| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| QuanQiu Wang, Pamela B Davis, Xin Qi, Shu G Chen, Mark E Gurney, George Perry, P Murali Doraiswamy, Rong X. Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34670619. |
interactions between the gut microbiota, microglia, and aging may modulate alzheimer's disease (ad) pathogenesis but the precise nature of such interactions is not known. |
2021-10-28 |
2023-08-13 |
Not clear |
| Kazuya Miyanishi, Arisa Sato, Nanako Kihara, Ryo Utsunomiya, Junya Tanak. Synaptic elimination by microglia and disturbed higher brain functions. Neurochemistry international. vol 142. 2021-10-27. PMID:33181238. |
in addition to the roles of microglia in normal developing and mature brains, impaired microglial phagocytosis functions also correlate with disturbances to these higher brain functions that are caused by neurological, mental, and developmental disorders; parkinson's and alzheimer's diseases, autism spectrum disorder, attention deficit/hyperactivity disorder, and schizophrenia. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jae-Won Shin, James C Le. Roles of microglial membranes in Alzheimer's disease. Current topics in membranes. vol 86. 2021-10-25. PMID:33837697. |
the majority of alzheimer's disease (ad) risk genes are highly and selectively expressed by microglia in the brain. |
2021-10-25 |
2023-08-13 |
Not clear |
| Charlotte Isabelle Delage, Eva Šimončičová, Marie-Ève Trembla. Microglial heterogeneity in aging and Alzheimer's disease: Is sex relevant? Journal of pharmacological sciences. vol 146. issue 3. 2021-10-25. PMID:34030799. |
recent evidence has uncovered the role of microglia, the immunocompetent cells of the brain, in dysfunctions linked to neurodegenerative diseases such as is alzheimer's disease (ad). |
2021-10-25 |
2023-08-13 |
Not clear |
| Melissa K Edler, Isha Mhatre-Winters, Jason R Richardso. Microglia in Aging and Alzheimer's Disease: A Comparative Species Review. Cells. vol 10. issue 5. 2021-10-25. PMID:34066847. |
microglia in aging and alzheimer's disease: a comparative species review. |
2021-10-25 |
2023-08-13 |
Not clear |
| Melissa K Edler, Isha Mhatre-Winters, Jason R Richardso. Microglia in Aging and Alzheimer's Disease: A Comparative Species Review. Cells. vol 10. issue 5. 2021-10-25. PMID:34066847. |
aging also has a profound effect on microglia, leading to chronic inflammation and an increase in the brain's susceptibility to neurodegenerative processes that occur in alzheimer's disease. |
2021-10-25 |
2023-08-13 |
Not clear |
| Ayeisha Milligan Armstrong, Tenielle Porter, Hazel Quek, Anthony White, John Haynes, Connie Jackaman, Victor Villemagne, Kylie Munyard, Simon M Laws, Giuseppe Verdile, David Grot. Chronic stress and Alzheimer's disease: the interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia. Biological reviews of the Cambridge Philosophical Society. vol 96. issue 5. 2021-10-25. PMID:34159699. |
chronic stress and alzheimer's disease: the interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia. |
2021-10-25 |
2023-08-13 |
Not clear |
| Zhong-Qing Sun, Jin-Feng Liu, Wei Luo, Ching-Hin Wong, Kwok-Fai So, Yong Hu, Kin Chi. Neural regeneration research. vol 17. issue 1. 2021-10-22. PMID:34100457. |
one of the main mechanisms of alzheimer's disease is that microglia activated by amyloid beta (aβ) transform from the resting state to an m1 state and release pro-inflammatory cytokines to the surrounding environment. |
2021-10-22 |
2023-08-13 |
Not clear |
| Christina Fröhlich, Kristin Paarmann, Johannes Steffen, Jan Stenzel, Markus Krohn, Hans-Jochen Heinze, Jens Pahnk. Genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of Alzheimer's disease. European journal of microbiology & immunology. vol 3. issue 1. 2021-10-21. PMID:23814667. |
genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of alzheimer's disease. |
2021-10-21 |
2023-08-12 |
mouse |
| R E Mrak, W St Griffi. Role of Activated Glia and of Glial Cytokines in Alzheimer's Disease: A Review. Eos (Rome, Italy). vol 16. issue 3-4. 2021-10-21. PMID:24478534. |
we review the role of activated microglia and activated astrocytes, and of glia-derived cytokines and other molecules, in the pathogenesis and pathophysiology of alzheimer's disease. |
2021-10-21 |
2023-08-12 |
Not clear |
| R E Mrak, W St Griffi. Role of Activated Glia and of Glial Cytokines in Alzheimer's Disease: A Review. Eos (Rome, Italy). vol 16. issue 3-4. 2021-10-21. PMID:24478534. |
activated microglia overexpressing the potent immune-response cytokine interleukin-1, and activated astrocytes over-expressing the neurotrophic cytokine s100β, are near-constant components of neuritic plaques in alzheimer's disease, and are frequent components of early, non-neuritic, amyloid deposits. |
2021-10-21 |
2023-08-12 |
Not clear |
| Yang Wang, Bing Xu, Jin Zhou, Jinchun Wang, Guoqing Wang, Yunpeng Ca. An Aβ3‑10‑KLH vaccine decreases Aβ plaques and astrocytes and microglia activation in the brain of APP/PS1 transgenic mice. Acta neurobiologiae experimentalis. vol 81. issue 3. 2021-10-21. PMID:34672292. |
this study aimed to investigate β‑amyloid peptide (aβ) plaques and changes of astroglia and microglia in mice with alzheimer's disease (ad). |
2021-10-21 |
2023-08-13 |
mouse |
| Toru Murakawa-Hirachi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshinori Haraguchi, Akira Monj. Effect of memantine, an anti-Alzheimer's drug, on rodent microglial cells in vitro. Scientific reports. vol 11. issue 1. 2021-10-18. PMID:33731780. |
the pathophysiology of alzheimer's disease (ad) is related to neuroinflammatory responses mediated by microglia. |
2021-10-18 |
2023-08-13 |
Not clear |
| Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua O. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:34265833. |
the nod-like receptor 3 (nlrp3) inflammasome assembles inside of microglia on activation, which plays an important role in neurodegeneration such as alzheimer disease. |
2021-10-18 |
2023-08-13 |
rat |
| Si-Yi Wang, Yan Liu, Xiao-Mao Li, Adnan Mohammed Algradi, Hai Jiang, Yan-Ping Sun, Wei Guan, Juan Pan, Hai-Xue Kuang, Bing-You Yan. Discovery of Active Ingredients Targeted TREM2 by SPR Biosensor-UPLC/MS Recognition System, and Investigating the Mechanism of Anti-Neuroinflammatory Activity on the Lignin-Amides from Molecules (Basel, Switzerland). vol 26. issue 19. 2021-10-16. PMID:34641490. |
discovery of active ingredients targeted trem2 by spr biosensor-uplc/ms recognition system, and investigating the mechanism of anti-neuroinflammatory activity on the lignin-amides from as a new target protein for alzheimer's disease (ad), the triggering receptor expressed on myeloid cells 2 (trem2) was expressed on the surface of microglia, which was shown to regulate neuroinflammation, be associated with a variety of neuropathologic, and regarded as a potential indicator for monitoring ad. |
2021-10-16 |
2023-08-13 |
Not clear |
| Lushuang Xie, Yi Liu, Ning Zhang, Chenyu Li, Aaron F Sandhu, George Williams, Yan Shen, Hongying Li, Qiaofeng Wu, Shuguang Y. Electroacupuncture Improves M2 Microglia Polarization and Glia Anti-inflammation of Hippocampus in Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-10-15. PMID:34646113. |
electroacupuncture improves m2 microglia polarization and glia anti-inflammation of hippocampus in alzheimer's disease. |
2021-10-15 |
2023-08-13 |
Not clear |
| Douglas P Wightman, Iris E Jansen, Jeanne E Savage, Alexey A Shadrin, Shahram Bahrami, Dominic Holland, Arvid Rongve, Sigrid Børte, Bendik S Winsvold, Ole Kristian Drange, Amy E Martinsen, Anne Heidi Skogholt, Cristen Willer, Geir Bråthen, Ingunn Bosnes, Jonas Bille Nielsen, Lars G Fritsche, Laurent F Thomas, Linda M Pedersen, Maiken E Gabrielsen, Marianne Bakke Johnsen, Tore Wergeland Meisingset, Wei Zhou, Petroula Proitsi, Angela Hodges, Richard Dobson, Latha Velayudhan, Karl Heilbron, Adam Auton, Julia M Sealock, Lea K Davis, Nancy L Pedersen, Chandra A Reynolds, Ida K Karlsson, Sigurdur Magnusson, Hreinn Stefansson, Steinunn Thordardottir, Palmi V Jonsson, Jon Snaedal, Anna Zettergren, Ingmar Skoog, Silke Kern, Margda Waern, Henrik Zetterberg, Kaj Blennow, Eystein Stordal, Kristian Hveem, John-Anker Zwart, Lavinia Athanasiu, Per Selnes, Ingvild Saltvedt, Sigrid B Sando, Ingun Ulstein, Srdjan Djurovic, Tormod Fladby, Dag Aarsland, Geir Selbæk, Stephan Ripke, Kari Stefansson, Ole A Andreassen, Danielle Posthum. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. Nature genetics. vol 53. issue 9. 2021-10-14. PMID:34493870. |
this study highlights microglia, immune cells and protein catabolism as relevant to late-onset alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. |
2021-10-14 |
2023-08-13 |
Not clear |
| Victoria E von Saucken, Taylor R Jay, Gary E Landret. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of disease. vol 145. 2021-10-12. PMID:32890775. |
genetic studies identified mutations in several immune-related genes that confer increased risk for developing alzheimer's disease (ad), suggesting a key role for microglia in ad pathology. |
2021-10-12 |
2023-08-13 |
mouse |
| Luca Muzio, Alice Viotti, Gianvito Martin. Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy. Frontiers in neuroscience. vol 15. 2021-10-12. PMID:34630027. |
there is solid and sound evidence suggesting that regulating microglia functions during disease pathology might represent a strategy to develop future therapies aimed at counteracting brain degeneration in multiple sclerosis, alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis. |
2021-10-12 |
2023-08-13 |
Not clear |
| Tongya Yu, Yingying Lin, Yuzhen Xu, Yunxiao Dou, Feihong Wang, Hui Quan, Yanxin Zhao, Xueyuan Li. Repressor Element 1 Silencing Transcription Factor (REST) Governs Microglia-Like BV2 Cell Migration via Progranulin (PGRN). Neural plasticity. vol 2020. 2021-10-11. PMID:33299399. |
microglia activation contributes to alzheimer's disease (ad) etiology, and microglia migration is a fundamental function during microglia activation. |
2021-10-11 |
2023-08-13 |
Not clear |