| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuji Wakatsuki, Toshiyuki Arak. Novel insights into the mechanism of reactive oxygen species-mediated neurodegeneration. Neural regeneration research. vol 18. issue 4. 2022-10-07. PMID:36204830. |
neurite degeneration, a major component of many neurodegenerative diseases, such as parkinson's disease, alzheimer's disease, and amyotrophic lateral sclerosis, is not part of the typical apoptosis signaling mechanism, but rather it appears that a self-destructive process is in action. |
2022-10-07 |
2023-08-14 |
Not clear |
| Dewei He, Yanting Liu, Jie Li, Hefei Wang, Bojian Ye, Yuan He, Zhe Li, Xiyu Gao, Shoupeng Fu, Dianfeng Li. Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease. Cells. vol 11. issue 18. 2022-09-23. PMID:36139502. |
parkinson's disease (pd) is a neurodegenerative disease in which neuronal apoptosis and associated inflammation are involved in its pathogenesis. |
2022-09-23 |
2023-08-14 |
mouse |
| Chaemoon Lim, Ao Xuan Zhen, Sungwoo Ok, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Jin Won Hyu. Hesperidin Protects SH-SY5Y Neuronal Cells against High Glucose-Induced Apoptosis via Regulation of MAPK Signaling. Antioxidants (Basel, Switzerland). vol 11. issue 9. 2022-09-23. PMID:36139782. |
neurodegenerative diseases are associated with neuronal cell death through apoptosis. |
2022-09-23 |
2023-08-14 |
Not clear |
| Christian Ardianto, Robert Shen, Jimmy F A Barus, Poppy Kristina Sasmita, Yuda Turana, Lilis Lilis, Veronika Maria Sidhart. Secretome as neuropathology-targeted intervention of Parkinson's disease. Regenerative therapy. vol 21. 2022-09-12. PMID:36092507. |
parkinson's disease (pd) is the second most common progressive neurodegenerative disease, characterized by apoptosis of dopaminergic neurons in substansia nigra pars compacta (snpc) caused by ⍺-synuclein aggregation. |
2022-09-12 |
2023-08-14 |
Not clear |
| Yongjie Xu, Haizhi Li, Gang Chen, Liying Zhu, Hairong Lin, Changyudong Huang, Sijia Wei, Tingting Yang, Wen Qian, Xing Li, Shuyun Zhao, Wei Pa. Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076547. |
though the histone deacetylase 4 (hdac4), hdac5, hdac7, and hdac9 form class iia of the hdac superfamily have been found participating in multiple neurodegenerative diseases, while jnk signaling pathway activation was hypothesized as a key cause leading to cell apoptosis, the correlation between hdac4 and jnk signaling pathway remains unknown. |
2022-09-09 |
2023-08-14 |
rat |
| Chenghe Fan, Yu Tian, Yilin Zhang, Junfang Teng, Xinyu Zha. Ceramide induces macrophage migration inhibitory factor -mediated parthanatos in mouse neurons by increasing ROS levels. Neuroscience letters. 2022-09-08. PMID:36075319. |
ceramides, the key component of sphingolipid metabolism and second messengers, have been associated with neurodegenerative diseases progression and pathology, and can induce neuronal apoptosis and necrosis, but the effect of ceramide on parthanatos has not been fully elucidated. |
2022-09-08 |
2023-08-14 |
mouse |
| Sheikh Shohag, Shomaya Akhter, Shahidul Islam, Tonmoy Sarker, Moinuddin Khan Sifat, Md Mominur Rahman, Md Rezaul Islam, Rohit Sharm. Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review. Oxidative medicine and cellular longevity. vol 2022. 2022-09-05. PMID:36062188. |
when reactive oxygen species and antioxidants are in imbalance in our bodies, they can cause cell structure damage, neurodegenerative diseases, diabetes, hypercholesterolemia, atherosclerosis, cancer, cardiovascular diseases, metabolic disorders, and other obesity-related disorders, as well as protein misfolding, mitochondrial dysfunction, glial cell activation, and subsequent cellular apoptosis. |
2022-09-05 |
2023-08-14 |
human |
| Ye Tao, Sean X Leng, Haiyan Zhan. Ketogenic diet: an effective treatment approach for neurodegenerative diseases. Current neuropharmacology. 2022-08-31. PMID:36043794. |
this review systematically summarizes the scientific literature supporting this effective treatment approach for neurodegenerative diseases, including effects on mitochondrial function, oxidative stress, neuronal apoptosis, neuroinflammation, and the microbiota-gut-brain axis. |
2022-08-31 |
2023-08-14 |
Not clear |
| Chih-Hsiung Hsieh, Yi-Ching Wan. Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment. The Kaohsiung journal of medical sciences. 2022-08-09. PMID:35942641. |
the protein expression of gelsolin, an actin scavenger controlling cytoskeletal remodeling, cell morphology, differentiation, movement, and apoptosis, has been found to be significantly decreased in several pathological conditions including neurodegenerative diseases, inflammatory disorders, and cancers. |
2022-08-09 |
2023-08-14 |
Not clear |
| Shu-Chao Wang, Xi-Min Hu, Kun Xion. The regulatory role of Pin1 in neuronal death. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799512. |
aside from the involvement of pin1 in the apoptosis that accompanies neurodegenerative diseases, accumulating evidence suggests that pin1 also plays a role in regulated necrosis and autophagy, thereby exhibiting distinct effects, including both neurotoxic and neuroprotective effects. |
2022-07-08 |
2023-08-14 |
Not clear |
| Tim Bilbrough, Emanuele Piemontese, Oliver Seit. Dissecting the role of protein phosphorylation: a chemical biology toolbox. Chemical Society reviews. 2022-06-21. PMID:35726784. |
secondly, we showcase illustrative examples that applied these tools to answer biological questions pertaining to proteins involved in signal transduction, control of transcription, neurodegenerative diseases and aggregation, apoptosis and autophagy, and transmembrane proteins. |
2022-06-21 |
2023-08-14 |
Not clear |
| Riaz Ahmad, Amjad Khan, Inayat Ur Rehman, Hyeon Jin Lee, Ibrahim Khan, Myeong Ok Ki. Lupeol Treatment Attenuates Activation of Glial Cells and Oxidative-Stress-Mediated Neuropathology in Mouse Model of Traumatic Brain Injury. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682768. |
previous studies have established that lupeol provides neuroprotection through modulation of inflammation, oxidative stress, and apoptosis in aβ and lps model and neurodegenerative disease. |
2022-06-10 |
2023-08-14 |
mouse |
| Agnieszka Fus-Kujawa, Łukasz Sieroń, Estera Dobrzyńska, Łukasz Chajec, Barbara Mendrek, Natalia Jarosz, Łukasz Głowacki, Kamila Dubaj, Wojciech Dubaj, Agnieszka Kowalczuk, Karolina Bajdak-Rusine. Star Polymers as Non-Viral Carriers for Apoptosis Induction. Biomolecules. vol 12. issue 5. 2022-05-28. PMID:35625536. |
apoptosis is a widely controlled, programmed cell death, defects in which are the source of various diseases such as neurodegenerative diseases as well as cancer. |
2022-05-28 |
2023-08-13 |
human |
| Miguel A Jiménez-Acosta, Lory Jhenifer Rochin Hernández, Mayte Lizeth Padilla Cristerna, Marco A Meraz-Río. Mini-Review: Mesenchymal stem cells. New alternatives for nervous system disorders. Current stem cell research & therapy. 2022-05-13. PMID:35546750. |
these cells could facilitate functional recovery in multiple models of neurodegenerative diseases and nervous system injuries by using their trophic capacities, reducing inflammation in the injured area, reducing apoptosis, and enhancing endogenous neurogenesis through the secretion of bioactive factors. |
2022-05-13 |
2023-08-13 |
Not clear |
| Rui Han, Yao Yu, Kanghong Zhao, Jing Wei, Yuhu Hui, Jin-Ming Ga. Lignans from Eucommia ulmoides Oliver leaves exhibit neuroprotective effects via activation of the PI3K/Akt/GSK-3β/Nrf2 signaling pathways in H Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 101. 2022-04-29. PMID:35487038. |
lignans from eucommia ulmoides oliver leaves exhibit neuroprotective effects via activation of the pi3k/akt/gsk-3β/nrf2 signaling pathways in h neuronal apoptosis and oxidative stress have the most crucial influence on neurodegenerative diseases, including parkinson's disease. |
2022-04-29 |
2023-08-13 |
rat |
| Xiaoting Dang, Xuejie Huan, Xixun Du, Xi Chen, Mingxia Bi, Chunling Yan, Qian Jiao, Hong Jian. Correlation of Ferroptosis and Other Types of Cell Death in Neurodegenerative Diseases. Neuroscience bulletin. 2022-04-28. PMID:35482278. |
this review focuses on current research on ferroptosis and summarizes the cross-talk among ferroptosis, apoptosis, and autophagy that are implicated in neurodegenerative diseases. |
2022-04-28 |
2023-08-13 |
Not clear |
| Christy Lite, Ajay Guru, Melita Juliet, Jesu Arockiara. Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety-like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae. Environmental toxicology. 2022-04-26. PMID:35470536. |
the primary cause for the impairment in cognitive and emotional neurobehvioural outcomes in neurodegenerative disease was found to be associated with neuronal apoptosis. |
2022-04-26 |
2023-08-13 |
human |
| Elle E M Scheijen, David M Wilso. Genome Integrity and Neurological Disease. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35456958. |
while the precise molecular mechanisms that underlie neuronal cell loss remain under debate, evidence indicates that the accumulation of genomic dna damage and consequent cellular responses can promote apoptosis and neurodegenerative disease. |
2022-04-23 |
2023-08-13 |
Not clear |
| Dhiraj Kumar, Md Imtaiyaz Hassa. Targeted protein degraders march towards the clinic for neurodegenerative diseases. Ageing research reviews. 2022-04-04. PMID:35378298. |
researchers strive to develop clinical candidates employing chemical degraders' technologies, including hydrophobic tagging, molecular glues, proteolysis targeting chimeras (protacs), specific and nongenetic inhibitor of apoptosis protein (iap)-dependent protein erasers (snipers), autophagy targeted chimeras, and autophagosome-tethered compounds for targeted degradation of pathological markers in neurodegenerative disease. |
2022-04-04 |
2023-08-13 |
Not clear |
| Luis Varela, Maria E R Garcia-Renduele. Oncogenic Pathways in Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328644. |
however, whereas in cancer, these alterations lead to cell survival and proliferation, neurodegenerative diseases trigger cell death and apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |