| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Henry H Ruiz, Tiffany Chi, Andrew C Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettne. Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 8. 2017-10-06. PMID:26928090. |
increased susceptibility to metabolic dysregulation in a mouse model of alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated bcaa levels. |
2017-10-06 |
2023-08-13 |
mouse |
| Roberta Semprini, Giacomo Koch, Lorena Belli, Francesco D Lorenzo, Mauro Ragonese, Guglielmo Manenti, Gian P Sorice, Alessandro Martoran. Insulin and the Future Treatment of Alzheimer's Disease. CNS & neurological disorders drug targets. vol 15. issue 6. 2017-10-03. PMID:27189471. |
insulin and the future treatment of alzheimer's disease. |
2017-10-03 |
2023-08-13 |
Not clear |
| Roberta Semprini, Giacomo Koch, Lorena Belli, Francesco D Lorenzo, Mauro Ragonese, Guglielmo Manenti, Gian P Sorice, Alessandro Martoran. Insulin and the Future Treatment of Alzheimer's Disease. CNS & neurological disorders drug targets. vol 15. issue 6. 2017-10-03. PMID:27189471. |
intriguingly, changes of metabolic activity of cortical neurons are associated with reduced or absent sensitivity to insulin in alzheimer's disease brain. |
2017-10-03 |
2023-08-13 |
Not clear |
| Roberta Semprini, Giacomo Koch, Lorena Belli, Francesco D Lorenzo, Mauro Ragonese, Guglielmo Manenti, Gian P Sorice, Alessandro Martoran. Insulin and the Future Treatment of Alzheimer's Disease. CNS & neurological disorders drug targets. vol 15. issue 6. 2017-10-03. PMID:27189471. |
here we review most of the available data regarding relationship between alzheimer's disease and insulin and propose new direction to deepen our understanding about insulin involvement in the pathogenesis of alzheimer's dementia. |
2017-10-03 |
2023-08-13 |
Not clear |
| Mahdi Karimi, Masoud Eslami, Parham Sahandi-Zangabad, Fereshteh Mirab, Negar Farajisafiloo, Zahra Shafaei, Deepanjan Ghosh, Mahnaz Bozorgomid, Fariba Dashkhaneh, Michael R Hambli. pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. vol 8. issue 5. 2017-10-02. PMID:26762467. |
furthermore, ph-sensitive systems possess applications in delivery of metal ions and biomolecules such as proteins, insulin, etc., as well as co-delivery of cargos, dual ph-sensitive nanocarriers, dual/multi stimuli-responsive nanosystems, and even in the search for new solutions for therapy of diseases such as alzheimer's. |
2017-10-02 |
2023-08-13 |
Not clear |
| Farzaneh Rostami, Mohammad Javan, Ali Moghimi, Aliakbar Haddad-Mashadrizeh, Masoud Fereidon. Streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic Alzheimer model. Life sciences. vol 188. 2017-09-29. PMID:28867578. |
streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic alzheimer model. |
2017-09-29 |
2023-08-13 |
rat |
| Farzaneh Rostami, Mohammad Javan, Ali Moghimi, Aliakbar Haddad-Mashadrizeh, Masoud Fereidon. Streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic Alzheimer model. Life sciences. vol 188. 2017-09-29. PMID:28867578. |
insulin signaling malfunction has recently been suggested as a preliminary event involved in the etiology of sporadic alzheimer's disease (sad). |
2017-09-29 |
2023-08-13 |
rat |
| Farzaneh Rostami, Mohammad Javan, Ali Moghimi, Aliakbar Haddad-Mashadrizeh, Masoud Fereidon. Streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic Alzheimer model. Life sciences. vol 188. 2017-09-29. PMID:28867578. |
despite some proposed mechanisms, such as insulin malfunction, neuroinflammation, and gliosis, icv-stz mechanism of action is not fully understood yet and streptozotocin-induced rat model of alzheimer has still major shortcomings. |
2017-09-29 |
2023-08-13 |
rat |
| Elodie Marciniak, Antoine Leboucher, Emilie Caron, Tariq Ahmed, Anne Tailleux, Julie Dumont, Tarik Issad, Ellen Gerhardt, Patrick Pagesy, Margaux Vileno, Clément Bournonville, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Dominique Demeyer, Sabiha Eddarkaoui, Emmanuelle Vallez, Didier Vieau, Sandrine Humez, Emilie Faivre, Benjamin Grenier-Boley, Tiago F Outeiro, Bart Staels, Philippe Amouyel, Detlef Balschun, Luc Buee, David Blu. Tau deletion promotes brain insulin resistance. The Journal of experimental medicine. vol 214. issue 8. 2017-09-26. PMID:28652303. |
the present data have far-reaching clinical implications and raise the hypothesis that pathophysiological tau loss-of-function favors brain insulin resistance, which is instrumental for cognitive and metabolic impairments in alzheimer's disease patients. |
2017-09-26 |
2023-08-13 |
mouse |
| Mahmoud Balbaa, Shaymaa A Abdulmalek, Sofia Khali. Oxidative stress and expression of insulin signaling proteins in the brain of diabetic rats: Role of Nigella sativa oil and antidiabetic drugs. PloS one. vol 12. issue 5. 2017-09-20. PMID:28505155. |
insulin resistance of the brain is a specific form of type2-diabetes mellitus (t2dm) and the active insulin-signaling pathway plays a neuroprotective role against damaging conditions and alzheimer's progression. |
2017-09-20 |
2023-08-13 |
rat |
| R Mazrooie, K Rohampour, M Zamani, N Hosseinmardi, M Zeraat. Intracerebroventricular administration of adiponectin attenuates streptozotocin-induced memory impairment in rats. Physiology international. vol 104. issue 2. 2017-09-14. PMID:28395518. |
alzheimer's disease (ad) has been reported to be linked with diabetes mellitus and insulin resistance. |
2017-09-14 |
2023-08-13 |
rat |
| Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Cheng-Hung Yan. The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population. PloS one. vol 12. issue 2. 2017-08-17. PMID:28225792. |
evidence indicates that the pathophysiologic mechanisms associated with insulin resistance may contribute to cognitive aging and alzheimer's diseases. |
2017-08-17 |
2023-08-13 |
human |
| Weijie Xu, Juanhong Liu, Delin Ma, Gang Yuan, Yan Lu, Yan Yan. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PloS one. vol 12. issue 2. 2017-08-17. PMID:28225806. |
type 2 diabetes (t2d) is a high-risk factor for alzheimer's disease (ad) due to impaired insulin signaling pathway in brain. |
2017-08-17 |
2023-08-13 |
rat |
| D Allan Butterfield, Marzia Perluig. Redox Proteomics: A Key Tool for New Insights into Protein Modification with Relevance to Disease. Antioxidants & redox signaling. vol 26. issue 7. 2017-08-10. PMID:27835924. |
the topics related to redox proteomics range from basic chemistry of sulfur radical-induced redox modifications in proteins, to the thiol secretome and inflammatory network, to reversible thiol oxidation in proteomes, to the role of glutamine synthetase in peripheral and central environments on inflammation and insulin resistance, to bioanalytical aspects of tyrosine nitrated proteins, to protein oxidation in human smokers and models thereof, and to alzheimer disease, including articles on the brain ubiquitinylome and the "triangle of death" composed of oxidatively modified proteins involved in energy metabolism, mammalian target of rampamycin activation, and the proteostasis network. |
2017-08-10 |
2023-08-13 |
human |
| Nona Abolhassani, Julio Leon, Zijing Sheng, Sugako Oka, Hideomi Hamasaki, Toru Iwaki, Yusaku Nakabepp. Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain. Mechanisms of ageing and development. vol 161. issue Pt A. 2017-08-07. PMID:27233446. |
recent progress in alzheimer's disease (ad) research revealed that insulin production and signaling are severely impaired in ad brain, thereby resulting in mitochondrial dysfunction and increased oxidative stress. |
2017-08-07 |
2023-08-13 |
mouse |
| Ni Tang, Rongrong Jiang, Xiaobin Wang, Jian Wen, Li Liu, Jiali Wu, Chunxiang Zhan. Insulin resistance plays a potential role in postoperative cognitive dysfunction in patients following cardiac valve surgery. Brain research. vol 1657. 2017-08-07. PMID:28048971. |
severe insulin resistance (ir) promotes the development of alzheimer disease. |
2017-08-07 |
2023-08-13 |
human |
| Y-L Zhou, Y-F Du, H Du, P Sha. Insulin resistance in Alzheimer's disease (AD) mouse intestinal macrophages is mediated by activation of JNK. European review for medical and pharmacological sciences. vol 21. issue 8. 2017-07-31. PMID:28485801. |
insulin resistance in alzheimer's disease (ad) mouse intestinal macrophages is mediated by activation of jnk. |
2017-07-31 |
2023-08-13 |
mouse |
| Y-L Zhou, Y-F Du, H Du, P Sha. Insulin resistance in Alzheimer's disease (AD) mouse intestinal macrophages is mediated by activation of JNK. European review for medical and pharmacological sciences. vol 21. issue 8. 2017-07-31. PMID:28485801. |
alzheimer's disease (ad) has been considered as a metabolic disorder disease, which closely related to insulin signaling impairment. |
2017-07-31 |
2023-08-13 |
mouse |
| Amira S Ahmed, Rehab M Elgharabawy, Amal H Al-Najja. Ameliorating effect of anti-Alzheimer's drugs on the bidirectional association between type 2 diabetes mellitus and Alzheimer's disease. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 13. 2017-07-31. PMID:28534431. |
this study reveals the role of amyloid beta 40, amyloid beta 42, insulin, hba1c, lipid profile disturbance, c-reactive protein, d-dimer, and magnesium in the bidirectional correlation between t2d and pathogenesis of alzheimer's disease, that is powered by their correlations, and therefore the possibility of utilizing aβ as a biochemical marker of t2d in alzheimer's patients is recommended. |
2017-07-31 |
2023-08-13 |
human |
| Amira S Ahmed, Rehab M Elgharabawy, Amal H Al-Najja. Ameliorating effect of anti-Alzheimer's drugs on the bidirectional association between type 2 diabetes mellitus and Alzheimer's disease. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 13. 2017-07-31. PMID:28534431. |
additionally, this work reveals the role of aβ40, aβ42, insulin, hba1c, lipid profile disturbance, crp, d-dimer, and magnesium in the bidirectional association between t2d and the pathogenesis of ad, that is powered by their correlations, and therefore the possibility of utilizing aβ as a biochemical marker of t2d in alzheimer's patients is recommended. |
2017-07-31 |
2023-08-13 |
human |