| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N W Pedigo, L D Minor, T N Krumre. Cholinergic drug effects and brain muscarinic receptor binding in aged rats. Neurobiology of aging. vol 5. issue 3. 1985-02-21. PMID:6514108. |
cholinergic neurotransmission in cerebral cortex and hippocampus is also severely impaired in a major age-related neurological disorder, alzheimer's disease. |
1985-02-21 |
2023-08-12 |
rat |
| J R Scott, H Frase. Degenerative hippocampal pathology in mice infected with scrapie. Acta neuropathologica. vol 65. issue 1. 1985-02-19. PMID:6542738. |
scrapie-induced hippocampal sclerosis provides an experimental system for investigating the basis for similar lesions, which occur in a variety of conditions, such as alzheimer's disease and epilepsy. |
1985-02-19 |
2023-08-12 |
mouse |
| M J Ball, M Fisman, V Hachinski, W Blume, A Fox, V A Kral, A J Kirshen, H Fox, H Merske. A new definition of Alzheimer's disease: a hippocampal dementia. Lancet (London, England). vol 1. issue 8419. 1985-01-31. PMID:2856948. |
a new definition of alzheimer's disease: a hippocampal dementia. |
1985-01-31 |
2023-08-11 |
Not clear |
| D M Jacobowitz, W E Heydor. Two-dimensional gel electrophoresis used in neurobiological studies of proteins in discrete areas of the rat brain. Clinical chemistry. vol 30. issue 12 Pt 1. 1985-01-17. PMID:6499172. |
finally, we developed a possible animal model for studying proteins related to alzheimer's disease by depleting the cholinergic innervation to the cortex and the hippocampus. |
1985-01-17 |
2023-08-12 |
rat |
| E Perdahl, R Adolfsson, I Alafuzoff, K A Albert, E J Nestler, P Greengard, B Winbla. Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multi-infarct dementia. Journal of neural transmission. vol 60. issue 2. 1984-12-12. PMID:6436437. |
synapsin i (protein i), a neuron-specific phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from alzheimer disease/senile dementia of alzheimer type (ad/sdat), from patients with multi-infarct dementia (mid), and from age-matched controls. |
1984-12-12 |
2023-08-12 |
Not clear |
| D G Brownstein, E A Johnson, A L Smit. Spontaneous Reye's-like syndrome in BALB/cByJ mice. Laboratory investigation; a journal of technical methods and pathology. vol 51. issue 4. 1984-11-13. PMID:6482384. |
necropsy findings included swollen, diffusely pale yellow livers with panlobular microvesicular fatty change, pale renal cortices with epithelial fat droplets of the proximal convoluted tubules, and alzheimer type ii astrocytosis of the neocortex, corpus striatum, hippocampus, and thalamus. |
1984-11-13 |
2023-08-12 |
mouse |
| S M Sagar, M F Beal, P E Marshall, D M Landis, J B Marti. Implications of neuropeptides in neurological diseases. Peptides. vol 5 Suppl 1. 1984-11-09. PMID:6207511. |
somatostatin concentration is reduced in the hippocampus and neocortex of patients dying with alzheimer's type dementia. |
1984-11-09 |
2023-08-12 |
human |
| P E Sylveste. Nutritional aspects of Down's syndrome with special reference to the nervous system. The British journal of psychiatry : the journal of mental science. vol 145. 1984-10-02. PMID:6235883. |
the brain in downs's syndrome does not develop adequately; one area, the hippocampus, which is concerned with memory, is poorly developed and is also involved in the pathological changes of alzheimer's disease. |
1984-10-02 |
2023-08-12 |
Not clear |
| I Grundke-Iqbal, K Iqbal, Y C Tung, H M Wisniewsk. Alzheimer paired helical filaments: immunochemical identification of polypeptides. Acta neuropathologica. vol 62. issue 4. 1984-07-25. PMID:6428153. |
these anti- phf sera immunolabeled both ant in sections of alzheimer hippocampus and ant which were isolated and extracted with sodium dodecyl sulfate (sds). |
1984-07-25 |
2023-08-12 |
Not clear |
| M A Bell, W G Scarro. Staining for microvascular alkaline phosphatase in thick celloidin sections of nervous tissue: morphometric and pathological applications. Microvascular research. vol 27. issue 2. 1984-05-04. PMID:6369077. |
examples are drawn from current studies of the hippocampal and calcarine microvasculatures and their relation to senile plaques in normal aging and senile dementia of the alzheimer type. |
1984-05-04 |
2023-08-12 |
Not clear |
| I N Ferrier, A J Cross, J A Johnson, G W Roberts, T J Crow, J A Corsellis, Y C Lee, D O'Shaughnessy, T E Adrian, G P McGrego. Neuropeptides in Alzheimer type dementia. Journal of the neurological sciences. vol 62. issue 1-3. 1984-04-25. PMID:6199464. |
five neuropeptides (cholecystokinin (cck), vasoactive intestinal polypeptide (vip), somatostatin (srif), neurotensin (nt) and substance p (sp)) were measured in 14 brain areas (4 cortical areas, hippocampus, amygdala, 3 striatal areas, 2 thalamic areas and 3 subcortical areas-- septum, substantia innominata and hypothalamus) in 12 brains with neuropathologically confirmed alzheimer type change and in 13 control brains. |
1984-04-25 |
2023-08-12 |
cat |
| R J Rylett, M J Ball, E H Colhou. Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease. Brain research. vol 289. issue 1-2. 1984-03-12. PMID:6661641. |
evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with alzheimer's disease. |
1984-03-12 |
2023-08-12 |
human |
| R J Rylett, M J Ball, E H Colhou. Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease. Brain research. vol 289. issue 1-2. 1984-03-12. PMID:6661641. |
hippocampal and neocortical cholinergic nerve cell endings, prepared as synaptosomes, from brains of patients with alzheimer's disease, also accumulated choline by a high-affinity mechanism; however, the velocity of uptake into both brain areas was decreased in comparison with controls. |
1984-03-12 |
2023-08-12 |
human |
| R J Rylett, M J Ball, E H Colhou. Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease. Brain research. vol 289. issue 1-2. 1984-03-12. PMID:6661641. |
choline transport into synaptosomes from alzheimer frontal cortex was reduced approximately 50%, while uptake into alzheimer hippocampal synaptosomes represented only 20% of the control activity. |
1984-03-12 |
2023-08-12 |
human |
| H A Hartmann, S K White, R L Levin. Neuroaxonal dystrophy with neuromelanin deposition, neurofibrillary tangles, and neuronal loss. Light- and electron-microscopic changes in a 45-year-old woman with progressive psychomotor deterioration. Acta neuropathologica. vol 61. issue 3-4. 1984-01-27. PMID:6650130. |
neurofibrillary degeneration, senile plaques, and granulovacuolar degeneration in the hippocampus produced a picture of alzheimer's disease. |
1984-01-27 |
2023-08-12 |
Not clear |
| T D Bird, S Stranahan, S M Sumi, M Raskin. Alzheimer's disease: choline acetyltransferase activity in brain tissue from clinical and pathological subgroups. Annals of neurology. vol 14. issue 3. 1983-12-20. PMID:6227276. |
choline acetyltransferase activity was significantly lower in patients with early-onset alzheimer's disease than in age-matched control subjects in frontal cortex, temporal cortex, hippocampus, and cerebellum. |
1983-12-20 |
2023-08-12 |
human |
| T D Bird, S Stranahan, S M Sumi, M Raskin. Alzheimer's disease: choline acetyltransferase activity in brain tissue from clinical and pathological subgroups. Annals of neurology. vol 14. issue 3. 1983-12-20. PMID:6227276. |
in contrast, choline acetyltransferase activity in patients with late-onset alzheimer's disease was significantly lower than in age-matched control subjects only in hippocampus. |
1983-12-20 |
2023-08-12 |
human |
| G L Mancardi, B H Liwnicz, T I Mandybu. Fibrous astrocytes in Alzheimer's disease and senile dementia of Alzheimer's type. Acta neuropathologica. vol 61. issue 1. 1983-11-23. PMID:6353837. |
in four patients with alzheimer's disease (ad), on patient with senile dementia of alzheimer's type (sdat) and five age-matched controls, occipital cortex, frontal cortex, and hippocampus were evaluated for the distribution of fibrous astrocytes (fa), using peroxidase-anti-peroxidase for glial fibrillary acidic protein (gfap). |
1983-11-23 |
2023-08-12 |
Not clear |
| D M Mann, A M Tinkler, P O Yate. Neurological disease and herpes simplex virus. An immunohistochemical study. Acta neuropathologica. vol 60. issue 1-2. 1983-09-23. PMID:6308942. |
in the patient with alzheimer's disease va was present within nerve and glial cells of the amygdala, within oligodendrocytes of the optic and olfactory tracts and in macrophages within the temporal cortex hippocampus and cerebellum. |
1983-09-23 |
2023-08-12 |
Not clear |
| A Probst, V Basler, B Bron, J Ulric. Neuritic plaques in senile dementia of Alzheimer type: a Golgi analysis in the hippocampal region. Brain research. vol 268. issue 2. 1983-09-20. PMID:6191831. |
neuritic plaques in senile dementia of alzheimer type: a golgi analysis in the hippocampal region. |
1983-09-20 |
2023-08-12 |
Not clear |