| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuying Fan, Nan Wang, Altea Rocchi, Weiran Zhang, Robert Vassar, Yifa Zhou, Congcong H. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. vol 13. issue 1. 2017-12-08. PMID:27791467. |
induction of autophagy by rg2 enhances the clearance of protein aggregates in a cell-based model, improves cognitive behaviors in a mouse model of alzheimer disease, and prevents high-fat diet-induced insulin resistance. |
2017-12-08 |
2023-08-13 |
mouse |
| Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W Mandell, George S Bloo. mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 2. 2017-12-04. PMID:27693185. |
mtor and neuronal cell cycle reentry: how impaired brain insulin signaling promotes alzheimer's disease. |
2017-12-04 |
2023-08-13 |
Not clear |
| Aaron M Koenig, Dawn Mechanic-Hamilton, Sharon X Xie, Martha F Combs, Anne R Cappola, Long Xie, John A Detre, David A Wolk, Steven E Arnol. Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study. Alzheimer disease and associated disorders. vol 31. issue 2. 2017-12-04. PMID:28538088. |
effects of the insulin sensitizer metformin in alzheimer disease: pilot data from a randomized placebo-controlled crossover study. |
2017-12-04 |
2023-08-13 |
human |
| Aaron M Koenig, Dawn Mechanic-Hamilton, Sharon X Xie, Martha F Combs, Anne R Cappola, Long Xie, John A Detre, David A Wolk, Steven E Arnol. Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study. Alzheimer disease and associated disorders. vol 31. issue 2. 2017-12-04. PMID:28538088. |
epidemiological studies have identified a robust association between type ii diabetes mellitus and alzheimer disease (ad), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with ad. |
2017-12-04 |
2023-08-13 |
human |
| Alexander Tups, Jonas Benzler, Domenico Sergi, Sharon R Ladyman, Lynda M William. Central Regulation of Glucose Homeostasis. Comprehensive Physiology. vol 7. issue 2. 2017-11-20. PMID:28333388. |
disruptions of central insulin signaling and glucose metabolism not only lead to impairments in whole body glucose homeostasis, they also have other serious consequences, including the development of alzheimer's disease which is sometimes referred to as type 3 diabetes reflecting its common etiology with type 2 diabetes. |
2017-11-20 |
2023-08-13 |
mouse |
| Rebecca E K MacPherso. Filling the void: a role for exercise-induced BDNF and brain amyloid precursor protein processing. American journal of physiology. Regulatory, integrative and comparative physiology. vol 313. issue 5. 2017-11-20. PMID:28814391. |
inactivity, obesity, and insulin resistance are significant risk factors for the development of alzheimer's disease (ad). |
2017-11-20 |
2023-08-13 |
Not clear |
| Fan Su, Hao Shu, Qing Ye, Zan Wang, Chunming Xie, Baoyu Yuan, Zhijun Zhang, Feng Ba. Brain insulin resistance deteriorates cognition by altering the topological features of brain networks. NeuroImage. Clinical. vol 13. 2017-11-17. PMID:28050343. |
insulin resistance represents one of the mechanisms underlying the link between type 2 diabetes (t2d) and alzheimer's disease (ad), and we explored its in vivo neurobiology related to cognition based on a pathway-based genetic association analyses. |
2017-11-17 |
2023-08-13 |
human |
| Noriyasu Kame. Nose-to-Brain Delivery of Peptide Drugs Enhanced by Coadministration of Cell-penetrating Peptides: Therapeutic Potential for Dementia. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 137. issue 10. 2017-11-16. PMID:28966266. |
recent reports suggest that peptide drugs such as insulin have the potential to serve as therapeutics in neurodegenerative diseases such as alzheimer's disease. |
2017-11-16 |
2023-08-13 |
mouse |
| Roy Chun-Laam Ng, On-Yin Cheng, Min Jian, Jason Shing-Cheong Kwan, Philip Wing-Lok Ho, Kenneth King-Yip Cheng, Patrick Ka Kit Yeung, Lena Lei Zhou, Ruby Lai-Chong Hoo, Sookja Kim Chung, Aimin Xu, Karen Siu-Ling Lam, Koon Ho Cha. Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice. Molecular neurodegeneration. vol 11. issue 1. 2017-11-09. PMID:27884163. |
chronic adiponectin deficiency leads to alzheimer's disease-like cognitive impairments and pathologies through ampk inactivation and cerebral insulin resistance in aged mice. |
2017-11-09 |
2023-08-13 |
mouse |
| Roy Chun-Laam Ng, On-Yin Cheng, Min Jian, Jason Shing-Cheong Kwan, Philip Wing-Lok Ho, Kenneth King-Yip Cheng, Patrick Ka Kit Yeung, Lena Lei Zhou, Ruby Lai-Chong Hoo, Sookja Kim Chung, Aimin Xu, Karen Siu-Ling Lam, Koon Ho Cha. Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice. Molecular neurodegeneration. vol 11. issue 1. 2017-11-09. PMID:27884163. |
insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (t2dm) and these patients have doubled risk of alzheimer's disease (ad). |
2017-11-09 |
2023-08-13 |
mouse |
| Hong-Yan Cai, Zhao-Jun Wang, Christian Hölscher, Li Yuan, Jun Zhang, Peng Sun, Jing Li, Wei Yang, Mei-Na Wu, Jin-Shun Q. Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats. Behavioural brain research. vol 318. 2017-11-06. PMID:27776993. |
type 2 diabetes mellitus(t2dm) is a risk factor of alzheimer's disease (ad), which is most likely linked to impairments of insulin signaling in the brain. |
2017-11-06 |
2023-08-13 |
rat |
| Stephen Lowe, Emanuele Sher, Graham Wishart, Kimberley Jackson, Eunice Yuen, Claire Brittain, Siew Chinn Fong, David O Clarke, William H Landschul. An assessment of the central disposition of intranasally administered insulin lispro in the cerebrospinal fluid of healthy volunteers and beagle dogs. Drug delivery and translational research. vol 7. issue 1. 2017-10-26. PMID:27553192. |
intranasally administered regular insulin and insulin aspart have shown cognitive benefit for patients with alzheimer's disease (ad). |
2017-10-26 |
2023-08-13 |
human |
| Maud Gratuze, Emmanuel Plane. Regulation of brain insulin signaling: A new function for tau. The Journal of experimental medicine. vol 214. issue 8. 2017-10-26. PMID:28652305. |
they find that tau deletion impairs hippocampal response to insulin through irs-1 and pten dysregulation and suggest that, in alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function. |
2017-10-26 |
2023-08-13 |
Not clear |
| Motofumi Kumazoe, Mai Yamashita, Yuki Nakamura, Kanako Takamatsu, Jaehoon Bae, Shuya Yamashita, Shuhei Yamada, Hiroaki Onda, Takashi Nojiri, Kenji Kangawa, Hirofumi Tachiban. Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression. Journal of immunology (Baltimore, Md. : 1950). vol 199. issue 9. 2017-10-26. PMID:28954885. |
tlr signaling is critical to innate immune system regulation; however, aberrant tlr signaling is involved in several diseases, including insulin resistance, alzheimer's disease, and tumor metastasis. |
2017-10-26 |
2023-08-13 |
Not clear |
| Silke Herzer, Sascha Meldner, Klara Rehder, Hermann-Josef Gröne, Viola Nordströ. Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27639375. |
thus, we propose that gcs inhibition constitutes a potential target for protecting neurons from addl-mediated neurotoxicity and insulin resistance in alzheimer's disease. |
2017-10-25 |
2023-08-13 |
mouse |
| Siobhan M Hoscheidt, Erika J Starks, Jennifer M Oh, Henrik Zetterberg, Kaj Blennow, Rachel A Krause, Carey E Gleason, Luigi Puglielli, Craig S Atwood, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Barbara B Bendli. Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults. Journal of Alzheimer's disease : JAD. vol 52. issue 4. 2017-10-24. PMID:27079723. |
insulin resistance is associated with increased levels of cerebrospinal fluid biomarkers of alzheimer's disease and reduced memory function in at-risk healthy middle-aged adults. |
2017-10-24 |
2023-08-13 |
Not clear |
| Noriyasu Kamei, Misa Tanaka, Hayoung Choi, Nobuyuki Okada, Takamasa Ikeda, Rei Itokazu, Mariko Takeda-Morishit. Effect of an Enhanced Nose-to-Brain Delivery of Insulin on Mild and Progressive Memory Loss in the Senescence-Accelerated Mouse. Molecular pharmaceutics. vol 14. issue 3. 2017-10-24. PMID:28094952. |
insulin is now considered to be a new drug candidate for treating dementias, such as alzheimer's disease, whose pathologies are linked to insulin resistance in the brain. |
2017-10-24 |
2023-08-13 |
mouse |
| Kenji Ishibashi, Airin Onishi, Yoshinori Fujiwara, Kiichi Ishiwata, Kenji Ishi. Effects of glucose, insulin, and insulin resistance on cerebral 18F-FDG distribution in cognitively normal older subjects. PloS one. vol 12. issue 7. 2017-10-24. PMID:28715453. |
increasing plasma glucose levels and insulin resistance can alter the distribution pattern of fluorine-18-labeled fluorodeoxyglucose (18f-fdg) in the brain and relatively reduce 18f-fdg uptake in alzheimer's disease (ad)-related hypometabolic regions, leading to the appearance of an ad-like pattern. |
2017-10-24 |
2023-08-13 |
human |
| Sara Kenawy, Rehab Hegazy, Azza Hassan, Siham El-Shenawy, Nawal Gomaa, Hala Zaki, Amina Atti. Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin. PloS one. vol 12. issue 8. 2017-10-19. PMID:28832656. |
recently, emerging data suggest that impaired insulin signaling is the major contributor in the development of alzheimer's dementia (ad), which is the most common type of senile dementia. |
2017-10-19 |
2023-08-13 |
rat |
| Na Zhao, Chia-Chen Liu, Alexandra J Van Ingelgom, Yuka A Martens, Cynthia Linares, Joshua A Knight, Meghan M Painter, Patrick M Sullivan, Guojun B. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. vol 96. issue 1. 2017-10-10. PMID:28957663. |
diabetes and impaired brain insulin signaling are linked to the pathogenesis of alzheimer's disease (ad). |
2017-10-10 |
2023-08-13 |
mouse |