| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Cross, T J Crow, E K Perry, R H Perry, G Blessed, B E Tomlinso. Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease. British medical journal (Clinical research ed.). vol 282. issue 6258. 1981-04-21. PMID:6779929. |
enzyme activity was decreased in the frontal and temporal cortices and hippocampus in patients with alzheimer's disease, but was within the normal range in patients with depression, multiinfarct dementia, and terminal coma.the decrease in enzyme activity in alzheimer's disease may reflect an abnormality of cortical noradrenergic fibres in some patients with the disease. |
1981-04-21 |
2023-08-12 |
Not clear |
| I Tarbit, E K Perry, R H Perry, G Blessed, B E Tomlinso. Hippocampal free amino acids in Alzheimer's disease. Journal of neurochemistry. vol 35. issue 5. 1981-03-24. PMID:7452316. |
hippocampal free amino acids in alzheimer's disease. |
1981-03-24 |
2023-08-12 |
Not clear |
| I Tarbit, E K Perry, R H Perry, G Blessed, B E Tomlinso. Hippocampal free amino acids in Alzheimer's disease. Journal of neurochemistry. vol 35. issue 5. 1981-03-24. PMID:7452316. |
the free amino acid content of the hippocampus, obtained at postmortem, has been analysed in cases of alzheimer's disease and compared with normal cases. |
1981-03-24 |
2023-08-12 |
Not clear |
| M J Ball, K Nuttal. Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down Syndrome: quantitative comparison with Alzheimer dementia. Annals of neurology. vol 7. issue 5. 1980-09-28. PMID:6446875. |
by contrast, the number of alzheimer neurofibrillary tangles and loss of pyramidal neurons from the hippocampus exceeded levels found in considerably older subjects and fell into the same range of severity as was noted in 8 patients with alzheimer dementia. |
1980-09-28 |
2023-08-12 |
human |
| D P Perl, A R Brod. Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science (New York, N.Y.). vol 208. issue 4441. 1980-06-25. PMID:7367858. |
the elemental content of neurons of the hippocampus was studied by a combination of scanning electron microscopy and x-ray spectrometry in autopsy-derived brain tissue from three cases of senile dementia (alzheimer type) and three nondemented elderly controls. |
1980-06-25 |
2023-08-12 |
Not clear |
| R H Perry, G Blessed, E K Perry, B E Tomlinso. Histochemical observations on cholinesterase activities in the brains of elderly normal and demented (Alzheimer-type) patients. Age and ageing. vol 9. issue 1. 1980-05-30. PMID:7370097. |
the extent and distribution of acetylcholinesterase staining in the hippocampus has been compared in normal elderly cases and patients with alzheimer's disease. |
1980-05-30 |
2023-08-12 |
Not clear |
| R H Perry, G Blessed, E K Perry, B E Tomlinso. Histochemical observations on cholinesterase activities in the brains of elderly normal and demented (Alzheimer-type) patients. Age and ageing. vol 9. issue 1. 1980-05-30. PMID:7370097. |
the positive staining of processes in senile plaques suggests that they are, at least partly, derived from cholinergic, axonal fibres and the decrease in acetylcholinesterase staining of nerve processes may indicate a diminution in cholinergic, afferent input fibres to the hippocampus in alzheimer's disease. |
1980-05-30 |
2023-08-12 |
Not clear |
| I Grundke-Iqbal, A B Johnson, R D Terry, H M Wisniewski, K Iqba. Alzheimer neurofibrillary tangles: antiserum and immunohistological staining. Annals of neurology. vol 6. issue 6. 1980-04-26. PMID:394670. |
the reactivity of the anti-paired helical filament protein serum with neurofibrillary tangles was studied by immunofluorescence on cryostat sections of hippocampus from alzheimer autopsy tissue and by the peroxidase-antiperoxidase technique on paraffin sections of an alzheimer brain biopsy. |
1980-04-26 |
2023-08-11 |
human |
| H Okazaki, T J Reagan, R J Campbel. Clinicopathologic studies of primary cerebral amyloid angiopathy. Mayo Clinic proceedings. vol 54. issue 1. 1979-03-29. PMID:759733. |
alzheimer's neurofibrillary tangles were absent or were limited to the hippocampal region in all but two cases. |
1979-03-29 |
2023-08-11 |
Not clear |
| E K Perry, R H Perry, G Blessed, B E Tomlinso. Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathology and applied neurobiology. vol 4. issue 4. 1978-12-29. PMID:703927. |
acetylcholinesterase was significantly reduced and butyrylcholinesterase significantly increased, compared with the normal, in the hippocampus and temporal cortex of the alzheimer cases. |
1978-12-29 |
2023-08-11 |
Not clear |
| C M Smith, M Swas. Possible biochemical basis of memory disorder in Alzheimer disease. Annals of neurology. vol 3. issue 6. 1978-09-25. PMID:209723. |
the most common presenting symptom of alzheimer disease is loss of short-term memory, and histologically the hippocampus is characteristically affected. |
1978-09-25 |
2023-08-11 |
human |
| M J Bal. Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study. Acta neuropathologica. vol 42. issue 2. 1978-07-26. PMID:654888. |
topographic analysis was performed of the distribution of alzheimer's neurofibrillary tangles and the granulovacuolar degeneration of simchowicz in the hippocampal cortex of patients with alzheimer's dementia and mentally normal aged controls. |
1978-07-26 |
2023-08-11 |
Not clear |
| P H Gibson, B E Tomlinso. Numbers of Hirano bodies in the hippocampus of normal and demented people with Alzheimer's disease. Journal of the neurological sciences. vol 33. issue 1-2. 1977-11-25. PMID:903782. |
numbers of hirano bodies in the hippocampus of normal and demented people with alzheimer's disease. |
1977-11-25 |
2023-08-11 |
human |
| P H Gibson, B E Tomlinso. Numbers of Hirano bodies in the hippocampus of normal and demented people with Alzheimer's disease. Journal of the neurological sciences. vol 33. issue 1-2. 1977-11-25. PMID:903782. |
hirano bodies were counted in the pyramidal layer of the hippocampus in the brains of 34 demented patients with alzheimer's disease or senile dementia of the alzheimer type and 24 non-demented subjects of 60 years and over who had been psychometrically assessed. |
1977-11-25 |
2023-08-11 |
human |
| M J Bal. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta neuropathologica. vol 37. issue 2. 1977-05-25. PMID:848276. |
the number of pyramidal neurones in the hippocampal cortex was determined in serially sectioned mesial temporal lobe from brains of 18 mentally normal people, as well as those of 8 demented patients with pathologically confirmed alzheimer's disease. |
1977-05-25 |
2023-08-11 |
Not clear |
| M J Bal. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta neuropathologica. vol 37. issue 2. 1977-05-25. PMID:848276. |
the posterior portion of the hippocampus may be considerably more susceptible to the degenerative nerve cell changes prominent in dementia of the alzheimer type. |
1977-05-25 |
2023-08-11 |
Not clear |
| M W Hopper, F S Voge. The limbic system in Alzheimer's disease. A neuropathologic investigation. The American journal of pathology. vol 85. issue 1. 1976-12-01. PMID:135514. |
the morphologic alterations of alzheimer's disease, presenile and senile dementia, have conventionally been associated with the cerebral cortex; however, it is clear that other areas of the brain, notably the hippocampus and amygdala, are involved as well. |
1976-12-01 |
2023-08-11 |
Not clear |
| M Morimatsu, S Hirai, A Muramatsu, M Yoshikaw. Senile degenerative brain lesions and dementia. Journal of the American Geriatrics Society. vol 23. issue 9. 1975-10-30. PMID:50338. |
in a study of senile degenerative lesions-including alzheimer's neurofibrillary changes, senile plaques and amyloid angiopathy-the hippocampal area of the brain was examined by thioflavine t fluorescence microscopy in 146 consecutive autopsy patients over the age of 49. |
1975-10-30 |
2023-08-11 |
Not clear |