| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenji Matsushita, Masae Yamada-Furukawa, Mie Kurosawa, Yosuke Shikam. Periodontal Disease and Periodontal Disease-Related Bacteria Involved in the Pathogenesis of Alzheimer's Disease. Journal of inflammation research. vol 13. 2020-09-28. PMID:32636667. |
alzheimer's disease (ad) is the most common cause of dementia, and it exhibits pathological properties such as deposition of extracellular amyloid β (aβ) and abnormally phosphorylated tau in nerve cells and a decrease of synapses. |
2020-09-28 |
2023-08-13 |
Not clear |
| Mercedes A Hernández-Sapiéns, Edwin E Reza-Zaldívar, Ricardo R Cevallos, Ana L Márquez-Aguirre, Karlen Gazarian, Alejandro A Canales-Aguirr. A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32655369. |
alzheimer's disease (ad) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-β (aβ) and intracellular accumulation of hyperphosphorylated tau protein, primarily in areas implicated in memory and learning as prefrontal cortex and hippocampus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hoon Lim, Dahm Lee, Wan Kyu Choi, Soo Jin Choi, Wonil Oh, Dong Hyun Ki. Galectin-3 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Reduces Aberrant Tau Phosphorylation in an Alzheimer Disease Model. Stem cells international. vol 2020. 2020-09-28. PMID:32733573. |
galectin-3 secreted by human umbilical cord blood-derived mesenchymal stem cells reduces aberrant tau phosphorylation in an alzheimer disease model. |
2020-09-28 |
2023-08-13 |
human |
| Anna Vasilevskaya, Foad Taghdiri, Namita Multani, Cassandra Anor, Karen Misquitta, Sylvain Houle, Charles Burke, David Tang-Wai, Anthony E Lang, Susan Fox, Elizabeth Slow, Pablo Rusjan, Maria C Tartagli. PET Tau Imaging and Motor Impairments Differ Between Corticobasal Syndrome and Progressive Supranuclear Palsy With and Without Alzheimer's Disease Biomarkers. Frontiers in neurology. vol 11. 2020-09-28. PMID:32754109. |
pet tau imaging and motor impairments differ between corticobasal syndrome and progressive supranuclear palsy with and without alzheimer's disease biomarkers. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sarah Houben, Marie-Ange de Fisenne, Kunie Ando, Virginie Vanden Dries, Luc Poncelet, Zehra Yilmaz, Salwa Mansour, Robert De Decker, Jean-Pierre Brion, Karelle Lero. Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32765217. |
intravenous injection of phf-tau proteins from alzheimer brain exacerbates neuroinflammation, amyloid beta, and tau pathologies in 5xfad transgenic mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Sarah Houben, Marie-Ange de Fisenne, Kunie Ando, Virginie Vanden Dries, Luc Poncelet, Zehra Yilmaz, Salwa Mansour, Robert De Decker, Jean-Pierre Brion, Karelle Lero. Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32765217. |
alzheimer's disease (ad) is characterized by the accumulation in the brain of intraneuronal aggregates of abnormally and hyperphosphorylated tau proteins and of extracellular deposits of amyloid-β surrounded by dystrophic neurites. |
2020-09-28 |
2023-08-13 |
mouse |
| Hui-Fu Wang, Xue-Ning Shen, Jie-Qiong Li, John Suckling, Chen-Chen Tan, Yan-Jiang Wang, Lei Feng, Can Zhang, Lan Tan, Qiang Dong, Jacques Touchon, Serge Gauthier, Jin-Tai Y. Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2020-09-28. PMID:32793801. |
amyloid beta (aβ) deposition was identified to precede tau pathology and neurodegeneration in familial alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Athanasia K Papazafiropoulou, Chris Koros, Andreas Melidonis, Stavros Antonopoulo. Diabetes and dementia - the two faces of Janus. Archives of medical sciences. Atherosclerotic diseases. vol 5. 2020-09-28. PMID:32832719. |
in addition, experimental studies on patients with diabetes and alzheimer's disease have shown beneficial effects on synaptic plasticity, metabolism of amyloid-β, and microtubule-associated protein tau. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yanyan Kong, Cuiping Liu, Yinping Zhou, Jingxuan Qi, Chencheng Zhang, Bomin Sun, Jiao Wang, Yihui Gua. Progress of RAGE Molecular Imaging in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32848706. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by senile plaques (sps), which are caused by amyloid beta (aβ) deposition and neurofibrillary tangles (nfts) of abnormal hyperphosphorylated tau protein. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sanjib Guha, Sarah Fischer, Anson Cheng, Gail V W Johnson, Keith Nehrk. A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer's disease Causes Activation of the Mitochondrial Unfolded Protein Response in microPublication biology. vol 2020. 2020-09-28. PMID:32939445. |
a t231e mutant that mimics pathologic phosphorylation of tau in alzheimer's disease causes activation of the mitochondrial unfolded protein response in |
2020-09-28 |
2023-08-13 |
Not clear |
| Anna L Cranston, Adrianna Wysocka, Marta Steczkowska, Maciej Zadrożny, Ewelina Palasz, Charles R Harrington, Franz Theuring, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954291. |
cholinergic and inflammatory phenotypes in transgenic tau mouse models of alzheimer's disease and frontotemporal lobar degeneration. |
2020-09-28 |
2023-08-13 |
mouse |
| Anna L Cranston, Adrianna Wysocka, Marta Steczkowska, Maciej Zadrożny, Ewelina Palasz, Charles R Harrington, Franz Theuring, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954291. |
we recently presented two mouse models: line 1, expressing the truncated tau fragment identified as the core of the alzheimer's paired helical filament, and line 66, expressing full-length human tau carrying a double mutation (p301s and g335d). |
2020-09-28 |
2023-08-13 |
mouse |
| Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba, Rita Florio, Roberta Ciarapica, Roberto Coccurello, Marcello D'Amelio, Martine Ammassari-Teule, Claudio Grassi, Pietro Calissano, Giuseppina Amador. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954296. |
passive immunotherapy for n-truncated tau ameliorates the cognitive deficits in two mouse alzheimer's disease models. |
2020-09-28 |
2023-08-13 |
mouse |
| Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba, Rita Florio, Roberta Ciarapica, Roberto Coccurello, Marcello D'Amelio, Martine Ammassari-Teule, Claudio Grassi, Pietro Calissano, Giuseppina Amador. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954296. |
clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of alzheimer's disease. |
2020-09-28 |
2023-08-13 |
mouse |
| Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba, Rita Florio, Roberta Ciarapica, Roberto Coccurello, Marcello D'Amelio, Martine Ammassari-Teule, Claudio Grassi, Pietro Calissano, Giuseppina Amador. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954296. |
we have explored whether passive immunization with the 12a12 monoclonal antibody (26-36aa of tau protein) could improve the alzheimer's disease phenotype of two well-established mouse models, tg2576 and 3xtg mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Alireza Faridar, Aaron D Thome, Weihua Zhao, Jason R Thonhoff, David R Beers, Belen Pascual, Joseph C Masdeu, Stanley H Appe. Restoring regulatory T-cell dysfunction in Alzheimer's disease through Brain communications. vol 2. issue 2. 2020-09-28. PMID:32954348. |
while neuroprotective microglia are important for containment/clearance of amyloid plaques and maintaining neuronal survival, alzheimer inflammatory microglia may play a detrimental role by eliciting tau pathogenesis and accelerating neurotoxicity. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yan-Hui Zhang, Xin-Zhu Yan, Shuang-Feng Xu, Zhong-Qiu Pang, Lin-Bo Li, Yang Yang, Yong-Gang Fan, Zhuo Wang, Xin Yu, Chuang Guo, Qiang A. α-Lipoic Acid Maintains Brain Glucose Metabolism Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32973490. |
α-lipoic acid maintains brain glucose metabolism the microtubule-associated protein tau is closely correlated with hypometabolism in alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
mouse |
| Sajini D Hettiarachchi, Yiqun Zhou, Elif Seven, Madepalli K Lakshmana, Ajeet K Kaushik, Hitendra S Chand, Roger M Leblan. Nanoparticle-mediated approaches for Alzheimer's disease pathogenesis, diagnosis, and therapeutics. Journal of controlled release : official journal of the Controlled Release Society. vol 314. 2020-09-25. PMID:31647979. |
deposition of the amyloid β plaques has been identified as the most common ad pathology; however, the excessive accumulation of phosphorylated or total tau proteins, reactive oxygen species, and higher acetylcholinesterase activity are also strongly associated with alzheimer's dementia. |
2020-09-25 |
2023-08-13 |
Not clear |
| Diana K Franco-Bocanegra, Bethany George, Laurie C Lau, Clive Holmes, James A R Nicoll, Delphine Boch. Microglial motility in Alzheimer's disease and after Aβ42 immunotherapy: a human post-mortem study. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31703599. |
experimental evidence suggests impaired microglial motility in alzheimer's disease (ad) and therefore we have investigated whether the expression of proteins associated with motility is altered in ad and affected by the aβ immunotherapy using post-mortem brain tissue of 32 controls, 44 ad cases, and 16 ad cases from our unique group of patients immunised against aβ42 (iad).sections of brain were immunolabelled and quantified for (i) the motility-related microglial proteins iba1, cofilin 1 (cfl1), coronin-1a (coro1a) and p2ry12, and (ii) pan-aβ, aβ42 and phosphorylated tau (ptau). |
2020-09-25 |
2023-08-13 |
human |
| Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31722749. |
intraneuronal insoluble inclusions made of tau protein are neuropathological hallmarks of alzheimer disease (ad). |
2020-09-25 |
2023-08-13 |
mouse |