| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E Lauri, S Kaukinen, T Kinnunen, A Ylinen, S Imai, K Kaila, T Taira, H Rauval. Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 4. 1999-02-25. PMID:9952400. |
heparan sulfates (hss) constitute a group of glycosaminoglycans that accumulate in the beta-amyloid deposits in alzheimer's disease and influence the development of neuron-target contacts by interacting with other cell surface and matrix molecules. |
1999-02-25 |
2023-08-12 |
rat |
| J T Gallaghe. Structure-activity relationship of heparan sulphate. Biochemical Society transactions. vol 25. issue 4. 1998-04-13. PMID:9449976. |
in addition to the issues already discussed, it has a profound effect on cell adhesion and migration through its interaction with many extracellular matrix proteins, most notably fibronectin and thrombospondin; it is closely linked to lipid metabolism through its capacity to bind low-density lipoprotein and lipoprotein lipase; and aberrations in hs structure and degradation are linked to human malignancy and alzheimer's disease [26,27]. |
1998-04-13 |
2023-08-12 |
human |
| J Cáceres, E Branda. Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. Journal of cellular biochemistry. vol 65. issue 2. 1997-06-19. PMID:9136074. |
the interaction between the alzheimer amyloid precursor protein (app) and an intact extracellular matrix (ecm), matrigel, obtained from engelbreth-holm-swarm tumors was evaluated. |
1997-06-19 |
2023-08-12 |
Not clear |
| J Cáceres, E Branda. Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. Journal of cellular biochemistry. vol 65. issue 2. 1997-06-19. PMID:9136074. |
interaction between alzheimer's disease beta a4 precursor protein (app) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. |
1997-06-19 |
2023-08-12 |
Not clear |
| P E Gottschall, S De. Regulation of matrix metalloproteinase expressions in astrocytes, microglia and neurons. Neuroimmunomodulation. vol 3. issue 2-3. 1997-05-19. PMID:8945720. |
the upregulated expression of several extracellular matrix proteins in astrocytes located surrounding a neuritic plaque in alzheimer's disease is a good example of such a response. |
1997-05-19 |
2023-08-12 |
rat |
| A Matsumoto, T Enomoto, Y Fujiwara, H Baba, R Matsumot. Enhanced aggregation of beta-amyloid-containing peptides by extracellular matrix and their degradation by the 68 kDa serine protease prepared from human brain. Neuroscience letters. vol 220. issue 3. 1997-04-02. PMID:8994217. |
to explore whether extracellular matrix components in human brain affect the deposition and aggregation of beta-amyloid containing peptides, human brain samples from patients with sporadic alzheimer's disease and normal aged were analyzed by western blot analysis. |
1997-04-02 |
2023-08-12 |
human |
| F C Bronfman, J Garrido, A Alvarez, C Morgan, N C Inestros. Laminin inhibits amyloid-beta-peptide fibrillation. Neuroscience letters. vol 218. issue 3. 1997-03-04. PMID:8945763. |
laminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-beta-peptide (a beta) deposits in alzheimer brains. |
1997-03-04 |
2023-08-12 |
Not clear |
| K Beyreuther, G Multhaup, U Mönning, R Sandbrink, D Beher, L Hesse, D H Small, C L Master. Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines. Annals of the New York Academy of Sciences. vol 777. 1996-06-14. PMID:8624129. |
we have identified and characterized the ligand binding properties of the alzheimer's disease (ad) beta a4 amyloid protein precursor (app), mapped the app ligand binding sites and analyzed the regulation of app expression, biogenesis and metabolism by components of the extracellular matrix (ecm) and cytokines. |
1996-06-14 |
2023-08-12 |
Not clear |
| T Wyss-Coray, L Feng, E Masliah, M D Ruppe, H S Lee, S M Toggas, E M Rockenstein, L Muck. Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. The American journal of pathology. vol 147. issue 1. 1995-08-08. PMID:7604885. |
as an effective inducer of extracellular matrix components, tgf-beta 1 may also contribute to the development of other neuropathological alterations, eg, the formation of amyloid plaques in alzheimer's disease. |
1995-08-08 |
2023-08-12 |
mouse |
| H Fillit, B Leveugl. Disorders of the extracellular matrix and the pathogenesis of senile dementia of the Alzheimer's type. Laboratory investigation; a journal of technical methods and pathology. vol 72. issue 3. 1995-04-26. PMID:7898045. |
disorders of the extracellular matrix and the pathogenesis of senile dementia of the alzheimer's type. |
1995-04-26 |
2023-08-12 |
Not clear |
| M Jucker, L C Walker, H Kuo, M Tian, D K Ingra. Age-related fibrillar deposits in brains of C57BL/6 mice. A review of localization, staining characteristics, and strain specificity. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7534088. |
although the deposits do not represent senile plaques with beta-amyloid deposition, they might mimic the deposition of extracellular matrix molecules that is thought to be an early event in amyloidogenesis in the aged brain and in alzheimer's disease. |
1995-04-18 |
2023-08-12 |
mouse |
| P E Gottschall, X Y. Cytokines regulate gelatinase A and B (matrix metalloproteinase 2 and 9) activity in cultured rat astrocytes. Journal of neurochemistry. vol 64. issue 4. 1995-04-18. PMID:7891077. |
little is known about the function of matrix metalloproteinases or agents that regulate their production in adult brain; however, it has been shown that the activity of a calcium-dependent metalloproteinase is elevated in alzheimer's hippocampus. |
1995-04-18 |
2023-08-12 |
rat |
| N Peress, E Perillo, S Zucke. Localization of tissue inhibitor of matrix metalloproteinases in Alzheimer's disease and normal brain. Journal of neuropathology and experimental neurology. vol 54. issue 1. 1995-02-08. PMID:7815076. |
localization of tissue inhibitor of matrix metalloproteinases in alzheimer's disease and normal brain. |
1995-02-08 |
2023-08-12 |
Not clear |
| E Brandan, N C Inestros. Extracellular matrix components and amyloid in neuritic plaques of Alzheimer's disease. General pharmacology. vol 24. issue 5. 1994-02-01. PMID:8270163. |
extracellular matrix components and amyloid in neuritic plaques of alzheimer's disease. |
1994-02-01 |
2023-08-12 |
Not clear |
| D H Small, V Nurcombe, H Clarris, K Beyreuther, C L Master. The role of extracellular matrix in the processing of the amyloid protein precursor of Alzheimer's disease. Annals of the New York Academy of Sciences. vol 695. 1993-12-10. PMID:8239278. |
the role of extracellular matrix in the processing of the amyloid protein precursor of alzheimer's disease. |
1993-12-10 |
2023-08-12 |
chicken |
| E H Koo, L Park, D J Selko. Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 10. 1993-07-02. PMID:8506329. |
our results suggest that insoluble a beta in the cerebral neuropil may serve as a neurite-promoting matrix, perhaps explaining the apparent regenerative response of neurites observed around amyloid plaques in alzheimer disease. |
1993-07-02 |
2023-08-12 |
rat |
| E A van der Wal, F Gómez-Pinilla, C W Cotma. Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. Neuroreport. vol 4. issue 1. 1993-04-16. PMID:8453039. |
transforming growth factor-beta (tgf-beta) is a major modulator of the extracellular matrix and cell growth, and shows affinity for and interaction with several substances present in plaques in alzheimer's disease (ad). |
1993-04-16 |
2023-08-12 |
Not clear |
| S Narindrasorasak, D E Lowery, R A Altman, P A Gonzalez-DeWhitt, B D Greenberg, R Kisilevsk. Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins. Laboratory investigation; a journal of technical methods and pathology. vol 67. issue 5. 1992-12-14. PMID:1434542. |
we have therefore been examining interactions between extracellular matrix components and the alzheimer's amyloid precursors (aaps). |
1992-12-14 |
2023-08-11 |
Not clear |
| D H Small, V Nurcombe, R Moir, S Michaelson, D Monard, K Beyreuther, C L Master. Association and release of the amyloid protein precursor of Alzheimer's disease from chick brain extracellular matrix. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 11. 1992-12-11. PMID:1279136. |
association and release of the amyloid protein precursor of alzheimer's disease from chick brain extracellular matrix. |
1992-12-11 |
2023-08-11 |
human |
| D H Small, V Nurcombe, R Moir, S Michaelson, D Monard, K Beyreuther, C L Master. Association and release of the amyloid protein precursor of Alzheimer's disease from chick brain extracellular matrix. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 11. 1992-12-11. PMID:1279136. |
the amyloid protein precursor (app) of alzheimer's disease was found to bind saturably (kd = 60 nm) to embryonic chick brain extracellular matrix (ecm). |
1992-12-11 |
2023-08-11 |
human |