphics & modelling. vol 25. issue 6. 2007-06-26. PMID:17018257. |
glycogen synthase kinase-3 (gsk-3), a serine/threonine kinase, is a fascinating enzyme with diverse biological actions in intracellular signaling systems, making it an emerging target for diseases such as diabetes mellitus, cancer, chronic inflammation, bipolar disorders and alzheimer's disease. |
2007-06-26 |
2023-08-12 |
Not clear |
| Shih-Jen Tsa. The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants. Medical hypotheses. vol 68. issue 1. 2007-01-30. PMID:16890384. |
in addition, bdnf is also implicated in several psychiatric diseases such as schizophrenia, bipolar disorder, attention-deficit hyperactivity disorder and alzheimer's disease; whether p11 and other components related to the tpa/plasminogen pathway may be related to the pathogenesis of these diseases needs further exploration. |
2007-01-30 |
2023-08-12 |
mouse |
| Tobias Engel, Félix Hernández, Jesús Avila, José J Luca. Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 19. 2006-05-31. PMID:16687499. |
dysregulation of gsk-3 activity is believed to play a key role in the pathogenesis of cns chronic disorders such as alzheimer's disease (ad), bipolar disorder, and huntington's disease, and of metabolic disorders such as type ii diabetes. |
2006-05-31 |
2023-08-12 |
mouse |
| U N Da. Angiotensin-II behaves as an endogenous pro-inflammatory molecule. The Journal of the Association of Physicians of India. vol 53. 2005-11-15. PMID:16124358. |
since ace is present in many tissues, this suggests that angiotensin-ii may play a significant role in atherosclerosis, congestive cardiac failure, stroke, bipolar disorder, schizophrenia, dementia, alzheimer's disease, psoriasis, atopic and non-atopic dermatitis, eczema, several acute and chronic inflammatory diseases, and cancer, conditions in which inflammation is an aetiopathogenic factor. |
2005-11-15 |
2023-08-12 |
Not clear |
| Undurti N Da. Is angiotensin-II an endogenous pro-inflammatory molecule? Medical science monitor : international medical journal of experimental and clinical research. vol 11. issue 5. 2005-07-11. PMID:15874906. |
since ace is present in many tissues including: the uterus, placenta, vascular tissue, heart, brain, adrenal cortex and kidney, leukocytes, alveolar macrophages, peripheral monocytes, neuronal cells and epididymal cells, this suggests that angiotensin-ii may have a role in atherosclerosis, congestive cardiac failure, stroke, bipolar disorder, schizophrenia, dementia, alzheimer's disease, psoriasis, atopic and non-atopic dermatitis, eczema, several acute and chronic inflammatory diseases, and cancer, conditions in which inflammation is known to play a significant role. |
2005-07-11 |
2023-08-12 |
Not clear |
| Blaise D Frederick, In Kyoon Lyoo, Andrew Satlin, Kyung Heup Ahn, Minue J Kim, Deborah A Yurgelun-Todd, Bruce M Cohen, Perry F Rensha. In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 8. 2005-03-07. PMID:15588758. |
patients with a diagnosis of mild to moderate probable alzheimer's disease (n = 22), non-alzheimer's dementia (depression, multiinfarct dementia, parkinson's disease, korsakoff's psychosis, and bipolar disorder; n = 13), and healthy comparison subjects (n = 18) were examined with respect to possible differences in metabolites using proton mrs in a 3.4-ml anterior temporal lobe voxel. |
2005-03-07 |
2023-08-12 |
human |
| Margaret J Smith, Robyn A Sharples, Geneviève Evin, Catriona A McLean, Brian Dean, Geoff Pavey, Emmanuelle Fantino, Richard G H Cotton, Kazunori Imaizumi, Colin L Masters, Roberto Cappai, Janetta G Culveno. Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex. Brain research. Molecular brain research. vol 127. issue 1-2. 2004-12-22. PMID:15306129. |
expression of truncated presenilin 2 splice variant in alzheimer's disease, bipolar disorder, and schizophrenia brain cortex. |
2004-12-22 |
2023-08-12 |
human |
| Margaret J Smith, Robyn A Sharples, Geneviève Evin, Catriona A McLean, Brian Dean, Geoff Pavey, Emmanuelle Fantino, Richard G H Cotton, Kazunori Imaizumi, Colin L Masters, Roberto Cappai, Janetta G Culveno. Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex. Brain research. Molecular brain research. vol 127. issue 1-2. 2004-12-22. PMID:15306129. |
we have analysed the expression of a truncated variant presenilin 2 protein (ps2v) in frontal cortex from subjects with alzheimer's disease (ad) and age-matched controls, and compared these results with cortex from bipolar disorder (bp), schizophrenia (sz) and controls in a second brain bank collection. |
2004-12-22 |
2023-08-12 |
human |
| Todd D Gould, Neil A Gray, Husseini K Manj. Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacological research. vol 48. issue 1. 2004-07-09. PMID:12770514. |
glycogen synthase kinase-3 (gsk-3) is an intermediary enzyme in various cellular pathways, and has been implicated in the pathophysiology and treatment of numerous diseases, including alzheimer's disease, diabetes, and bipolar disorder. |
2004-07-09 |
2023-08-12 |
mouse |
| M Alonso, A Martine. GSK-3 inhibitors: discoveries and developments. Current medicinal chemistry. vol 11. issue 6. 2004-05-27. PMID:15032729. |
glycogen synthase kinase 3 (gsk-3) in the 21(st) century emerged as one of the most attractive therapeutic target for the development of selective inhibitors as new promising drugs for unmet pathologies including alzheimer's disease, stroke, bipolar disorders, chronic inflammatory processes, cancer and diabetes type ii. |
2004-05-27 |
2023-08-12 |
Not clear |
| Süleyman Salih Zoroğlu, Muhittin Yürekli, Iclal Meram, Sadik Söğüt, Hamdi Tutkun, Ozer Yetkin, Ercan Sivasli, Haluk Asuman Savaş, Medaim Yanik, Hasan Herken, Omer Akyo. Pathophysiological role of nitric oxide and adrenomedullin in autism. Cell biochemistry and function. vol 21. issue 1. 2003-09-16. PMID:12579522. |
several studies indicate that nitric oxide (no) is involved in the aetiopathogenesis of many neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, alzheimer's disease, hungtington disease and stroke. |
2003-09-16 |
2023-08-12 |
human |
| L Naylor, B Dean, A Pereira, A Mackinnon, A Kouzmenko, D Copolo. No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter in human hippocampus. Molecular medicine (Cambridge, Mass.). vol 4. issue 10. 1999-03-04. PMID:9848084. |
allelic association case-control analysis of a deletion/insertion polymorphism in the serotonin transporter-linked polymorphic region (5-httlpr) has suggested associations with unipolar disorder, bipolar disorder, depression, and alzheimer's disease. |
1999-03-04 |
2023-08-12 |
human |