| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rick A C M Boonen, Paula van Tijn, Danica Zivkovi. Wnt signaling in Alzheimer's disease: up or down, that is the question. Ageing research reviews. vol 8. issue 2. 2009-06-03. PMID:19101658. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder, neuropathologically characterized by amyloid-beta (abeta) plaques and hyperphosphorylated tau accumulation. |
2009-06-03 |
2023-08-12 |
Not clear |
| H Axer, S Hüge, C Wilhelm, M Axer, A Kunze, J R Reichenbach, M Freesmeyer, J Kohlhase, H Sauer, K-J Bä. [Hereditary Alzheimer's disease with amyloid angiopathy caused by amyloid precursor protein locus]. Der Nervenarzt. vol 80. issue 1. 2009-05-29. PMID:18781290. |
the csf showed increased levels of tau protein and decreased amyloid beta (ratio 42:40) typical for alzheimer's disease. |
2009-05-29 |
2023-08-12 |
Not clear |
| Morihisa Saitoh, Jun Kunitomo, Eiji Kimura, Yoji Hayase, Hiromi Kobayashi, Noriko Uchiyama, Tomohiro Kawamoto, Toshimasa Tanaka, Clifford D Mol, Douglas R Dougan, Garret S Textor, Gyorgy P Snell, Fumio Ito. Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. Bioorganic & medicinal chemistry. vol 17. issue 5. 2009-05-29. PMID:19200745. |
glycogen synthase kinase-3beta (gsk-3beta) is implicated in abnormal hyperphosphorylation of tau protein and its inhibitors are expected to be a promising therapeutic agents for the treatment of alzheimer's disease. |
2009-05-29 |
2023-08-12 |
Not clear |
| Alexis Bretteville, Kunie Ando, Antoine Ghestem, Anne Loyens, Séverine Bégard, Jean-Claude Beauvillain, Nicolas Sergeant, Malika Hamdane, Luc Bué. Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes. PloS one. vol 4. issue 3. 2009-05-28. PMID:19290042. |
the role of tau phosphorylation in neurofibrillary degeneration linked to alzheimer's disease remains to be established. |
2009-05-28 |
2023-08-12 |
mouse |
| Alexis Bretteville, Kunie Ando, Antoine Ghestem, Anne Loyens, Séverine Bégard, Jean-Claude Beauvillain, Nicolas Sergeant, Malika Hamdane, Luc Bué. Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes. PloS one. vol 4. issue 3. 2009-05-28. PMID:19290042. |
in fact, this pattern is also displayed before tau pathology onset in a well established mouse model relevant to tau aggregation in alzheimer's disease. |
2009-05-28 |
2023-08-12 |
mouse |
| Tomás L Falzone, Gorazd B Stokin, Concepción Lillo, Elizabeth M Rodrigues, Eileen L Westerman, David S Williams, Lawrence S B Goldstei. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 18. 2009-05-28. PMID:19420244. |
while mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp17) causes aberrant microtubule binding and assembly of tau into filaments, the pathways leading to tau-mediated neurotoxicity in alzheimer's disease and other neurodegenerative disorders in which tau protein is not genetically modified remain unknown. |
2009-05-28 |
2023-08-12 |
mouse |
| Tomás L Falzone, Gorazd B Stokin, Concepción Lillo, Elizabeth M Rodrigues, Eileen L Westerman, David S Williams, Lawrence S B Goldstei. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 18. 2009-05-28. PMID:19420244. |
thus, directly interfering with axonal transport is sufficient to activate stress kinase pathways initiating a biochemical cascade that drives normal tau protein into a pathological state found in a variety of neurodegenerative disorders including alzheimer's disease. |
2009-05-28 |
2023-08-12 |
mouse |
| Maya K Desai, Kelly L Sudol, Michelle C Janelsins, Michael A Mastrangelo, Maria E Frazer, William J Bower. Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia. vol 57. issue 1. 2009-05-26. PMID:18661556. |
triple-transgenic alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. |
2009-05-26 |
2023-08-12 |
mouse |
| Philipp A Thomann, Elmar Kaiser, Peter Schönknecht, Johannes Pantel, Marco Essig, Johannes Schröde. Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. Journal of psychiatry & neuroscience : JPN. vol 34. issue 2. 2009-05-21. PMID:19270764. |
association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and alzheimer disease. |
2009-05-21 |
2023-08-12 |
Not clear |
| Philipp A Thomann, Elmar Kaiser, Peter Schönknecht, Johannes Pantel, Marco Essig, Johannes Schröde. Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. Journal of psychiatry & neuroscience : JPN. vol 34. issue 2. 2009-05-21. PMID:19270764. |
we sought to examine the association of levels of total tau (t-tau) and phosphorylated tau 181 (p-tau181) protein with brain morphology in mild cognitive impairment, as defined by the concept of aging-associated cognitive decline (aacd) and alzheimer disease. |
2009-05-21 |
2023-08-12 |
Not clear |
| Timothy D Vaden, Sally A N Gowers, Lavina C Snoe. Observation of beta-sheet aggregation in a gas-phase tau-peptide dimer. Journal of the American Chemical Society. vol 131. issue 7. 2009-05-18. PMID:19178142. |
in alzheimer's disease, the tau protein forms intracellular amyloid fibrils in which the (306)vqivyk(311) sequence adopts parallel beta-sheets, enabling fibril formation via cross-beta "steric zippers". |
2009-05-18 |
2023-08-12 |
Not clear |
| Xiaoqin Run, Zhihou Liang, Lan Zhang, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gon. Anesthesia induces phosphorylation of tau. Journal of Alzheimer's disease : JAD. vol 16. issue 3. 2009-05-18. PMID:19276556. |
abnormal hyperphosphorylation and aggregation of microtubule-associated protein tau play a crucial role in neurodegeneration of alzheimer's disease (ad). |
2009-05-18 |
2023-08-12 |
Not clear |
| Steven D Buckingham, Andrew K Jones, Laurence A Brown, David B Sattell. Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. Pharmacological reviews. vol 61. issue 1. 2009-05-14. PMID:19293145. |
alzheimer's disease (ad), the major contributor to dementia in the elderly, involves accumulation in the brain of extracellular plaques containing the beta-amyloid protein (abeta) and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. |
2009-05-14 |
2023-08-12 |
Not clear |
| Christoph Laske, Elke Stransky, Andreas Fritsche, Gerhard W Eschweiler, Thomas Leyh. Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Abeta 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia. European archives of psychiatry and clinical neuroscience. vol 259. issue 2. 2009-05-13. PMID:18806919. |
hypercortisolemia and increased levels of hyperphosphorylated tau proteins in cerebrospinal fluid (csf) are common features with pathogenic relevance in alzheimer;s disease (ad). |
2009-05-13 |
2023-08-12 |
Not clear |
| Jiang Fang, Rong Liu, Qing Tian, Xiao-ping Hong, Shao-hui Wang, Fu-yuan Cao, Xi-ping Pan, Jian-zhi Wan. Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices. Acta pharmacologica Sinica. vol 28. issue 11. 2009-05-12. PMID:17959021. |
this study was to investigate the effect of dehydroevodiamine (dhed) on alzheimer's disease (ad)-like tau hyperphosphorylation induced by calyculin a (ca), an inhibitor of protein phosphatase (pp)-2a and pp-1, and the involvement of pp-2a in metabolically competent rat brain slices. |
2009-05-12 |
2023-08-12 |
rat |
| Jan Mares, P Kanovsky, R Herzig, D Stejskal, J Vavrouskova, P Hlustik, H Vranova, S Burval, J Zapletalova, V Pidrman, R Obereigneru, A Suchy, J Vesely, J Podivinsky, K Urbane. The assessment of beta amyloid, tau protein and cystatin C in the cerebrospinal fluid: laboratory markers of neurodegenerative diseases. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 30. issue 1. 2009-05-08. PMID:19153649. |
to assess the role of tau protein, beta-amyloid(1-42) and cystatin c in the diagnostics of alzheimer dementia (ad) and other neurodegenerative diseases (nd) by comparing to the control groups (cg). |
2009-05-08 |
2023-08-12 |
human |
| Laziza Amniai, Pascale Barbier, Alain Sillen, Jean-Michel Wieruszeski, Vincent Peyrot, Guy Lippens, Isabelle Landrie. Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 4. 2009-05-01. PMID:19074508. |
alzheimer disease specific phosphoepitopes of tau interfere with assembly of tubulin but not binding to microtubules. |
2009-05-01 |
2023-08-12 |
Not clear |
| Laziza Amniai, Pascale Barbier, Alain Sillen, Jean-Michel Wieruszeski, Vincent Peyrot, Guy Lippens, Isabelle Landrie. Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 4. 2009-05-01. PMID:19074508. |
in alzheimer disease (ad)-affected neurons, the tau protein is found in an aggregated and hyperphosphorylated state. |
2009-05-01 |
2023-08-12 |
Not clear |
| Volker Welge, Oliver Fiege, Piotr Lewczuk, Brit Mollenhauer, Hermann Esselmann, Hans-Wolfgang Klafki, Stefanie Wolf, Claudia Trenkwalder, Markus Otto, Johannes Kornhuber, Jens Wiltfang, Mirko Bib. Combined CSF tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 2. 2009-04-30. PMID:19142572. |
combined csf tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing alzheimer's disease. |
2009-04-30 |
2023-08-12 |
Not clear |
| Moran Boimel, Nikolaos Grigoriadis, Athanassios Lourbopoulos, Olga Touloumi, David Rosenmann, Oded Abramsky, Hanna Rosenman. Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy. Journal of neuropathology and experimental neurology. vol 68. issue 3. 2009-04-30. PMID:19225406. |
no animal studies have reported effects of statins on tau aggregates and neurofibrillary tangles (nfts), the pathological hallmarks of alzheimer disease that correlate with dementia. |
2009-04-30 |
2023-08-12 |
mouse |