| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ichiro Akiguchi, Mercè Pallàs, Herbert Budka, Haruhiko Akiyama, Masaki Ueno, Jingxian Han, Hideo Yagi, Tomohumi Nishikawa, Yoichi Chiba, Hiroshi Sugiyama, Ryoya Takahashi, Keiko Unno, Keiichi Higuchi, Masanori Hosokaw. SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 4. 2018-05-03. PMID:28261874. |
as for the hallmarks of alzheimer brains, tau morphology has not yet been confirmed regardless of the age-related increase in phosphorylated tau in samp8 mice brains, but early age-related aβ deposition in the hippocampus has recently been published. |
2018-05-03 |
2023-08-13 |
mouse |
| Ana I Rojo, Marta Pajares, Patricia Rada, Angel Nuñez, Alejo J Nevado-Holgado, Richard Killik, Fred Van Leuven, Elena Ribe, Simon Lovestone, Masayuki Yamamoto, Antonio Cuadrad. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology. Redox biology. vol 13. 2018-05-03. PMID:28704727. |
nrf2 deficiency replicates transcriptomic changes in alzheimer's patients and worsens app and tau pathology. |
2018-05-03 |
2023-08-13 |
mouse |
| F Biundo, C d'Abramo, M D Tambini, H Zhang, D Del Prete, F Vitale, L Giliberto, O Arancio, L D'Adami. Abolishing Tau cleavage by caspases at Aspartate Translational psychiatry. vol 7. issue 8. 2018-05-03. PMID:28786980. |
abolishing tau cleavage by caspases at aspartate tau mutations are genetically linked to fronto-temporal dementia (ftd) and hyper-phosphorylated aggregates of tau form neurofibrillary tangles (nfts) that constitute a pathological hallmark of alzheimer disease (ad) and ftd. |
2018-05-03 |
2023-08-13 |
Not clear |
| Dmitriy V Prokopovich, John W Whittaker, Micaiah M Muthee, Azka Ahmed, Luca Larin. Impact of Phosphorylation and Pseudophosphorylation on the Early Stages of Aggregation of the Microtubule-Associated Protein Tau. The journal of physical chemistry. B. vol 121. issue 9. 2018-05-02. PMID:28218850. |
as a consequence, dysfunction of tau is associated with many forms of dementia as well as alzheimer's disease. |
2018-05-02 |
2023-08-13 |
Not clear |
| Dmitriy V Prokopovich, John W Whittaker, Micaiah M Muthee, Azka Ahmed, Luca Larin. Impact of Phosphorylation and Pseudophosphorylation on the Early Stages of Aggregation of the Microtubule-Associated Protein Tau. The journal of physical chemistry. B. vol 121. issue 9. 2018-05-02. PMID:28218850. |
in alzheimer's disease, tau is present in an abnormal phosphorylation state. |
2018-05-02 |
2023-08-13 |
Not clear |
| Hend M Hussien, Aml Abd-Elmegied, Doaa A Ghareeb, Hani S Hafez, Hany E A Ahmed, Nehad Abd El-Monea. Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 111. 2018-05-01. PMID:29170048. |
they play a role in the precipitation of abnormal β-amyloid protein and hyper-phosphorylated tau, the main hallmarks of alzheimer's disease (ad). |
2018-05-01 |
2023-08-13 |
rat |
| Manon Domise, Sébastien Didier, Claudia Marinangeli, Haitian Zhao, Pallavi Chandakkar, Luc Buée, Benoit Viollet, Peter Davies, Philippe Marambaud, Valérie Vingtdeu. AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo. Scientific reports. vol 6. 2018-04-30. PMID:27230293. |
recently, it has been demonstrated that amp-activated protein kinase (ampk) was deregulated in the brain of alzheimer's disease (ad) patients where it co-localized with phosphorylated tau in pre-tangle and tangle-bearing neurons. |
2018-04-30 |
2023-08-13 |
mouse |
| Jui-Heng Tseng, Ling Xie, Sheng Song, Youmei Xie, Lauren Allen, Deepa Ajit, Jau-Shyong Hong, Xian Chen, Rick B Meeker, Todd J Cohe. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell reports. vol 20. issue 9. 2018-04-30. PMID:28854366. |
the initiating events that promote tau mislocalization and pathology in alzheimer's disease (ad) are not well defined, partly because of the lack of endogenous models that recapitulate tau dysfunction. |
2018-04-30 |
2023-08-13 |
mouse |
| C J Garwood, L E Ratcliffe, J E Simpson, P R Heath, P G Ince, S B Wharto. Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. Neuropathology and applied neurobiology. vol 43. issue 4. 2018-04-26. PMID:27442752. |
astrocytes respond to both the neurofibrillary tangles and plaques of alzheimer's disease, to hyperphosphorylated tau and aβ, eliciting an effect which may be neuroprotective or deleterious. |
2018-04-26 |
2023-08-13 |
Not clear |
| A J Ehrenberg, A K Nguy, P Theofilas, S Dunlop, C K Suemoto, A T Di Lorenzo Alho, R P Leite, R Diehl Rodriguez, M B Mejia, U Rüb, J M Farfel, R E de Lucena Ferretti-Rebustini, C F Nascimento, R Nitrini, C A Pasquallucci, W Jacob-Filho, B Miller, W W Seeley, H Heinsen, L T Grinber. Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease. Neuropathology and applied neurobiology. vol 43. issue 5. 2018-04-26. PMID:28117917. |
quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early alzheimer's disease. |
2018-04-26 |
2023-08-13 |
Not clear |
| A J Ehrenberg, A K Nguy, P Theofilas, S Dunlop, C K Suemoto, A T Di Lorenzo Alho, R P Leite, R Diehl Rodriguez, M B Mejia, U Rüb, J M Farfel, R E de Lucena Ferretti-Rebustini, C F Nascimento, R Nitrini, C A Pasquallucci, W Jacob-Filho, B Miller, W W Seeley, H Heinsen, L T Grinber. Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease. Neuropathology and applied neurobiology. vol 43. issue 5. 2018-04-26. PMID:28117917. |
hyperphosphorylated tau neuronal cytoplasmic inclusions (ht-nci) are the best protein correlate of clinical decline in alzheimer's disease (ad). |
2018-04-26 |
2023-08-13 |
Not clear |
| Alexander Stepanov, Tatiana Karelina, Nikolai Markevich, Oleg Demin, Timothy Nichola. A mathematical model of multisite phosphorylation of tau protein. PloS one. vol 13. issue 2. 2018-04-26. PMID:29408874. |
abnormal tau metabolism followed by formation of tau deposits causes a number of neurodegenerative diseases called tauopathies including alzheimer's disease. |
2018-04-26 |
2023-08-13 |
Not clear |
| Alexander Stepanov, Tatiana Karelina, Nikolai Markevich, Oleg Demin, Timothy Nichola. A mathematical model of multisite phosphorylation of tau protein. PloS one. vol 13. issue 2. 2018-04-26. PMID:29408874. |
our results suggest that kinase inhibition may more specifically prevent tau hyperphosphorylation, e.g., on phf sites, which are key biomarkers of pathological changes in alzheimer's disease. |
2018-04-26 |
2023-08-13 |
Not clear |
| Yaling Yin, Yali Wang, Di Gao, Jinwang Ye, Xin Wang, Lin Fang, Dongqin Wu, Guilin Pi, Chengbiao Lu, Xin-Wen Zhou, Ying Yang, Jian-Zhi Wan. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. Scientific reports. vol 6. 2018-04-25. PMID:27277673. |
cholinergic impairments and tau accumulation are hallmark pathologies in sporadic alzheimer's disease (ad), however, the intrinsic link between tau accumulation and cholinergic deficits is missing. |
2018-04-25 |
2023-08-13 |
human |
| Ana Gabriela Henriques, Thorsten Müller, Joana Machado Oliveira, Marta Cova, Cristóvão B da Cruz E Silva, Odete A B da Cruz E Silv. Altered protein phosphorylation as a resource for potential AD biomarkers. Scientific reports. vol 6. 2018-04-23. PMID:27466139. |
in fact several alzheimer's disease related proteins, such as app and tau, exhibit pathology associated hyperphosphorylated states. |
2018-04-23 |
2023-08-13 |
Not clear |
| Sergey O Bachurin, Elena V Bovina, Aleksey A Ustyugo. Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends. Medicinal research reviews. vol 37. issue 5. 2018-04-23. PMID:28084618. |
alzheimer's disease (ad) is characterized by a chronic and progressive neurodegenerative process resulting from the intracellular and extracellular accumulation of fibrillary proteins: beta-amyloid and hyperphosphorylated tau. |
2018-04-23 |
2023-08-13 |
Not clear |
| Kurt Giles, Amanda L Woerman, David B Berry, Stanley B Prusine. Bioassays and Inactivation of Prions. Cold Spring Harbor perspectives in biology. vol 9. issue 8. 2018-04-23. PMID:28246183. |
a wealth of recent data argues that both β-amyloid (aβ) and tau proteins form prions that cause alzheimer's disease, and α-synuclein forms prions that cause multiple system atrophy and parkinson's disease. |
2018-04-23 |
2023-08-13 |
Not clear |
| Ellis Patrick, Sathyapriya Rajagopal, Hon-Kit Andus Wong, Cristin McCabe, Jishu Xu, Anna Tang, Selina H Imboywa, Julie A Schneider, Nathalie Pochet, Anna M Krichevsky, Lori B Chibnik, David A Bennett, Philip L De Jage. Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28668092. |
dissecting the role of non-coding rnas in the accumulation of amyloid and tau neuropathologies in alzheimer's disease. |
2018-04-17 |
2023-08-13 |
human |
| Cecilia A Brunello, Xu Yan, Henri J Huttune. Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules. Scientific reports. vol 6. 2018-04-16. PMID:27460788. |
tau is a central pathological protein in alzheimer's disease and other tauopathies, and misfolded, aggregated tau is capable of propagating pathology via cell-to-cell transmission. |
2018-04-16 |
2023-08-13 |
Not clear |
| William A McEwan, Benjamin Falcon, Marina Vaysburd, Dean Clift, Adrian L Oblak, Bernardino Ghetti, Michel Goedert, Leo C Jame. Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 3. 2018-04-16. PMID:28049840. |
alzheimer's disease (ad) and other neurodegenerative disorders are associated with the cytoplasmic aggregation of microtubule-associated protein tau. |
2018-04-16 |
2023-08-13 |
Not clear |