| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert K Fujimura, Teresita Reiner, Fangchao Ma, Virginia Phillips, Alicia de las Pozas, Dennis W Dickson, Bernard A Roos, Guy A Howard, Carlos Perez-Stabl. Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 19. issue 1. 2010-08-10. PMID:20061629. |
changes in the expression of genes associated with intraneuronal amyloid-beta and tau in alzheimer's disease. |
2010-08-10 |
2023-08-12 |
Not clear |
| Wolfgang Härtig, Simone Goldhammer, Ute Bauer, Florian Wegner, Oliver Wirths, Thomas A Bayer, Jens Grosch. Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice. Journal of chemical neuroanatomy. vol 40. issue 1. 2010-08-09. PMID:20347032. |
here, we present a novel triple immunofluorescence labelling of amino- and differently carboxy-terminally truncated beta-amyloid peptides in cortical plaques from a case with alzheimer's disease, senile macaques and baboons, and triple transgenic mice with age-dependent beta-amyloidosis and tau hyperphosphorylation. |
2010-08-09 |
2023-08-12 |
mouse |
| Philip J Dolan, Gail V W Johnso. A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. The Journal of biological chemistry. vol 285. issue 29. 2010-08-06. PMID:20466727. |
the microtubule-associated protein tau plays a central role in the pathogenesis of alzheimer disease (ad) and abnormally accumulates as neurofibrillary tangles; therefore, the pathways by which tau is degraded have been examined extensively. |
2010-08-06 |
2023-08-12 |
Not clear |
| Tilman Grune, Diana Botzen, Martina Engels, Peter Voss, Barbara Kaiser, Tobias Jung, Stefanie Grimm, Gennady Ermak, Kelvin J A Davie. Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions. Archives of biochemistry and biophysics. vol 500. issue 2. 2010-08-06. PMID:20478262. |
tau is the major protein exhibiting intracellular accumulation in alzheimer disease. |
2010-08-06 |
2023-08-12 |
Not clear |
| Min Liu, Eleni Girma, Marcie A Glicksman, Ross L Stei. Kinetic mechanistic studies of Cdk5/p25-catalyzed H1P phosphorylation: metal effect and solvent kinetic isotope effect. Biochemistry. vol 49. issue 23. 2010-08-05. PMID:20491486. |
cdk5/p25 is a member of the cyclin-dependent, ser/thr kinase family and has been identified as one of the principle alzheimer's disease-associated kinases that promote the formation of hyperphosphorylated tau, the major component of neurofibrillary tangles. |
2010-08-05 |
2023-08-12 |
cat |
| Moran Boimel, Nikolaos Grigoriadis, Athanasios Lourbopoulos, Esther Haber, Oded Abramsky, Hanna Rosenman. Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Experimental neurology. vol 224. issue 2. 2010-07-30. PMID:20546729. |
as an abnormally folded and aggregated protein, tau composed of neurofibrillary tangles (nfts) in alzheimer's disease and other tauopathies seems to be a candidate for immunotherapy. |
2010-07-30 |
2023-08-12 |
mouse |
| Shaohua Xu, Kurt R Brunden, John Q Trojanowski, Virginia M-Y Le. Characterization of tau fibrillization in vitro. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 6. issue 2. 2010-07-29. PMID:20298971. |
the assembly of tau proteins into paired helical filaments, the building blocks of neurofibrillary tangles, is linked to neurodegeneration in alzheimer's disease and related tauopathies. |
2010-07-29 |
2023-08-12 |
human |
| Wonhee Kim, Sangmook Lee, Garth F Hal. Secretion of human tau fragments resembling CSF-tau in Alzheimer's disease is modulated by the presence of the exon 2 insert. FEBS letters. vol 584. issue 14. 2010-07-27. PMID:20553717. |
secretion of human tau fragments resembling csf-tau in alzheimer's disease is modulated by the presence of the exon 2 insert. |
2010-07-27 |
2023-08-12 |
human |
| Wonhee Kim, Sangmook Lee, Garth F Hal. Secretion of human tau fragments resembling CSF-tau in Alzheimer's disease is modulated by the presence of the exon 2 insert. FEBS letters. vol 584. issue 14. 2010-07-27. PMID:20553717. |
abnormal tau cleavage is prominent in the neurofibrillary degeneration characteristic of alzheimer's disease (ad) and related tauopathies. |
2010-07-27 |
2023-08-12 |
human |
| Tomohiro Miyasaka, Sinji Sato, Yoshitaka Tatebayashi, Akihiko Takashim. Microtubule destruction induces tau liberation and its subsequent phosphorylation. FEBS letters. vol 584. issue 14. 2010-07-27. PMID:20561519. |
neurofibrillary tangle-bearing neurons, a pathological hallmark of alzheimer's disease, are mostly devoid of normal microtubule (mt) structure and instead have paired helical filaments that are composed of abnormal hyperphosphorylated tau. |
2010-07-27 |
2023-08-12 |
Not clear |
| Wei Qian, Jianhua Shi, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong, Fei Li. PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. Journal of Alzheimer's disease : JAD. vol 19. issue 4. 2010-07-22. PMID:20308788. |
abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in alzheimer's disease (ad). |
2010-07-22 |
2023-08-12 |
human |
| A Marx, C Nugoor, S Panneerselvam, E Mandelko. Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 6. 2010-07-21. PMID:20071654. |
hyperphosphorylation of tau causes defects in neuronal transport and may induce abnormal aggregation of tau in alzheimer disease and other tauopathies. |
2010-07-21 |
2023-08-12 |
caenorhabditis_elegans |
| Kanae Iijima-Ando, LiJuan Zhao, Anthony Gatt, Christopher Shenton, Koichi Iijim. A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. Human molecular genetics. vol 19. issue 10. 2010-07-21. PMID:20159774. |
hyperphosphorylation of the microtubule associated protein tau is detected in the brains of individuals with a range of neurodegenerative diseases including alzheimer's disease (ad). |
2010-07-21 |
2023-08-12 |
human |
| Jürgen Götz, Yun-An Lim, Yazi D Ke, Anne Eckert, Lars M Ittne. Dissecting toxicity of tau and beta-amyloid. Neuro-degenerative diseases. vol 7. issue 1-3. 2010-07-21. PMID:20160450. |
how beta-amyloid (abeta) and tau exert toxicity in alzheimer's disease is only partly understood. |
2010-07-21 |
2023-08-12 |
Not clear |
| Branislav Kovacech, Rostislav Skrabana, Michal Nova. Transition of tau protein from disordered to misordered in Alzheimer's disease. Neuro-degenerative diseases. vol 7. issue 1-3. 2010-07-21. PMID:20160453. |
transition of tau protein from disordered to misordered in alzheimer's disease. |
2010-07-21 |
2023-08-12 |
human |
| Branislav Kovacech, Rostislav Skrabana, Michal Nova. Transition of tau protein from disordered to misordered in Alzheimer's disease. Neuro-degenerative diseases. vol 7. issue 1-3. 2010-07-21. PMID:20160453. |
the tau protein forms insoluble fibrils in the brain of people suffering from alzheimer's disease (ad) and other tauopathies and plays a key role in the neurodegenerative process. |
2010-07-21 |
2023-08-12 |
human |
| Astrid Sydow, Eva-Maria Mandelko. 'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy. Neuro-degenerative diseases. vol 7. issue 1-3. 2010-07-21. PMID:20160454. |
aggregates of the tau protein are a hallmark of alzheimer's and several other neurodegenerative diseases. |
2010-07-21 |
2023-08-12 |
mouse |
| Sihem Doggui, Jonathan Brouillette, Jean-Guy Chabot, Mark Farso, Rémi Quirio. Possible involvement of transthyretin in hippocampal beta-amyloid burden and learning behaviors in a mouse model of Alzheimer's disease (TgCRND8). Neuro-degenerative diseases. vol 7. issue 1-3. 2010-07-21. PMID:20173334. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by progressive memory loss, possibly triggered by the accumulation of beta-amyloid (abeta) peptides and the hyperphosphorylation of tau neurofilament protein. |
2010-07-21 |
2023-08-12 |
mouse |
| Antoneta Granic, Jaya Padmanabhan, Michelle Norden, Huntington Potte. Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP. Molecular biology of the cell. vol 21. issue 4. 2010-07-19. PMID:20032300. |
alzheimer abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and app. |
2010-07-19 |
2023-08-12 |
mouse |
| Randall L Woltjer, Kevin Duerson, Joseph M Fullmer, Paramita Mookherjee, Allison M Ryan, Thomas J Montine, Jeffrey A Kaye, Joseph F Quinn, Lisa Silbert, Deniz Erten-Lyons, James B Leverenz, Thomas D Bird, David V Pow, Kohichi Tanaka, G Stennis Watson, David G Coo. Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 69. issue 7. 2010-07-19. PMID:20535038. |
alzheimer disease (ad) is characterized by deposition of amyloid-beta, tau, and other specific proteins that accumulate in the brain in detergent-insoluble complexes. |
2010-07-19 |
2023-08-12 |
human |