| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Feng, Zi-Han Wei, Chao Liu, Guo-Yan Li, Xiao-Zhi Qiao, Ya-Jing Gan, Chu-Chu Zhang, Yan-Chun Den. Genetic variations in GABA metabolism and epilepsy. Seizure. vol 101. 2022-07-19. PMID:35850019. |
gamma-aminobutyric acid (gaba) is the most important inhibitory neurotransmitter in the brain and plays an important role in the occurrence and development of epilepsy. |
2022-07-19 |
2023-08-14 |
Not clear |
| Yan Feng, Zi-Han Wei, Chao Liu, Guo-Yan Li, Xiao-Zhi Qiao, Ya-Jing Gan, Chu-Chu Zhang, Yan-Chun Den. Genetic variations in GABA metabolism and epilepsy. Seizure. vol 101. 2022-07-19. PMID:35850019. |
abnormalities in all aspects of gaba metabolism, including gaba synthesis, transport, genes encoding gaba receptors, and gaba inactivation, may lead to epilepsy. |
2022-07-19 |
2023-08-14 |
Not clear |
| Yan Feng, Zi-Han Wei, Chao Liu, Guo-Yan Li, Xiao-Zhi Qiao, Ya-Jing Gan, Chu-Chu Zhang, Yan-Chun Den. Genetic variations in GABA metabolism and epilepsy. Seizure. vol 101. 2022-07-19. PMID:35850019. |
gabra1, gabra2, gabra5, gabrb1, gabrb2, gabrb3, gabrg2 and gabbr2 are genes that encode gaba receptors and are commonly associated with epilepsy. |
2022-07-19 |
2023-08-14 |
Not clear |
| Yan Feng, Zi-Han Wei, Chao Liu, Guo-Yan Li, Xiao-Zhi Qiao, Ya-Jing Gan, Chu-Chu Zhang, Yan-Chun Den. Genetic variations in GABA metabolism and epilepsy. Seizure. vol 101. 2022-07-19. PMID:35850019. |
mutations of these genes result in symptoms related to deficiency of gaba transaminase and succinate semi aldehyde dehydrogenase, such as epilepsy and cognitive impairment. |
2022-07-19 |
2023-08-14 |
Not clear |
| Yan Feng, Zi-Han Wei, Chao Liu, Guo-Yan Li, Xiao-Zhi Qiao, Ya-Jing Gan, Chu-Chu Zhang, Yan-Chun Den. Genetic variations in GABA metabolism and epilepsy. Seizure. vol 101. 2022-07-19. PMID:35850019. |
this review focuses on advances in understanding the relationship between genetic variation in gaba metabolism and epilepsy to establish a basis for the accurate diagnosis and treatment of epilepsy. |
2022-07-19 |
2023-08-14 |
Not clear |
| Felicia Mermer, Sarah Poliquin, Shuizhen Zhou, Xiaodong Wang, Yifeng Ding, Fei Yin, Wangzhen Shen, Juexin Wang, Kathryn Rigsby, Dong Xu, Taralynn Mack, Gerald Nwosu, Carson Flamm, Matthew Stein, Jing-Qiong Kan. Astrocytic GABA transporter 1 deficit in novel SLC6A1 variants mediated epilepsy: Connected from protein destabilization to seizures in mice and humans. Neurobiology of disease. 2022-07-15. PMID:35840120. |
astrocytic gaba transporter 1 deficit in novel slc6a1 variants mediated epilepsy: connected from protein destabilization to seizures in mice and humans. |
2022-07-15 |
2023-08-14 |
mouse |
| Felicia Mermer, Sarah Poliquin, Shuizhen Zhou, Xiaodong Wang, Yifeng Ding, Fei Yin, Wangzhen Shen, Juexin Wang, Kathryn Rigsby, Dong Xu, Taralynn Mack, Gerald Nwosu, Carson Flamm, Matthew Stein, Jing-Qiong Kan. Astrocytic GABA transporter 1 deficit in novel SLC6A1 variants mediated epilepsy: Connected from protein destabilization to seizures in mice and humans. Neurobiology of disease. 2022-07-15. PMID:35840120. |
mutations in γ-aminobutyric acid (gaba) transporter 1 (gat-1)-encoding slc6a1 have been associated with myoclonic atonic epilepsy and other phenotypes. |
2022-07-15 |
2023-08-14 |
mouse |
| Juan A Moncayo, Ivan N Ayala, Jennifer M Argudo, Alex S Aguirre, Jashank Parwani, Ana Pachano, Diego Ojeda, Steven Cordova, Maria Gracia Mora, Christiany M Tapia, Juan Fernando Orti. Understanding Protein Protocadherin-19 (PCDH19) Syndrome: A Literature Review of the Pathophysiology. Cureus. vol 14. issue 6. 2022-07-13. PMID:35822151. |
gaba(a)(r) dysfunction and expression cause decreased effective inhibitory currents predisposing patients to epilepsy. |
2022-07-13 |
2023-08-14 |
Not clear |
| Schweta Rane, Sama Elrahi, Joseph Villarreal, Haneef Zulfi, Xiang Fang, Daniel Graf, Rafael Rodriguez, Amanda Garza, Neeharika Thottempudi, Prashant Rai, Todd Mase. Low Serum Pyridoxine Levels Worsen Seizure Control in Adult Epilepsy Patients. Cureus. vol 14. issue 6. 2022-07-11. PMID:35812624. |
given our knowledge of the role of vitamin b6 in the conversion of glutamate to gaba, its effect on seizure control in infants with specific epilepsy subtypes, reports of adult-onset seizures associated with vitamin b6 deficiency, and vitamin b6's role in terminating status epilepticus in adult patients with other types of epilepsy, we suspect that low vitamin b6 levels in adult epilepsy patients may correlate with poor seizure control across all epilepsy subtypes. this study seeks to determine whether there is a relationship between pyridoxine levels and the level of seizure control in adults with epilepsy, regardless of their seizure type. |
2022-07-11 |
2023-08-14 |
Not clear |
| Jason Tyler Dell'Aquila, Varun Sot. Sleep deprivation: a risk for epileptic seizures. Sleep science (Sao Paulo, Brazil). vol 15. issue 2. 2022-06-27. PMID:35755914. |
interestingly, a decrease in gamma-aminobutyric acid (gaba)-mediated tonic inhibition has been shown in both epilepsy and sleep deprivation. |
2022-06-27 |
2023-08-14 |
Not clear |
| Veronica Alfano, Alessia Romagnolo, James D Mills, Pierangelo Cifelli, Alessandro Gaeta, Alessandra Morano, Angelika Mühlebner, Eleonora Aronica, Eleonora Palma, Gabriele Ruffol. Unexpected Effect of IL-1β on the Function of GABA Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741692. |
unexpected effect of il-1β on the function of gaba focal cortical dysplasia (fcd) type ii is an epileptogenic malformation of the neocortex, as well as a leading cause of drug-resistant focal epilepsy in children and young adults. |
2022-06-24 |
2023-08-14 |
Not clear |
| Qin Zhou, Qiong Wang, Baomei He, Haibo Kong, Huanjun Luo, Xiaowei Wang, Wenlan Wan. MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-06-01. PMID:35647304. |
exogenous mir-322-5p reduced the expression of inflammatory molecules and increased the gaba levels in se rats, and also reduced hippocampal neuronal cell apoptosis caused by epilepsy. |
2022-06-01 |
2023-08-13 |
rat |
| Tamia Phoenix, Tia M Foster, Edward J Catapane, Craig Hinkley, Margaret A Carrol. Genomic Study of GABA Receptor Ligand Binding Sites of the Bivalve Mollusc Crassostrea virginica. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556591. |
in humans, impairment of gaba neurotransmission can cause epilepsy. |
2022-05-13 |
2023-08-13 |
mouse |
| Sara Olivotto, Anna Freddi, Rossella Lavatelli, Eleonora Basso, Alessia Leidi, Barbara Castellotti, Luigina Spaccini, Stefania Maria Bova, Pierangelo Veggiott. Successful use of perampanel in GABRA1-related myoclonic epilepsy with photosensitivity. Epilepsy & behavior reports. vol 19. 2022-05-06. PMID:35520951. |
pathogenic variants in gamma-aminobutyric acid type a receptor subunit alpha1 (gabra1) is a protein coding gene that has been associated with a broad phenotypic spectrum of epilepsies. |
2022-05-06 |
2023-08-13 |
Not clear |
| Tabea Kürten, Natascha Ihbe, Timo Ueberbach, Ute Distler, Malte Sielaff, Stefan Tenzer, Thomas Mittman. GABA International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409261. |
gaba posttraumatic epilepsy (pte) is a major public health concern and strongly contributes to human epilepsy cases worldwide. |
2022-04-12 |
2023-08-13 |
human |
| Florian P Fischer, Ameya S Kasture, Thomas Hummel, Sonja Suci. Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders. Frontiers in molecular biosciences. vol 9. 2022-03-17. PMID:35295842. |
molecular and clinical repercussions of gaba transporter 1 variants gone amiss: links to epilepsy and developmental spectrum disorders. |
2022-03-17 |
2023-08-13 |
human |
| Valerio Frazzini, Bertrand Mathon, Florian Donneger, Louis Cousyn, Aurélie Hanin, V-H Nguyen-Michel, Claude Adam, Virginie Lambrecq, Sophie Dupont, Jean Christophe Poncer, Franck Bielle, Vincent Navarr. Epilepsy related to focal neuronal lipofuscinosis: extra-frontal localization, EEG signatures and GABA involvement. Journal of neurology. 2022-03-07. PMID:35254479. |
epilepsy related to focal neuronal lipofuscinosis: extra-frontal localization, eeg signatures and gaba involvement. |
2022-03-07 |
2023-08-13 |
Not clear |
| Maryam Amjad, Atiya Tabassum, Khalid Sher, Suneel Kumar, Sitwat Zehra, Sehrish Fatim. Impact of GABA Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2022-02-12. PMID:35150350. |
impact of gaba epilepsy is one of the most common neurological disorders with the incidence rate higher in developing states. |
2022-02-12 |
2023-08-13 |
human |
| H S Nandini, K L Krishna, Chinnappa Apattir. Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer's disease. Journal of chemical neuroanatomy. 2022-01-01. PMID:34973350. |
it also observed that treatment has decreased the excitoneurotoxicity evidenced by decreased glutamate and increased gaba levels and thus provided protection against epilepsy. |
2022-01-01 |
2023-08-13 |
human |
| Felicia Mermer, Sarah Poliquin, Kathryn Rigsby, Anuj Rastogi, Wangzhen Shen, Alejandra Romero-Morales, Gerald Nwosu, Patrick McGrath, Scott Demerast, Jason Aoto, Ganna Bilousova, Dennis Lal, Vivian Gama, Jing-Qiong Kan. Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:34028503. |
interestingly, we did not find a clear correlation of gaba uptake function and the disease phenotypes, such as myoclonic atonic epilepsy versus developmental delay, in this study. |
2021-12-08 |
2023-08-13 |
human |