| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Molly Stanley, Shannon L Macauley, David M Holtzma. Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence? The Journal of experimental medicine. vol 213. issue 8. 2017-07-27. PMID:27432942. |
changes in insulin and insulin signaling in alzheimer's disease: cause or consequence? |
2017-07-27 |
2023-08-13 |
Not clear |
| Antonella Tramutola, Andrea Arena, Chiara Cini, D Allan Butterfield, Eugenio Baron. Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer's disease pathology. Expert review of neurotherapeutics. vol 17. issue 1. 2017-07-24. PMID:27715341. |
post-mortem analyses of alzheimer disease (ad) subjects revealed insulin resistance in the brain, suggesting a role of this condition in cognitive deficits observed in ad. |
2017-07-24 |
2023-08-13 |
human |
| Matthias Grall. The neuronal insulin receptor in its environment. Journal of neurochemistry. vol 140. issue 3. 2017-07-13. PMID:27889917. |
insulin and the ir are also present in the brain, and since there is evidence that neuronal insulin signaling regulates synaptic plasticity and that it is impaired in disease, this pathway might be the key to protection or reversal of symptoms, especially in alzheimer's disease. |
2017-07-13 |
2023-08-13 |
Not clear |
| Jerzy Leszek, Elzbieta Trypka, Vadim V Tarasov, Ghulam Md Ashraf, Gjumrakch Alie. Type 3 Diabetes Mellitus: A Novel Implication of Alzheimers Disease. Current topics in medicinal chemistry. vol 17. issue 12. 2017-07-05. PMID:28049395. |
the brain of patients with alzheimer disease (ad) showed the evidence of reduced expression of insulin and neuronal insulin receptors, as compared with those of age-matched controls. |
2017-07-05 |
2023-08-13 |
Not clear |
| Kazimierz Gasiorowski, Barbara Brokos, Jerzy Leszek, Vadim V Tarasov, Ghulam Md Ashraf, Gjumrakch Alie. Insulin Resistance in Alzheimer Disease: p53 and MicroRNAs as Important Players. Current topics in medicinal chemistry. vol 17. issue 12. 2017-07-05. PMID:28049397. |
insulin resistance in alzheimer disease: p53 and micrornas as important players. |
2017-07-05 |
2023-08-13 |
Not clear |
| Kazimierz Gasiorowski, Barbara Brokos, Jerzy Leszek, Vadim V Tarasov, Ghulam Md Ashraf, Gjumrakch Alie. Insulin Resistance in Alzheimer Disease: p53 and MicroRNAs as Important Players. Current topics in medicinal chemistry. vol 17. issue 12. 2017-07-05. PMID:28049397. |
reduced sensitivity of cells to insulin and impaired insulin signaling in brain neurons participate in the pathogenesis of alzheimer disease (ad). |
2017-07-05 |
2023-08-13 |
Not clear |
| Rizwanul Haque, Aamir Nazi. Identification and functional characterization of a putative IDE, C28F5.4 (ceIDE-1), in Caenorhabditis elegans: Implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1860. issue 11 Pt A. 2017-06-26. PMID:27443962. |
insulin-degrading enzyme (ide) is a zinc metalloprotease, known to degrade insulin peptide and amyloid-beta (aβ); the key protein involved in alzheimer's disease (ad). |
2017-06-26 |
2023-08-13 |
human |
| P W Franks, N Atabaki-Pasda. Causal inference in obesity research. Journal of internal medicine. vol 281. issue 3. 2017-06-26. PMID:27933671. |
in a systematic review of the literature in this field, we found: (i) probable causal relationships between adiposity and bone health/disease, cancers (colorectal, lung and kidney cancers), cardiometabolic traits (blood pressure, fasting insulin, inflammatory markers and lipids), uric acid concentrations, coronary heart disease and venous thrombosis (in the presence of pulmonary embolism), (ii) possible causal relationships between adiposity and gray matter volume, depression and common mental disorders, oesophageal cancer, macroalbuminuria, end-stage renal disease, diabetic kidney disease, nuclear cataract and gall stone disease, and (iii) no evidence for causal relationships between adiposity and alzheimer's disease, pancreatic cancer, venous thrombosis (in the absence of pulmonary embolism), liver function and periodontitis. |
2017-06-26 |
2023-08-13 |
Not clear |
| Sorabh Sharma, Rajeev Taliya. Epigenetic modifications by inhibiting histone deacetylases reverse memory impairment in insulin resistance induced cognitive deficit in mice. Neuropharmacology. vol 105. 2017-06-22. PMID:26805421. |
insulin resistance has been reported as a strong risk factor for alzheimer's disease. |
2017-06-22 |
2023-08-13 |
mouse |
| E M Ribe, S Loveston. Insulin signalling in Alzheimer's disease and diabetes: from epidemiology to molecular links. Journal of internal medicine. vol 280. issue 5. 2017-06-14. PMID:27739227. |
insulin signalling in alzheimer's disease and diabetes: from epidemiology to molecular links. |
2017-06-14 |
2023-08-13 |
Not clear |
| E M Ribe, S Loveston. Insulin signalling in Alzheimer's disease and diabetes: from epidemiology to molecular links. Journal of internal medicine. vol 280. issue 5. 2017-06-14. PMID:27739227. |
we will discuss the impact of direct links between insulin and igf-1 signalling and the alzheimer's disease-associated pathological events as well as the impact of other processes such as inflammation, oxidative stress and mitochondrial dysfunction either common to both conditions or perhaps responsible for a mechanistic link between metabolic and neurodegenerative disease. |
2017-06-14 |
2023-08-13 |
Not clear |
| S Farzampour, A Majdi, S Sadigh-Etegha. Intranasal insulin treatment improves memory and learning in a rat amyloid-beta model of Alzheimer's disease. Physiology international. vol 103. issue 3. 2017-06-12. PMID:28229638. |
intranasal insulin treatment improves memory and learning in a rat amyloid-beta model of alzheimer's disease. |
2017-06-12 |
2023-08-13 |
rat |
| S Farzampour, A Majdi, S Sadigh-Etegha. Intranasal insulin treatment improves memory and learning in a rat amyloid-beta model of Alzheimer's disease. Physiology international. vol 103. issue 3. 2017-06-12. PMID:28229638. |
recently, insulin has been used as a pro-cognitive agent for the potential treatment of alzheimer's disease (ad), because of its ability to cross the brain-blood barrier (bbb) by a saturable transport system. |
2017-06-12 |
2023-08-13 |
rat |
| Mini Sajan, Barbara Hansen, Robert Ivey, Joshua Sajan, Csilla Ari, Shijie Song, Ursula Braun, Michael Leitges, Margaret Farese-Higgs, Robert V Fares. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development. Diabetes. vol 65. issue 7. 2017-06-05. PMID:26895791. |
brain insulin signaling is increased in insulin-resistant states and decreases in foxos and pgc-1α and increases in aβ1-40/42 and phospho-tau may abet alzheimer development. |
2017-06-05 |
2023-08-13 |
mouse |
| Mini Sajan, Barbara Hansen, Robert Ivey, Joshua Sajan, Csilla Ari, Shijie Song, Ursula Braun, Michael Leitges, Margaret Farese-Higgs, Robert V Fares. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development. Diabetes. vol 65. issue 7. 2017-06-05. PMID:26895791. |
increased coexistence of alzheimer disease (ad) and type 2 diabetes mellitus (t2dm) suggests that insulin resistance abets neurodegenerative processes, but linkage mechanisms are obscure. |
2017-06-05 |
2023-08-13 |
mouse |
| Yan-Fang Mao, Zhangyu Guo, Tingting Zheng, Yasi Jiang, Yaping Yan, Xinzhen Yin, Yanxing Chen, Baorong Zhan. Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice. Aging cell. vol 15. issue 5. 2017-06-05. PMID:27457264. |
brain insulin signaling deficits contribute to multiple pathological features of alzheimer's disease (ad). |
2017-06-05 |
2023-08-13 |
mouse |
| Therese S Salameh, Elizabeth M Rhea, William A Banks, Angela J Hanso. Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 15. 2017-06-05. PMID:27470930. |
insulin resistance, dyslipidemia, and apolipoprotein e interactions as mechanisms in cognitive impairment and alzheimer's disease. |
2017-06-05 |
2023-08-13 |
Not clear |
| Therese S Salameh, Elizabeth M Rhea, William A Banks, Angela J Hanso. Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 15. 2017-06-05. PMID:27470930. |
an increased risk for alzheimer's disease is associated with dyslipidemia and insulin resistance. |
2017-06-05 |
2023-08-13 |
Not clear |
| Therese S Salameh, Elizabeth M Rhea, William A Banks, Angela J Hanso. Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 15. 2017-06-05. PMID:27470930. |
understanding how apolipoprotein e carrier protein, lipids, amyloid β peptides, glucose, central nervous system insulin, and peripheral insulin interact with one another in alzheimer's disease is an area of increasing interest. |
2017-06-05 |
2023-08-13 |
Not clear |
| Therese S Salameh, Elizabeth M Rhea, William A Banks, Angela J Hanso. Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 15. 2017-06-05. PMID:27470930. |
here, we will review the evidence relating apolipoprotein e carrier protein, lipids, and insulin action to alzheimer's disease and aβ peptides and then propose mechanisms as to how these factors might interact with one another to impair cognition and promote alzheimer's disease. |
2017-06-05 |
2023-08-13 |
Not clear |