| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana I Duarte, Paula I Moreira, Catarina R Oliveir. Insulin in central nervous system: more than just a peripheral hormone. Journal of aging research. vol 2012. 2012-08-23. PMID:22500228. |
more interestingly, insulin has been also faced as the potential missing link between diabetes and aging in cns, with alzheimer's disease (ad) considered as the "brain-type diabetes." |
2012-08-23 |
2023-08-12 |
human |
| L Arab, R Sadeghi, D G Walker, L-F Lue, M N Sabbag. Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimer's Disease. Current neuropharmacology. vol 9. issue 4. 2012-08-23. PMID:22654727. |
consequences of aberrant insulin regulation in the brain: can treating diabetes be effective for alzheimer's disease. |
2012-08-23 |
2023-08-12 |
Not clear |
| Lorna Moll, Markus Schuber. The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia. Current gerontology and geriatrics research. vol 2012. 2012-08-23. PMID:22654904. |
furthermore, insulin and igf-1-induced signaling is reduced in the brains of patients suffering from alzheimer's disease (ad). |
2012-08-23 |
2023-08-12 |
caenorhabditis_elegans |
| Lap Ho, Shrishailam Yemul, Lindsay Knable, Pavel Katsel, Rudy Zhao, Vahram Haroutunian, Giulio Maria Pasinett. Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22666619. |
we investigated the contents of the insulin receptor-beta subunit (irβ) and [tyr1162/1163]-phosphorylated irβ as surrogate indices of total ir content and ir activation in postmortem hippocampal formation brain specimens from nondiabetic sporadic alzheimer's disease (ad) cases. |
2012-08-23 |
2023-08-12 |
Not clear |
| Kerry Hunter, Christian Hölsche. Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC neuroscience. vol 13. 2012-08-10. PMID:22443187. |
type 2 diabetes is a risk factor for alzheimer's disease (ad), most likely linked to an impairment of insulin signalling in the brain. |
2012-08-10 |
2023-08-12 |
Not clear |
| David A Camfield, Lauren Owen, Andrew B Scholey, Andrew Pipingas, Con Stoug. Dairy constituents and neurocognitive health in ageing. The British journal of nutrition. vol 106. issue 2. 2012-08-06. PMID:21338538. |
these search terms for dairy products were combined with the following search terms related to cognition and health: cognition, cognitive decline, dementia, alzheimer's disease, metabolic syndrome, diabetes, insulin resistance and glucose regulation. |
2012-08-06 |
2023-08-12 |
Not clear |
| Heike Kölsch, Donald J Lehmann, Carla A Ibrahim-Verbaas, Onofre Combarros, Cornelia M van Duijn, Naomi Hammond, Olivia Belbin, Mario Cortina-Borja, Michael G Lehmann, Yurii S Aulchenko, Maaike Schuur, Monique Breteler, Gordon K Wilcock, Kristelle Brown, Patrick G Kehoe, Rachel Barber, Eliecer Coto, Victoria Alvarez, Panos Deloukas, Ignacio Mateo, Wolfgang Maier, Kevin Morgan, Donald R Warden, A David Smith, Reinhard Heu. Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 4. 2012-07-30. PMID:22065208. |
interaction of insulin and ppar-α genes in alzheimer's disease: the epistasis project. |
2012-07-30 |
2023-08-12 |
Not clear |
| Zhiheng Liu, Haihao Zhu, Guang Guang Fang, Kathryn Walsh, Mkaya Mwamburi, Benjamin Wolozin, Samer O Abdul-Hay, Tsuneya Ikezu, Malcolm A Leissring, Wei Qiao Qi. Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease? Journal of Alzheimer's disease : JAD. vol 29. issue 2. 2012-07-26. PMID:22232014. |
characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in alzheimer's disease? |
2012-07-26 |
2023-08-12 |
human |
| Thangiah Geetha, Nilmini Vishwaprakash, Marina Sycheva, Jeganathan Ramesh Bab. Sequestosome 1/p62: across diseases. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. vol 17. issue 2. 2012-07-23. PMID:22296116. |
sequestosome 1/p62 is gaining attention as it is involved in several diseases including parkinson disease, alzheimer disease, liver and breast cancer, paget's disease of bone, obesity and insulin resistance. |
2012-07-23 |
2023-08-12 |
human |
| Jeffrey M Burns, Robyn A Honea, Eric D Vidoni, Lewis J Hutfles, William M Brooks, Russell H Swerdlo. Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging. Biochimica et biophysica acta. vol 1822. issue 3. 2012-07-10. PMID:21745566. |
insulin is differentially related to cognitive decline and atrophy in alzheimer's disease and aging. |
2012-07-10 |
2023-08-12 |
Not clear |
| Jeffrey M Burns, Robyn A Honea, Eric D Vidoni, Lewis J Hutfles, William M Brooks, Russell H Swerdlo. Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging. Biochimica et biophysica acta. vol 1822. issue 3. 2012-07-10. PMID:21745566. |
we assessed the relationship of insulin resistance with cognitive decline and brain atrophy over two years in early alzheimer's disease (ad, n=48) and nondemented controls (n=61). |
2012-07-10 |
2023-08-12 |
Not clear |
| Latha Devi, Melissa J Alldred, Stephen D Ginsberg, Masuo Ohn. Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease. PloS one. vol 7. issue 3. 2012-07-09. PMID:22403710. |
mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of alzheimer's disease. |
2012-07-09 |
2023-08-12 |
mouse |
| Latha Devi, Melissa J Alldred, Stephen D Ginsberg, Masuo Ohn. Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease. PloS one. vol 7. issue 3. 2012-07-09. PMID:22403710. |
although evidence is accumulating that diabetes mellitus is an important risk factor for sporadic alzheimer's disease (ad), the mechanisms by which defects in insulin signaling may lead to the acceleration of ad progression remain unclear. |
2012-07-09 |
2023-08-12 |
mouse |
| Theresa R Bomfim, Leticia Forny-Germano, Luciana B Sathler, Jordano Brito-Moreira, Jean-Christophe Houzel, Helena Decker, Michael A Silverman, Hala Kazi, Helen M Melo, Paula L McClean, Christian Holscher, Steven E Arnold, Konrad Talbot, William L Klein, Douglas P Munoz, Sergio T Ferreira, Fernanda G De Felic. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. The Journal of clinical investigation. vol 122. issue 4. 2012-07-06. PMID:22476196. |
an anti-diabetes agent protects the mouse brain from defective insulin signaling caused by alzheimer's disease- associated aβ oligomers. |
2012-07-06 |
2023-08-12 |
mouse |
| Theresa R Bomfim, Leticia Forny-Germano, Luciana B Sathler, Jordano Brito-Moreira, Jean-Christophe Houzel, Helena Decker, Michael A Silverman, Hala Kazi, Helen M Melo, Paula L McClean, Christian Holscher, Steven E Arnold, Konrad Talbot, William L Klein, Douglas P Munoz, Sergio T Ferreira, Fernanda G De Felic. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. The Journal of clinical investigation. vol 122. issue 4. 2012-07-06. PMID:22476196. |
defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with alzheimer's disease (ad). |
2012-07-06 |
2023-08-12 |
mouse |
| Konrad Talbot, Hoau-Yan Wang, Hala Kazi, Li-Ying Han, Kalindi P Bakshi, Andres Stucky, Robert L Fuino, Krista R Kawaguchi, Andrew J Samoyedny, Robert S Wilson, Zoe Arvanitakis, Julie A Schneider, Bryan A Wolf, David A Bennett, John Q Trojanowski, Steven E Arnol. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. The Journal of clinical investigation. vol 122. issue 4. 2012-07-06. PMID:22476197. |
demonstrated brain insulin resistance in alzheimer's disease patients is associated with igf-1 resistance, irs-1 dysregulation, and cognitive decline. |
2012-07-06 |
2023-08-12 |
Not clear |
| Konrad Talbot, Hoau-Yan Wang, Hala Kazi, Li-Ying Han, Kalindi P Bakshi, Andres Stucky, Robert L Fuino, Krista R Kawaguchi, Andrew J Samoyedny, Robert S Wilson, Zoe Arvanitakis, Julie A Schneider, Bryan A Wolf, David A Bennett, John Q Trojanowski, Steven E Arnol. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. The Journal of clinical investigation. vol 122. issue 4. 2012-07-06. PMID:22476197. |
while a potential causal factor in alzheimer's disease (ad), brain insulin resistance has not been demonstrated directly in that disorder. |
2012-07-06 |
2023-08-12 |
Not clear |
| Bilal Çakir, Onur Dağliyan, Ezgi Dağyildiz, İbrahim Bariş, Ibrahim Halil Kavakli, Seda Kizilel, Metin Türka. Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. PloS one. vol 7. issue 2. 2012-06-18. PMID:22355395. |
insulin-degrading enzyme (ide) is an allosteric zn(+2) metalloprotease involved in the degradation of many peptides including amyloid-β, and insulin that play key roles in alzheimer's disease (ad) and type 2 diabetes mellitus (t2dm), respectively. |
2012-06-18 |
2023-08-12 |
human |
| Michael J Urban, Rick T Dobrowsky, Brian S J Blag. Heat shock response and insulin-associated neurodegeneration. Trends in pharmacological sciences. vol 33. issue 3. 2012-06-14. PMID:22172248. |
dysfunctional insulin and insulin-like growth factor-i (igf-i) signaling contributes to the pathological progression of diabetes, diabetic peripheral neuropathy (dpn), alzheimer's (ad), parkinson's (pd) and huntington's diseases (hd). |
2012-06-14 |
2023-08-12 |
Not clear |
| Suzanne M de la Mont. Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22329651. |
brain insulin resistance and deficiency as therapeutic targets in alzheimer's disease. |
2012-06-14 |
2023-08-12 |
Not clear |