| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J McDougle, L Scahill, J T McCracken, M G Aman, E Tierney, L E Arnold, B J Freeman, A Martin, J J McGough, P Cronin, D J Posey, M A Riddle, L Ritz, N B Swiezy, B Vitiello, F R Volkmar, N A Votolato, P Walso. Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidone. Child and adolescent psychiatric clinics of North America. vol 9. issue 1. 2000-02-29. PMID:10674197. |
risperidone has potent effects on 5-ht and da neuronal systems, both of which have been implicated in the pathophysiology of autism. |
2000-02-29 |
2023-08-12 |
Not clear |
| E Hollander, S Novotny, A Allen, B Aronowitz, C Cartwright, C DeCari. The relationship between repetitive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 2. 2000-02-14. PMID:10649829. |
thus, the severity of a specific behavioral dimension in autism (repetitive behaviors) parallels the sensitivity of the 5-ht 1d receptor, as manifest by sumatriptan elicited gh response. |
2000-02-14 |
2023-08-12 |
Not clear |
| E Maestrini, C Lai, A Marlow, N Matthews, S Wallace, A Bailey, E H Cook, D E Weeks, A P Monac. Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. The International Molecular Genetic Study of Autism Consortium. American journal of medical genetics. vol 88. issue 5. 1999-11-17. PMID:10490705. |
serotonin transporter (5-htt) and gamma-aminobutyric acid receptor subunit beta3 (gabrb3) gene polymorphisms are not associated with autism in the imgsa families. |
1999-11-17 |
2023-08-12 |
Not clear |
| E Maestrini, C Lai, A Marlow, N Matthews, S Wallace, A Bailey, E H Cook, D E Weeks, A P Monac. Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. The International Molecular Genetic Study of Autism Consortium. American journal of medical genetics. vol 88. issue 5. 1999-11-17. PMID:10490705. |
previous studies have suggested that the serotonin transporter (5-htt) gene and the gamma-aminobutyric acid receptor subunit beta3 (gabrb3) gene, or other genes in the 15q11-q13 region, are possibly involved in susceptibility to autism. |
1999-11-17 |
2023-08-12 |
Not clear |
| L Scahill, K Koeni. Pharmacotherapy in children and adolescents with pervasive developmental disorders. Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc. vol 12. issue 1. 1999-10-07. PMID:10347430. |
children with autism and the related pdds may benefit from serotonin reuptake inhibitors such as clomipramine, fluoxetine, fluvoxamine, and sertraline for targeting repetitive thoughts and behaviors, anxiety, and depressed mood. |
1999-10-07 |
2023-08-12 |
Not clear |
| M Leboyer, A Philippe, M Bouvard, M Guilloud-Bataille, D Bondoux, F Tabuteau, J Feingold, M C Mouren-Simeoni, J M Launa. Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives. Biological psychiatry. vol 45. issue 2. 1999-05-24. PMID:9951562. |
whole blood serotonin (5-ht) and c-terminally directed beta-endorphin protein immunoreactivity (c-ter-beta-ep-ir) are known to be elevated in autistic subjects and might be possible markers of genetic liability to autism. |
1999-05-24 |
2023-08-12 |
human |
| G Trottier, L Srivastava, C D Walke. Etiology of infantile autism: a review of recent advances in genetic and neurobiological research. Journal of psychiatry & neuroscience : JPN. vol 24. issue 2. 1999-05-19. PMID:10212552. |
neurochemical studies have investigated the role of serotonin, epinephrine and norepinephrine, since levels of these neurotransmitters are altered in autism, although other hypotheses implicate overactive brain opioid systems and changes in oxytocin neurotransmission. |
1999-05-19 |
2023-08-12 |
Not clear |
| D C Chugani, O Muzik, M Behen, R Rothermel, J J Janisse, J Lee, H T Chugan. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Annals of neurology. vol 45. issue 3. 1999-03-29. PMID:10072042. |
global brain values for serotonin synthesis capacity (k complex) were obtained for autistic children (n = 30), their nonautistic siblings (n = 8), and epileptic children without autism (n = 16). |
1999-03-29 |
2023-08-12 |
Not clear |
| M L Carlsso. Hypothesis: is infantile autism a hypoglutamatergic disorder? Relevance of glutamate - serotonin interactions for pharmacotherapy. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 4-5. 1998-10-30. PMID:9720980. |
possible future pharmacological interventions in autism are discussed in the light of the intimate interplay between central glutamate and serotonin, notably the serotonin (5-ht) 2a receptor. |
1998-10-30 |
2023-08-12 |
human |
| P A McBride, G M Anderson, M E Hertzig, M E Snow, S M Thompson, V D Khait, T Shapiro, D J Cohe. Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry. vol 37. issue 7. 1998-07-29. PMID:9666633. |
effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. |
1998-07-29 |
2023-08-12 |
Not clear |
| P A McBride, G M Anderson, M E Hertzig, M E Snow, S M Thompson, V D Khait, T Shapiro, D J Cohe. Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry. vol 37. issue 7. 1998-07-29. PMID:9666633. |
to reevaluate platelet serotonin (5-ht) levels in autism, measuring and controlling for effects of race and puberty. |
1998-07-29 |
2023-08-12 |
Not clear |
| C J McDougle, J P Holmes, D C Carlson, G H Pelton, D J Cohen, L H Pric. A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Archives of general psychiatry. vol 55. issue 7. 1998-07-23. PMID:9672054. |
neurobiological research has implicated the dopamine and serotonin systems in the pathogenesis of autism. |
1998-07-23 |
2023-08-12 |
Not clear |
| P Q Levy, M P Bich. [Platelet serotonin as a biological marker of autism]. Acta medica portuguesa. vol 10. issue 12. 1998-05-13. PMID:9522491. |
[platelet serotonin as a biological marker of autism]. |
1998-05-13 |
2023-08-12 |
human |
| S M Klauck, F Poustka, A Benner, K P Lesch, A Poustk. Serotonin transporter (5-HTT) gene variants associated with autism? Human molecular genetics. vol 6. issue 13. 1998-03-18. PMID:9361027. |
serotonin transporter (5-htt) gene variants associated with autism? |
1998-03-18 |
2023-08-12 |
Not clear |
| S M Klauck, F Poustka, A Benner, K P Lesch, A Poustk. Serotonin transporter (5-HTT) gene variants associated with autism? Human molecular genetics. vol 6. issue 13. 1998-03-18. PMID:9361027. |
an association study was performed to elucidate the role of the serotonin transporter (5-htt) gene as a susceptibility factor for autism as treatment of patients with antidepressant drugs which selectively target 5-htt reduced autistic or concomitant symptoms, such as repetitive behavior and aggression, and ameliorate language use. |
1998-03-18 |
2023-08-12 |
Not clear |
| S M Klauck, F Poustka, A Benner, K P Lesch, A Poustk. Serotonin transporter (5-HTT) gene variants associated with autism? Human molecular genetics. vol 6. issue 13. 1998-03-18. PMID:9361027. |
the implications for genetic variants of the serotonin transporter in the etiology of autism and possible subgroups of patients, therefore, needs clarification in further studies with other and larger patient samples. |
1998-03-18 |
2023-08-12 |
Not clear |
| D C Chugani, O Muzik, R Rothermel, M Behen, P Chakraborty, T Mangner, E A da Silva, H T Chugan. Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Annals of neurology. vol 42. issue 4. 1997-11-07. PMID:9382481. |
based on reports of increased platelet serotonin in 30 to 50% of autistic subjects, abnormal serotonergic neurotransmission may be important in the pathogenesis of autism. |
1997-11-07 |
2023-08-12 |
human |
| J Levine, A Aviram, A Holan, A Ring, Y Barak, R H Belmake. Inositol treatment of autism. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 2-3. 1997-09-03. PMID:9203092. |
recent studies suggest that serotonin reuptake inhibitors are helpful in at least some symptoms of autism. |
1997-09-03 |
2023-08-12 |
Not clear |
| E Fernell, Y Watanabe, I Adolfsson, Y Tani, M Bergström, P Hartvig, A Lilja, A L von Knorring, C Gillberg, B Långströ. Possible effects of tetrahydrobiopterin treatment in six children with autism--clinical and positron emission tomography data: a pilot study. Developmental medicine and child neurology. vol 39. issue 5. 1997-08-21. PMID:9236697. |
six children, between 3 and 5 years of age, having infantile autism according to dsm-iii-r, were treated for 3 months with 6r-l-erythro-5,6,7,8-tetrahydrobiopterin (r-bh4), a cofactor for tyrosine hydroxylases in the biosynthetic pathway of catecholamines and serotonin. |
1997-08-21 |
2023-08-12 |
Not clear |
| J Levin. Controlled trials of inositol in psychiatry. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 7. issue 2. 1997-07-21. PMID:9169302. |
recent studies suggest that serotonin re-uptake inhibitors are helpful in at least some symptoms of autism. |
1997-07-21 |
2023-08-12 |
Not clear |