| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anastasie Mate de Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both fibrillar and oligomeric tau. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034629. |
we prepared sarkosyl insoluble and hmw tau from the frontal cortex of alzheimer patients compared their properties using a variety of biophysical and bioactivity assays. |
2023-04-10 |
2023-08-14 |
mouse |
| Anastasie Mate de Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both fibrillar and oligomeric tau. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034629. |
these data suggest that soluble hmw tau has similar properties with regard to tau seeding potential but may be equal or even more bioactive with respect to propagation across neural systems and activation of glial responses, both relevant tau-related alzheimer phenotypes. |
2023-04-10 |
2023-08-14 |
mouse |
| Jie-Qiong Li, Jing-Hui Song, John Suckling, Yan-Jiang Wang, Chuan-Tao Zuo, Can Zhang, Jing- Gao, Yu-Qiang Song, An-Mu Xie, Lan Tan, Jin-Tai Y. Disease trajectories in elders with suspected non-Alzheimer's pathophysiology and its comparison with Alzheimer's disease pathophysiology: a longitudinal study. Research square. 2023-04-10. PMID:37034751. |
methods we included individuals with available baseline cerebrospinal fluid (csf) aβ (a), csf phosphorylated tau examination (t) and 18f-fluorodeoxyglucose pet or volumetric magnetic resonance imaging (n) from the alzheimer's disease neuroimaging initiative database. |
2023-04-10 |
2023-08-14 |
Not clear |
| Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Alper Kilci, Matthew Jenkins, Guangxin Sun, Sherif Rashad, Jingjing Sun, Peter C Dedon, Sarah Anne Daley, Weiming Xia, Alejandro Rondón Ortiz, Luke Dorrian, Takashi Saito, Takaomi C Saido, Benjamin Wolozi. Accumulation of m bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034774. |
accumulation of m the study for the pathophysiology study of alzheimer's disease (ad) has been hampered by lack animal models that recapitulate the major ad pathologies, including extracellular β-amyloid (aβ) deposition, intracellular aggregation of microtubule associated protein tau (mapt), inflammation and neurodegeneration. |
2023-04-10 |
2023-08-14 |
Not clear |
| Qian Liu, Xin Wang, Yu Hu, Jun-Ning Zhao, Chun-Hui Huang, Ting Li, Bing-Ge Zhang, Ye He, Yan-Qing Wu, Zai-Jun Zhang, Guo-Ping Wang, Gong-Ping Li. Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis. Redox biology. vol 62. 2023-04-10. PMID:37037158. |
increased tau acetylation at k274 and k281 has been observed in the brains of alzheimer's disease (ad) patients and animal models, and mitochondrial dysfunction are noticeable and early features of ad. |
2023-04-10 |
2023-08-14 |
human |
| Josué Llamas-Rodríguez, Jan Oltmer, Michael Marshall, Samantha Champion, Matthew P Frosch, Jean C Augustinac. TDP-43 and tau concurrence in the entorhinal subfields in primary age-related tauopathy and preclinical Alzheimer's disease. Brain pathology (Zurich, Switzerland). 2023-04-10. PMID:37037195. |
tdp-43 and tau concurrence in the entorhinal subfields in primary age-related tauopathy and preclinical alzheimer's disease. |
2023-04-10 |
2023-08-14 |
Not clear |
| Josué Llamas-Rodríguez, Jan Oltmer, Michael Marshall, Samantha Champion, Matthew P Frosch, Jean C Augustinac. TDP-43 and tau concurrence in the entorhinal subfields in primary age-related tauopathy and preclinical Alzheimer's disease. Brain pathology (Zurich, Switzerland). 2023-04-10. PMID:37037195. |
phosphorylated tau (p-tau) pathology correlates strongly with cognitive decline and is a pathological hallmark of alzheimer's disease (ad). |
2023-04-10 |
2023-08-14 |
Not clear |
| Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiav. Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons. Toxicon : official journal of the International Society on Toxinology. 2023-04-10. PMID:37037273. |
pathological tau aggregates propagate across functionally connected neuronal networks in human neurodegenerative pathologies, such as alzheimer's disease. |
2023-04-10 |
2023-08-14 |
mouse |
| Meng Meng, Fang Liu, Yilong Ma, Wen Qin, Lining Guo, Shichun Peng, Marc L Gordon, Yue Wang, Nan Zhan. The identification and cognitive correlation of perfusion patterns measured with arterial spin labeling MRI in Alzheimer's disease. Alzheimer's research & therapy. vol 15. issue 1. 2023-04-10. PMID:37038198. |
vascular dysfunction, including cerebral hypoperfusion, plays an important role in the pathogenesis and progression of alzheimer's disease (ad), independent of amyloid and tau pathology. |
2023-04-10 |
2023-08-14 |
Not clear |
| Shreya Gupta, Sanjay K A Jinka, Saugat Khanal, Neha Bhavnani, Fayez Almashhori, Jason Lallo, Amy Mathias, Yasmine Al-Rhayyel, Danielle Herman, John G Holden, Sheila M Fleming, Priya Rama. Cognitive dysfunction and increased phosphorylated tau are associated with reduced O-GlcNAc signaling in an aging mouse model of metabolic syndrome. Journal of neuroscience research. 2023-04-09. PMID:37031439. |
recent studies in patients and mouse models suggest a putative link between hyperphosphorylated tau, a component of alzheimer's disease-related dementia (adrd) pathology, and cerebral glucose hypometabolism. |
2023-04-09 |
2023-08-14 |
mouse |
| Kensaku Kasuga, Tamao Tsukie, Masataka Kikuchi, Takayoshi Tokutake, Kazuo Washiyama, Soichiro Shimizu, Hiroshi Yoshizawa, Yasuko Kuroha, Ryuji Yajima, Hiroshi Mori, Yasuaki Arakawa, Kiyoshi Onda, Akinori Miyashita, Osamu Onodera, Takeshi Iwatsubo, Takeshi Ikeuch. The clinical application of optimized AT(N) classification in Alzheimer's clinical syndrome (ACS) and non-ACS conditions. Neurobiology of aging. vol 127. 2023-04-08. PMID:37030016. |
we measured the cerebrospinal fluid levels of amyloid-β (aβ) 42, aβ40, phosphorylated tau, total tau, and neurofilament light chain (nfl) in samples from 230 patients with alzheimer's clinical syndrome (acs) and 328 patients with non-acs. |
2023-04-08 |
2023-08-14 |
Not clear |
| Maurizio Bergamino, Megan R Nelson, Asfia Numani, Matthew Scarpelli, Deborah Healey, Alberto Fuentes, Gregory Turner, Ashley M Stoke. Assessment of complementary white matter microstructural changes and grey matter atrophy in a preclinical model of Alzheimer's disease. Magnetic resonance imaging. 2023-04-07. PMID:37028608. |
alzheimer's disease (ad) has been associated with amyloid and tau pathology, as well as neurodegeneration. |
2023-04-07 |
2023-08-14 |
mouse |
| Qin Zhang, Bohan Yin, Yingying Huang, Yutian Gu, Jiaxiang Yan, Jiareng Chen, Chuanqi Li, Yu Zhang, Siu Hong Dexter Wong, Mo Yan. A dual "turn-on" biosensor based on AIE effect and FRET for in situ detection of miR-125b biomarker in early Alzheimer's disease. Biosensors & bioelectronics. vol 230. 2023-04-06. PMID:37023551. |
microrna-125b (mir-125b) is highly associated with synaptic dysfunction and tau hyperphosphorylation in the early pathogenesis of alzheimer's disease (ad), making it a promising biomarker for early ad diagnosis. |
2023-04-06 |
2023-08-14 |
Not clear |
| Tracy L Young-Pearse, Hyo Lee, Yi-Chen Hsieh, Vicky Chou, Dennis J Selko. Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease. Trends in neurosciences. 2023-04-05. PMID:37019812. |
moving beyond amyloid and tau to capture the biological heterogeneity of alzheimer's disease. |
2023-04-05 |
2023-08-14 |
Not clear |
| Erin M Jonaitis, Shorena Janelidze, Karly A Cody, Rebecca Langhough, Lianlian Du, Nathaniel A Chin, Niklas Mattsson-Carlgren, Kirk J Hogan, Bradley T Christian, Tobey J Betthauser, Oskar Hansson, Sterling C Johnso. Plasma phosphorylated tau 217 in preclinical Alzheimer's disease. Brain communications. vol 5. issue 2. 2023-04-04. PMID:37013174. |
plasma phosphorylated tau 217 in preclinical alzheimer's disease. |
2023-04-04 |
2023-08-14 |
Not clear |
| Ines S Amorim, Sylvie Challal, Laetitia Cistarelli, Thierry Dorval, Laurene Abjean, Manuelle Touzard, Nicolas Arbez, Arnaud François, Fany Panayi, Ross Jeggo, Erika Cecon, Atsuro Oishi, Julie Dam, Ralf Jockers, Patricia Machad. A seeding-based neuronal model of tau aggregation for use in drug discovery. PloS one. vol 18. issue 4. 2023-04-04. PMID:37014877. |
intracellular accumulation of tau protein is a hallmark of alzheimer's disease and progressive supranuclear palsy, as well as other neurodegenerative disorders collectively known as tauopathies. |
2023-04-04 |
2023-08-14 |
mouse |
| Aleksandra Parka, Christiane Volbracht, Benjamin Hall, Jesper F Bastlund, Maiken Nedergaard, Bettina Laursen, Paolo Botta, Florence Sott. Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model. Journal of Alzheimer's disease : JAD. 2023-04-03. PMID:37005884. |
tauopathies such as alzheimer's disease (ad) and frontotemporal dementia (ftd) are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau protein. |
2023-04-03 |
2023-08-14 |
mouse |
| Tania Guadalupe Montero-Cosme, Luz Irene Pascual-Mathey, María Elena Hernández-Aguilar, Deissy Herrera-Covarrubias, Fausto Rojas-Durán, Gonzalo Emiliano Aranda-Abre. Potential drugs for the treatment of Alzheimer's disease. Pharmacological reports : PR. 2023-04-03. PMID:37005970. |
it is well known that amyloid precursor protein (app), the enzyme β-secretase 1 (bace1), cyclooxygenase 2 (cox-2), nicastrin (nct), and hyperphosphorylated tau protein (p-tau) are closely related to the development of alzheimer's disease (ad). |
2023-04-03 |
2023-08-14 |
Not clear |
| A Anand Ganapathy, Vijayakumari M Haripriya, Niyati Acharya, Sasidhar B Somappa, Alaganandam Kumara. Ethnobotanical significance of medicinal plants: Beta-amyloid and tau aggregation inhibitors against Alzheimer's disease. Journal of biochemical and molecular toxicology. 2023-04-03. PMID:37009720. |
ethnobotanical significance of medicinal plants: beta-amyloid and tau aggregation inhibitors against alzheimer's disease. |
2023-04-03 |
2023-08-14 |
Not clear |
| Xavier Morató, Marta Marquié, Juan Pablo Tartari, Asunción Lafuente, Carla Abdelnour, Montserrat Alegret, Sara Jofresa, Mar Buendía, Ana Pancho, Núria Aguilera, Marta Ibarria, Susana Diego, Rosario Cuevas, Laia Cañada, Anna Calvet, Ester Esteban-De Antonio, Alba Pérez-Cordón, Ángela Sanabria, Itziar de Rojas, Raúl Nuñez-Llaves, Amanda Cano, Adelina Orellana, Laura Montrreal, Pilar Cañabate, Maitée Rosende-Roca, Liliana Vargas, Urszula Bojaryn, Mario Ricciardi, Diana M Ariton, Ana Espinosa, Gemma Ortega, Nathalia Muñoz, Núria Lleonart, Emilio Alarcón-Martín, Mariola Moreno, Silvia Preckler, Natalia Tantinya, Maribel Ramis, Ana Belen Nogales, Susanna Seguer, Elvira Martín, Vanesa Pytel, Sergi Valero, Miren Gurruchaga, Lluís Tárraga, Agustín Ruiz, Mercè Boad. A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress. Scientific reports. vol 13. issue 1. 2023-04-03. PMID:37012306. |
although beta-amyloid (aβ) and phosphorylated tau remain the preferred targets for disease-modifying treatments (dmt) against alzheimer's disease (ad), part of the pathophysiological mechanisms of cognitive impairment are related to neuroinflammation and oxidative stress. |
2023-04-03 |
2023-08-14 |
human |