| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mehwish Riaz, Muddasir Hassan Abbasi, Nadeem Sheikh, Tayyaba Saleem, Ahmad Omair Vir. GABRA1 and GABRA6 gene mutations in idiopathic generalized epilepsy patients. Seizure. vol 93. 2021-12-08. PMID:34740144. |
the gaba receptor is an important epilepsy-associated candidate gene, and has always been a focus in etiology and in the treatment of epilepsy. |
2021-12-08 |
2023-08-13 |
Not clear |
| Mehwish Riaz, Muddasir Hassan Abbasi, Nadeem Sheikh, Tayyaba Saleem, Ahmad Omair Vir. GABRA1 and GABRA6 gene mutations in idiopathic generalized epilepsy patients. Seizure. vol 93. 2021-12-08. PMID:34740144. |
this study explores the genetic association between gaba receptor gene polymorphisms and epilepsy in a cohort of the pakistani population. |
2021-12-08 |
2023-08-13 |
Not clear |
| Mehwish Riaz, Muddasir Hassan Abbasi, Nadeem Sheikh, Tayyaba Saleem, Ahmad Omair Vir. GABRA1 and GABRA6 gene mutations in idiopathic generalized epilepsy patients. Seizure. vol 93. 2021-12-08. PMID:34740144. |
therefore, both the gaba receptor genes may play critical roles in the development of epilepsy in pakistani patients. |
2021-12-08 |
2023-08-13 |
Not clear |
| Dhir Gala, Vikram Gurusamy, Krishna Patel, Sreedevi Damodar, Girish Swaminath, Gautam Ulla. Stem Cell Therapy for Post-Traumatic Stress Disorder: A Novel Therapeutic Approach. Diseases (Basel, Switzerland). vol 9. issue 4. 2021-12-03. PMID:34842629. |
epilepsy is characterized by repetitive seizures caused by imbalance in the gaba and glutamate neurotransmission following neuronal damage. |
2021-12-03 |
2023-08-13 |
Not clear |
| Gabriele Deidda, Vincenzo Crunelli, Giuseppe Di Giovann. 5-HT/GABA interaction in epilepsy. Progress in brain research. vol 259. 2021-11-24. PMID:33541679. |
here we review preclinical and human evidence showing that serotonin modulates epilepsy that this likely happens via a major modulation/interaction with gaba. |
2021-11-24 |
2023-08-13 |
human |
| Marcello Scala, Evelien Zonneveld-Huijssoon, Marianna Brienza, Oriano Mecarelli, Annemarie H van der Hout, Elena Zambrelli, Katherine Turner, Federico Zara, Angela Peron, Aglaia Vignoli, Pasquale Strian. De novo ARHGEF9 missense variants associated with neurodevelopmental disorder in females: expanding the genotypic and phenotypic spectrum of ARHGEF9 disease in females. Neurogenetics. vol 22. issue 1. 2021-11-18. PMID:32939676. |
individuals harboring pathogenic variants in arhgef9, encoding an essential submembrane protein for gamma-aminobutyric acid (gaba)-ergic synapses named collybistin, show intellectual disability (id), facial dysmorphism, behavioral disorders, and epilepsy. |
2021-11-18 |
2023-08-13 |
Not clear |
| Günther Sperk, Susanne Pirker, Elisabeth Gasser, Anna Wieselthaler, Anneliese Bukovac, Giorgi Kuchukhidze, Hans Maier, Meinrad Drexel, Christoph Baumgartner, Marin Ortler, Thomas Czec. Increased expression of GABA Brain communications. vol 3. issue 4. 2021-10-30. PMID:34708207. |
increased expression of gaba epilepsy animal models indicate pronounced changes in the expression and rearrangement of gaba |
2021-10-30 |
2023-08-13 |
Not clear |
| Chun-Hong Shen, Gao-Li Fang, Fan Yang, Meng-Ting Cai, Yang Zheng, Wei Fang, Yi Guo, Yin-Xi Zhang, Mei-Ping Din. Seizures and risk of epilepsy in anti-NMDAR, anti-LGI1, and anti-GABA Annals of clinical and translational neurology. vol 7. issue 8. 2021-10-15. PMID:32710704. |
we aimed to evaluate seizure outcomes and potential factors associated with the development of epilepsy in patients with anti-n-methyl-d-aspartate receptor (nmdar), anti-leucine-rich glioma-inactivated 1 (lgi1), and anti-gamma-aminobutyric-acid b receptor (gaba |
2021-10-15 |
2023-08-13 |
Not clear |
| Uzair Nisar, Maha Shahid, Maryam Askani, Saima Mahmood Malhi, Farzana Shaheen, Shabana Usman Simje. In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. Pakistan journal of pharmaceutical sciences. vol 33. issue 4. 2021-10-13. PMID:33583776. |
an imbalance between inhibitory (gaba) and excitatory (glutamate) neurotransmission contribute to the development of epilepsy. |
2021-10-13 |
2023-08-13 |
mouse |
| Uzair Nisar, Maha Shahid, Maryam Askani, Saima Mahmood Malhi, Farzana Shaheen, Shabana Usman Simje. In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. Pakistan journal of pharmaceutical sciences. vol 33. issue 4. 2021-10-13. PMID:33583776. |
earlier studies reported that dysregulation of gaba and glutamatergic activities resulted in status epilepticus (se) and ultimately support the development of temporal lobe epilepsy (tle), a type of resistant epilepsy. |
2021-10-13 |
2023-08-13 |
mouse |
| Sarah Poliquin, Inna Hughes, Wangzhen Shen, Felicia Mermer, Juexin Wang, Taralynn Mack, Dong Xu, Jing-Qiong Kan. Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD. Experimental neurology. vol 342. 2021-10-11. PMID:33961861. |
mutations in slc6a1, encoding γ-aminobutyric acid (gaba) transporter 1 (gat-1), have been recently associated with a spectrum of neurodevelopmental disorders ranging from variable epilepsy syndromes, intellectual disability (id), autism and others. |
2021-10-11 |
2023-08-13 |
Not clear |
| Mario Mastrangel. Epilepsy in inherited neurotransmitter disorders: Spotlights on pathophysiology and clinical management. Metabolic brain disease. vol 36. issue 1. 2021-10-07. PMID:33095372. |
this review analyzes the epileptogenic mechanisms, the epilepsy phenotypes and the principle for the clinical management of epilepsy in primary and secondary inherited disorders of neurotransmitter metabolism (disorders of gaba, serine and glycine metabolism, disorders of neurotransmitter receptors and secondary neurotransmitter diseases). |
2021-10-07 |
2023-08-13 |
Not clear |
| Xinxiao Li, Shengnan Guo, Siying Xu, Zhangping Chen, Lei Wang, Jiangwei Ding, Junming Huo, Lifei Xiao, Zhenquan He, Zhe Jin, Feng Wang, Tao Su. Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice. Cell death & disease. vol 12. issue 6. 2021-10-05. PMID:34050134. |
mutations in the gabrg2 gene encoding the γ-aminobutyric acid (gaba) a receptor gamma 2 subunit are associated with genetic epilepsy with febrile seizures plus, febrile seizures plus, febrile seizures, and other symptoms of epilepsy. |
2021-10-05 |
2023-08-13 |
mouse |
| Gabrielle L Sarlo, Kathleen F Holto. Brain concentrations of glutamate and GABA in human epilepsy: A review. Seizure. vol 91. 2021-09-13. PMID:34233236. |
brain concentrations of glutamate and gaba in human epilepsy: a review. |
2021-09-13 |
2023-08-13 |
human |
| Gabrielle L Sarlo, Kathleen F Holto. Brain concentrations of glutamate and GABA in human epilepsy: A review. Seizure. vol 91. 2021-09-13. PMID:34233236. |
this review aims to summarize the microdialysis and magnetic resonance spectroscopy (mrs) literature investigating glutamate and gaba concentrations in epilepsy patients, present limitations, and suggest future directions to help direct the search for novel epilepsy treatments. |
2021-09-13 |
2023-08-13 |
human |
| Gabrielle L Sarlo, Kathleen F Holto. Brain concentrations of glutamate and GABA in human epilepsy: A review. Seizure. vol 91. 2021-09-13. PMID:34233236. |
understanding the importance of brain glutamate and gaba levels in epilepsy may provide direction for future therapies and treatments. |
2021-09-13 |
2023-08-13 |
human |
| Tao Gong, Yubo Liu, Yufan Chen, Liangjie Lin, Youting Lin, Guangbin Wan. Focal corticarl dysplasia in epilepsy is associated with GABA increase. NeuroImage. Clinical. vol 31. 2021-09-13. PMID:34280836. |
focal corticarl dysplasia in epilepsy is associated with gaba increase. |
2021-09-13 |
2023-08-13 |
Not clear |
| Tao Gong, Yubo Liu, Yufan Chen, Liangjie Lin, Youting Lin, Guangbin Wan. Focal corticarl dysplasia in epilepsy is associated with GABA increase. NeuroImage. Clinical. vol 31. 2021-09-13. PMID:34280836. |
the aim of this study is to detect alterations of γ-aminobutyric acid (gaba), glutathione (gsh), and the composite of glutamate and glutamine (glx) in mri-typical and neuropathologically confirmed fcd-associated epilepsy using hadamard encoding and reconstruction of mega-edited spectroscopy (hermes). |
2021-09-13 |
2023-08-13 |
Not clear |
| Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Darisi Venkata Kishore, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasa. Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways. Neurotoxicity research. vol 38. issue 4. 2021-08-20. PMID:32803629. |
acteoside isolated from colebrookea oppositifolia smith attenuates epilepsy in mice via modulation of gamma-aminobutyric acid pathways. |
2021-08-20 |
2023-08-13 |
mouse |
| Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali, Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Cian. A GABA Neurobiology of disease. vol 153. 2021-08-20. PMID:33621640. |
a gaba cdkl5 (cyclin-dependent kinase-like 5) deficiency disorder (cdd) is a severe neurodevelopmental encephalopathy characterized by early-onset epilepsy and intellectual disability. |
2021-08-20 |
2023-08-13 |
mouse |