| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy Veenstra-VanderWeele, Soo-Jeong Kim, Catherine Lord, Rachel Courchesne, Natasha Akshoomoff, Bennett L Leventhal, Eric Courchesne, Edwin H Coo. Transmission disequilibrium studies of the serotonin 5-HT2A receptor gene (HTR2A) in autism. American journal of medical genetics. vol 114. issue 3. 2002-06-17. PMID:11920848. |
this well-replicated finding and subsequent studies of platelet serotonin receptors in autism indicate that the serotonin 2a receptor gene (htr2a) on chromosome 13q is a primary candidate gene in autism. |
2002-06-17 |
2023-08-12 |
Not clear |
| C Betancur, M Corbex, C Spielewoy, A Philippe, J L Laplanche, J M Launay, C Gillberg, M C Mouren-Siméoni, M Hamon, B Giros, M Nosten-Bertrand, M Leboye. Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder. Molecular psychiatry. vol 7. issue 1. 2002-04-19. PMID:11803447. |
previous studies have provided conflicting evidence regarding the association of the serotonin transporter (5-htt) gene with autism. |
2002-04-19 |
2023-08-12 |
human |
| C Betancur, M Corbex, C Spielewoy, A Philippe, J L Laplanche, J M Launay, C Gillberg, M C Mouren-Siméoni, M Hamon, B Giros, M Nosten-Bertrand, M Leboye. Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder. Molecular psychiatry. vol 7. issue 1. 2002-04-19. PMID:11803447. |
thus, we examined the association of the 5-httlpr and vntr polymorphisms of the 5-htt gene with autism, and we investigated the relationship between 5-htt variants and whole-blood 5-ht. |
2002-04-19 |
2023-08-12 |
human |
| C Kauffmann, H Vance, A J Pumariega, B Mille. Fluvoxamine treatment of a child with severe PDD: a single case study. Psychiatry. vol 64. issue 3. 2002-03-13. PMID:11708052. |
recent reports suggest that selective serotonin reuptake inhibitors (ssris) are useful in the treatment of individuals with autism and other pervasive developmental disorders. |
2002-03-13 |
2023-08-12 |
Not clear |
| S Tordjman, L Gutknecht, M Carlier, E Spitz, C Antoine, F Slama, V Carsalade, D J Cohen, P Ferrari, P L Roubertoux, G M Anderso. Role of the serotonin transporter gene in the behavioral expression of autism. Molecular psychiatry. vol 6. issue 4. 2001-09-06. PMID:11443529. |
role of the serotonin transporter gene in the behavioral expression of autism. |
2001-09-06 |
2023-08-12 |
Not clear |
| S Tordjman, L Gutknecht, M Carlier, E Spitz, C Antoine, F Slama, V Carsalade, D J Cohen, P Ferrari, P L Roubertoux, G M Anderso. Role of the serotonin transporter gene in the behavioral expression of autism. Molecular psychiatry. vol 6. issue 4. 2001-09-06. PMID:11443529. |
the promoter polymorphism of the serotonin transporter gene (htt, locus slc6a4) is of special interest in autism given the well-replicated platelet hyperserotonemia of autism, treatment effects of serotonin reuptake inhibitors, and the role of serotonin in limbic functioning and neurodevelopment. |
2001-09-06 |
2023-08-12 |
Not clear |
| N Yirmiya, T Pilowsky, L Nemanov, S Arbelle, T Feinsilver, I Fried, R P Ebstei. Evidence for an association with the serotonin transporter promoter region polymorphism and autism. American journal of medical genetics. vol 105. issue 4. 2001-07-19. PMID:11378854. |
evidence for an association with the serotonin transporter promoter region polymorphism and autism. |
2001-07-19 |
2023-08-12 |
Not clear |
| N Yirmiya, T Pilowsky, L Nemanov, S Arbelle, T Feinsilver, I Fried, R P Ebstei. Evidence for an association with the serotonin transporter promoter region polymorphism and autism. American journal of medical genetics. vol 105. issue 4. 2001-07-19. PMID:11378854. |
we have examined three functional polymorphisms, serotonin transporter promoter region polymorphism (5-httlpr), dopamine d4 exon iii repeat region (drd4), and catechol-o-methyltransferase (comt), in a small family-based design toward identifying candidate genes that confer risk for autism. |
2001-07-19 |
2023-08-12 |
Not clear |
| N Yirmiya, T Pilowsky, L Nemanov, S Arbelle, T Feinsilver, I Fried, R P Ebstei. Evidence for an association with the serotonin transporter promoter region polymorphism and autism. American journal of medical genetics. vol 105. issue 4. 2001-07-19. PMID:11378854. |
additionally, elevated serotonin levels have been consistently found in 30%-50% of autistic patients and may represent a marker for familial autism. |
2001-07-19 |
2023-08-12 |
Not clear |
| N Yirmiya, T Pilowsky, L Nemanov, S Arbelle, T Feinsilver, I Fried, R P Ebstei. Evidence for an association with the serotonin transporter promoter region polymorphism and autism. American journal of medical genetics. vol 105. issue 4. 2001-07-19. PMID:11378854. |
hyperserotonemia in autism appears to be due to enhanced 5-ht uptake, as free 5-ht levels are normal and the current report of an excess of the long/long 5-httlpr genotype in autism could provide a partial molecular explanation for high platelet serotonin content in autism. |
2001-07-19 |
2023-08-12 |
Not clear |
| J K Buitelaar, S H Willemsen-Swinkel. Medication treatment in subjects with autistic spectrum disorders. European child & adolescent psychiatry. vol 9 Suppl 1. 2001-02-22. PMID:11140783. |
the most robust and well-replicated neurobiological abnormality in autism is an elevation of whole blood serotonin found in over 30% of the patients. |
2001-02-22 |
2023-08-12 |
human |
| J K Luiselli, P Blew, S Thibadea. Therapeutic effects and long-term efficacy of antidepressant medication for persons with developmental disabilities. Behavioral assessment in two cases of treatment-resistant aggression and self-injury. Behavior modification. vol 25. issue 1. 2001-02-15. PMID:11151486. |
behavioral assessment data documented that sertraline (a serotonin selective reuptake inhibitor) was effective in reducing self-injurious behaviors in a 20-year-old man with severe mental retardation and clomipramine (a tricyclic antidepressant) was associated with the elimination of aggressive behavior in a 14-year-old boy with autism. |
2001-02-15 |
2023-08-12 |
Not clear |
| D Marazziti, F Muratori, A Cesari, I Masala, S Baroni, G Giannaccini, L Dell'Osso, A Cosenza, P Pfanner, G B Cassan. Increased density of the platelet serotonin transporter in autism. Pharmacopsychiatry. vol 33. issue 5. 2000-12-07. PMID:11071017. |
increased density of the platelet serotonin transporter in autism. |
2000-12-07 |
2023-08-12 |
human |
| D Marazziti, F Muratori, A Cesari, I Masala, S Baroni, G Giannaccini, L Dell'Osso, A Cosenza, P Pfanner, G B Cassan. Increased density of the platelet serotonin transporter in autism. Pharmacopsychiatry. vol 33. issue 5. 2000-12-07. PMID:11071017. |
various data have shown the involvement of serotonin (5-ht) in autism. |
2000-12-07 |
2023-08-12 |
human |
| J K Buitelaar, S H Willemsen-Swinkel. Autism: current theories regarding its pathogenesis and implications for rational pharmacotherapy. Paediatric drugs. vol 2. issue 1. 2000-08-29. PMID:10937459. |
the most robust and well replicated neurobiological abnormality in autism is an elevation of whole blood serotonin (5-hydroxytryptamine; 5-ht) found in over 30% of patients. |
2000-08-29 |
2023-08-12 |
Not clear |
| S Novotny, E Hollander, A Allen, S Mosovich, B Aronowitz, C Cartwright, C DeCaria, R Dolgoff-Kaspa. Increased growth hormone response to sumatriptan challenge in adult autistic disorders. Psychiatry research. vol 94. issue 2. 2000-07-17. PMID:10808042. |
serotonergic (5-ht) abnormalities have been documented in autism. |
2000-07-17 |
2023-08-12 |
human |
| S Novotny, E Hollander, A Allen, S Mosovich, B Aronowitz, C Cartwright, C DeCaria, R Dolgoff-Kaspa. Increased growth hormone response to sumatriptan challenge in adult autistic disorders. Psychiatry research. vol 94. issue 2. 2000-07-17. PMID:10808042. |
therefore, abnormalities in 5-ht regulation in autism may be related to increased sensitivity of the 5-ht1d inhibitory receptor in autism. |
2000-07-17 |
2023-08-12 |
human |
| E Hollander, A Kaplan, C Cartwright, D Reichma. Venlafaxine in children, adolescents, and young adults with autism spectrum disorders: an open retrospective clinical report. Journal of child neurology. vol 15. issue 2. 2000-03-29. PMID:10695900. |
while selective serotonin reuptake inhibitors have demonstrated efficacy in treating core symptoms of autism, norepinephrine reuptake inhibitors have demonstrated efficacy in symptoms of attention-deficit hyperactivity disorder (adhd). |
2000-03-29 |
2023-08-12 |
human |
| N L Flattem, R D Blakel. Modified structure of the human serotonin transporter promoter. Molecular psychiatry. vol 5. issue 1. 2000-03-17. PMID:10673778. |
recently, several studies have reported an association between anxiety traits, affective disorders and autism and alleles of a functional promoter polymorphism (5htt-lpr) in the human serotonin transporter (5htt, sert).1-3 the mechanistic basis for allelic differences in transporter transcription are presently unknown. |
2000-03-17 |
2023-08-12 |
human |
| J Croonenberghs, L Delmeire, R Verkerk, A H Lin, A Meskal, H Neels, M Van der Planken, S Scharpe, D Deboutte, G Pison, M Mae. Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 3. 2000-03-13. PMID:10693155. |
the results suggest that: 1) serotonergic disturbances, such as defects in the 5-ht transporter system and lowered plasma tryptophan, may play a role in the pathophysiology of autism; 2) autism is not associated with alterations in the noradrenergic system; and 3) the metabolism of serotonin in humans undergoes significant changes between the ages of 12 and 18 years. |
2000-03-13 |
2023-08-12 |
human |