| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donata De Marco, Renske Taggenbrock, Rosa Crespo, Wouter Koudstaal, Elizabeth Ramsburg, Adrian Apetr. Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia. Journal of visualized experiments : JoVE. issue 141. 2019-05-20. PMID:30474638. |
alzheimer's disease (ad) is a progressive neurodegenerative condition in which aggregated tau and amyloid proteins accumulate in the brain causing neuronal dysfunction which eventually leads to cognitive decline. |
2019-05-20 |
2023-08-13 |
mouse |
| Suzanne E Schindler, Courtney L Sutphen, Charlotte Teunissen, Lena M McCue, John C Morris, David M Holtzman, Sandra D Mulder, Philip Scheltens, Chengjie Xiong, Anne M Faga. Upward drift in cerebrospinal fluid amyloid β 42 assay values for more than 10 years. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 1. 2019-05-17. PMID:28710906. |
the best-established cerebrospinal fluid (csf) biomarkers for alzheimer's disease are levels of amyloid β 42 (aβ42), total tau (tau), and phosphorylated tau 181 (ptau). |
2019-05-17 |
2023-08-13 |
Not clear |
| Ivan A Kuznetsov, Andrey V Kuznetso. Investigating sensitivity coefficients characterizing the response of a model of tau protein transport in an axon to model parameters. Computer methods in biomechanics and biomedical engineering. vol 22. issue 1. 2019-05-17. PMID:30580604. |
this is an important problem due to the relevance of tau transport and agglomeration to alzheimer's disease and other tauopathies, such as some forms of parkinsonism. |
2019-05-17 |
2023-08-13 |
Not clear |
| Joseph Park, Isaac Wetzel, Ian Marriott, Didier Dréau, Carla D'Avanzo, Doo Yeon Kim, Rudolph E Tanzi, Hansang Ch. A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease. Nature neuroscience. vol 21. issue 7. 2019-05-16. PMID:29950669. |
alzheimer's disease (ad) is characterized by beta-amyloid accumulation, phosphorylated tau formation, hyperactivation of glial cells, and neuronal loss. |
2019-05-16 |
2023-08-13 |
human |
| Heidi I L Jacobs, Trey Hedden, Aaron P Schultz, Jorge Sepulcre, Rodrigo D Perea, Rebecca E Amariglio, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnso. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature neuroscience. vol 21. issue 3. 2019-05-15. PMID:29403032. |
animal models of alzheimer's disease have suggested that tau pathology propagation, facilitated by amyloid pathology, may occur along connected pathways. |
2019-05-15 |
2023-08-13 |
Not clear |
| Zhen Zhang, Jingyu Yang, Chen Liu, Jun Xie, Shi Qiu, Xue Yang, Chunfu W. Pseudoginsenoside-F11 alleviates cognitive deficits and Alzheimer's disease-type pathologies in SAMP8 mice. Pharmacological research. vol 139. 2019-05-14. PMID:30394318. |
alzheimer's disease (ad) is a common neurodegenerative disease which is characterized by aggregation of amyloid beta (aβ) and hyperphosphorylated tau. |
2019-05-14 |
2023-08-13 |
mouse |
| Michael Honer, Luca Gobbi, Henner Knust, Hiroto Kuwabara, Dieter Muri, Matthias Koerner, Heather Valentine, Robert F Dannals, Dean F Wong, Edilio Borron. Preclinical Evaluation of Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 4. 2019-05-13. PMID:28970331. |
preclinical evaluation of tau aggregates and amyloid-β (aβ) plaques are key histopathologic features in alzheimer disease (ad) and are considered targets for therapeutic intervention as well as biomarkers for diagnostic in vivo imaging agents. |
2019-05-13 |
2023-08-13 |
human |
| Joanna K Chang, Allison Leso, Gehad M Subaiea, Asma Lahouel, Anwar Masoud, Foqia Mushtaq, Reem Deeb, Aseel Eid, Miriam Dash, Syed W Bihaqi, Nasser H Zawi. Tolfenamic Acid: A Modifier of the Tau Protein and its Role in Cognition and Tauopathy. Current Alzheimer research. vol 15. issue 7. 2019-05-13. PMID:29357795. |
tangles are deposits of hyperphosphorylated tau, which are found in multiple neurodegenerative disorders that are referred to as tauopathies, of which alzheimer's disease (ad) is the most common. |
2019-05-13 |
2023-08-13 |
Not clear |
| Yunsheng Liu, Lan Cao, Xiaoxu Zhang, Yan Liang, Yuxia Xu, Cuiqing Zh. Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice. Neural plasticity. vol 2019. 2019-05-13. PMID:30906318. |
exposure to chronic psychiatric stress has been linked to alzheimer's disease-related tau hyperphosphorylation and abnormalities in glutamate neurotransmission. |
2019-05-13 |
2023-08-13 |
mouse |
| Jorge Sepulcre, Michel J Grothe, Federico d'Oleire Uquillas, Laura Ortiz-Terán, Ibai Diez, Hyun-Sik Yang, Heidi I L Jacobs, Bernard J Hanseeuw, Quanzheng Li, Georges El-Fakhri, Reisa A Sperling, Keith A Johnso. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature medicine. vol 24. issue 12. 2019-05-08. PMID:30374196. |
tau and amyloid beta (aβ) proteins accumulate along neuronal circuits in alzheimer's disease. |
2019-05-08 |
2023-08-13 |
human |
| Zhibin Liang, Qing X L. Discovery of Selective, Substrate-Competitive, and Passive Membrane Permeable Glycogen Synthase Kinase-3β Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling of New C-Glycosylflavones. ACS chemical neuroscience. vol 9. issue 5. 2019-05-07. PMID:29381861. |
glycogen synthase kinase-3β (gsk-3β) is a key enzyme responsible for tau hyperphosphorylation and is a viable therapeutic target of alzheimer's disease (ad). |
2019-05-07 |
2023-08-13 |
Not clear |
| Federico d'Oleire Uquillas, Heidi I L Jacobs, Kelsey D Biddle, Michael Properzi, Bernard Hanseeuw, Aaron P Schultz, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Nancy J Donova. Regional tau pathology and loneliness in cognitively normal older adults. Translational psychiatry. vol 8. issue 1. 2019-05-06. PMID:30563962. |
this study examined whether greater loneliness was associated with tau pathology, the other defining feature of alzheimer's disease, in 117 cognitively normal older adults. |
2019-05-06 |
2023-08-13 |
Not clear |
| Federico d'Oleire Uquillas, Heidi I L Jacobs, Kelsey D Biddle, Michael Properzi, Bernard Hanseeuw, Aaron P Schultz, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Nancy J Donova. Regional tau pathology and loneliness in cognitively normal older adults. Translational psychiatry. vol 8. issue 1. 2019-05-06. PMID:30563962. |
we found that higher tau pathology in the right entorhinal cortex was associated with greater loneliness, controlling for age, sex, and apolipoprotein e ε4, the alzheimer's disease genetic risk marker. |
2019-05-06 |
2023-08-13 |
Not clear |
| Javier Oroz, Bliss J Chang, Piotr Wysoczanski, Chung-Tien Lee, Ángel Pérez-Lara, Pijush Chakraborty, Romina V Hofele, Jeremy D Baker, Laura J Blair, Jacek Biernat, Henning Urlaub, Eckhard Mandelkow, Chad A Dickey, Markus Zweckstette. Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature communications. vol 9. issue 1. 2019-05-03. PMID:30382094. |
here, we report the solution structures of human full-length hsp90 in complex with the ppiase fkbp51, as well as the 280 kda hsp90/fkbp51 complex bound to the alzheimer's disease-related protein tau. |
2019-05-03 |
2023-08-13 |
human |
| Jacob I Ayers, Benoit I Giasson, David R Borchel. Prion-like Spreading in Tauopathies. Biological psychiatry. vol 83. issue 4. 2019-05-01. PMID:28506438. |
misfolded and aggregated forms of tau produce pathological structures in a number of neurodegenerative diseases, including alzheimer's disease (ad) and tauopathy dementias. |
2019-05-01 |
2023-08-13 |
mouse |
| Sudeepti Southekal, Michael D Devous, Ian Kennedy, Michael Navitsky, Ming Lu, Abhinay D Joshi, Michael J Pontecorvo, Mark A Mintu. Flortaucipir F 18 Quantitation Using Parametric Estimation of Reference Signal Intensity. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 6. 2019-05-01. PMID:29191858. |
pet imaging of tau pathology in alzheimer disease may benefit from the use of white matter reference regions. |
2019-05-01 |
2023-08-13 |
Not clear |
| Michael D Devous, Abhinay D Joshi, Michael Navitsky, Sudeepti Southekal, Michael J Pontecorvo, Haiqing Shen, Ming Lu, William R Shankle, John P Seibyl, Ken Marek, Mark A Mintu. Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 6. 2019-05-01. PMID:29284675. |
alzheimer disease (ad) is characterized by β-amyloid (aβ) plaques and tau neurofibrillary tangles. |
2019-05-01 |
2023-08-13 |
Not clear |
| Ruiqing Ni, Bin Ji, Maiko Ono, Naruhiko Sahara, Ming-Rong Zhang, Ichio Aoki, Agneta Nordberg, Tetsuya Suhara, Makoto Higuch. Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 6. 2019-05-01. PMID:29419480. |
fibrillary tau aggregates in alzheimer disease and allied neurodegenerative disorders have been visualized in vivo by pet, whereas mechanistic links between pet-detectable tau deposits and neurotoxicity remain elusive. |
2019-05-01 |
2023-08-13 |
mouse |
| Shuko Taked. Progression of Alzheimer's disease, tau propagation, and its modifiable risk factors. Neuroscience research. vol 141. 2019-05-01. PMID:30120962. |
progression of alzheimer's disease, tau propagation, and its modifiable risk factors. |
2019-05-01 |
2023-08-13 |
Not clear |
| Won-Hee Nam, Young Pyo Cho. In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain. Prion. vol 13. issue 1. 2019-05-01. PMID:30422056. |
in vitro generation of tau aggregates conformationally distinct from parent tau seeds of alzheimer's brain. |
2019-05-01 |
2023-08-13 |
Not clear |