| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beixi Wang, Christopher B Lietz, Ellen D Inutan, Samantha M Leach, Sarah Trimpi. Producing highly charged ions without solvent using laserspray ionization: a total solvent-free analysis approach at atmospheric pressure. Analytical chemistry. vol 83. issue 11. 2011-12-01. PMID:21520968. |
preparing the matrix/analyte sample without the use of solvent provides the ability to perform total solvent-free analysis (tsa) consisting of solvent-free ionization and solvent-free gas-phase separation using ion mobility spectrometry (ims) ms. peptides and small proteins such as non-β-amyloid components of alzheimer's disease and bovine insulin are examples in which lsi and tsa were combined to produce multiply charged ions, similar to electrospray ionization, but without the use of solvent. |
2011-12-01 |
2023-08-12 |
cattle |
| Naoyuki Sato, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Tomomi Fujisawa, Hiromi Rakugi, Ryuichi Morishit. Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. Current aging science. vol 4. issue 2. 2011-11-23. PMID:21235496. |
role of insulin signaling in the interaction between alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. |
2011-11-23 |
2023-08-12 |
mouse |
| Christian Hölsche. Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease. Biochemical Society transactions. vol 39. issue 4. 2011-11-15. PMID:21787319. |
diabetes as a risk factor for alzheimer's disease: insulin signalling impairment in the brain as an alternative model of alzheimer's disease. |
2011-11-15 |
2023-08-12 |
mouse |
| Peter Riederer, Jasmin Bartl, Gerd Laux, Edna Grünblat. Diabetes type II: a risk factor for depression-Parkinson-Alzheimer? Neurotoxicity research. vol 19. issue 2. 2011-11-09. PMID:20552313. |
chronic stress and hypercortisolaemia are conditions, which have been suggested to be causal for alzheimer's disease (ad) as brain insulin resistance is associated with β-amyloid-accumulation and hyperphosphorylation of tau-protein. |
2011-11-09 |
2023-08-12 |
Not clear |
| N Mody, A Agouni, G D McIlroy, B Platt, M Delibegovi. Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein. Diabetologia. vol 54. issue 8. 2011-11-08. PMID:21538175. |
obesity is a major risk factor for development of insulin resistance, a proximal cause of type 2 diabetes and is also associated with an increased relative risk of alzheimer's disease. |
2011-11-08 |
2023-08-12 |
mouse |
| N Mody, A Agouni, G D McIlroy, B Platt, M Delibegovi. Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein. Diabetologia. vol 54. issue 8. 2011-11-08. PMID:21538175. |
we therefore investigated the susceptibility of transgenic mice carrying human mutated transgenes for amyloid precursor protein (app (swe)) and presenilin 1 (psen1 (a246e)) (app/psen1), or psen1 (a246e) alone, which are well-characterised animal models of alzheimer's disease, to develop obesity, glucose intolerance and insulin resistance, and whether this was age- and/or diet-dependent. |
2011-11-08 |
2023-08-12 |
mouse |
| Nicholas Noinaj, Sonia K Bhasin, Eun Suk Song, Kirsten E Scoggin, Maria A Juliano, Luiz Juliano, Louis B Hersh, David W Rodger. Identification of the allosteric regulatory site of insulysin. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731629. |
insulin degrading enzyme (ide) is responsible for the metabolism of insulin and plays a role in clearance of the aβ peptide associated with alzheimer's disease. |
2011-11-02 |
2023-08-12 |
Not clear |
| Olivia Belbin, Michael Crump, Gina D Bisceglio, Minerva M Carrasquillo, Kevin Morgan, Steven G Younki. Multiple insulin degrading enzyme variants alter in vitro reporter gene expression. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731745. |
the insulin degrading enzyme (ide) variant, v311 (rs6583817), is associated with increased post-mortem cerebellar ide mrna, decreased plasma β-amyloid (aβ), decreased risk for alzheimer's disease (ad) and increased reporter gene expression, suggesting that it is a functional variant driving increased ide expression. |
2011-11-02 |
2023-08-12 |
Not clear |
| Ying Liu, Fei Liu, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gon. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. The Journal of pathology. vol 225. issue 1. 2011-10-24. PMID:21598254. |
deficient brain insulin signalling pathway in alzheimer's disease and diabetes. |
2011-10-24 |
2023-08-12 |
Not clear |
| Dingzhen Luo, Xunyao Hou, Liang Hou, Meixia Wang, Song Xu, Chuanfang Dong, Xueping Li. Effect of pioglitazone on altered expression of Aβ metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance. European journal of pharmacology. vol 664. issue 1-3. 2011-10-06. PMID:21549699. |
an optimal brain insulin level promotes aβ clearance, which may play protective roles against alzheimer's disease. |
2011-10-06 |
2023-08-12 |
rat |
| Sónia C Correia, Renato X Santos, George Perry, Xiongwei Zhu, Paula I Moreira, Mark A Smit. Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease? Ageing research reviews. vol 10. issue 2. 2011-09-21. PMID:21262392. |
severe abnormalities in brain glucose/energy metabolism and insulin signaling have been documented to take a pivotal role in early sporadic alzheimer's disease (sad) pathology. |
2011-09-21 |
2023-08-12 |
rat |
| Xin Liu, Yi-na Zhang, Zong-yan Teng, Li-hong Jian. [Abnormal expression of insulin receptor induced by Aβ(1-42) in rat hippocampus neuron]. Zhonghua yi xue za zhi. vol 90. issue 41. 2011-09-15. PMID:21211393. |
to detect the expression change of insulin receptor under the induction of aβ(1-42) in rat hippocampus neuron and thus from the receptor level explore the disorder of central nervous insulin signaling and molecular mechanism of alzheimer's disease. |
2011-09-15 |
2023-08-12 |
rat |
| Shuko Takeda, Naoyuki Sato, Hiromi Rakugi, Ryuichi Morishit. Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. Molecular bioSystems. vol 7. issue 6. 2011-09-07. PMID:21431241. |
molecular mechanisms linking diabetes mellitus and alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. |
2011-09-07 |
2023-08-12 |
mouse |
| Jennifer L Bayer-Carter, Pattie S Green, Thomas J Montine, Brian VanFossen, Laura D Baker, G Stennis Watson, Laura M Bonner, Maureen Callaghan, James B Leverenz, Brooke K Walter, Elaine Tsai, Stephen R Plymate, Nadia Postupna, Charles W Wilkinson, Jing Zhang, Johanna Lampe, Steven E Kahn, Suzanne Craf. Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Archives of neurology. vol 68. issue 6. 2011-08-12. PMID:21670398. |
to compare the effects of a 4-week high-saturated fat/high-glycemic index (high) diet with a low-saturated fat/low-glycemic index (low) diet on insulin and lipid metabolism, cerebrospinal fluid (csf) markers of alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (amci). |
2011-08-12 |
2023-08-12 |
Not clear |
| Sho-ichi Yamagish. Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes. Experimental gerontology. vol 46. issue 4. 2011-08-09. PMID:21111800. |
a non-enzymatic reaction between ketones or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and to the development and progression of various age-related disorders such as vascular complications of diabetes, alzheimer's disease, cancer growth and metastasis, insulin resistance and degenerative bone disease. |
2011-08-09 |
2023-08-12 |
Not clear |
| Paresh Dandona, Islam Mohamed, Husam Ghanim, Chang Ling Sia, Sandeep Dhindsa, Sonny Dandona, Antoine Makdissi, Ajay Chaudhur. Insulin suppresses the expression of amyloid precursor protein, presenilins, and glycogen synthase kinase-3beta in peripheral blood mononuclear cells. The Journal of clinical endocrinology and metabolism. vol 96. issue 6. 2011-08-05. PMID:21411544. |
our objective was to determine whether peripheral blood mononuclear cells express amyloid precursor protein (app) and other mediators involved in the pathogenesis of alzheimer's disease and whether their expression is suppressed by insulin. |
2011-08-05 |
2023-08-12 |
Not clear |
| Sebastian Jimenez, Manuel Torres, Marisa Vizuete, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Laura Trujillo-Estrada, Irene Carmona-Cuenca, Cristina Caballero, Diego Ruano, Antonia Gutierrez, Javier Vitoric. Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model. The Journal of biological chemistry. vol 286. issue 21. 2011-07-28. PMID:21460223. |
alterations in ngf, bdnf, igf-1, or insulin signaling are implicated in the pathogenesis of alzheimer disease. |
2011-07-28 |
2023-08-12 |
mouse |
| Ayelén Bulloj, María C Leal, Ezequiel I Surace, Xue Zhang, Huaxi Xu, Maria D Ledesma, Eduardo M Castaño, Laura Morell. Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation. Molecular neurodegeneration. vol 3. 2011-07-14. PMID:19117523. |
insulin degrading enzyme (ide) is implicated in the regulation of amyloid beta (abeta) steady-state levels in the brain, and its deficient expression and/or activity may be a risk factor in sporadic alzheimer's disease (ad). |
2011-07-14 |
2023-08-12 |
Not clear |
| Noriko Sato, Akinori Ueki, Hideo Ueno, Hidetaka Shinjo, Yoshio Morit. IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's Type. Current gerontology and geriatrics research. 2011-07-14. PMID:19415148. |
insulin degrading enzyme (ide) degrades amyloid beta (abeta), which may inhibit the accumulation of abeta in a brain affected with dementia of alzheimer's type (dat). |
2011-07-14 |
2023-08-12 |
Not clear |
| Xu Wang, Wei Zheng, Jing-Wei Xie, Tao Wang, Si-Ling Wang, Wei-Ping Teng, Zhan-You Wan. Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:21044348. |
insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an alzheimer transgenic mouse model. |
2011-07-14 |
2023-08-12 |
mouse |