| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Rodrigo O Kulji\\xc5\\xa1, Melita Salkovi\\xc4\\x87-Petri\\xc5\\xa1i\\xc4\\x8. Dementia, diabetes, Alzheimer\'s disease, and insulin resistance in the brain: progress, dilemmas, new opportunities, and a hypothesis to tackle intersecting epidemics. Journal of Alzheimer\'s disease : JAD. vol 25. issue 1. 2012-06-04. PMID:21335659.' |
dementia, diabetes, alzheimer's disease, and insulin resistance in the brain: progress, dilemmas, new opportunities, and a hypothesis to tackle intersecting epidemics. |
2012-06-04 |
2023-08-12 |
Not clear |
| Suzanne M de la Mont. Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease. Frontiers in bioscience (Elite edition). vol 4. 2012-05-14. PMID:22201977. |
therapeutic targets of brain insulin resistance in sporadic alzheimer's disease. |
2012-05-14 |
2023-08-12 |
Not clear |
| Suzanne M de la Mont. Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease. Frontiers in bioscience (Elite edition). vol 4. 2012-05-14. PMID:22201977. |
growing evidence supports roles for brain insulin and insulin-like growth factor (igf) resistance and metabolic dysfunction in the pathogenesis of alzheimer's disease (ad). |
2012-05-14 |
2023-08-12 |
Not clear |
| A T Isik, E Bozoglu, D Eke. aChE and BuChE inhibition by rivastigmin have no effect on peripheral insulin resistance in elderly patients with Alzheimer disease. The journal of nutrition, health & aging. vol 16. issue 2. 2012-05-07. PMID:22323348. |
ache and buche inhibition by rivastigmin have no effect on peripheral insulin resistance in elderly patients with alzheimer disease. |
2012-05-07 |
2023-08-12 |
Not clear |
| A T Isik, E Bozoglu, D Eke. aChE and BuChE inhibition by rivastigmin have no effect on peripheral insulin resistance in elderly patients with Alzheimer disease. The journal of nutrition, health & aging. vol 16. issue 2. 2012-05-07. PMID:22323348. |
insulin resistance (ir) may play a role in most pathogenic processes that promote the development of late onset alzheimer disease (load). |
2012-05-07 |
2023-08-12 |
Not clear |
| V Ott, C Benedict, B Schultes, J Born, M Hallschmi. Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism. Diabetes, obesity & metabolism. vol 14. issue 3. 2012-05-04. PMID:21883804. |
furthermore, evidence is reviewed that suggests a pathophysiological role of impaired brain insulin signaling in obesity and type 2 diabetes, which are hallmarked by peripheral and possibly central nervous insulin resistance, as well as in conditions such as alzheimer's disease where cns insulin resistance might contribute to cognitive dysfunction. |
2012-05-04 |
2023-08-12 |
Not clear |
| Brian C Shonesy, Kariharan Thiruchelvam, Kodeeswaran Parameshwaran, Engy Abdel Rahman, Senthilkumar S Karuppagounder, Kevin W Huggins, Carl A Pinkert, Rajesh Amin, Muralikrishnan Dhanasekaran, Vishnu Suppiramania. Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:21256630. |
to better understand the role of insulin signaling in the development of alzheimer's disease (ad), we utilized an animal model (intracerebroventricular injection of streptozotocin-ic-streptozotocin (stz)) that displays insulin resistance only in the brain and exhibits ad pathology. |
2012-04-19 |
2023-08-12 |
Not clear |
| Julien Dumurgier, Claire Paquet, Katell Peoc'h, Pauline Lapalus, François Mouton-Liger, Sarah Benisty, Stéphanie Chasseigneaux, Hughes Chabriat, Jacques Hugo. CSF Aβ₁₋₄₂ levels and glucose metabolism in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 4. 2012-04-16. PMID:21897007. |
glucose dysmetabolism has been consistently associated with an increased risk of cognitive disorders, and brain insulin resistance could play a role in alzheimer's disease (ad) pathogenesis. |
2012-04-16 |
2023-08-12 |
Not clear |
| Alvina W M To, Elena M Ribe, Tsu Tshen Chuang, Joern E Schroeder, Simon Loveston. The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice. PloS one. vol 6. issue 2. 2012-04-02. PMID:21347323. |
impaired insulin signalling is increasingly thought to contribute to alzheimer's disease (ad). |
2012-04-02 |
2023-08-12 |
mouse |
| Therése Klingstedt, Andreas Aslund, Rozalyn A Simon, Leif B G Johansson, Jeffrey J Mason, Sofie Nyström, Per Hammarström, K Peter R Nilsso. Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates. Organic & biomolecular chemistry. vol 9. issue 24. 2012-03-30. PMID:22051883. |
certain molecular requirements were shown to be necessary for detecting (i) early non-thioflavinophilic protein assemblies of aβ1-42 and insulin preceding the formation of amyloid fibrils and (ii) for obtaining distinct spectral signatures of the two main pathological hallmarks observed in human alzheimer's diease brain tissue (aβ plaques and neurofibrillary tangles). |
2012-03-30 |
2023-08-12 |
human |
| Suzanne M de la Mont. Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease. Drugs. vol 72. issue 1. 2012-03-29. PMID:22191795. |
contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in alzheimer's disease. |
2012-03-29 |
2023-08-12 |
Not clear |
| Suzanne Craft, Laura D Baker, Thomas J Montine, Satoshi Minoshima, G Stennis Watson, Amy Claxton, Matthew Arbuckle, Maureen Callaghan, Elaine Tsai, Stephen R Plymate, Pattie S Green, James Leverenz, Donna Cross, Brooke Gerto. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Archives of neurology. vol 69. issue 1. 2012-02-21. PMID:21911655. |
intranasal insulin therapy for alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. |
2012-02-21 |
2023-08-12 |
Not clear |
| Suzanne Craft, Laura D Baker, Thomas J Montine, Satoshi Minoshima, G Stennis Watson, Amy Claxton, Matthew Arbuckle, Maureen Callaghan, Elaine Tsai, Stephen R Plymate, Pattie S Green, James Leverenz, Donna Cross, Brooke Gerto. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Archives of neurology. vol 69. issue 1. 2012-02-21. PMID:21911655. |
to examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or alzheimer disease (ad). |
2012-02-21 |
2023-08-12 |
Not clear |
| Paul J Meakin, Alex J Harper, D Lee Hamilton, Jennifer Gallagher, Alison D McNeilly, Laura A Burgess, Lobke M Vaanholt, Kirsten A Bannon, Judy Latcham, Ishrut Hussain, John R Speakman, David R Howlett, Michael L J Ashfor. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. The Biochemical journal. vol 441. issue 1. 2012-02-16. PMID:21880018. |
insulin resistance and impaired glucose homoeostasis are important indicators of type 2 diabetes and are early risk factors of ad (alzheimer's disease). |
2012-02-16 |
2023-08-12 |
mouse |
| Natalie L Rasgon, Heather A Kenna, Tonita E Wroolie, Ryan Kelley, Daniel Silverman, John Brooks, Katherine E Williams, Bevin N Powers, Joachim Hallmayer, Allan Reis. Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease. Neurobiology of aging. vol 32. issue 11. 2012-01-18. PMID:20031276. |
insulin resistance and hippocampal volume in women at risk for alzheimer's disease. |
2012-01-18 |
2023-08-12 |
Not clear |
| Natalie L Rasgon, Heather A Kenna, Tonita E Wroolie, Ryan Kelley, Daniel Silverman, John Brooks, Katherine E Williams, Bevin N Powers, Joachim Hallmayer, Allan Reis. Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease. Neurobiology of aging. vol 32. issue 11. 2012-01-18. PMID:20031276. |
insulin resistance (ir) is the main pathological condition underlying vascular disorders, such as diabetes and cardiovascular disease, which are well established risk factors for cognitive decline and alzheimer disease (ad). |
2012-01-18 |
2023-08-12 |
Not clear |
| Mark S Stein, Samuel C Scherer, Kylie S Ladd, Leonard C Harriso. A randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21694461. |
a randomized controlled trial of high-dose vitamin d2 followed by intranasal insulin in alzheimer's disease. |
2012-01-11 |
2023-08-12 |
Not clear |
| Mark S Stein, Samuel C Scherer, Kylie S Ladd, Leonard C Harriso. A randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21694461. |
after run-in (8 weeks), they were randomized to additional high-dose d/placebo for 8 weeks, followed immediately by randomization to nasal insulin (60 iu qid)/placebo for 48 h. primary outcome measures were alzheimer's disease assessment scale-cognitive subscale (adas-cog) and disability assessment in dementia (after high-dose d) and adas-cog and wechsler memory scale-revised logical memory (wms-r lm) for immediate and delayed recall (after nasal insulin). |
2012-01-11 |
2023-08-12 |
Not clear |
| Guo-Chang Fan, Evangelia G Krania. Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure. Journal of molecular and cellular cardiology. vol 51. issue 4. 2012-01-06. PMID:20869365. |
recently, hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and alzheimer's disease. |
2012-01-06 |
2023-08-12 |
human |
| Domenico Bosco, Antonietta Fava, Massimiliano Plastino, Tiziana Montalcini, Arturo Puji. Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis. Journal of cellular and molecular medicine. vol 15. issue 9. 2012-01-05. PMID:21435176. |
possible implications of insulin resistance and glucose metabolism in alzheimer's disease pathogenesis. |
2012-01-05 |
2023-08-12 |
Not clear |