| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wojciech Michno, Patrick M Wehrli, Srinivas Koutarapu, Christian Marsching, Karolina Minta, Junyue Ge, Sven W Meyer, Henrik Zetterberg, Kaj Blennow, Corinna Henkel, Janina Oetjen, Carsten Hopf, Jörg Hanriede. Structural Amyloid Plaque Polymorphism is Associated with Distinct Lipid Accumulations Revealed by Trapped Ion Mobility Mass Spectrometry Imaging (TIMS MSI). Journal of neurochemistry. 2021-12-09. PMID:34882796. |
herein, we used matrix assisted laser desorption/ionization mass spectrometry imaging (maldi-msi) trapped ion mobility spectrometry time-of-flight (tims tof) in combination with hyperspectral confocal microscopy to probe the lipidomic microenvironment associated with structural polymorphism of aβ plaques in transgenic alzheimer's disease mice (tgapp |
2021-12-09 |
2023-08-13 |
mouse |
| Rohmad Yudi Utomo, Yasunobu Asawa, Satoshi Okada, Hyun Seung Ban, Atsushi Yoshimori, Jürgen Bajorath, Hiroyuki Nakamur. Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach. Bioorganic & medicinal chemistry. vol 46. 2021-11-15. PMID:34391121. |
development of curcumin-based amyloid β aggregation inhibitors for alzheimer's disease using the sar matrix approach. |
2021-11-15 |
2023-08-13 |
Not clear |
| Yeonwoo Chung, Hyunju Le. Correlation between Alzheimer's disease and type 2 diabetes using non-negative matrix factorization. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34315930. |
correlation between alzheimer's disease and type 2 diabetes using non-negative matrix factorization. |
2021-11-08 |
2023-08-13 |
Not clear |
| Kai Wei, Wei Kong, Shuaiqun Wan. Associating brain imaging phenotypes and genetic in Alzheimer's disease via JSCCA approach with autocorrelation constraints. Medical & biological engineering & computing. 2021-10-29. PMID:34714488. |
to improve the performance and interpretability of scca, we proposed a penalty method based on the autocorrelation matrix for discovering the possible biological mechanism between single nucleotide polymorphisms (snp) variations and brain regions changes of alzheimer's disease (ad). |
2021-10-29 |
2023-08-13 |
Not clear |
| Dongmei Gu, Fang Liu, Meng Meng, Liling Zhang, Marc L Gordon, Ying Wang, Li Cai, Nan Zhan. Elevated matrix metalloproteinase-9 levels in neuronal extracellular vesicles in Alzheimer's disease. Annals of clinical and translational neurology. vol 7. issue 9. 2021-10-18. PMID:32790155. |
elevated matrix metalloproteinase-9 levels in neuronal extracellular vesicles in alzheimer's disease. |
2021-10-18 |
2023-08-13 |
Not clear |
| Dongmei Gu, Fang Liu, Meng Meng, Liling Zhang, Marc L Gordon, Ying Wang, Li Cai, Nan Zhan. Elevated matrix metalloproteinase-9 levels in neuronal extracellular vesicles in Alzheimer's disease. Annals of clinical and translational neurology. vol 7. issue 9. 2021-10-18. PMID:32790155. |
this study aimed to investigate plasma neuronally derived extracellular vesicle (ndev) levels of core pathological markers [amyloid-β (aβ) and phosphorylated tau] and inflammatory biomarkers, including interleukin 6 (il-6) and matrix metalloproteinase-9 (mmp-9) in patients with alzheimer's disease (ad). |
2021-10-18 |
2023-08-13 |
Not clear |
| Charis Ringland, Jonas Elias Schweig, Maxwell Eisenbaum, Daniel Paris, Ghania Ait-Ghezala, Michael Mullan, Fiona Crawford, Laila Abdullah, Corbin Bachmeie. MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer's disease. BMC neuroscience. vol 22. issue 1. 2021-10-11. PMID:34034683. |
matrix metallopeptidase 9 (mmp9) has been implicated in a variety of neurological disorders, including alzheimer's disease (ad), where mmp9 levels are elevated in the brain and cerebrovasculature. |
2021-10-11 |
2023-08-13 |
mouse |
| Chunlei Zheng, Rong X. Molecular subtyping of Alzheimer's disease with consensus non-negative matrix factorization. PloS one. vol 16. issue 5. 2021-10-06. PMID:34014928. |
molecular subtyping of alzheimer's disease with consensus non-negative matrix factorization. |
2021-10-06 |
2023-08-13 |
Not clear |
| Yahan Sun, Sen Xu, Ming Jiang, Xia Liu, Liang Yang, Zhantao Bai, Qinghu Yan. Role of the Extracellular Matrix in Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512308. |
role of the extracellular matrix in alzheimer's disease. |
2021-09-14 |
2023-08-13 |
Not clear |
| Erika Hemmerová, Tomáš Špringer, Zdeňka Krištofiková, Jiří Homol. Study of Biomolecular Interactions of Mitochondrial Proteins Related to Alzheimer's Disease: Toward Multi-Interaction Biomolecular Processes. Biomolecules. vol 10. issue 9. 2021-09-06. PMID:32825572. |
progressive mitochondrial dysfunction due to the accumulation of amyloid beta (aβ) peptide within the mitochondrial matrix represents one of the key characteristics of alzheimer's disease (ad) and appears already in its early stages. |
2021-09-06 |
2023-08-13 |
Not clear |
| Sehwan Moon, Hyunju Le. JDSNMF: Joint Deep Semi-Non-Negative Matrix Factorization for Learning Integrative Representation of Molecular Signals in Alzheimer's Disease. Journal of personalized medicine. vol 11. issue 8. 2021-08-31. PMID:34442330. |
jdsnmf: joint deep semi-non-negative matrix factorization for learning integrative representation of molecular signals in alzheimer's disease. |
2021-08-31 |
2023-08-13 |
human |
| Julie Hoogmartens, Elisabeth Hens, Sebastiaan Engelborghs, Peter Paul De Deyn, Julie van der Zee, Christine Van Broeckhoven, Rita Cacac. Investigation of the role of matrix metalloproteinases in the genetic etiology of Alzheimer's disease. Neurobiology of aging. vol 104. 2021-08-23. PMID:33892965. |
investigation of the role of matrix metalloproteinases in the genetic etiology of alzheimer's disease. |
2021-08-23 |
2023-08-13 |
Not clear |
| Raquel L Lieberman, Minh Thu M. Molecular Insights into Myocilin and Its Glaucoma-Causing Misfolded Olfactomedin Domain Variants. Accounts of chemical research. vol 54. issue 9. 2021-08-20. PMID:33847483. |
the working hypothesis is that the intracellular aggregates cause a toxic gain of function: tm cell death is thought to lead to tm matrix dysfunction, hastening elevated intraocular pressure and subsequent vision loss.our lab has provided molecular underpinnings for myocilin structure and misfolding, placing myocilin-associated glaucoma within the context of amyloid diseases like alzheimer and diabetes. |
2021-08-20 |
2023-08-13 |
human |
| Kai Wei, Wei Kong, Shuaiqun Wan. Integration of Imaging Genomics Data for the Study of Alzheimer's Disease Using Joint-Connectivity-Based Sparse Nonnegative Matrix Factorization. Journal of molecular neuroscience : MN. 2021-08-19. PMID:34410569. |
integration of imaging genomics data for the study of alzheimer's disease using joint-connectivity-based sparse nonnegative matrix factorization. |
2021-08-19 |
2023-08-13 |
Not clear |
| Mamatha Damodarasamy, Robert B Vernon, Jasmine L Pathan, C Dirk Keene, Anthony J Day, William A Banks, May J Ree. The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA). Fluids and barriers of the CNS. vol 17. issue 1. 2021-08-16. PMID:32993718. |
the microvascular extracellular matrix in brains with alzheimer's disease neuropathologic change (adnc) and cerebral amyloid angiopathy (caa). |
2021-08-16 |
2023-08-13 |
Not clear |
| Charis Ringland, Jonas Elias Schweig, Daniel Paris, Ben Shackleton, Cillian E Lynch, Maxwell Eisenbaum, Michael Mullan, Fiona Crawford, Laila Abdullah, Corbin Bachmeie. Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease. Neurobiology of aging. vol 95. 2021-07-09. PMID:32758917. |
apolipoprotein e isoforms differentially regulate matrix metallopeptidase 9 function in alzheimer's disease. |
2021-07-09 |
2023-08-13 |
human |
| Lipika Mirdha, Hirak Chakrabort. Fluorescence-based techniques for the detection of the oligomeric status of proteins: implication in amyloidogenic diseases. European biophysics journal : EBJ. vol 50. issue 5. 2021-07-07. PMID:33564930. |
the aggregation of such proteins either in the intracellular context or extracellular matrix is associated with several adverse pathophysiological conditions such as alzheimer's, parkinson's, and huntington's diseases, spinocerebellar ataxia, and type-ii diabetes. |
2021-07-07 |
2023-08-13 |
Not clear |
| Mai M Anwar, Esra Özkan, Yasemin Gürsoy-Özdemi. The role of extracellular matrix alterations in mediating astrocyte damage and pericyte dysfunction in Alzheimer's disease: A comprehensive review. The European journal of neuroscience. 2021-07-05. PMID:34182602. |
the role of extracellular matrix alterations in mediating astrocyte damage and pericyte dysfunction in alzheimer's disease: a comprehensive review. |
2021-07-05 |
2023-08-13 |
Not clear |
| Geethu Krishna, Palanimuthu T Sivakumar, Ajit B Dahale, Thomas Gregor Issac, Shiva Shanker Reddy Mukku, Lakshmi Prabha M, Anu Kn Unni, Preeti Sinha, Mathew Varghese, Sarada Subramania. Increased prolidase activity in Alzheimer's dementia: A case-control study. Asian journal of psychiatry. vol 53. 2021-06-21. PMID:32590139. |
prolidase enzyme, which catalyzes the final step in collagen metabolism can influence the cognitive functions through changes in extracellular matrix (ecm) resulting in altered synaptic connectivity in alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
human |
| Gajanan Sathe, Marilyn Albert, Jacqueline Darrow, Atsushi Saito, Juan Troncoso, Akhilesh Pandey, Abhay Mogheka. Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease. Journal of neurochemistry. vol 156. issue 6. 2021-06-18. PMID:32614981. |
alzheimer's disease (ad) is a chronic neurodegenerative disease characterized by intracellular formation of neurofibrillary tangles and extracellular deposition of β-amyloid protein (aβ) in the extracellular matrix. |
2021-06-18 |
2023-08-13 |
Not clear |