| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Frank P Bymaster, Jason S Katner, David L Nelson, Susan K Hemrick-Luecke, Penny G Threlkeld, John H Heiligenstein, S Michelle Morin, Donald R Gehlert, Kenneth W Perr. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 5. 2002-12-26. PMID:12431845. |
we hypothesize that the atomoxetine-induced increase of catecholamines in pfc, a region involved in attention and memory, mediates the therapeutic effects of atomoxetine in adhd. |
2002-12-26 |
2023-08-12 |
human |
| Stewart H Mostofsky, Karen L Cooper, Wendy R Kates, Martha B Denckla, Walter E Kaufman. Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder. Biological psychiatry. vol 52. issue 8. 2002-12-16. PMID:12372650. |
anatomic magnetic resonance imaging (mri) studies of attention-deficit/hyperactivity disorder (adhd) have been limited by use of callosal rather than sulcal/gyral landmarks in defining cerebral lobes and functionally relevant sublobar regions (e.g., prefrontal cortex). |
2002-12-16 |
2023-08-12 |
Not clear |
| Vivienne Ann Russel. Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat. Behavioural brain research. vol 130. issue 1-2. 2002-05-16. PMID:11864734. |
these findings are consistent with the hypothesis that the behavioral disturbances of adhd are the result of an imbalance between noradrenergic and dopaminergic systems in the prefrontal cortex, with inhibitory dopaminergic activity being decreased and noradrenergic activity increased relative to controls. |
2002-05-16 |
2023-08-12 |
rat |
| G Spalletta, A Pasini, F Pau, G Guido, L Menghini, C Caltagiron. Prefrontal blood flow dysregulation in drug naive ADHD children without structural abnormalities. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 10. 2002-04-16. PMID:11725823. |
recent studies suggest a role for prefrontal cortex abnormalities in the pathogenesis of attention deficit/hyperactivity disorder (adhd). |
2002-04-16 |
2023-08-12 |
human |
| G Spalletta, A Pasini, F Pau, G Guido, L Menghini, C Caltagiron. Prefrontal blood flow dysregulation in drug naive ADHD children without structural abnormalities. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 10. 2002-04-16. PMID:11725823. |
we evaluated young drug-naive adhd outpatients without mri structural abnormalities to detect prefrontal cortex regional cerebral blood flow (rcbf) functional dysregulation; correlation between age and rcbf; and correlation between symptoms profile and rcbf. |
2002-04-16 |
2023-08-12 |
human |
| D D Langleben, G Austin, G Krikorian, H W Ridlehuber, M L Goris, H W Straus. Interhemispheric asymmetry of regional cerebral blood flow in prepubescent boys with attention deficit hyperactivity disorder. Nuclear medicine communications. vol 22. issue 12. 2002-02-13. PMID:11711904. |
reversal of functional prefrontal asymmetry in boys with severe motor hyperactivity supports the hypothesis of right prefrontal cortex dysfunction in adhd. |
2002-02-13 |
2023-08-12 |
human |
| V A Russell, T M Wiggin. Increased glutamate-stimulated norepinephrine release from prefrontal cortex slices of spontaneously hypertensive rats. Metabolic brain disease. vol 15. issue 4. 2001-10-18. PMID:11383554. |
the results are consistent with the suggestion that the noradrenergic system is overactive in prefrontal cortex of shr, the animal model for adhd. |
2001-10-18 |
2023-08-12 |
rat |
| B Hesslinger, T Thiel, L Tebartz van Elst, J Hennig, D Eber. Attention-deficit disorder in adults with or without hyperactivity: where is the difference? A study in humans using short echo (1)H-magnetic resonance spectroscopy. Neuroscience letters. vol 304. issue 1-2. 2001-07-19. PMID:11335068. |
there was a significant group difference in n-acetylaspartate (naa) concentration in the left dorsolateral prefrontal cortex distinguishing patients with the adhd from patients with pure add and healthy controls. |
2001-07-19 |
2023-08-12 |
Not clear |
| V Russell, S Allie, T Wiggin. Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat. Behavioural brain research. vol 117. issue 1-2. 2001-02-08. PMID:11099759. |
these findings are consistent with the hypothesis that the behavioral disturbances of adhd are the result of an imbalance between ne and da systems in the prefrontal cortex, with inhibitory da activity being decreased and ne activity increased relative to controls. |
2001-02-08 |
2023-08-12 |
rat |
| M G Paule, A S Rowland, S A Ferguson, J J Chelonis, R Tannock, J M Swanson, F X Castellano. Attention deficit/hyperactivity disorder: characteristics, interventions and models. Neurotoxicology and teratology. vol 22. issue 5. 2001-01-11. PMID:11106857. |
additionally, functional imaging studies, coupled with pharmacological manipulations, suggest decreased blood flow and energy utilization in prefrontal cortex and striatum and the dysregulation of catecholamine systems in persons with adhd. |
2001-01-11 |
2023-08-12 |
mouse |
| J L Bradshaw, D M Sheppar. The neurodevelopmental frontostriatal disorders: evolutionary adaptiveness and anomalous lateralization. Brain and language. vol 73. issue 2. 2000-08-16. PMID:10856179. |
the frontostriatal system (dorsolateral prefrontal cortex, lateral orbitofrontal cortex, anterior cingulate, supplementary motor area, and associated basal-ganglia structures) is subject to a range of neurodevelopmental disorders: tourette's syndrome (ts), obsessive compulsive disorder (ocd), attention deficit hyperactivity disorder (adhd), schizophrenia (scz), autism, and probably depression. |
2000-08-16 |
2023-08-12 |
human |
| M C Wilso. Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder. Neuroscience and biobehavioral reviews. vol 24. issue 1. 2000-02-17. PMID:10654661. |
this suggests that haploinsufficiency of snap-25 reveals a specific vulnerability of the nigrostriatal pathway which regulates motor activity and may provide a model for impaired striatal input into executive functions encoded by the prefrontal cortex associated with adhd. |
2000-02-17 |
2023-08-12 |
mouse |
| Vincent J Monastra, Joel F Lubar, Michael Linden, Peter VanDeusen, George Green, William Wing, Arthur Phillips, T Nick Fenge. Assessing attention deficit hyperactivity disorder via quantitative electroencephalography: an initial validation study. Neuropsychology. vol 13. issue 3. 1999-10-29. PMID:10447303. |
quantitative electroencephalographic (qeeg) findings indicated significant maturational effects in cortical arousal in the prefrontal cortex as well as evidence of cortical slowing in both adhd groups, regardless of age or sex. |
1999-10-29 |
2023-08-12 |
human |
| S H Mostofsky, A L Reiss, P Lockhart, M B Denckl. Evaluation of cerebellar size in attention-deficit hyperactivity disorder. Journal of child neurology. vol 13. issue 9. 1998-12-04. PMID:9733289. |
this includes domains of executive function that are normally attributed to the prefrontal cortex and are typically deficient in individuals with attention-deficit hyperactivity disorder (adhd). |
1998-12-04 |
2023-08-12 |
human |
| M Ernst, A J Zametkin, J A Matochik, P H Jons, R M Cohe. DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18]fluorodopa positron emission tomographic study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 15. 1998-08-07. PMID:9671677. |
of three composite regions (prefrontal cortex, striatum, and midbrain), only the prefrontal cortex showed significantly different f18-dopa ratios in adhd as compared with control adults (p < 0.01). |
1998-08-07 |
2023-08-12 |
Not clear |
| M Ernst, A J Zametkin, J A Matochik, P H Jons, R M Cohe. DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18]fluorodopa positron emission tomographic study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 15. 1998-08-07. PMID:9671677. |
similarly, the interaction [sex x diagnosis] was significant only in the prefrontal cortex (p < 0.02): lower ratios in men than in women in adhd and vice versa in controls. |
1998-08-07 |
2023-08-12 |
Not clear |
| E Niedermeye. Frontal lobe functions and dysfunctions. Clinical EEG (electroencephalography). vol 29. issue 2. 1998-07-02. PMID:9571295. |
a special form of frontal-motor cortex disconnection may occur in childhood: in the rare rett syndrome and, with limitation to the prefrontal cortex, in the common attention deficit hyperactivity disorder (adhd). |
1998-07-02 |
2023-08-12 |
human |
| D G Amen, B D Carmichae. High-resolution brain SPECT imaging in ADHD. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 9. issue 2. 1997-09-23. PMID:9242893. |
sixty-fiver percent of the adhd group revealed decreased perfusion in the prefrontal cortex with intellectual stress, compared to only 5% of the control group. |
1997-09-23 |
2023-08-12 |
human |
| B J Casey, F X Castellanos, J N Giedd, W L Marsh, S D Hamburger, A B Schubert, Y C Vauss, A C Vaituzis, D P Dickstein, S E Sarfatti, J L Rapopor. Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 36. issue 3. 1997-04-15. PMID:9055518. |
to examine the relation between specific frontostriatal structures (prefrontal cortex and basal ganglia) and response inhibition deficits observed in attention-deficit/hyperactivity disorder (adhd). |
1997-04-15 |
2023-08-12 |
Not clear |
| R G Ross, D Hommer, D Breiger, C Varley, A Radan. Eye movement task related to frontal lobe functioning in children with attention deficit disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 33. issue 6. 1994-10-11. PMID:8083144. |
attention-deficit hyperactivity disorder (adhd) has been postulated to be related to dysfunction of the prefrontal cortex. |
1994-10-11 |
2023-08-12 |
human |