| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kensaku Kasuga, Takayoshi Tokutake, Atsushi Ishikawa, Tsuyoshi Uchiyama, Takahiko Tokuda, Osamu Onodera, Masatoyo Nishizawa, Takeshi Ikeuch. Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 6. 2010-06-23. PMID:20522869. |
differential levels of alpha-synuclein, beta-amyloid42 and tau in csf between patients with dementia with lewy bodies and alzheimer's disease. |
2010-06-23 |
2023-08-12 |
Not clear |
| Kensaku Kasuga, Takayoshi Tokutake, Atsushi Ishikawa, Tsuyoshi Uchiyama, Takahiko Tokuda, Osamu Onodera, Masatoyo Nishizawa, Takeshi Ikeuch. Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 6. 2010-06-23. PMID:20522869. |
here the utility of quantification of alpha-synuclein, beta-amyloid42 (abeta42) and tau in the csf of patients with dlb, alzheimer's disease (ad) and other dementias was examined. |
2010-06-23 |
2023-08-12 |
Not clear |
| Yong-Whan Lim, Seung-Yong Yoon, Jung-Eun Choi, Sang-Min Kim, Hui-Sun Lee, Han Choe, Seung-Chul Lee, Dong-Hou Ki. Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model. Biochemical and biophysical research communications. vol 395. issue 2. 2010-06-21. PMID:20362550. |
glycogen synthase kinase-3beta (gsk3beta) is recognized as one of major kinases to phosphorylate tau in alzheimer's disease (ad), thus lots of ad drug discoveries target gsk3beta. |
2010-06-21 |
2023-08-12 |
rat |
| Umesh K Jinwal, John C O'Leary, Sergiy I Borysov, Jeffrey R Jones, Qingyou Li, John Koren, Jose F Abisambra, Grant D Vestal, Lisa Y Lawson, Amelia G Johnson, Laura J Blair, Ying Jin, Yoshinari Miyata, Jason E Gestwicki, Chad A Dicke. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of biological chemistry. vol 285. issue 22. 2010-06-17. PMID:20308058. |
in a group of neurodegenerative diseases, such as alzheimer disease and other tauopathies, conformational changes in tau are associated with the initial stages of disease pathology. |
2010-06-17 |
2023-08-12 |
Not clear |
| Umesh K Jinwal, John C O'Leary, Sergiy I Borysov, Jeffrey R Jones, Qingyou Li, John Koren, Jose F Abisambra, Grant D Vestal, Lisa Y Lawson, Amelia G Johnson, Laura J Blair, Ying Jin, Yoshinari Miyata, Jason E Gestwicki, Chad A Dicke. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of biological chemistry. vol 285. issue 22. 2010-06-17. PMID:20308058. |
folding of tau into the mc1 conformation, where the amino acids at residues 7-9 interact with residues 312-342, is one of the earliest pathological alterations of tau in alzheimer disease. |
2010-06-17 |
2023-08-12 |
Not clear |
| Fiona Grueninger, Bernd Bohrmann, Christian Czech, Theresa Maria Ballard, Johann R Frey, Claudia Weidensteiner, Markus von Kienlin, Laurence Ozme. Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice. Neurobiology of disease. vol 37. issue 2. 2010-06-15. PMID:19781645. |
amyloid beta peptides and microtubule-associated protein tau are misfolded and form aggregates in brains of alzheimer's disease patients. |
2010-06-15 |
2023-08-12 |
mouse |
| Fiona Grueninger, Bernd Bohrmann, Christian Czech, Theresa Maria Ballard, Johann R Frey, Claudia Weidensteiner, Markus von Kienlin, Laurence Ozme. Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice. Neurobiology of disease. vol 37. issue 2. 2010-06-15. PMID:19781645. |
to examine their specific roles in the pathogenesis of alzheimer's disease and their relevance in neurodegenerative processes, we have created taups2app triple transgenic mice that express human mutated amyloid precursor protein, presenilin 2 and tau. |
2010-06-15 |
2023-08-12 |
mouse |
| Sébastien Feuillette, Laetitia Miguel, Thierry Frébourg, Dominique Campion, Magalie Lecourtoi. Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein. Journal of neurochemistry. vol 113. issue 4. 2010-06-15. PMID:20193038. |
tauopathies, including alzheimer's disease and fronto-temporal dementia with parkinsonism linked to chromosome 17, are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally and hyperphosphorylated tau. |
2010-06-15 |
2023-08-12 |
human |
| Dara L Dickstein, Hannah Brautigam, Steven D Stockton, James Schmeidler, Patrick R Ho. Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau. Brain structure & function. vol 214. issue 2-3. 2010-06-15. PMID:20213269. |
neurofibrillary tangles (nfts) are composed of insoluble, hyperphosphorylated aggregates of the microtubule-associated protein tau and are present in various neurodegenerative diseases, including alzheimer's disease (ad). |
2010-06-15 |
2023-08-12 |
mouse |
| I Taes, A Goris, R Lemmens, M A van Es, L H van den Berg, A Chio, B J Traynor, A Birve, P Andersen, A Slowik, B Tomik, R H Brown, C E Shaw, A Al-Chalabi, S Boonen, L Van Den Bosch, B Dubois, P Van Damme, W Robberech. Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse. Neurology. vol 74. issue 21. 2010-06-15. PMID:20498436. |
furthermore, tau hyperphosphorylation and aggregation is a hallmark of alzheimer disease (ad), and reducing endogenous tau has been reported to ameliorate cognitive impairment in a mouse model for ad. |
2010-06-15 |
2023-08-12 |
mouse |
| Ayodeji A Asuni, V Hugh Perry, Vincent O'Conno. Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease. Biochemical Society transactions. vol 38. issue 2. 2010-06-11. PMID:20298219. |
hyperphosphorylation of the microtubule-associated protein tau is a significant determinant in ad (alzheimer's disease), where it is associated with disrupted axonal transport and probably causes synaptic dysfunction. |
2010-06-11 |
2023-08-12 |
mouse |
| Carlo Ballatore, Kurt R Brunden, Francesco Piscitelli, Michael J James, Alex Crowe, Yuemang Yao, Edward Hyde, John Q Trojanowski, Virginia M-Y Lee, Amos B Smit. Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation. Journal of medicinal chemistry. vol 53. issue 9. 2010-06-11. PMID:20392114. |
agents capable of preventing the misfolding and sequestration of the microtubule-stabilizing protein tau into insoluble fibrillar aggregates hold considerable promise for the prevention and/or treatment of neurodegenerative tauopathies such as alzheimer's disease. |
2010-06-11 |
2023-08-12 |
mouse |
| Susanna Schraen-Maschke, Nicolas Sergeant, Claire-Marie Dhaenens, Stéphanie Bombois, Vincent Deramecourt, Marie-Laure Caillet-Boudin, Florence Pasquier, Claude-Alain Maurage, Bernard Sablonnière, Eugeen Vanmechelen, Luc Bué. Tau as a biomarker of neurodegenerative diseases. Biomarkers in medicine. vol 2. issue 4. 2010-06-10. PMID:20477391. |
the rationale for tau as a biomarker of neurodegenerative diseases is that it is a major component of abnormal intraneuronal aggregates observed in numerous tauopathies, including alzheimer's disease. |
2010-06-10 |
2023-08-12 |
Not clear |
| Susanna Schraen-Maschke, Nicolas Sergeant, Claire-Marie Dhaenens, Stéphanie Bombois, Vincent Deramecourt, Marie-Laure Caillet-Boudin, Florence Pasquier, Claude-Alain Maurage, Bernard Sablonnière, Eugeen Vanmechelen, Luc Bué. Tau as a biomarker of neurodegenerative diseases. Biomarkers in medicine. vol 2. issue 4. 2010-06-10. PMID:20477391. |
as peripheral biomarkers of alzheimer's disease in the cerebrospinal fluid, tau proteins are now validated for diagnosis and predictive purposes. |
2010-06-10 |
2023-08-12 |
Not clear |
| Harry Levine, Lary C Walke. Molecular polymorphism of Abeta in Alzheimer's disease. Neurobiology of aging. vol 31. issue 4. 2010-06-08. PMID:18619711. |
alzheimer's disease is defined pathologically by the presence of senile plaques, which consist primarily of extracellular aggregates of fibrillar abeta peptide, and neurofibrillary tangles, which are abnormal, intracellular bundles of fibrillar tau protein. |
2010-06-08 |
2023-08-12 |
Not clear |
| Florence Clavaguera, Michel Goedert, Markus Tolna. [Induction and spreading of tau pathology in a mouse model of Alzheimer's disease]. Medecine sciences : M/S. vol 26. issue 2. 2010-06-08. PMID:20188034. |
[induction and spreading of tau pathology in a mouse model of alzheimer's disease]. |
2010-06-08 |
2023-08-12 |
mouse |
| Niklas Mattsson, Karin Sävman, Gustaf Osterlundh, Kaj Blennow, Henrik Zetterber. Converging molecular pathways in human neural development and degeneration. Neuroscience research. vol 66. issue 3. 2010-06-07. PMID:19961883. |
animal studies suggest that phosphorylation of microtubule-associated protein tau is a physiological way of destabilizing axons in the developing brain, promoting synaptic plasticity, while in the adult human brain tau phosphorylation is a specific sign of alzheimer's disease. |
2010-06-07 |
2023-08-12 |
human |
| Niklas Mattsson, Karin Sävman, Gustaf Osterlundh, Kaj Blennow, Henrik Zetterber. Converging molecular pathways in human neural development and degeneration. Neuroscience research. vol 66. issue 3. 2010-06-07. PMID:19961883. |
tau phosphorylation in alzheimer's disease may be a physiological response to alzheimer-associated synaptotoxicity. |
2010-06-07 |
2023-08-12 |
human |
| Alix de Calignon, Leora M Fox, Rose Pitstick, George A Carlson, Brian J Bacskai, Tara L Spires-Jones, Bradley T Hyma. Caspase activation precedes and leads to tangles. Nature. vol 464. issue 7292. 2010-06-07. PMID:20357768. |
studies of post-mortem tissue have shown that the location of fibrillar tau deposits, called neurofibrillary tangles (nft), matches closely with regions of massive neuronal death, severe cytological abnormalities, and markers of caspase activation and apoptosis, leading to the idea that tangles cause neurodegeneration in alzheimer's disease and tau-related frontotemporal dementia. |
2010-06-07 |
2023-08-12 |
mouse |
| Thibaud Lebouvier, Timothy M E Scales, Ritchie Williamson, Wendy Noble, Charles Duyckaerts, Diane P Hanger, C Hugh Reynolds, Brian H Anderton, Pascal Derkindere. The microtubule-associated protein tau is also phosphorylated on tyrosine. Journal of Alzheimer's disease : JAD. vol 18. issue 1. 2010-06-04. PMID:19542604. |
tau protein is the principal component of the neurofibrillary tangles found in alzheimer's disease (ad), where it is hyperphosphorylated on serine and threonine residues. |
2010-06-04 |
2023-08-12 |
human |