| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiani Yin, Wu Chen, Hongxing Yang, Mingshan Xue, Christian P Schaa. Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes. Scientific reports. vol 7. 2018-10-10. PMID:28045139. |
the alpha7 nicotinic acetylcholine receptor, encoded by the chrna7 gene, has been implicated in various psychiatric and behavioral disorders, including schizophrenia, bipolar disorder, epilepsy, autism, alzheimer's disease, and parkinson's disease, and is considered a potential target for therapeutic intervention. |
2018-10-10 |
2023-08-13 |
mouse |
| Shih-Jen Tsa. Effects of interleukin-1beta polymorphisms on brain function and behavior in healthy and psychiatric disease conditions. Cytokine & growth factor reviews. vol 37. 2018-05-29. PMID:28599834. |
this review describes previous studies on the genetic effects of il1b, which relate it to psychiatric diseases such as major depressive disorder, bipolar disorder, schizophrenia, and alzheimer's disease, as well as cognitive function in normal individuals. |
2018-05-29 |
2023-08-13 |
Not clear |
| Michael S Marshall, Benas Jakubauskas, Wil Bogue, Monika Stoskute, Zane Hauck, Emily Rue, Matthew Nichols, Lisa L DiAntonio, Richard B van Breemen, Jeffrey H Kordower, Carlos A Saavedra-Matiz, Ernesto R Bongarzon. Analysis of age-related changes in psychosine metabolism in the human brain. PloS one. vol 13. issue 2. 2018-05-25. PMID:29481565. |
we investigated psychosine accumulation and galc activity in the aging brain using fresh frozen post-mortem tissue from parkinson's (pd, n = 10), alzheimer's (ad, n = 10), and healthy control patients (n = 9), along with tissue from neuropsychiatric patients (schizophrenia, bipolar disorder and depression, n = 15 each). |
2018-05-25 |
2023-08-13 |
human |
| Uma Suryadevara, Dawn M Bruijnzeel, Meena Nuthi, Darin A Jagnarine, Rajiv Tandon, Adriaan W Bruijnzee. Pros and Cons of Medical Cannabis use by People with Chronic Brain Disorders. Current neuropharmacology. vol 15. issue 6. 2018-04-23. PMID:27804883. |
cannabis is widely used to self-medicate by older people and people with brain disorders such as amyotrophic lateral sclerosis (als), multiple sclerosis (ms), alzheimer's disease (ad), parkinson's disease (pd), bipolar disorder, and schizophrenia. |
2018-04-23 |
2023-08-13 |
Not clear |
| Na Chen, Yanping Bao, Yanxue Xue, Yan Sun, Die Hu, Shiqiu Meng, Lin Lu, Jie Sh. Meta-analyses of RELN variants in neuropsychiatric disorders. Behavioural brain research. vol 332. 2017-12-19. PMID:28506622. |
here, we conducted meta-analyses of reln gene snps and related neuropsychiatric disorders (schizophrenia, autistic spectrum disorders, attention-deficit hyperactivity disorder, alzheimer's disease and bipolar disorders). |
2017-12-19 |
2023-08-13 |
Not clear |
| C Sat. Releasing Mechanism of Neurotrophic Factors via Polysialic Acid. Vitamins and hormones. vol 104. 2017-11-02. PMID:28215308. |
the concentration of bdnf in body fluid is highly related to several neurodevelopmental and psychiatric diseases, including alzheimer's diseases, depression, schizophrenia, and bipolar disorder. |
2017-11-02 |
2023-08-13 |
Not clear |
| Bahar Güntekin, Erol Başa. Review of evoked and event-related delta responses in the human brain. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. vol 103. 2017-10-30. PMID:25660301. |
the present manuscript comprehensively reviews the studies on delta oscillatory responses upon cognitive stimulation in healthy subjects and in different pathologies, namely alzheimer's disease, mild cognitive impairment (mci), bipolar disorder, schizophrenia and alcoholism. |
2017-10-30 |
2023-08-13 |
human |
| Bahar Güntekin, Erol Başa. Review of evoked and event-related delta responses in the human brain. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. vol 103. 2017-10-30. PMID:25660301. |
a decrease of delta oscillatory responses could be a general electrophysiological marker for cognitive dysfunction (alzheimer's disease, mci, bipolar disorder, schizophrenia and alcoholism). |
2017-10-30 |
2023-08-13 |
human |
| David R Skvarc, Olivia M Dean, Linda K Byrne, Laura Gray, Stephen Lane, Matthew Lewis, Brisa S Fernandes, Michael Berk, Andrew Marriot. The effect of N-acetylcysteine (NAC) on human cognition - A systematic review. Neuroscience and biobehavioral reviews. vol 78. 2017-10-26. PMID:28438466. |
a systematic review of the literature specifically examining the effect of nac administration on human cognition revealed twelve suitable articles for inclusion: four examining alzheimer's disease; three examining healthy participants; two examining physical trauma; one examining bipolar disorder, one examining schizophrenia, and one examining ketamine-induced psychosis. |
2017-10-26 |
2023-08-13 |
human |
| Imran Khan, Mushtaq A Tantray, Mohammad Sarwar Alam, Hinna Hami. Natural and synthetic bioactive inhibitors of glycogen synthase kinase. European journal of medicinal chemistry. vol 125. 2017-03-07. PMID:27689729. |
aberrant gsk-3 has been involved in diabetes, inflammation, cancer, alzheimer's and bipolar disorder. |
2017-03-07 |
2023-08-13 |
Not clear |
| M Ferrari, C Comi, F Marino, L Magistrelli, F De Marchi, R Cantello, G Riboldazzi, G Bono, M Cosentin. Polymorphisms of dopamine receptor genes and risk of visual hallucinations in Parkinson's patients. European journal of clinical pharmacology. vol 72. issue 11. 2017-02-23. PMID:27497990. |
previous studies showed an association between dopamine receptor (dr) gene (dr) variants and psychosis in alzheimer's disease, addictions, schizophrenia, and bipolar disorder. |
2017-02-23 |
2023-08-13 |
Not clear |
| Michael H Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C Hermida, Ruana Tiseo, Linda L Sackett-Lundeen, Erhard L Hau. Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions. Sleep medicine reviews. vol 21. 2016-04-08. PMID:25129839. |
the symptom intensity and mortality of human diseases, conditions, and syndromes exhibit diurnal or 24 h patterning, e.g., skin: atopic dermatitis, urticaria, psoriasis, and palmar hyperhidrosis; gastrointestinal: esophageal reflux, peptic ulcer (including perforation and hemorrhage), cyclic vomiting syndrome, biliary colic, hepatic variceal hemorrhage, and proctalgia fugax; infection: susceptibility, fever, and mortality; neural: frontal, parietal, temporal, and occipital lobe seizures, parkinson's and alzheimer's disease, hereditary progressive dystonia, and pain (cancer, post-surgical, diabetic neuropathic and foot ulcer, tooth caries, burning mouth and temporomandibular syndromes, fibromyalgia, sciatica, intervertebral vacuum phenomenon, multiple sclerosis muscle spasm, and migraine, tension, cluster, hypnic, and paroxysmal hemicranial headache); renal: colic and nocturnal enuresis and polyuria; ocular: bulbar conjunctival redness, keratoconjunctivitis sicca, intraocular pressure and anterior ischemic optic neuropathy, and recurrent corneal erosion syndrome; psychiatric/behavioral: major and seasonal affective depressive disorders, bipolar disorder, parasuicide and suicide, dementia-associated agitation, and addictive alcohol, tobacco, and heroin cravings and withdrawal phenomena; plus autoimmune and musculoskeletal: rheumatoid arthritis, osteoarthritis, axial spondylarthritis, gout, sjögren's syndrome, and systemic lupus erythematosus. |
2016-04-08 |
2023-08-13 |
human |
| Deepmala, John Slattery, Nihit Kumar, Leanna Delhey, Michael Berk, Olivia Dean, Charles Spielholz, Richard Fry. Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. Neuroscience and biobehavioral reviews. vol 55. 2016-04-04. PMID:25957927. |
in this systematic review we find favorable evidence for the use of nac in several psychiatric and neurological disorders, particularly autism, alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy. |
2016-04-04 |
2023-08-13 |
Not clear |
| Melissa L Sinkus, Sharon Graw, Robert Freedman, Randal G Ross, Henry A Lester, Sherry Leonar. The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function. Neuropharmacology. vol 96. issue Pt B. 2016-03-22. PMID:25701707. |
chrna7 is genetically linked to multiple disorders with cognitive deficits, including schizophrenia, bipolar disorder, adhd, epilepsy, alzheimer's disease, and rett syndrome. |
2016-03-22 |
2023-08-13 |
human |
| Andrew G Hort. Development of [(18)F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomography. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26232729. |
exploration of the brain nicotinic acetylcholine receptors (nachrs) using positron-emission tomography (pet) will make it possible to better understand the important role of this receptor and to study its involvement in schizophrenia, bipolar disorder, alzheimer's and parkinson's diseases, drug dependence, inflammation and many other disorders and simplify the development of nicotinic drugs for treatment of these disorders. |
2016-02-09 |
2023-08-13 |
human |
| Beimeng Yang, Xiaoye Huang, Liemin Ruan, Tao Yu, Xin Li, Forrest Fabian Jesse, Yanfei Cao, Xingwang Li, Baocheng Liu, Fengping Yang, Yong-Seok Lee, Lin He, Weidong Li, Guang H. No association of SLC6A3 and SLC6A4 gene polymorphisms with schizophrenia in the Han Chinese population. Neuroscience letters. vol 579. 2015-05-12. PMID:25019689. |
abnormal expression and genetic polymorphism of slc6a3 and slc6a4 genes may increase the risk of developing mental illness, such as schizophrenia, bipolar disorder, adhd, and aggressive behavior in alzheimer disease, etc. |
2015-05-12 |
2023-08-13 |
Not clear |
| George S Zubenko, Hugh B Hughes, Rick M Jordan, James Lyons-Weiler, Bruce M Cohe. Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 165B. issue 6. 2015-03-30. PMID:25059218. |
pathway analyses highlighted 11 kegg pathways: the phosphatidylinositol signaling system, which has been widely implicated in mdd, bipolar disorder, and the action of mood stabilizers; gap junction and long-term potentiation, which mediate cognition and memory functions often impaired in mdd; cardiac muscle contraction, insulin signaling pathway, and three neurodegenerative brain disorders (alzheimer's, parkinson's, and huntington's diseases) that are associated with mdd; ribosome and proteasome pathways affecting protein synthesis/degradation; and the oxidative phosphorylation pathway that is key to energy production. |
2015-03-30 |
2023-08-13 |
mouse |
| Ye Chen, Judd Storrs, Lirong Tan, Lawrence J Mazlack, Jing-Huei Lee, Long J L. Detecting brain structural changes as biomarker from magnetic resonance images using a local feature based SVM approach. Journal of neuroscience methods. vol 221. 2014-08-13. PMID:24041480. |
we apply this approach to 3d mr images of alzheimer's disease, parkinson's disease and bipolar disorder. |
2014-08-13 |
2023-08-12 |
Not clear |
| Maud Cochet-Bissuel, Philippe Lory, Arnaud Montei. The sodium leak channel, NALCN, in health and disease. Frontiers in cellular neuroscience. vol 8. 2014-06-24. PMID:24904279. |
in addition, genes encoding nalcn, nlf- 1, unc-79, and unc-80 proteins may be susceptibility loci for several diseases including bipolar disorder, schizophrenia, alzheimer's disease, autism, epilepsy, alcoholism, cardiac diseases and cancer. |
2014-06-24 |
2023-08-13 |
human |
| Mary Ann Raghanti, Melissa K Edler, Richard S Meindl, Jessica Sudduth, Tatiana Bohush, Joseph M Erwin, Cheryl D Stimpson, Patrick R Hof, Chet C Sherwoo. Humans and great apes share increased neocortical neuropeptide Y innervation compared to other haplorhine primates. Frontiers in human neuroscience. vol 8. 2014-03-11. PMID:24616688. |
a decrease in neocortical npy has been reported for alzheimer's disease, schizophrenia, bipolar disorder, and depression, potentially contributing to associated cognitive deficits. |
2014-03-11 |
2023-08-12 |
monkey |