| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pawan Kumar, Deepak Sheokand, Annu Grewal, Vandana Saini, Ajit Kuma. Drug repositioning for idiopathic epilepsy using gene expression signature data. Bioinformation. vol 18. issue 10. 2023-09-01. PMID:37654844. |
these compounds were docked against identified epilepsy targets- voltage-gated sodium channel subunit α2 (nav1.2); gaba receptor α1-β1; and voltage-gated calcium channel α1g (cav3.1)using carbamazepine, clonazepam, and pregabalin as standard drugs, respectively. |
2023-09-01 |
2023-09-07 |
human |
| Emilio Perucca, Meir Bialer, H Steve Whit. New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System. CNS drugs. 2023-08-21. PMID:37603262. |
γ-aminobutyric acid (gaba) is the most prevalent inhibitory neurotransmitter in the mammalian brain and has been found to play an important role in the pathogenesis or the expression of many neurological diseases, including epilepsy. |
2023-08-21 |
2023-09-07 |
Not clear |
| Nihan Çarçak, Filiz Onat, Evgenia Sitnikov. Astrocytes as a target for therapeutic strategies in epilepsy: current insights. Frontiers in molecular neuroscience. vol 16. 2023-08-16. PMID:37583518. |
several promising new strategies that attempted to modify astroglial functions for treating epilepsy are being developed: (1) selective targeting of glia-related molecular mechanisms of glutamate transport; (2) modulation of tonic gaba release from astrocytes; (3) gliotransmission; (4) targeting the astrocytic kir4.1-bdnf system; (5) astrocytic na |
2023-08-16 |
2023-09-07 |
human |
| Nana Liu, Jinliang Li, Kai Gao, Riley E Perszyk, Jing Zhang, Jingmin Wang, Ye Wu, Andrew Jenkins, Hongjie Yuan, Stephen F Traynelis, Yuwu Jian. De novo CLPTM1 variants with reduced GABA Epilepsia. 2023-08-14. PMID:37577761. |
de novo clptm1 variants with reduced gaba to investigate the clinical feature and potential pathogenesis mechanism of de novo clptm1 variants associated with epilepsy. |
2023-08-14 |
2023-08-16 |
Not clear |
| Vasily A Aleshin, Anastasia V Graf, Artem V Artiukhov, Alexander L Ksenofontov, Lev G Zavileyskiy, Maria V Maslova, Victoria I Buni. Pentylenetetrazole-Induced Seizures Are Increased after Kindling, Exhibiting Vitamin-Responsive Correlations to the Post-Seizures Behavior, Amino Acids Metabolism and Key Metabolic Regulators in the Rat Brain. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569781. |
epilepsy is characterized by recurrent seizures due to a perturbed balance between glutamate and gaba neurotransmission. |
2023-08-12 |
2023-08-16 |
rat |
| Eline J H van Hugte, Dirk Schubert, Nael Nadif Kasr. E/I balance in epilepsies and neurodevelopmental disorders: depolarizing GABA as a common mechanism. Epilepsia. 2023-05-17. PMID:37195166. |
e/i balance in epilepsies and neurodevelopmental disorders: depolarizing gaba as a common mechanism. |
2023-05-17 |
2023-08-14 |
Not clear |
| Pawan Kumar, Deepak Sheokand, Annu Grewal, Vandana Saini, Ajit Kuma. Clinical side-effects based drug repositioning for anti-epileptic activity. Journal of biomolecular structure & dynamics. 2023-04-12. PMID:37042987. |
molecular docking studies were performed for selected 26 hits (drugs) against previously identified epilepsy target receptors: voltage-gated sodium channel α2 (nav1.2), gaba receptor α1-β1 (gabar α1-β1), and voltage-gated calcium channel α-1 g (cav3.1). |
2023-04-12 |
2023-08-14 |
Not clear |
| Itay Tokatly Latzer, Mariarita Bertoldi, Melissa L DiBacco, Erland Arning, Melissa Tsuboyama, Paul MacMullin, Daniyal Sachee, Alexander Rotenberg, Henry H C Lee, Deniz Aygun, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Jean-Baptiste Roullet, K Michael Gibson, Phillip L Pear. The Presence and Severity of Epilepsy Coincide with Reduced GABA and Cortical Excitatory Markers in SSADH Deficiency. Epilepsia. 2023-03-24. PMID:36961285. |
the presence and severity of epilepsy coincide with reduced gaba and cortical excitatory markers in ssadh deficiency. |
2023-03-24 |
2023-08-14 |
Not clear |
| Punam Salaria, Parameswari Akshinthala, Ravikumar Kapavarapu, Amarendar Reddy . Identification of novel C-15 fluoro isosteviol derivatives for GABA-AT inhibition by in silico investigations. Journal of molecular modeling. vol 29. issue 3. 2023-02-24. PMID:36826597. |
the treatment of epilepsy is associated with the inhibition of γ-aminobutyric acid-aminotransferase (gaba-at), which suppresses the concentration of a key neurotransmitter gaba. |
2023-02-24 |
2023-08-14 |
Not clear |
| Jens V Andersen, Arne Schousboe, Petrine Wellendorp. Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling. Essays in biochemistry. 2023-02-22. PMID:36806927. |
disrupted inhibitory signaling and dysfunctional astrocyte gaba handling are implicated in several diseases including epilepsy and alzheimer's disease. |
2023-02-22 |
2023-08-14 |
Not clear |
| Aya A Zayed, Mae M Seleem, Hebatallah A Darwish, Amira A Shahee. Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients. Metabolic brain disease. 2023-02-22. PMID:36807083. |
this study investigated the expression levels of lncrnas; bdnf-as and 17a in the sera of egyptian patients with idiopathic generalized and symptomatic focal epilepsy and correlated their levels with brain-derived neurotrophic factor (bdnf), phosphorylated camp reaction element -binding protein (p-creb), gamma- aminobutyric acid (gaba) and glutamate, to underline their related molecular mechanism. |
2023-02-22 |
2023-08-14 |
Not clear |
| Sana Javaid, Faleh Alqahtani, Waseem Ashraf, Syed Muhammad Muneeb Anjum, Muhammad Fawad Rasool, Tanveer Ahmad, Fawaz Alasmari, Abdullah F Alasmari, Saleh Abdullah Alqarni, Imran Imra. Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 160. 2023-02-15. PMID:36791567. |
tiagabine (tia), a new-generation antiseizure drug that mimics the gabaergic signaling by inhibiting gaba transporter type-1, is the least studied molecule in chronic epilepsy models with comorbid neurobehavioral and neuroinflammatory parameters. |
2023-02-15 |
2023-08-14 |
mouse |
| Ankita Rajput, Palvi Sharma, Nitish Kumar, Sarabjit Kaur, Saroj Aror. Neuroprotective activity of novel phenanthrene derivative from Grewia tiliaefolia by in vitro and in silico studies. Scientific reports. vol 13. issue 1. 2023-02-10. PMID:36765125. |
in silico study was conducted to predict its action on proteins playing crucial role in neurological and neurodegenerative disorders such as gamma amino butyric acid (gaba) receptor and glutamate α amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (glu ampa) receptor in epilepsy and ache enzyme in alzheimer's diseases. |
2023-02-10 |
2023-08-14 |
Not clear |
| Andreea Nissenkorn, Gerhard Kluger, Susanne Schubert-Bast, Allan Bayat, Marya Bobylova, Paolo Bonanni, Berten Ceulemans, Antonietta Coppola, Carlo Di Bonaventura, Martha Feucht, Anne Fuchs, Gudrun Gröppel, Gali Heimer, Brigitte Herdt, Sviatlana Kulikova, Konstantin Mukhin, Stefania Nicassio, Alessandro Orsini, Maria Panagiotou, Milka Pringsheim, Burkhard Puest, Olga Pylaeva, Georgia Ramantani, Maria Tsekoura, Paolo Ricciardelli, Tally Lerman Sagie, Brigit Stark, Pasquale Striano, Andreas van Baalen, Matthias De Wachter, Emanuele Cerulli Irelli, Claudia Cuccurullo, Celina von Stülpnagel, Angelo Russ. Perampanel as Precision Therapy in Rare Genetic Epilepsies. Epilepsia. 2023-02-03. PMID:36734057. |
special interest holds epilepsies with loss of gaba inhibition (e.g. |
2023-02-03 |
2023-08-14 |
Not clear |
| Manuela Gernert, Devlin MacKeigan, Lillian Deking, Edith Kaczmarek, Malte Fej. Acute and chronic convection-enhanced muscimol delivery into the rat subthalamic nucleus induces antiseizure effects associated with high responder rates. Epilepsy research. vol 190. 2023-02-03. PMID:36736200. |
in rat seizure and epilepsy models, the gaba |
2023-02-03 |
2023-08-14 |
rat |
| Alexander Bryson, Christopher Reid, Steven Petro. GABA Journal of neurochemistry. 2023-01-22. PMID:36681890. |
gaba epilepsy is a common neurological disorder associated with alterations of excitation-inhibition balance within brain neuronal networks. |
2023-01-22 |
2023-08-14 |
Not clear |
| Gabriele Ruffolo, Veronica Alfano, Alessia Romagnolo, Till Zimmer, James D Mills, Pierangelo Cifelli, Alessandro Gaeta, Alessandra Morano, Jasper Anink, Angelika Mühlebner, Annamaria Vezzani, Eleonora Aronica, Eleonora Palm. GABA Scientific reports. vol 12. issue 1. 2022-10-26. PMID:36289354. |
gaba gangliogliomas (ggs) are low-grade brain tumours that cause intractable focal epilepsy in children and adults. |
2022-10-26 |
2023-08-14 |
xenopus_laevis |
| Konrad Platzer, Heinrich Sticht, Caleb Bupp, Mythily Ganapathi, Elaine M Pereira, Gwenaël Le Guyader, Frederic Bilan, Lindsay B Henderson, Johannes R Lemke, Holger Taschenberger, Nils Brose, Rami Abou Jamra, Sonja M Wojci. De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission. Annals of neurology. 2022-09-08. PMID:36073542. |
rare inherited missense variants in slc32a1, the gene that encodes the vesicular gamma-aminobutyric acid (gaba) transporter, have recently been shown to cause genetic epilepsy with febrile seizures plus. |
2022-09-08 |
2023-08-14 |
Not clear |
| Linlin Zhang, Xinjie Li. Clinical phenotype and genotype of children with GABA Frontiers in neurology. vol 13. 2022-08-08. PMID:35937053. |
clinical phenotype and genotype of children with gaba this study aimed to summarize the clinical phenotype and genotype of children with epilepsy caused by gabra1 gene variants. |
2022-08-08 |
2023-08-14 |
Not clear |
| Yan Feng, Zi-Han Wei, Chao Liu, Guo-Yan Li, Xiao-Zhi Qiao, Ya-Jing Gan, Chu-Chu Zhang, Yan-Chun Den. Genetic variations in GABA metabolism and epilepsy. Seizure. vol 101. 2022-07-19. PMID:35850019. |
genetic variations in gaba metabolism and epilepsy. |
2022-07-19 |
2023-08-14 |
Not clear |