| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suzanne Craf. Alzheimer disease: Insulin resistance and AD--extending the translational path. Nature reviews. Neurology. vol 8. issue 7. 2012-12-03. PMID:22710630. |
alzheimer disease: insulin resistance and ad--extending the translational path. |
2012-12-03 |
2023-08-12 |
Not clear |
| Kerry L Hildreth, Rachael E Van Pelt, Robert S Schwart. Obesity, insulin resistance, and Alzheimer's disease. Obesity (Silver Spring, Md.). vol 20. issue 8. 2012-11-29. PMID:22310232. |
obesity, insulin resistance, and alzheimer's disease. |
2012-11-29 |
2023-08-12 |
Not clear |
| Thomas M van Himbergen, Alexa S Beiser, Masumi Ai, Sudha Seshadri, Seiko Otokozawa, Rhoda Au, Nuntakorn Thongtang, Philip A Wolf, Ernst J Schaefe. Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. Archives of neurology. vol 69. issue 5. 2012-11-19. PMID:22213409. |
biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the framingham heart study. |
2012-11-19 |
2023-08-12 |
Not clear |
| Thomas M van Himbergen, Alexa S Beiser, Masumi Ai, Sudha Seshadri, Seiko Otokozawa, Rhoda Au, Nuntakorn Thongtang, Philip A Wolf, Ernst J Schaefe. Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. Archives of neurology. vol 69. issue 5. 2012-11-19. PMID:22213409. |
to investigate the contribution of biomarkers of glucose homeostasis (adiponectin, glucose, glycated albumin, and insulin levels) and inflammation (high-sensitivity c-reactive protein and lipoprotein-associated phospholipase a(2) levels) to the risk of developing alzheimer disease (ad) and all-cause dementia. |
2012-11-19 |
2023-08-12 |
Not clear |
| Manav Batra, Husam Ghanim, Paresh Dandon. Insulin and Alzheimer disease. Archives of neurology. vol 69. issue 5. 2012-11-19. PMID:22782516. |
insulin and alzheimer disease. |
2012-11-19 |
2023-08-12 |
Not clear |
| Mikko Hiltunen, Vinoth K M Khandelwal, Nagendra Yaluri, Tea Tiilikainen, Maija Tusa, Henna Koivisto, Marine Krzisch, Saila Vepsäläinen, Petra Mäkinen, Susanna Kemppainen, Pasi Miettinen, Annakaisa Haapasalo, Hilkka Soininen, Markku Laakso, Heikki Tanil. Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice. Journal of cellular and molecular medicine. vol 16. issue 6. 2012-11-06. PMID:21762376. |
contribution of genetic and dietary insulin resistance to alzheimer phenotype in app/ps1 transgenic mice. |
2012-11-06 |
2023-08-12 |
mouse |
| William A Bank. Brain meets body: the blood-brain barrier as an endocrine interface. Endocrinology. vol 153. issue 9. 2012-10-29. PMID:22778219. |
by dividing a hormone's receptors into central and peripheral pools, the former of which may not be part of the hormone's negative feed back loop, the bbb fosters the development of variable hormone resistance syndromes, as exemplified by evidence that altered insulin action in the cns can contribute to alzheimer's disease. |
2012-10-29 |
2023-08-12 |
Not clear |
| Brain insulin resistance may exacerbate Alzheimer's progression. Researchers call it "Type III" diabetes. DukeMedicine healthnews. vol 18. issue 9. 2012-10-24. PMID:23029691. |
brain insulin resistance may exacerbate alzheimer's progression. |
2012-10-24 |
2023-08-12 |
Not clear |
| Ritchie Williamson, Alison McNeilly, Calum Sutherlan. Insulin resistance in the brain: an old-age or new-age problem? Biochemical pharmacology. vol 84. issue 6. 2012-10-19. PMID:22634336. |
epidemiological evidence suggests an increased risk of developing dementia (including alzheimer's disease) in individuals with obesity and type 2 diabetes but also in those with poor insulin sensitivity without diabetes, implicating a mechanistic link between adiposity, insulin sensitivity and dementia. |
2012-10-19 |
2023-08-12 |
Not clear |
| b' Zorica Jovanovi\\xc4\\x8. [Mechanisms of neurodegeneration in Alzheimer\'s disease]. Medicinski pregled. vol 65. issue 7-8. 2012-10-05. PMID:22924250.' |
insulin resistance and alzheimer's disease: insulin plays a role in alzheimer's disease, as it is involved in the metabolism of beta-amyloid. |
2012-10-05 |
2023-08-12 |
Not clear |
| b' Zorica Jovanovi\\xc4\\x8. [Mechanisms of neurodegeneration in Alzheimer\'s disease]. Medicinski pregled. vol 65. issue 7-8. 2012-10-05. PMID:22924250.' |
treatment of central insulin resistance may be a promising avenue, not only in metabolic syndrom, but also in alzheimer's disease. |
2012-10-05 |
2023-08-12 |
Not clear |
| Ji Zhao, Lilin Li, Malcolm A Leissrin. Insulin-degrading enzyme is exported via an unconventional protein secretion pathway. Molecular neurodegeneration. vol 4. 2012-10-02. PMID:19144176. |
insulin-degrading enzyme (ide) is a ubiquitously expressed zinc-metalloprotease that degrades several pathophysiologically significant extracellular substrates, including insulin and the amyloid beta-protein (abeta), and accumulating evidence suggests that ide dysfunction may be operative in both type 2 diabetes mellitus and alzheimer disease (ad). |
2012-10-02 |
2023-08-12 |
Not clear |
| Oksana Kaidanovich-Beilin, Danielle S Cha, Roger S McIntyr. Crosstalk between metabolic and neuropsychiatric disorders. F1000 biology reports. vol 4. 2012-10-02. PMID:22802875. |
moreover, the role of insulin underscores its importance in the development of several neuropsychiatric disorders, including, but not limited to, mechanisms involved in the pathogenesis and progression towards diabetes, obesity, and neurodegenerative disorders, such as alzheimer's disease. |
2012-10-02 |
2023-08-12 |
human |
| Qing-Chun Li, Gui-Ian Wand, Bao-Yu Li, Hui Sun, Nai-Chang Jian. [The effect of insulin on the spatial learning and memory abilities of the Alzheimer's disease model rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 24. issue 4. 2012-10-01. PMID:21158163. |
[the effect of insulin on the spatial learning and memory abilities of the alzheimer's disease model rats]. |
2012-10-01 |
2023-08-12 |
rat |
| Qing-Chun Li, Gui-Ian Wand, Bao-Yu Li, Hui Sun, Nai-Chang Jian. [The effect of insulin on the spatial learning and memory abilities of the Alzheimer's disease model rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 24. issue 4. 2012-10-01. PMID:21158163. |
to investigate the mechanism through which insulin affect the learning and memory abilities of the alzheimer's disease-like rats. |
2012-10-01 |
2023-08-12 |
rat |
| Helgi B Schiöth, William H Frey, Samantha J Brooks, Christian Benedic. Insulin to treat Alzheimer's disease: just follow your nose? Expert review of clinical pharmacology. vol 5. issue 1. 2012-09-04. PMID:22142155. |
insulin to treat alzheimer's disease: just follow your nose? |
2012-09-04 |
2023-08-12 |
Not clear |
| Helgi B Schiöth, William H Frey, Samantha J Brooks, Christian Benedic. Insulin to treat Alzheimer's disease: just follow your nose? Expert review of clinical pharmacology. vol 5. issue 1. 2012-09-04. PMID:22142155. |
alzheimer's disease (ad) is linked to cns insulin resistance, decreased expression of insulin and insulin receptor genes, and lower cerebrospinal insulin levels. |
2012-09-04 |
2023-08-12 |
Not clear |
| Yudong Liu, Ying Su, Shenggang Sun, Tao Wang, Xian Qiao, Xiaoqin Run, Zhihou Lian. Tau phosphorylation and μ-calpain activation mediate the dexamethasone-induced inhibition on the insulin-stimulated Akt phosphorylation. PloS one. vol 7. issue 4. 2012-08-31. PMID:22536436. |
evidence has suggested that insulin resistance (ir) or high levels of glucocorticoids (gcs) may be linked with the pathogenesis and/or progression of alzheimer's disease (ad). |
2012-08-31 |
2023-08-12 |
human |
| Artur F Schuh, Carlos M Rieder, Liara Rizzi, Márcia Chaves, Matheus Roriz-Cru. Mechanisms of brain aging regulation by insulin: implications for neurodegeneration in late-onset Alzheimer's disease. ISRN neurology. vol 2011. 2012-08-23. PMID:22389813. |
mechanisms of brain aging regulation by insulin: implications for neurodegeneration in late-onset alzheimer's disease. |
2012-08-23 |
2023-08-12 |
human |
| Artur F Schuh, Carlos M Rieder, Liara Rizzi, Márcia Chaves, Matheus Roriz-Cru. Mechanisms of brain aging regulation by insulin: implications for neurodegeneration in late-onset Alzheimer's disease. ISRN neurology. vol 2011. 2012-08-23. PMID:22389813. |
conversely, insulin resistance increases with age, obesity, and sedentarism, all of which have been shown to be risk factors for late-onset alzheimer's disease (ad). |
2012-08-23 |
2023-08-12 |
human |