| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Solveig Horstmann, Leila Budig, Humphrey Gardner, James Koziol, Michael Deuschle, Claudia Schilling, Simone Wagne. Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease. International psychogeriatrics. vol 22. issue 6. 2010-12-16. PMID:20561382. |
the ability of several matrix metalloproteinases (mmps) to degrade amyloid precursor protein leading to aggregation of amyloid beta, as well as the increased expression of mmps in post mortem brain tissue of alzheimer's patients, indicate that mmps play an important role in the pathogenesis of ad. |
2010-12-16 |
2023-08-12 |
Not clear |
| Sally Hunter, Robert P Friedland, Carol Brayn. Time for a change in the research paradigm for Alzheimer's disease: the value of a chaotic matrix modeling approach. CNS neuroscience & therapeutics. vol 16. issue 4. 2010-10-21. PMID:20002628. |
time for a change in the research paradigm for alzheimer's disease: the value of a chaotic matrix modeling approach. |
2010-10-21 |
2023-08-12 |
Not clear |
| P Padilla, J M Górriz, J Ramírez, E W Lang, R Chaves, F Segovia, M López, D Salas-González, I Alvare. Analysis of SPECT brain images for the diagnosis of Alzheimer's disease based on NMF for feature extraction. Neuroscience letters. vol 479. issue 3. 2010-09-27. PMID:20641163. |
this letter presents a novel computer-aided diagnosis (cad) technique for the early diagnosis of alzheimer's disease (ad) based on non-negative matrix factorization (nmf) analysis applied to single photon emission computed tomography (spect) images. |
2010-09-27 |
2023-08-12 |
human |
| Christiane Reitz, Frank J A van Rooij, Holly D Soares, Moniek P M de Maat, Albert Hofman, Jacqueline C M Witteman, Monique M B Bretele. Matrix metalloproteinase 3 haplotypes and plasma amyloid beta levels: the Rotterdam Study. Neurobiology of aging. vol 31. issue 4. 2010-06-08. PMID:18606478. |
experimental studies suggest that matrix metalloproteinases (mmps) are involved in the degradation of amyloid beta (abeta) protein which plays a key role in the pathogenesis of alzheimer's disease. |
2010-06-08 |
2023-08-12 |
human |
| Ismael Santa-Maria, Jesus Avila, Alberto Raban. Differential gene expression analysis of human entorhinal cortex support a possible role of some extracellular matrix proteins in the onset of Alzheimer disease. Neuroscience letters. vol 468. issue 3. 2010-04-06. PMID:19922771. |
differential gene expression analysis of human entorhinal cortex support a possible role of some extracellular matrix proteins in the onset of alzheimer disease. |
2010-04-06 |
2023-08-12 |
human |
| L Palleschi, F Vetta, E De Gennaro, G Idone, G Sottosanti, W Gianni, V Mariglian. Effect of aerobic training on the cognitive performance of elderly patients with senile dementia of Alzheimer type. Archives of gerontology and geriatrics. vol 22 Suppl 1. 2009-12-14. PMID:18653007. |
the present study involved 15 males affected by senile dementia of alzheimer type (sdat) and assessed their functional capabilities by means of the following neuropsychological tests: test of attentional matrix, verbal span test, supraverbal span test, mini mental state examination. |
2009-12-14 |
2023-08-12 |
Not clear |
| Hiroyuki Mizoguchi, Kazuhiro Takuma, Emiko Fukuzaki, Daisuke Ibi, Eiichi Someya, Ko-hei Akazawa, Tursun Alkam, Hiroko Tsunekawa, Akihiro Mouri, Yukihiro Noda, Toshitaka Nabeshima, Kiyofumi Yamad. Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice. The Journal of pharmacology and experimental therapeutics. vol 331. issue 1. 2009-10-13. PMID:19587312. |
in alzheimer's disease (ad), the expression of matrix metalloproteases (mmps), which are capable of degrading extracellular matrix proteins, is increased in the brain. |
2009-10-13 |
2023-08-12 |
mouse |
| Sagrario Martín-Aragón, Paloma Bermejo-Bescós, Juana Benedí, Emanuela Felici, Pedro Gil, José Manuel Ribera, Angel Ma Villa. Metalloproteinase's activity and oxidative stress in mild cognitive impairment and Alzheimer's disease. Neurochemical research. vol 34. issue 2. 2009-03-30. PMID:18618244. |
matrix metalloproteinases (mmps) and oxidative stress have been implicated in neurological diseases such as alzheimer's disease (ad). |
2009-03-30 |
2023-08-12 |
human |
| Gerardino D'Errico, Giuseppe Vitiello, Ornella Ortona, Annamaria Tedeschi, Anna Ramunno, Anna Maria D'Urs. Interaction between Alzheimer's Abeta(25-35) peptide and phospholipid bilayers: the role of cholesterol. Biochimica et biophysica acta. vol 1778. issue 12. 2009-02-06. PMID:18706389. |
there is mounting evidence that the lipid matrix of neuronal cell membranes plays an important role in the accumulation of beta-amyloid peptides into senile plaques, one of the hallmarks of alzheimer's disease (ad). |
2009-02-06 |
2023-08-12 |
Not clear |
| Christiane Reitz, Frank J A van Rooij, Moniek P M de Maat, Tom den Heijer, Albert Hofman, Jacqueline C M Witteman, Monique M B Bretele. Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease. The Rotterdam Study. Neurobiology of aging. vol 29. issue 6. 2008-06-20. PMID:17316907. |
matrix metalloproteinase 3 haplotypes and dementia and alzheimer's disease. |
2008-06-20 |
2023-08-12 |
Not clear |
| Christiane Reitz, Frank J A van Rooij, Moniek P M de Maat, Tom den Heijer, Albert Hofman, Jacqueline C M Witteman, Monique M B Bretele. Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease. The Rotterdam Study. Neurobiology of aging. vol 29. issue 6. 2008-06-20. PMID:17316907. |
evidence by post-mortem and animal studies suggests that matrix metalloproteinases (mmps) may play an important role in the pathophysiology of alzheimer's disease (ad) through degradation of amyloid beta. |
2008-06-20 |
2023-08-12 |
Not clear |
| Argiris A Talamagas, Spiros Efthimiopoulos, Effie C Tsilibary, Maria E Figueiredo-Pereira, Athina K Tzini. Abeta(1-40)-induced secretion of matrix metalloproteinase-9 results in sAPPalpha release by association with cell surface APP. Neurobiology of disease. vol 28. issue 3. 2008-02-29. PMID:17761425. |
to understand matrix metalloproteinase-9 (mmp-9) involvement in alzheimer's disease, we examined mechanisms mediating increased expression of mmp-9 in the presence of abeta(1-40) and the role of mmp-9 on amyloid precursor protein (app) processing. |
2008-02-29 |
2023-08-12 |
Not clear |
| Elke Janig, Martin Haslbeck, Ariane Aigelsreiter, Nathalie Braun, Daniela Unterthor, Peter Wolf, Noor M Khaskhely, Johannes Buchner, Helmut Denk, Kurt Zatlouka. Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitro. The American journal of pathology. vol 171. issue 5. 2008-01-25. PMID:17872975. |
besides its presence in all human body fluids, clusterin associates with altered extracellular matrix proteins, such as beta-amyloid in alzheimer senile plaques in the brain. |
2008-01-25 |
2023-08-12 |
human |
| Catia Bellucci, Cinzia Lilli, Tiziano Baroni, Lucilla Parnetti, Sandro Sorbi, Carla Emiliani, Eleonora Lumare, Paolo Calabresi, Stefania Balloni, Maria Bod. Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 13. issue 9-10. 2007-12-06. PMID:17660861. |
differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial alzheimer's disease. |
2007-12-06 |
2023-08-12 |
Not clear |
| Catia Bellucci, Cinzia Lilli, Tiziano Baroni, Lucilla Parnetti, Sandro Sorbi, Carla Emiliani, Eleonora Lumare, Paolo Calabresi, Stefania Balloni, Maria Bod. Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 13. issue 9-10. 2007-12-06. PMID:17660861. |
extracellular matrix (ecm) molecules and growth factors, such as fibroblast growth factor (fgf), play a crucial role in alzheimer's disease (ad). |
2007-12-06 |
2023-08-12 |
Not clear |
| Yannick Bontemps, Nathalie Scamuffa, Fabien Calvo, Abdel-Majid Khati. Potential opportunity in the development of new therapeutic agents based on endogenous and exogenous inhibitors of the proprotein convertases. Medicinal research reviews. vol 27. issue 5. 2007-11-05. PMID:17019676. |
the proprotein convertases (pcs) are responsible for the endoproteolytic processing of various protein precursors (e.g., growth factors, receptors, adhesion molecules, and matrix metalloproteinases) implicated in several diseases such as obesity, diabetes, atherosclerosis, cancer, and alzheimer disease. |
2007-11-05 |
2023-08-12 |
Not clear |
| Katy A Chalmers, Seth Lov. Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons. Journal of neuropathology and experimental neurology. vol 66. issue 2. 2007-03-16. PMID:17279001. |
increased levels of tgfbeta in alzheimer disease (ad) are associated with perivascular deposition of extracellular matrix, which may impair clearance of beta-amyloid and contribute to the development of cerebral amyloid angiopathy. |
2007-03-16 |
2023-08-12 |
Not clear |
| Shuzhen Guo, Sophia Wang, Woo Jean Kim, Sun-Ryung Lee, Matthew P Frosch, Brian J Bacskai, Steven M Greenberg, Eng H L. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain research. vol 1111. issue 1. 2006-11-24. PMID:16919608. |
matrix metalloproteinase-9 (mmp-9) may play a role in the inflammatory glial response during alzheimer's disease (ad). |
2006-11-24 |
2023-08-12 |
rat |
| Michael Inspector, Judith Aharon-Perez, Lea Glass-Marmor, Ariel Mille. Matrix metalloproteinase-9, its tissue inhibitor(TIMP)-1 and CRP in Alzheimer's disease. European neurology. vol 53. issue 3. 2005-08-09. PMID:15942243. |
matrix metalloproteinase-9, its tissue inhibitor(timp)-1 and crp in alzheimer's disease. |
2005-08-09 |
2023-08-12 |
Not clear |
| Gad M Gilad, Herbert M Kagan, Varda H Gila. Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer's disease brain. Neuroscience letters. vol 376. issue 3. 2005-05-26. PMID:15721223. |
the study is based on the premise that the enzyme lysyl oxidase (lo), which catalyzes the crosslinking of extracellular matrix (ecm) proteins, participates in ecm modulation and senile plaque formation in alzheimer's disease (ad). |
2005-05-26 |
2023-08-12 |
Not clear |