| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinyi Lv, Zhaozhao Cheng, Qiong Wang, Feng Gao, Linbin Dai, Chen Du, Chang Liu, Qiang Xie, Yong Shen, Jiong Sh. High burdens of phosphorylated tau protein and distinct precuneus atrophy in sporadic early-onset Alzheimer's disease. Science bulletin. 2023-11-02. PMID:37919158. |
high burdens of phosphorylated tau protein and distinct precuneus atrophy in sporadic early-onset alzheimer's disease. |
2023-11-02 |
2023-11-08 |
human |
| Ryan T Muir, Zahinoor Ismail, Sandra E Black, Eric E Smit. Comparative methods for quantifying plasma biomarkers in Alzheimer's disease: Implications for the next frontier in cerebral amyloid angiopathy diagnostics. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-11-01. PMID:37908054. |
plasma amyloid beta (aβ) and tau are emerging as accessible biomarkers for alzheimer's disease (ad). |
2023-11-01 |
2023-11-08 |
Not clear |
| Airi Tarutani, Fuyuki Kametani, Marina Tahira, Yuko Saito, Mari Yoshida, Andrew C Robinson, David M A Mann, Shigeo Murayama, Taisuke Tomita, Masato Hasegaw. Distinct tau folds initiate templated seeding and alter the post-translational modification profile. Brain : a journal of neurology. 2023-10-31. PMID:37904205. |
pathological tau accumulates in the brain in tauopathies such as alzheimer's disease, pick's disease, progressive supranuclear palsy and corticobasal degeneration, and forms amyloid-like filaments incorporating various post-translational modifications (ptms). |
2023-10-31 |
2023-11-08 |
Not clear |
| Dandan Chu, Xingyue Yang, Jing Wang, Yan Zhou, Jin-Hua Gu, Jin Miao, Feng Wu, Fei Li. Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905868. |
tau truncation in the pathogenesis of alzheimer's disease: a narrative review. |
2023-10-31 |
2023-11-08 |
Not clear |
| Dandan Chu, Xingyue Yang, Jing Wang, Yan Zhou, Jin-Hua Gu, Jin Miao, Feng Wu, Fei Li. Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905868. |
alzheimer's disease is characterized by two major neuropathological hallmarks-the extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated tau protein. |
2023-10-31 |
2023-11-08 |
Not clear |
| Dandan Chu, Xingyue Yang, Jing Wang, Yan Zhou, Jin-Hua Gu, Jin Miao, Feng Wu, Fei Li. Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905868. |
recent studies suggest that dysregulation of the microtubule-associated protein tau, especially specific proteolysis, could be a driving force for alzheimer's disease neurodegeneration. |
2023-10-31 |
2023-11-08 |
Not clear |
| Dandan Chu, Xingyue Yang, Jing Wang, Yan Zhou, Jin-Hua Gu, Jin Miao, Feng Wu, Fei Li. Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905868. |
this review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments, investigates the role of specific truncations in physiological and pathological states of alzheimer's disease, and summarizes the latest applications of strategies targeting tau fragments in the diagnosis and treatment of alzheimer's disease. |
2023-10-31 |
2023-11-08 |
Not clear |
| Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer Gupta, Christine T O Nguyen, David I Finkelstein, Yuyi You, Paul A Haynes, Ghasem H Salekdeh, Stuart L Graham, Mehdi Mirzae. Amyloid-beta and tau protein beyond Alzheimer's disease. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905874. |
amyloid-beta and tau protein beyond alzheimer's disease. |
2023-10-31 |
2023-11-08 |
human |
| Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer Gupta, Christine T O Nguyen, David I Finkelstein, Yuyi You, Paul A Haynes, Ghasem H Salekdeh, Stuart L Graham, Mehdi Mirzae. Amyloid-beta and tau protein beyond Alzheimer's disease. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905874. |
the aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. |
2023-10-31 |
2023-11-08 |
human |
| Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer Gupta, Christine T O Nguyen, David I Finkelstein, Yuyi You, Paul A Haynes, Ghasem H Salekdeh, Stuart L Graham, Mehdi Mirzae. Amyloid-beta and tau protein beyond Alzheimer's disease. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905874. |
recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like glaucoma and age-related macular degeneration. |
2023-10-31 |
2023-11-08 |
human |
| Zheng Shen, Daxiao Sun, Adriana Savastano, Sára Joana Varga, Maria-Sol Cima-Omori, Stefan Becker, Alf Honigmann, Markus Zweckstette. Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density. Nature communications. vol 14. issue 1. 2023-10-30. PMID:37891164. |
cognitive impairment in alzheimer's disease has been associated with the localization of the microtubule-associated protein tau at the postsynapse. |
2023-10-30 |
2023-11-08 |
Not clear |
| Ethan D Smith, Quan Vo, Benoit I Giasson, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau. Acta neuropathologica communications. vol 11. issue 1. 2023-10-30. PMID:37891635. |
using detergent-insoluble tau isolated from alzheimer's disease (ad-tau) or progressive supranuclear palsy (psp-tau) patients, we provide insights into whether phosphorylation of critical residues determine templated tau seeding. |
2023-10-30 |
2023-11-08 |
human |
| Melina J Lim, Suelen L Boschen, Aishe Kurti, Monica Castanedes Casey, Virginia R Phillips, John D Fryer, Dennis Dickson, Karen R Jansen-West, Leonard Petrucelli, Marion Delenclos, Pamela J McLea. Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893236. |
lbd falls within an undefined range between alzheimer's disease (ad) and parkinson's disease (pd) due to the potential pathogenic synergistic effects of tau, beta-amyloid (aβ), and alpha-synuclein (αsyn). |
2023-10-30 |
2023-11-08 |
mouse |
| Phuong H Nguyen, Philippe Derreumau. Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer's Disease. Molecules (Basel, Switzerland). vol 28. issue 20. 2023-10-30. PMID:37894559. |
recent computational advances regarding amyloid-β and tau membrane interactions in alzheimer's disease. |
2023-10-30 |
2023-11-08 |
human |
| Ángel Abdiel Robles-Gómez, Benito Ordaz, Jonathan-Julio Lorea-Hernández, Fernando Peña-Orteg. Deleterious and protective effects of epothilone-D alone and in the context of amyloid β- and tau-induced alterations. Frontiers in molecular neuroscience. vol 16. 2023-10-30. PMID:37900942. |
amyloid-β (aβ) and hyperphosphorylated tau (p-tau) are alzheimer's disease (ad) biomarkers that interact in a complex manner to induce most of the cognitive and brain alterations observed in this disease. |
2023-10-30 |
2023-11-08 |
mouse |
| Amanda L Edwards, Jessica A Collins, Candice Junge, Holly Kordasiewicz, Laurence Mignon, Shuang Wu, Yumeng Li, Lin Lin, Jonathan DuBois, R Matthew Hutchison, Nick Ziogas, Melanie Shulman, Laurent Martarello, Danielle Graham, Roger Lane, Samantha Budd Haeberlein, John Beave. Exploratory Tau Biomarker Results From a Multiple Ascending-Dose Study of BIIB080 in Alzheimer Disease: A Randomized Clinical Trial. JAMA neurology. 2023-10-30. PMID:37902726. |
exploratory tau biomarker results from a multiple ascending-dose study of biib080 in alzheimer disease: a randomized clinical trial. |
2023-10-30 |
2023-11-08 |
Not clear |
| Amanda L Edwards, Jessica A Collins, Candice Junge, Holly Kordasiewicz, Laurence Mignon, Shuang Wu, Yumeng Li, Lin Lin, Jonathan DuBois, R Matthew Hutchison, Nick Ziogas, Melanie Shulman, Laurent Martarello, Danielle Graham, Roger Lane, Samantha Budd Haeberlein, John Beave. Exploratory Tau Biomarker Results From a Multiple Ascending-Dose Study of BIIB080 in Alzheimer Disease: A Randomized Clinical Trial. JAMA neurology. 2023-10-30. PMID:37902726. |
accumulation of hyperphosphorylated, tangled microtubule-associated protein tau (mapt) is a pathological hallmark of alzheimer disease (ad) associated with disease progression and cognitive decline. |
2023-10-30 |
2023-11-08 |
Not clear |
| Yi Dong, Tingting Hou, Yuanjing Li, Rui Liu, Lin Cong, Keke Liu, Cuicui Liu, Xiaolei Han, Yifei Ren, Shi Tang, Bengt Winblad, Kaj Blennow, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Plasma Amyloid-β, Total Tau, and Neurofilament Light Chain Across the Alzheimer's Disease Clinical Spectrum: A Population-Based Study. Journal of Alzheimer's disease : JAD. 2023-10-29. PMID:37899059. |
plasma amyloid-β, total tau, and neurofilament light chain across the alzheimer's disease clinical spectrum: a population-based study. |
2023-10-29 |
2023-11-08 |
Not clear |
| Lanxia Meng, Congcong Liu, Miao Liu, Jiehui Chen, Chaoyang Liu, Zhaohui Zhang, Guiqin Chen, Zhentao Zhan. The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897723. |
the molecular mechanisms that trigger tau aggregation in alzheimer's disease (ad) remain elusive. |
2023-10-28 |
2023-11-08 |
mouse |
| Madeline Ally, Michael A Sugarman, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Thomas K Karikari, Hugo J Aparicio, Brandon Frank, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Lindsay A Farrer, Gyungah R Jun, Katherine W Turk, Andrew E Budson, Maureen K O'Connor, Rhoda Au, Lee E Goldstein, Neil W Kowall, Ronald Killiany, Robert A Stern, Thor D Stein, Ann C McKee, Wei Qiao Qiu, Jesse Mez, Michael L Alosc. Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 15. issue 4. 2023-10-27. PMID:37885919. |
this study examined plasma glial fibrillary acidic protein (gfap) as a biomarker of cognitive impairment due to alzheimer's disease (ad) with and against plasma neurofilament light chain (nfl), and phosphorylated tau (p-tau) |
2023-10-27 |
2023-11-08 |
Not clear |