| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Ren, Bin Xiao, Lin-Ping Wang, Ying-Shun Li, Hua Jin, Qing-Hua Ji. Nitric oxide impairs spatial learning and memory in a rat model of Alzheimer's disease via disturbance of glutamate response in the hippocampal dentate gyrus during spatial learning. Behavioural brain research. 2022-01-16. PMID:35033612. |
nitric oxide impairs spatial learning and memory in a rat model of alzheimer's disease via disturbance of glutamate response in the hippocampal dentate gyrus during spatial learning. |
2022-01-16 |
2023-08-13 |
rat |
| Peng Ren, Bin Xiao, Lin-Ping Wang, Ying-Shun Li, Hua Jin, Qing-Hua Ji. Nitric oxide impairs spatial learning and memory in a rat model of Alzheimer's disease via disturbance of glutamate response in the hippocampal dentate gyrus during spatial learning. Behavioural brain research. 2022-01-16. PMID:35033612. |
nitric oxide (no)-dependent pathways may play a significant role in the decline of synaptic and cognitive functions in alzheimer's disease (ad). |
2022-01-16 |
2023-08-13 |
rat |
| Balbir Singh, Hasandeep Singh, Brahmjot Singh, Navkaran Kumar, Ankita Rajput, Disha Sidhu, Amandeep Kaur, Saroj Arora, Sarabjit Kau. A comprehensive review on medicinal herbs and novel formulations for the prevention of Alzheimer's disease. Current drug delivery. 2021-11-15. PMID:34779370. |
alzheimer's disease (ad) is thought to occur due to the accumulation of β-amyloid (aβ) in the neocortex portion of the brain, nitric oxide mediated dysfunctioning of blood-brain barrier, reduced activity of serine racemase enzyme, cell cycle disturbances, damage of n-methyl-d-aspartate (nmda) receptors and glutamatergic neurotransmission. |
2021-11-15 |
2023-08-13 |
Not clear |
| Maja Przybyłowska, Krystyna Dzierzbicka, Szymon Kowalski, Klaudia Chmielewska, Iwona Inkielewicz-Stepnia. Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors. Current neuropharmacology. vol 19. issue 8. 2021-11-05. PMID:33342413. |
in this account, we summarize the efforts toward the development and characterization of non-toxic inhibitors of cholinesterases based on mentioned drugs with various interesting additional properties such as antioxidant, decreasing β-amyloid plaque aggregation, nitric oxide production, pro-inflammatory cytokines release, monoamine oxidase-b activity, cytotoxicity and oxidative stress in vitro and in animal model that classify these hybrids as potential multifunctional therapeutic agents for alzheimer's disease. |
2021-11-05 |
2023-08-13 |
Not clear |
| George B Stefano, Tobias Esch, Radek Ptacek, Richard M Krea. Dysregulation of Nitric Oxide Signaling in Microglia: Multiple Points of Functional Convergence in the Complex Pathophysiology of Alzheimer Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32975239. |
dysregulation of nitric oxide signaling in microglia: multiple points of functional convergence in the complex pathophysiology of alzheimer disease. |
2021-05-20 |
2023-08-13 |
Not clear |
| Paul J Meakin, Bethany M Coull, Zofia Tuharska, Christopher McCaffery, Ioannis Akoumianakis, Charalambos Antoniades, Jane Brown, Kathryn J Griffin, Fiona Platt, Claire H Ozber, Nadira Y Yuldasheva, Natallia Makava, Anna Skromna, Alan Prescott, Alison D McNeilly, Moneeza Siddiqui, Colin Na Palmer, Faisel Khan, Michael Lj Ashfor. Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction. The Journal of clinical investigation. vol 130. issue 8. 2021-02-02. PMID:32407295. |
diabetes, obesity, and alzheimer's disease (ad) are associated with vascular complications and impaired nitric oxide (no) production. |
2021-02-02 |
2023-08-13 |
mouse |
| Laibaik Park, Joan Zhou, Kenzo Koizumi, Gang Wang, Antoine Anfray, Sung Ji Ahn, James Seo, Ping Zhou, Lingzhi Zhao, Steven Paul, Josef Anrather, Costantino Iadecol. tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 42. 2021-02-01. PMID:32928888. |
the amyloid-β (aβ) peptide, a key pathogenic factor in alzheimer's disease, attenuates the increase in cerebral blood flow (cbf) evoked by neural activity (functional hyperemia), a vital homeostatic response in which nmda receptors (nmdars) play a role through nitric oxide, and the cbf increase produced by endothelial factors. |
2021-02-01 |
2023-08-13 |
mouse |
| Massimo Venturelli, Anna Pedrinolla, Ilaria Boscolo Galazzo, Cristina Fonte, Nicola Smania, Stefano Tamburin, Ettore Muti, Lucia Crispoltoni, Annamaria Stabile, Alessandra Pistilli, Mario Rende, Francesca B Pizzini, Federico Schen. Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease. Frontiers in physiology. vol 9. 2020-09-30. PMID:29593548. |
impact of nitric oxide bioavailability on the progressive cerebral and peripheral circulatory impairments during aging and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Massimo Venturelli, Anna Pedrinolla, Ilaria Boscolo Galazzo, Cristina Fonte, Nicola Smania, Stefano Tamburin, Ettore Muti, Lucia Crispoltoni, Annamaria Stabile, Alessandra Pistilli, Mario Rende, Francesca B Pizzini, Federico Schen. Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease. Frontiers in physiology. vol 9. 2020-09-30. PMID:29593548. |
advanced aging, vascular dysfunction, and nitric oxide (no) bioavailability are recognized risk factors for alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
Not clear |
| Hamed Parsa Khankandi, Sahar Behzad, Faraz Mojab, Mohammad Mahdi Ahmadian-Attari, Shamim Sahranavar. Effects of Some Lamiaceae Species on NO Production and Cell Injury in Hydrogen Peroxide-induced Stress. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 2. 2020-09-30. PMID:31531065. |
nitric oxide (no) is a key mediator that plays an important role in pathogenesis of various chronic diseases like alzheimer's disease and parkinson's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zahra Rezaeiasl, Mahmoud Salami, Gholamreza Sepehr. The Effects of Probiotic Preventive nutrition and food science. vol 24. issue 3. 2020-09-30. PMID:31608251. |
the effects of probiotic this study assessed the effects of probiotic supplementation on spatial learning and memory, long-term potentiation (ltp), paired-pulse facilitation (ppf) ratios, nitric oxide (no) concentrations, and lipid profiles in a rat model of amyloid beta (aβ)(1-42)-induced alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
rat |
| Xiaoyi Tang, Zhuang Li, Weiwei Zhang, Zhongxiang Ya. Nitric oxide might be an inducing factor in cognitive impairment in Alzheimer's disease via downregulating the monocarboxylate transporter 1. Nitric oxide : biology and chemistry. vol 91. 2020-05-22. PMID:31326499. |
nitric oxide might be an inducing factor in cognitive impairment in alzheimer's disease via downregulating the monocarboxylate transporter 1. |
2020-05-22 |
2023-08-13 |
Not clear |
| Jereme G Spiers, Hsiao-Jou Cortina Chen, Julie-Myrtille Bourgognon, Joern R Steiner. Dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in Alzheimer's disease. Free radical biology & medicine. vol 134. 2020-04-21. PMID:30716433. |
dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in alzheimer's disease. |
2020-04-21 |
2023-08-13 |
Not clear |
| Robert Siblerud, Joachim Mutter, Elaine Moore, Johannes Naumann, Harald Walac. A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer's Disease. International journal of environmental research and public health. vol 16. issue 24. 2020-03-23. PMID:31861093. |
enzyme dysfunction in patients with alzheimer's disease include bace 1, gamma secretase, cyclooxygenase-2, cytochrome-c-oxidase, protein kinases, monoamine oxidase, nitric oxide synthetase, acetyl choline transferase, and caspases, all which can be explained by mercury toxicity. |
2020-03-23 |
2023-08-13 |
Not clear |
| Zdenka Kristofikova, Jana Sirova, Jan Klaschka, Saak V Ovsepia. Acute and Chronic Sleep Deprivation-Related Changes in N-methyl-D-aspartate Receptor-Nitric Oxide Signalling in the Rat Cerebral Cortex with Reference to Aging and Brain Lateralization. International journal of molecular sciences. vol 20. issue 13. 2019-12-20. PMID:31277281. |
aging and chronic sleep deprivation (sd) are well-recognized risk factors for alzheimer's disease (ad), with n-methyl-d-aspartate receptor (nmda) and downstream nitric oxide (no) signalling implicated in the process. |
2019-12-20 |
2023-08-13 |
rat |
| D Cervia, C Perrotta, C Moscheni, C De Palma, E Clement. Nitric oxide and sphingolipids control apoptosis and autophagy with a significant impact on Alzheimer's disease. Journal of biological regulators and homeostatic agents. vol 27. issue 2 Suppl. 2019-11-20. PMID:24813312. |
nitric oxide and sphingolipids control apoptosis and autophagy with a significant impact on alzheimer's disease. |
2019-11-20 |
2023-08-13 |
human |
| Austin Horton, Kevin Nash, Ethel Tackie-Yarboi, Alexander Kostrevski, Adam Novak, Aparna Raghavan, Jatin Tulsulkar, Qasim Alhadidi, Nathan Wamer, Bryn Langenderfer, Kalee Royster, Maxwell Ducharme, Katelyn Hagood, Megan Post, Zahoor A Shah, Isaac T Schiefe. Furoxans (Oxadiazole-4 N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. Journal of medicinal chemistry. vol 61. issue 10. 2019-06-03. PMID:29683322. |
nitric oxide (no) mimetics and other agents capable of enhancing no/cgmp signaling have demonstrated efficacy as potential therapies for alzheimer's disease. |
2019-06-03 |
2023-08-13 |
mouse |
| Harikesh Dubey, Kavita Gulati, Arunabha Ra. Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats. Neurotoxicology. vol 66. 2019-03-21. PMID:29522778. |
amelioration by nitric oxide (no) mimetics on neurobehavioral and biochemical changes in experimental model of alzheimer's disease in rats. |
2019-03-21 |
2023-08-13 |
rat |
| Diana Cifuentes, Marine Poittevin, Philippe Bonnin, Anta Ngkelo, Nathalie Kubis, Tatyana Merkulova-Rainon, Bernard I Lév. Inactivation of Nitric Oxide Synthesis Exacerbates the Development of Alzheimer Disease Pathology in APPPS1 Mice (Amyloid Precursor Protein/Presenilin-1). Hypertension (Dallas, Tex. : 1979). vol 70. issue 3. 2019-02-28. PMID:28760945. |
inactivation of nitric oxide synthesis exacerbates the development of alzheimer disease pathology in appps1 mice (amyloid precursor protein/presenilin-1). |
2019-02-28 |
2023-08-13 |
mouse |
| Diana Cifuentes, Marine Poittevin, Philippe Bonnin, Anta Ngkelo, Nathalie Kubis, Tatyana Merkulova-Rainon, Bernard I Lév. Inactivation of Nitric Oxide Synthesis Exacerbates the Development of Alzheimer Disease Pathology in APPPS1 Mice (Amyloid Precursor Protein/Presenilin-1). Hypertension (Dallas, Tex. : 1979). vol 70. issue 3. 2019-02-28. PMID:28760945. |
we previously reported that hypertension aggravates the alzheimer-like pathology in appps1 mice (amyloid precursor protein/presenilin-1, mouse model of alzheimer disease) with angiotensin ii-induced hypertension, in relation with hypertension and nitric oxide deficiency. |
2019-02-28 |
2023-08-13 |
mouse |