| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Noaín, M Elena Avale, Carolina Wedemeyer, Daniel Calvo, Marcela Peper, Marcelo Rubinstei. Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice. The European journal of neuroscience. vol 24. issue 9. 2007-01-19. PMID:17100831. |
its leading expression in the prefrontal cortex supports the importance of the d4r in complex behaviours depending on cortical dopamine (da) transmission and its possible role in the etiopathophysiology of adhd. |
2007-01-19 |
2023-08-12 |
mouse |
| Craig W Berridge, David M Devilbiss, Matthew E Andrzejewski, Amy F T Arnsten, Ann E Kelley, Brooke Schmeichel, Christina Hamilton, Robert C Spence. Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological psychiatry. vol 60. issue 10. 2006-12-20. PMID:16806100. |
the prefrontal cortex (pfc) is implicated in adhd. |
2006-12-20 |
2023-08-12 |
Not clear |
| Timo D Vloet, Susanne Neufang, Beate Herpertz-Dahlmann, Kerstin Konra. [Neuroimaging data of ADHD, tic-disorder and obsessive-compulsive-disorder in children and adolescents]. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie. vol 34. issue 5. 2006-12-15. PMID:16981155. |
by comparison, findings in children with adhd point towards abnormal activity in the ventral prefrontal cortex. |
2006-12-15 |
2023-08-12 |
Not clear |
| Catherine Fassbender, Julie B Schweitze. Is there evidence for neural compensation in attention deficit hyperactivity disorder? A review of the functional neuroimaging literature. Clinical psychology review. vol 26. issue 4. 2006-12-12. PMID:16500007. |
we hypothesize that impaired prefrontal (pfc) and anterior cingulate (acc) cortex function in adhd reduces the ability to optimally recruit subsidiary brain regions and strategies to perform cognitive tasks. |
2006-12-12 |
2023-08-12 |
Not clear |
| Amy F T Arnste. Stimulants: Therapeutic actions in ADHD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 11. 2006-12-12. PMID:16855530. |
ihe prefrontal cortex regulates behavior and attention using representational knowledge, and imaging and neuropsychological studies have shown that the prefrontal cortex is weaker in subjects with adhd. |
2006-12-12 |
2023-08-12 |
human |
| Amy F T Arnste. Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways. The Journal of clinical psychiatry. vol 67 Suppl 8. 2006-09-18. PMID:16961424. |
neuropsychological and imaging studies have shown that attention-deficit/hyperactivity disorder (adhd) is associated with alterations in prefrontal cortex (pfc) and its connections to striatum and cerebellum. |
2006-09-18 |
2023-08-12 |
monkey |
| Amy F T Arnste. Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways. The Journal of clinical psychiatry. vol 67 Suppl 8. 2006-09-18. PMID:16961424. |
blockade of alpha2-receptors in the monkey pfc re-creates the symptoms of adhd, resulting in impaired working memory, increased impulsivity, and locomotor hyperactivity. |
2006-09-18 |
2023-08-12 |
monkey |
| Jeffrey M Halperin, Kurt P Schul. Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychological bulletin. vol 132. issue 4. 2006-08-24. PMID:16822167. |
most neural models for the pathophysiology of attention-deficit/hyperactivity disorder (adhd) have centered on the prefrontal cortex and its interconnections with the striatum and other subcortical structures. |
2006-08-24 |
2023-08-12 |
Not clear |
| Jeffrey M Halperin, Kurt P Schul. Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychological bulletin. vol 132. issue 4. 2006-08-24. PMID:16822167. |
the neural and functional development of the prefrontal cortex more closely parallels recovery from adhd as indicated by the developmental remission of symptomatology. |
2006-08-24 |
2023-08-12 |
Not clear |
| Jeffrey M Halperin, Kurt P Schul. Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychological bulletin. vol 132. issue 4. 2006-08-24. PMID:16822167. |
data supporting this neurodevelopmental model of prefrontal cortex function in adhd are reviewed. |
2006-08-24 |
2023-08-12 |
Not clear |
| C Z Zhu, Y F Zang, M Liang, L X Tian, Y He, X B Li, M Q Sui, Y F Wang, T Z Jian. Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 8. issue Pt 2. 2006-06-06. PMID:16685993. |
some abnormal brain regions identified by fisher brain, like prefrontal cortex and anterior cingulate cortex, are well consistent with that reported in neuroimaging studies on adhd. |
2006-06-06 |
2023-08-12 |
Not clear |
| Jill C Gitten, Jesse L Winer, Elena K Festa, William C Heinde. Conditional associative learning of spatial and object information in children with attention deficit/hyperactivity disorder. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence. vol 12. issue 1. 2006-05-11. PMID:16484101. |
rather, these findings suggest that the impaired conditional associative learning performance of children with adhd is attributable to deficits in strategic processes previously been found to be dependent upon the integrity of the prefrontal cortex. |
2006-05-11 |
2023-08-12 |
human |
| Ximena Carrasco, Paula Rothhammer, Mauricio Moraga, Hugo Henríquez, Ranajit Chakraborty, Francisco Aboitiz, Francisco Rothhamme. Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 1. 2006-03-28. PMID:16342279. |
increased density of dopamine transporter in adhd brains, along with abundance of 7-repeat d4 receptors in prefrontal cortex, which is impaired in adhd patients, make the observed gene-gene interaction worthy of further incisive studies. |
2006-03-28 |
2023-08-12 |
Not clear |
| Yu-Feng Zang, Zhen Jin, Xu-Chu Weng, Lei Zhang, Ya-Wei Zeng, Li Yang, Yu-Feng Wang, Larry J Seidman, Stephen V Faraon. Functional MRI in attention-deficit hyperactivity disorder: evidence for hypofrontality. Brain & development. vol 27. issue 8. 2006-03-15. PMID:15876503. |
(2) the activation volume (av) of prefrontal cortex (pfc) in both the neutral (nc) and interference conditions (ic) in adhd children off mph was smaller than in controls. |
2006-03-15 |
2023-08-12 |
Not clear |
| Peter Weber, Jürg Lütschg, Hubert Fahnenstic. Cerebral hemodynamic changes in response to an executive function task in children with attention-deficit hyperactivity disorder measured by near-infrared spectroscopy. Journal of developmental and behavioral pediatrics : JDBP. vol 26. issue 2. 2005-12-12. PMID:15827461. |
overall, the normal controls showed lateralized oxygen consumption in the left prefrontal cortex during an extended-attention task, whereas the boys with adhd showed an imbalance between oxygenated and deoxygenated hemoglobin during the short- and extended-attention tasks. |
2005-12-12 |
2023-08-12 |
Not clear |
| S Durston, J A Fossella, B J Casey, H E Hulshoff Pol, A Galvan, H G Schnack, M P Steenhuis, R B Minderaa, J K Buitelaar, R S Kahn, H van Engelan. Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls. Molecular psychiatry. vol 10. issue 7. 2005-12-07. PMID:15724142. |
we show that the dat1 gene, a gene expressed predominantly in the basal ganglia, preferentially influences caudate volume, whereas the drd4 gene, a gene expressed predominantly in the prefrontal cortex, preferentially influences prefrontal gray matter volume in a sample of subjects including subjects with adhd, their unaffected siblings, and healthy controls. |
2005-12-07 |
2023-08-12 |
human |
| Kurt P Schulz, Cheuk Y Tang, Jin Fan, David J Marks, Jeffrey H Newcorn, Angeles M Cheung, Jeffrey M Halperi. Differential prefrontal cortex activation during inhibitory control in adolescents with and without childhood attention-deficit/hyperactivity disorder. Neuropsychology. vol 19. issue 3. 2005-08-09. PMID:15910125. |
however, the adhd group demonstrated significantly greater activation of the left ventrolateral prefrontal cortex during interference control as well as greater activation of the left anterior cingulate cortex, right ventrolateral prefrontal cortex, and left basal ganglia during the dual task of interference control and response competition. |
2005-08-09 |
2023-08-12 |
human |
| Larry J Seidman, Eve M Valera, Nikos Makri. Structural brain imaging of attention-deficit/hyperactivity disorder. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15949998. |
the most replicated alterations in adhd in childhood include significantly smaller volumes in the dorsolateral prefrontal cortex, caudate, pallidum, corpus callosum, and cerebellum. |
2005-07-29 |
2023-08-12 |
human |
| George Bush, Eve M Valera, Larry J Seidma. Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15949999. |
convergent data from neuroimaging, neuropsychological, genetics, and neurochemical studies have implicated dysfunction of fronto-striatal structures (lateral prefrontal cortex, dorsal anterior cingulate cortex, caudate, and putamen) as likely contributing to the pathophysiology of adhd. |
2005-07-29 |
2023-08-12 |
Not clear |
| Adam R Aron, Russell A Poldrac. The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15950000. |
we show that response inhibition--operationalized by go/nogo or stop-signal tasks--requires the prefrontal cortex (pfc), in particular the right inferior frontal cortex (ifc); that patients with adhd have significant response inhibition deficits and show altered functional activation and gray matter volumes in right ifc; and that a number of studies indicate that response inhibition performance is heritable. |
2005-07-29 |
2023-08-12 |
Not clear |