| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vivienne A Russell, Terje Sagvolden, Espen Borgå Johanse. Animal models of attention-deficit hyperactivity disorder. Behavioral and brain functions : BBF. vol 1. 2005-07-29. PMID:16022733. |
aspects of adhd behaviour may result from an imbalance between increased noradrenergic and decreased dopaminergic regulation of neural circuits that involve the prefrontal cortex. |
2005-07-29 |
2023-08-12 |
human |
| b' Birim G\\xc3\\xbcnay Kili\\xc3\\xa. [Neuropsychology of attention deficit hyperactivity disorder: relevant theories and empirical studies]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 16. issue 2. 2005-07-25. PMID:15981150.' |
based on clinical and neuropsychological data it has been stated that both the orbitofrontal cortex and dorsolateral prefrontal cortex are functionally disturbed in adhd. |
2005-07-25 |
2023-08-12 |
human |
| Ozgür Oner, Pinar Oner, Ayla Aysev, Ozlem Küçük, Erkan Ibi. Regional cerebral blood flow in children with ADHD: changes with age. Brain & development. vol 27. issue 4. 2005-06-28. PMID:15862191. |
the results indicated that the left hemisphere dominance in the prefrontal cortex significantly increases with age in adhd cases. |
2005-06-28 |
2023-08-12 |
human |
| Karen Müller Smith, Lorri Bauer, Mariellen Fischer, Russell Barkley, Bradford A Navi. Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 133B. issue 1. 2005-03-14. PMID:15635701. |
dopaminergic cells of the vta provide innervation to the prefrontal cortex, believed to be of major importance in the etiology of adhd, suggesting that nr4a2 is a potential candidate gene for adhd susceptibility. |
2005-03-14 |
2023-08-12 |
human |
| Kurt P Schulz, Jeffrey H Newcorn, Jin Fan, Cheuk Y Tang, Jeffrey M Halperi. Brain activation gradients in ventrolateral prefrontal cortex related to persistence of ADHD in adolescent boys. Journal of the American Academy of Child and Adolescent Psychiatry. vol 44. issue 1. 2005-03-01. PMID:15608543. |
brain activation gradients in ventrolateral prefrontal cortex related to persistence of adhd in adolescent boys. |
2005-03-01 |
2023-08-12 |
Not clear |
| Kurt P Schulz, Jeffrey H Newcorn, Jin Fan, Cheuk Y Tang, Jeffrey M Halperi. Brain activation gradients in ventrolateral prefrontal cortex related to persistence of ADHD in adolescent boys. Journal of the American Academy of Child and Adolescent Psychiatry. vol 44. issue 1. 2005-03-01. PMID:15608543. |
to explore the possible role that functional abnormalities of the prefrontal cortex and basal ganglia play in the persistence of attention-deficit/hyperactivity disorder (adhd) in adolescents aged 15 to 19 years. |
2005-03-01 |
2023-08-12 |
Not clear |
| Florence Lev. Synaptic gating and ADHD: a biological theory of comorbidity of ADHD and anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 9. 2004-10-18. PMID:15114344. |
in conclusion, a dual theory incorporating long-term tonic/phasic mesolimbic da relationships and secondly impairment of pfc and hippocampal inputs to synaptic gating of anxiety at the accumbens has implications for comorbidity in adhd, as well as for possible pharmacological interventions, utilizing either stimulant or axiolytic interventions. |
2004-10-18 |
2023-08-12 |
Not clear |
| D Viggiano, L A Ruocco, S Arcieri, A G Sadil. Involvement of norepinephrine in the control of activity and attentive processes in animal models of attention deficit hyperactivity disorder. Neural plasticity. vol 11. issue 1-2. 2004-09-07. PMID:15303310. |
functional and morphological studies in children affected by attention deficit hyperactivity disorder (adhd) suggest a prefrontal cortex (pfc) dysfunction. |
2004-09-07 |
2023-08-12 |
mouse |
| D Viggiano, L A Ruocco, S Arcieri, A G Sadil. Involvement of norepinephrine in the control of activity and attentive processes in animal models of attention deficit hyperactivity disorder. Neural plasticity. vol 11. issue 1-2. 2004-09-07. PMID:15303310. |
some animal models of adhd, such as spontaneously hypertensive rats (shr), show alterations in the pfc and in the da system. |
2004-09-07 |
2023-08-12 |
mouse |
| Ron M Sullivan, Wayne G Brak. What the rodent prefrontal cortex can teach us about attention-deficit/hyperactivity disorder: the critical role of early developmental events on prefrontal function. Behavioural brain research. vol 146. issue 1-2. 2004-01-29. PMID:14643458. |
the present review surveys a broad range of findings on the functions of the rodent prefrontal cortex (pfc) in the context of the known pathophysiology of attention-deficit/hyperactivity disorder (adhd). |
2004-01-29 |
2023-08-12 |
rat |
| Ron M Sullivan, Wayne G Brak. What the rodent prefrontal cortex can teach us about attention-deficit/hyperactivity disorder: the critical role of early developmental events on prefrontal function. Behavioural brain research. vol 146. issue 1-2. 2004-01-29. PMID:14643458. |
an overview of clinical findings concludes that dysfunction of the right pfc plays a critical role in adhd and that a number of early developmental factors conspire to increase the risk of the disorder. |
2004-01-29 |
2023-08-12 |
rat |
| Ron M Sullivan, Wayne G Brak. What the rodent prefrontal cortex can teach us about attention-deficit/hyperactivity disorder: the critical role of early developmental events on prefrontal function. Behavioural brain research. vol 146. issue 1-2. 2004-01-29. PMID:14643458. |
rodent studies are described which go far in explaining how the core processes which are deficient in adhd are mediated by the pfc and that the mesocortical dopamine (da) system plays a central role in modulating these functions. |
2004-01-29 |
2023-08-12 |
rat |
| Ron M Sullivan, Wayne G Brak. What the rodent prefrontal cortex can teach us about attention-deficit/hyperactivity disorder: the critical role of early developmental events on prefrontal function. Behavioural brain research. vol 146. issue 1-2. 2004-01-29. PMID:14643458. |
importantly, the pfc is highly vulnerable to a wide variety of early developmental insults, which parallel the known risk factors for adhd. |
2004-01-29 |
2023-08-12 |
rat |
| Ron M Sullivan, Wayne G Brak. What the rodent prefrontal cortex can teach us about attention-deficit/hyperactivity disorder: the critical role of early developmental events on prefrontal function. Behavioural brain research. vol 146. issue 1-2. 2004-01-29. PMID:14643458. |
abnormal development, particularly of the right pfc and its daergic afferents, is suggested to contribute directly to the core deficits of adhd through dysregulation of the right frontostriatal system. |
2004-01-29 |
2023-08-12 |
rat |
| Z M Mao, B M Li, A F Arnste. [Roles of alpha-2 adrenoceptor in prefrontal cortical cognitive functions]. Sheng li ke xue jin zhan [Progress in physiology]. vol 30. issue 1. 2003-06-27. PMID:12532843. |
several psychiatric disorders, including attention-deficit hyperactivity disorder (adhd), show prominent syndromes seen in cognitive deficits of the prefrontal cortex. |
2003-06-27 |
2023-08-12 |
Not clear |
| C H Klein, A Raschke, A Brandenbusc. Development of pro- and antisaccades in children with attention-deficit hyperactivity disorder (ADHD) and healthy controls. Psychophysiology. vol 40. issue 1. 2003-06-23. PMID:12756978. |
confirming barkley's (1997) neuropsychological theory of adhd, these results altogether point to alterations in "executive functions" in adhd patients that are presumably supported by frontal lobe structures, in particular the lateral prefrontal cortex and the frontal eye fields. |
2003-06-23 |
2023-08-12 |
Not clear |
| Normand Carrey, Frank P MacMaster, Sandra J Sparkes, Shakeela C Khan, Vivek Kusumaka. Glutamatergic changes with treatment in attention deficit hyperactivity disorder: a preliminary case series. Journal of child and adolescent psychopharmacology. vol 12. issue 4. 2003-05-07. PMID:12625993. |
symptoms of attention deficit hyperactivity disorder (adhd) improved in two children treated with methylphenidate and two children treated with atomoxetine, for whom pre- and posttreatment proton magnetic resonance spectroscopy examinations were obtained to assess the relation between the neurochemical profiles in the striatum and prefrontal cortex among symptom severity and response to treatment. |
2003-05-07 |
2023-08-12 |
human |
| Frank P MacMaster, Normand Carrey, Sandra Sparkes, Vivek Kusumaka. Proton spectroscopy in medication-free pediatric attention-deficit/hyperactivity disorder. Biological psychiatry. vol 53. issue 2. 2003-04-30. PMID:12547476. |
hence, we used proton magnetic resonance spectroscopy (1h-mrs) to examine metabolite levels in the prefrontal cortex of children with adhd. |
2003-04-30 |
2023-08-12 |
Not clear |
| Wendy R Kates, Melissa Frederikse, Stewart H Mostofsky, Bradley S Folley, Karen Cooper, Patricia Mazur-Hopkins, Ora Kofman, Harvey S Singer, Martha B Denckla, Godfrey D Pearlson, Walter E Kaufman. MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome. Psychiatry research. vol 116. issue 1-2. 2003-04-17. PMID:12426035. |
in adhd, we found volumetric reductions in both the gray and white matter of the prefrontal cortex. |
2003-04-17 |
2023-08-12 |
Not clear |
| Frank P Bymaster, Jason S Katner, David L Nelson, Susan K Hemrick-Luecke, Penny G Threlkeld, John H Heiligenstein, S Michelle Morin, Donald R Gehlert, Kenneth W Perr. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 5. 2002-12-26. PMID:12431845. |
in contrast, the psychostimulant methylphenidate, which is used in adhd therapy, increased ne(ex) and da(ex) equally in pfc, but also increased da(ex) in the striatum and nucleus accumbens to the same level. |
2002-12-26 |
2023-08-12 |
human |