| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung Min Son, Seokjo Kang, Heesun Choi, Inhee Mook-Jun. Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Molecular neurodegeneration. vol 10. 2016-08-24. PMID:26520569. |
insulin degrading enzyme (ide) is a major protease of amyloid beta peptide (aβ), a prominent toxic protein in alzheimer's disease (ad) pathogenesis. |
2016-08-24 |
2023-08-13 |
Not clear |
| Niraj Kumar Jha, Saurabh Kumar Jha, Dhiraj Kumar, Noopur Kejriwal, Renu Sharma, Rashmi K Ambasta, Pravir Kuma. Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications. Journal of Alzheimer's disease : JAD. vol 48. issue 4. 2016-08-03. PMID:26444774. |
impact of insulin degrading enzyme and neprilysin in alzheimer's disease biology: characterization of putative cognates for therapeutic applications. |
2016-08-03 |
2023-08-13 |
Not clear |
| Caihong Zhu, Petra Schwarz, Irina Abakumova, Adriano Aguzz. Unaltered Prion Pathogenesis in a Mouse Model of High-Fat Diet-Induced Insulin Resistance. PloS one. vol 10. issue 12. 2016-08-01. PMID:26658276. |
epidemiological, clinical, and experimental animal studies suggest a strong correlation between insulin resistance and alzheimer's disease. |
2016-08-01 |
2023-08-13 |
mouse |
| Caihong Zhu, Petra Schwarz, Irina Abakumova, Adriano Aguzz. Unaltered Prion Pathogenesis in a Mouse Model of High-Fat Diet-Induced Insulin Resistance. PloS one. vol 10. issue 12. 2016-08-01. PMID:26658276. |
in addition, impaired insulin signaling in the alzheimer's disease brain may promote aβ production, impair aβ clearance and induce tau hyperphosphorylation, thereby leading to deterioration of the disease. |
2016-08-01 |
2023-08-13 |
mouse |
| Erika J Starks, J Patrick O'Grady, Siobhan M Hoscheidt, Annie M Racine, Cynthia M Carlsson, Henrik Zetterberg, Kaj Blennow, Ozioma C Okonkwo, Luigi Puglielli, Sanjay Asthana, N Maritza Dowling, Carey E Gleason, Rozalyn M Anderson, Nancy J Davenport-Sis, LeAnn M DeRungs, Mark A Sager, Sterling C Johnson, Barbara B Bendli. Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOEɛ4 Carriers. Journal of Alzheimer's disease : JAD. vol 46. issue 2. 2016-07-11. PMID:25812851. |
insulin resistance (ir) is linked with the occurrence of pathological features observed in alzheimer's disease (ad), including neurofibrillary tangles and amyloid plaques. |
2016-07-11 |
2023-08-13 |
Not clear |
| Therese S Salameh, Kristin M Bullock, Isabel A Hujoel, Michael L Niehoff, Tami Wolden-Hanson, Junghyun Kim, John E Morley, Susan A Farr, William A Bank. Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition. Journal of Alzheimer's disease : JAD. vol 47. issue 3. 2016-07-06. PMID:26401706. |
intranasal insulin has shown efficacy in patients with alzheimer's disease (ad), but there are no preclinical studies determining whether or how it reaches the brain. |
2016-07-06 |
2023-08-13 |
mouse |
| Domenico Nuzzo, Pasquale Picone, Sara Baldassano, Luca Caruana, Elisa Messina, Antonella Marino Gammazza, Francesco Cappello, Flavia Mulè, Marta Di Carl. Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer's Disease. Current Alzheimer research. vol 12. issue 8. 2016-07-01. PMID:26159189. |
insulin resistance as common molecular denominator linking obesity to alzheimer's disease. |
2016-07-01 |
2023-08-13 |
mouse |
| Isabel Arrieta-Cruz, Colette M Knight, Roger Gutiérrez-Juáre. Acute Exposure of the Mediobasal Hypothalamus to Amyloid-β25-35 Perturbs Hepatic Glucose Metabolism. Journal of Alzheimer's disease : JAD. vol 46. issue 4. 2016-06-30. PMID:25869787. |
patients with alzheimer's disease (ad) have a higher risk for developing insulin resistance and diabetes. |
2016-06-30 |
2023-08-13 |
rat |
| Zhenwen Zhang, Penghua Fang, Mingyi Shi, Yan Zhu, Ping B. Elevated galanin may predict the risk of type 2 diabetes mellitus for development of Alzheimer's disease. Mechanisms of ageing and development. vol 150. 2016-06-30. PMID:26253934. |
the current data support that activating central galr2 attenuates insulin resistance and alzheimer's disease feature in animal models. |
2016-06-30 |
2023-08-13 |
human |
| Uwe Gröber, Joachim Schmidt, Klaus Kister. Magnesium in Prevention and Therapy. Nutrients. vol 7. issue 9. 2016-06-29. PMID:26404370. |
low levels of magnesium have been associated with a number of chronic diseases, such as alzheimer's disease, insulin resistance and type-2 diabetes mellitus, hypertension, cardiovascular disease (e.g., stroke), migraine headaches, and attention deficit hyperactivity disorder (adhd). |
2016-06-29 |
2023-08-13 |
human |
| Sara Ahmed, Zahra Mahmood, Saadia Zahi. Linking insulin with Alzheimer's disease: emergence as type III diabetes. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 10. 2016-06-28. PMID:26248483. |
linking insulin with alzheimer's disease: emergence as type iii diabetes. |
2016-06-28 |
2023-08-13 |
Not clear |
| Ashraf Virmani, Luigi Pinto, Otto Bauermann, Saf Zerelli, Andreas Diedenhofen, Zbigniew K Binienda, Syed F Ali, Feike R van der Lei. The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions. Molecular neurobiology. vol 52. issue 2. 2016-06-21. PMID:26041663. |
evolution of both parkinson's disease and alzheimer's disease is in some way linked to brain insulin and related metabolic dysfunctions with putative links also with the diabetes type 2. |
2016-06-21 |
2023-08-13 |
Not clear |
| Sevilay Muratli, Ozlem Soyluk, Fatih Tufa. Confounders Regarding the Association of Insulin Resistance and Alzheimer Disease. JAMA neurology. vol 73. issue 2. 2016-06-16. PMID:26719913. |
confounders regarding the association of insulin resistance and alzheimer disease. |
2016-06-16 |
2023-08-13 |
Not clear |
| Auriel A Willette, Barbara B Bendli. Confounders Regarding the Association of Insulin Resistance and Alzheimer Disease--Reply. JAMA neurology. vol 73. issue 2. 2016-06-16. PMID:26720090. |
confounders regarding the association of insulin resistance and alzheimer disease--reply. |
2016-06-16 |
2023-08-13 |
Not clear |
| Nicolas Kunath, Thomas van Groen, David B Allison, Ashish Kumar, Monique Dozier-Sharpe, Inga Kadis. Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer's disease mouse model. Scientific reports. vol 5. 2016-06-07. PMID:26090621. |
ghrelin agonist does not foster insulin resistance but improves cognition in an alzheimer's disease mouse model. |
2016-06-07 |
2023-08-13 |
mouse |
| Nicolas Kunath, Thomas van Groen, David B Allison, Ashish Kumar, Monique Dozier-Sharpe, Inga Kadis. Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer's disease mouse model. Scientific reports. vol 5. 2016-06-07. PMID:26090621. |
the present results suggest that ghrelin might improve cognition in alzheimer's disease via a central nervous system mechanism involving insulin signaling. |
2016-06-07 |
2023-08-13 |
mouse |
| Veena Theendakara, Clare A Peters-Libeu, Patricia Spilman, Karen S Poksay, Dale E Bredesen, Rammohan V Ra. Direct Transcriptional Effects of Apolipoprotein E. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 3. 2016-05-27. PMID:26791201. |
significance statement: this study shows for the first time that apolipoprotein e4 binds dna with high affinity and that its binding sites include 1700 promoter regions that include genes associated with neurotrophins, programmed cell death, synaptic function, sirtuins and aging, and insulin resistance, all processes that have been implicated in alzheimer's disease pathogenesis. |
2016-05-27 |
2023-08-13 |
mouse |
| Li-Juan Sun, Yong Zhang, Jian-Kang Li. [Exercise and aging: regulation of mitochondrial function and redox system]. Sheng li ke xue jin zhan [Progress in physiology]. vol 45. issue 5. 2016-05-26. PMID:25764789. |
the age-related declines in mitochondrial function and redox imbalance affect physical function, induce insulin resistance and neurodegenerative diseases, such as alzheimer's and parkinson's disease, thus, play a major role in regulation of life span. |
2016-05-26 |
2023-08-13 |
Not clear |
| Yanxing Chen, Jianfang Zhang, Baorong Zhang, Cheng-Xin Gon. Targeting Insulin Signaling for the Treatment of Alzheimer's Disease. Current topics in medicinal chemistry. vol 16. issue 5. 2016-05-13. PMID:26268336. |
targeting insulin signaling for the treatment of alzheimer's disease. |
2016-05-13 |
2023-08-13 |
Not clear |
| Yanxing Chen, Jianfang Zhang, Baorong Zhang, Cheng-Xin Gon. Targeting Insulin Signaling for the Treatment of Alzheimer's Disease. Current topics in medicinal chemistry. vol 16. issue 5. 2016-05-13. PMID:26268336. |
sporadic alzheimer's disease (ad) is caused by multiple etiological factors, among which impaired brain insulin signaling and decreased brain glucose metabolism are important metabolic factors. |
2016-05-13 |
2023-08-13 |
Not clear |