| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farideh Pousti, Ramesh Ahmadi, Fatemeh Mirahmadi, Narges Hosseinmardi, Kambiz Rohampou. Adiponectin modulates synaptic plasticity in hippocampal dentate gyrus. Neuroscience letters. vol 662. 2018-06-29. PMID:29079430. |
insulin dysfunction is known as an essential process in the pathogenesis of sporadic alzheimer's disease (ad). |
2018-06-29 |
2023-08-13 |
rat |
| Norimichi Nakamura, Yasumasa Ohyagi, Tomohiro Imamura, Yuki T Yanagihara, Kyoko M Iinuma, Naoko Soejima, Hiroyuki Murai, Ryo Yamasaki, Jun-Ichi Kir. Apomorphine Therapy for Neuronal Insulin Resistance in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550243. |
apomorphine therapy for neuronal insulin resistance in a mouse model of alzheimer's disease. |
2018-05-22 |
2023-08-13 |
mouse |
| Jill K Morris, Roxanne Adeline Z Uy, Eric D Vidoni, Heather M Wilkins, Ashley E Archer, John P Thyfault, John M Miles, Jeffrey M Burn. Effect of APOE ε4 Genotype on Metabolic Biomarkers in Aging and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550261. |
alzheimer's disease (ad) may have heterogeneous pathophysiological underpinnings, with risk factors including apolipoprotein rmvarep4 (apoe4) genotype and insulin resistance. |
2018-05-22 |
2023-08-13 |
human |
| b' Valeria Vetri, Federica Piccirilli, Johannes Krausser, Gianpiero Buscarino, Urszula \\xc5\\x81api\\xc5\\x84ska, Bente Vestergaard, Alessio Zaccone, Vito Foder\\xc3\\xa. Ethanol Controls the Self-Assembly and Mesoscopic Properties of Human Insulin Amyloid Spherulites. The journal of physical chemistry. B. vol 122. issue 12. 2018-05-16. PMID:29488762.' |
here, we identify a striking effect of the hydration of the single human insulin molecule and solvent properties in controlling hydrophobicity/hydrophilicity, structures, and morphologies of a superstructure named spherulite, observed in connection to alzheimer's disease. |
2018-05-16 |
2023-08-13 |
human |
| J M Fine, A C Forsberg, B M Stroebel, K A Faltesek, D R Verden, K A Hamel, E B Raney, J M Crow, L R Haase, K E Knutzen, K D Kaczmarczek, W H Frey, L R Hanso. Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease. Journal of the neurological sciences. vol 380. 2018-05-08. PMID:28870559. |
intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of alzheimer's disease. |
2018-05-08 |
2023-08-13 |
rat |
| J M Fine, A C Forsberg, B M Stroebel, K A Faltesek, D R Verden, K A Hamel, E B Raney, J M Crow, L R Haase, K E Knutzen, K D Kaczmarczek, W H Frey, L R Hanso. Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease. Journal of the neurological sciences. vol 380. 2018-05-08. PMID:28870559. |
in this study, we determine whether intranasally (in) administered dfo is beneficial in the intracerebroventricular streptozotocin (icv stz) rat model of sporadic alzheimer's disease, which is different from previous models in that it exhibits dysregulation of insulin metabolism as well as oxidative stress and inflammation. |
2018-05-08 |
2023-08-13 |
rat |
| M Carmen Crespo, Joao Tomé-Carneiro, Cristina Pintado, Alberto Dávalos, Francesco Visioli, Emma Burgos-Ramo. Hydroxytyrosol restores proper insulin signaling in an astrocytic model of Alzheimer's disease. BioFactors (Oxford, England). vol 43. issue 4. 2018-05-07. PMID:28317262. |
hydroxytyrosol restores proper insulin signaling in an astrocytic model of alzheimer's disease. |
2018-05-07 |
2023-08-13 |
Not clear |
| Małgorzata Bednarska-Makaruk, Ałła Graban, Anna Wiśniewska, Wanda Łojkowska, Anna Bochyńska, Magdalena Gugała-Iwaniuk, Ksenia Sławińska, Agnieszka Ługowska, Danuta Ryglewicz, Hanna Weh. Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia. Biogerontology. vol 18. issue 4. 2018-04-24. PMID:28421328. |
in 205 patients with dementia [89 with alzheimer's disease (ad), 47 with vascular dementia (vad), 69 with mixed dementia (md)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (il-6), c-reactive protein (hscrp) and chitotriosidase] and anti-inflammatory (25-oh vitamin d, hdl-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and homa-ir) were determined. |
2018-04-24 |
2023-08-13 |
human |
| Rohit Pardeshi, Nityanand Bolshette, Kundlik Gadhave, Ashutosh Ahire, Sahabuddin Ahmed, Tommaso Cassano, Veer Bala Gupta, Mangala Lahka. Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease. Psychoneuroendocrinology. vol 83. 2018-04-17. PMID:28624654. |
insulin signaling: an opportunistic target to minify the risk of alzheimer's disease. |
2018-04-17 |
2023-08-13 |
Not clear |
| Arantxa Rodriguez-Casado, Adolfo Toledano-Díaz, Adolfo Toledan. Defective Insulin Signalling, Mediated by Inflammation, Connects Obesity to Alzheimer Disease; Relevant Pharmacological Therapies and Preventive Dietary Interventions. Current Alzheimer research. vol 14. issue 8. 2018-04-11. PMID:28317485. |
defective insulin signalling, mediated by inflammation, connects obesity to alzheimer disease; relevant pharmacological therapies and preventive dietary interventions. |
2018-04-11 |
2023-08-13 |
Not clear |
| Elizabeth S Chan, Mahesh Shivarama Shetty, Sreedharan Sajikumar, Christopher Chen, Tuck Wah Soong, Boon-Seng Won. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Scientific reports. vol 6. 2018-03-27. PMID:27189808. |
apoe4 expression accelerates hippocampus-dependent cognitive deficits by enhancing aβ impairment of insulin signaling in an alzheimer's disease mouse model. |
2018-03-27 |
2023-08-13 |
mouse |
| Lilian Calderón-Garcidueñas, Suzanne M de la Mont. Apolipoprotein E4, Gender, Body Mass Index, Inflammation, Insulin Resistance, and Air Pollution Interactions: Recipe for Alzheimer's Disease Development in Mexico City Young Females. Journal of Alzheimer's disease : JAD. vol 58. issue 3. 2018-03-21. PMID:28527212. |
apolipoprotein e4, gender, body mass index, inflammation, insulin resistance, and air pollution interactions: recipe for alzheimer's disease development in mexico city young females. |
2018-03-21 |
2023-08-13 |
Not clear |
| Christian Grundahl Frankær, Pernille Sønderby, Maria Blanner Bang, Ramona Valentina Mateiu, Minna Groenning, Jens Bukrinski, Pernille Harri. Insulin fibrillation: The influence and coordination of Zn Journal of structural biology. vol 199. issue 1. 2018-03-21. PMID:28527712. |
insulin fibrillation: the influence and coordination of zn protein amyloid fibrillation is obtaining much focus because it is connected with amyloid-related human diseases such as alzheimer's disease, diabetes mellitus type 2, or parkinson's disease. |
2018-03-21 |
2023-08-13 |
human |
| Pierpaolo Sorrentino, Dagmar Nieboer, Jos W R Twisk, Cornelis J Stam, Linda Douw, Arjan Hillebran. The Hierarchy of Brain Networks Is Related to Insulin Growth Factor-1 in a Large, Middle-Aged, Healthy Cohort: An Exploratory Magnetoencephalography Study. Brain connectivity. vol 7. issue 5. 2018-03-19. PMID:28520468. |
recently, a large study demonstrated that lower serum levels of insulin growth factor-1 (igf-1) relate to brain atrophy and to a greater risk for developing alzheimer's disease in a healthy elderly population. |
2018-03-19 |
2023-08-13 |
Not clear |
| Najim Akhtar, Sanjay Kisan Metkar, Agnishwar Girigoswami, Koyeli Girigoswam. ZnO nanoflower based sensitive nano-biosensor for amyloid detection. Materials science & engineering. C, Materials for biological applications. vol 78. 2018-03-14. PMID:28576073. |
utilizing this property a reagentless biosensor has been developed for the detection of beta amyloids, a hallmark of neurodegenerative diseases like alzheimer's disease, creutzfeldt-jakob syndrome, insulin dependent type ii diabetes etc. |
2018-03-14 |
2023-08-13 |
Not clear |
| Elizabeth M Rhea, Samantha R Humann, Surabhi Nirkhe, Susan A Farr, John E Morley, William A Bank. Intranasal Insulin Transport is Preserved in Aged SAMP8 Mice and is Altered by Albumin and Insulin Receptor Inhibition. Journal of Alzheimer's disease : JAD. vol 57. issue 1. 2018-02-26. PMID:28222522. |
insulin delivered to the level of the cribriform plate (intranasal insulin) is being investigated for its ability to enhance memory in people with alzheimer's disease (ad). |
2018-02-26 |
2023-08-13 |
mouse |
| Suzanne Craft, Amy Claxton, Laura D Baker, Angela J Hanson, Brenna Cholerton, Emily H Trittschuh, Deborah Dahl, Erin Caulder, Bryan Neth, Thomas J Montine, Youngkyoo Jung, Joseph Maldjian, Christopher Whitlow, Seth Friedma. Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial. Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:28372335. |
effects of regular and long-acting insulin on cognition and alzheimer's disease biomarkers: a pilot clinical trial. |
2018-02-23 |
2023-08-13 |
Not clear |
| Suzanne Craft, Amy Claxton, Laura D Baker, Angela J Hanson, Brenna Cholerton, Emily H Trittschuh, Deborah Dahl, Erin Caulder, Bryan Neth, Thomas J Montine, Youngkyoo Jung, Joseph Maldjian, Christopher Whitlow, Seth Friedma. Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial. Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:28372335. |
long acting insulin detemir administered intranasally for three weeks enhanced memory for adults with alzheimer's disease dementia (ad) or amnestic mild cognitive impairment (mci). |
2018-02-23 |
2023-08-13 |
Not clear |
| Suzanne M de la Monte, Ming Tong, Irio Schiano, John Didsbur. Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27802237. |
alzheimer's disease (ad) is associated with progressive impairments in brain insulin, insulin-like growth factor (igf), and insulin receptor substrate (irs) signaling through akt pathways that regulate neuronal growth, survival, metabolism, and plasticity. |
2018-02-22 |
2023-08-13 |
Not clear |
| Kelsey E McLimans, Auriel A Willett. Autotaxin is Related to Metabolic Dysfunction and Predicts Alzheimer's Disease Outcomes. Journal of Alzheimer's disease : JAD. vol 56. issue 1. 2018-02-21. PMID:27911319. |
obesity and insulin resistance are associated with neuropathology and cognitive decline in alzheimer's disease (ad). |
2018-02-21 |
2023-08-13 |
Not clear |