| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Grace I Hallinan, Aleksandra P Pitera, Prutha Patel, Jonathan West, Katrin Deinhard. Minimalistic in vitro systems for investigating tau pathology. Journal of neuroscience methods. vol 319. 2020-08-19. PMID:30278185. |
neurofibrillary tangles, formed of hyperphosphorylated, misfolded tau accumulations, are a pathological hallmark of neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal dementia. |
2020-08-19 |
2023-08-13 |
Not clear |
| b' Mirta Boban, Mirjana Babi\\xc4\\x87 Leko, Terezija Mi\\xc5\\xa1ki\\xc4\\x87, Patrick R Hof, Goran \\xc5\\xa0imi\\xc4\\x8. Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species. Journal of neuroscience methods. vol 319. 2020-08-19. PMID:30278184.' |
early stages of alzheimer's disease (ad) are characterized by high phosphorylation of microtubule-associated protein tau, which may result from the downregulation of protein phosphatases. |
2020-08-19 |
2023-08-13 |
human |
| Henrik Zetterber. Blood-based biomarkers for Alzheimer's disease-An update. Journal of neuroscience methods. vol 319. 2020-08-19. PMID:30352211. |
cerebrospinal fluid (csf) biomarkers for alzheimer's disease (ad) are in clinical use in many parts of the world and show good to excellent diagnostic accuracy in regards to identifying cerebral amyloid β (aβ) and tau pathology irrespective of the clinical stage of the disease. |
2020-08-19 |
2023-08-13 |
Not clear |
| Lihong Ge, Yang Tia. Fluorescence Lifetime Imaging of p-tau Protein in Single Neuron with a Highly Selective Fluorescent Probe. Analytical chemistry. vol 91. issue 5. 2020-08-19. PMID:30706715. |
hyperphosphorylated tau (p-tau) protein is one of the key markers of alzheimer's disease (ad). |
2020-08-19 |
2023-08-13 |
Not clear |
| Amy Craig, Faisal Parvez, Jon Issberne. A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer's Disease in transgenic mice. Behavioural brain research. vol 372. 2020-08-19. PMID:31255671. |
alzheimer's disease (ad) presents as a gradual decline in cognitive function, with its characteristic pathology consisting of amyloid β (aβ) accumulation and hyperphosphorylated tau. |
2020-08-19 |
2023-08-13 |
mouse |
| Yachen Shi, Xiang Lu, Linhai Zhang, Hao Shu, Lihua Gu, Zan Wang, Lijuan Gao, Jianli Zhu, Haisan Zhang, Deyu Zhou, Zhijun Zhan. Potential Value of Plasma Amyloid-β, Total Tau, and Neurofilament Light for Identification of Early Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 8. 2020-08-18. PMID:31145586. |
potential value of plasma amyloid-β, total tau, and neurofilament light for identification of early alzheimer's disease. |
2020-08-18 |
2023-08-13 |
human |
| Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett, Mary E Hill, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31782760. |
to dissect contributions of individual pathologies to cognitive function, we used the tgf344-ad rat model, which recapitulates the salient hallmarks of alzheimer's disease pathology observed in patient populations (amyloid, tau inclusions, frank neuronal loss, and cognitive deficits). |
2020-08-18 |
2023-08-13 |
rat |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834353. |
we hypothesized that the cognitive impairment in drug-resistant temporal lobe epilepsy could be due to perturbations of amyloid and tau signalling pathways related to activation of stress kinases, similar to those observed in alzheimer's disease. |
2020-08-18 |
2023-08-13 |
Not clear |
| Tobey J Betthauser, Rebecca L Koscik, Erin M Jonaitis, Samantha L Allison, Karly A Cody, Claire M Erickson, Howard A Rowley, Charles K Stone, Kimberly D Mueller, Lindsay R Clark, Cynthia M Carlsson, Nathaniel A Chin, Sanjay Asthana, Bradley T Christian, Sterling C Johnso. Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31886494. |
this study investigated differences in retrospective cognitive trajectories between amyloid and tau pet biomarker stratified groups in initially cognitively unimpaired participants sampled from the wisconsin registry for alzheimer's prevention. |
2020-08-18 |
2023-08-13 |
human |
| Tobey J Betthauser, Rebecca L Koscik, Erin M Jonaitis, Samantha L Allison, Karly A Cody, Claire M Erickson, Howard A Rowley, Charles K Stone, Kimberly D Mueller, Lindsay R Clark, Cynthia M Carlsson, Nathaniel A Chin, Sanjay Asthana, Bradley T Christian, Sterling C Johnso. Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31886494. |
these results suggest that the combination of pathological amyloid and tau is detrimental to cognitive decline in preclinical alzheimer's disease during late middle-age. |
2020-08-18 |
2023-08-13 |
human |
| Jacob W Vogel, Yasser Iturria-Medina, Olof T Strandberg, Ruben Smith, Elizabeth Levitis, Alan C Evans, Oskar Hansso. Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-08-18. PMID:32457389. |
spread of pathological tau proteins through communicating neurons in human alzheimer's disease. |
2020-08-18 |
2023-08-13 |
human |
| Jacob W Vogel, Yasser Iturria-Medina, Olof T Strandberg, Ruben Smith, Elizabeth Levitis, Alan C Evans, Oskar Hansso. Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-08-18. PMID:32457389. |
tau is a hallmark pathology of alzheimer's disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (aβ). |
2020-08-18 |
2023-08-13 |
human |
| Jacob W Vogel, Yasser Iturria-Medina, Olof T Strandberg, Ruben Smith, Elizabeth Levitis, Alan C Evans, Oskar Hansso. Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-08-18. PMID:32457389. |
we test this hypothesis in humans using an epidemic spreading model (esm) to simulate tau spread, and compare these simulations to observed patterns measured using tau-pet in 312 individuals along alzheimer's disease continuum. |
2020-08-18 |
2023-08-13 |
human |
| Nicholas M Kanaan, Chelsey Hamel, Tessa Grabinski, Benjamin Comb. Liquid-liquid phase separation induces pathogenic tau conformations in vitro. Nature communications. vol 11. issue 1. 2020-08-18. PMID:32499559. |
recently, tau, a protein known for its involvement in alzheimer's disease and other tauopathies, was found to undergo liquid-liquid phase separation making it one of several proteins associated with neurodegenerative diseases to do so. |
2020-08-18 |
2023-08-13 |
Not clear |
| Yoshiyuki Soeda, Marino Saito, Sumihiro Maeda, Kohki Ishida, Akira Nakamura, Shuichi Kojima, Akihiko Takashim. Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 68. issue 4. 2020-08-17. PMID:30909223. |
methylene blue inhibits formation of tau fibrils but not of granular tau oligomers: a plausible key to understanding failure of a clinical trial for alzheimer's disease. |
2020-08-17 |
2023-08-13 |
mouse |
| Yoshiyuki Soeda, Marino Saito, Sumihiro Maeda, Kohki Ishida, Akira Nakamura, Shuichi Kojima, Akihiko Takashim. Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 68. issue 4. 2020-08-17. PMID:30909223. |
alzheimer's disease pathology is characterized by extracellular deposits of amyloid-β (aβ) and intracellular inclusions of hyperphosphorylated tau. |
2020-08-17 |
2023-08-13 |
mouse |
| Yoshiyuki Soeda, Marino Saito, Sumihiro Maeda, Kohki Ishida, Akira Nakamura, Shuichi Kojima, Akihiko Takashim. Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 68. issue 4. 2020-08-17. PMID:30909223. |
although genetic studies of familial alzheimer's disease suggest a causal link between aβ and disease symptoms, the failure of various aβ-targeted strategies to slow or halt disease progression has led to consideration of the idea that inhibition of tau aggregation might be a more promising therapeutic approach. |
2020-08-17 |
2023-08-13 |
mouse |
| Gwang-Ho Kim, Kyunghyun Lim, Hae Sung Yang, Ji-Kwang Lee, Yehlim Kim, Sang-Kyu Park, So-Hyeon Kim, Suhyeon Park, Tae-Hee Kim, Jong-Seok Moon, In Koo Hwang, Yeo Sung Yoon, Hyung Seok Seo, Sung Min Nam, Mi-Yeon Kim, Seul Gi Yoon, Je Kyung Seong, Sun Shin Y. Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. Journal of chemical neuroanatomy. vol 98. 2020-08-17. PMID:30951822. |
quantitative analysis of tau protein, which is a marker of alzheimer's disease, was performed in the sd rats and dba/2 mice by repeated pf oral administration and ptau/tau values were significantly decreased in pf-treated group than vehicle-treated group. |
2020-08-17 |
2023-08-13 |
mouse |
| Pei-Pei Guan, Xin Yu, Yan-Hui Zou, Pu Wan. Cyclooxygenase-2 is critical for the propagation of β-amyloid protein and reducing the glycosylation of tau in Alzheimer's disease. Cellular & molecular immunology. vol 16. issue 11. 2020-08-14. PMID:31551514. |
cyclooxygenase-2 is critical for the propagation of β-amyloid protein and reducing the glycosylation of tau in alzheimer's disease. |
2020-08-14 |
2023-08-13 |
Not clear |
| Yusuke Nakatsu, Yasuka Matsunaga, Koji Ueda, Takeshi Yamamotoya, Yuki Inoue, Masa-Ki Inoue, Yu Mizuno, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asan. Development of Pin1 Inhibitors and their Potential as Therapeutic Agents. Current medicinal chemistry. vol 27. issue 20. 2020-08-12. PMID:30394205. |
notably, pin1 deficiency or inactivation is a potential cause of alzheimer's disease, since pin1 induces the degradation of tau. |
2020-08-12 |
2023-08-13 |
mouse |