| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tuladhar Sunanda, Bipul Ray, Arehally M Mahalakshmi, Abid Bhat, Luay Rashan, Wiramon Rungratanawanich, Byoung-Joon Song, Musthafa Mohamed Essa, Meena Kishore Sakharkar, Saravana Babu Chidambara. Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson's Disease: The Role of Brain Renin Angiotensin System Components. Biomolecules. vol 11. issue 11. 2021-11-30. PMID:34827667. |
various reports indicate the detrimental involvement of the brain renin-angiotensin system (ras) in oxidative stress, neuroinflammation, and apoptosis in various neurodegenerative diseases. |
2021-11-30 |
2023-08-13 |
Not clear |
| Marina Betancor, Laura Moreno-Martínez, Óscar López-Pérez, Alicia Otero, Adelaida Hernaiz, Tomás Barrio, Juan José Badiola, Rosario Osta, Rosa Bolea, Inmaculada Martín-Burrie. Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease. Molecular neurobiology. vol 58. issue 10. 2021-11-27. PMID:34283400. |
previous in vivo studies have demonstrated the ability of this molecule to increase mice survival, inhibit apoptosis and regulate autophagy in murine models of neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. |
2021-11-27 |
2023-08-13 |
mouse |
| Rohan Gupta, Rashmi K Ambasta, Pravir Kuma. Multifaced role of protein deacetylase sirtuins in neurodegenerative disease. Neuroscience and biobehavioral reviews. 2021-11-21. PMID:34742724. |
sirtuins regulate biological and cellular processes, for instance, mitochondrial biogenesis, lipid and fatty acid oxidation, oxidative stress, gene transcriptional activity, apoptosis, inflammatory response, dna repair mechanism, and autophagic cell degradation, which are known components for the progression of the neurodegenerative diseases (ndds). |
2021-11-21 |
2023-08-13 |
Not clear |
| Emily A Borden, Matthew Furey, Nicholas J Gattone, Vedangi D Hambardikar, Xiao Hua Liang, Ernest R Scoma, Antonella Abou Samra, LaKeshia R D-Gary, Dayshaun J Dennis, Daniel Fricker, Cindy Garcia, ZeCheng Jiang, Shariq A Khan, Dheenadhayalan Kumarasamy, Hasmitha Kuppala, Savannah Ringrose, Evan J Rosenheim, Kimberly Van Exel, Hemanth Sai Vudhayagiri, Jiarui Zhang, Zhaowen Zhang, Mariona Guitart-Mampel, Pedro Urquiza, Maria E Solesi. Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration? Pharmacological research. vol 163. 2021-11-17. PMID:33010423. |
mitochondrial dysfunction - including increased apoptosis, calcium and protein dyshomeostasis within the organelle, and dysfunctional bioenergetics and oxidative status - is a common, early feature in all the major neurodegenerative diseases, including alzheimer's disease (ad) and parkinson's disease (pd). |
2021-11-17 |
2023-08-13 |
Not clear |
| Huimin Dong, Qian Sun, Ying Zhang, Yuntao Li, Fan'en Yuan, Shanping Mao, Baohui Li. Genetic deletion of Rnd3 suppresses apoptosis through NF‑κB signaling in the brain. Oncology reports. vol 45. issue 2. 2021-11-15. PMID:33416158. |
the present study suggested an alternative approach for the treatment of neurodegenerative diseases through regulation of apoptosis via the rnd3‑nf‑κb p65 signaling pathway in the central nervous system. |
2021-11-15 |
2023-08-13 |
mouse |
| Courtney MacMullen, Ronald L Davi. High-Throughput Phenotypic Assay for Compounds That Influence Mitochondrial Health Using iPSC-Derived Human Neurons. SLAS discovery : advancing life sciences R & D. vol 26. issue 6. 2021-11-15. PMID:33724077. |
most brain disorders, including neurodegenerative diseases, share the common neuropathology of mitochondria dysfunction, which can lead to apoptosis of neurons, overproduction of reactive oxygen species (ros), and other cellular neuropathologies characteristic of these diseases. |
2021-11-15 |
2023-08-13 |
human |
| Yongjie Xu, Shengju Liu, Liying Zhu, Longguang Dai, Wen Qian, Jingzhi Zhang, Xing Li, Wei Pa. Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling. Molecular medicine reports. vol 24. issue 2. 2021-11-12. PMID:34132368. |
in neurodegenerative diseases, including alzheimer's disease and parkinson's disease, activation of the jnk signaling pathway promotes neuronal apoptosis. |
2021-11-12 |
2023-08-13 |
rat |
| Tingting Wan, Xiudan Li, Yanbo L. The role of TRIM family proteins in autophagy, pyroptosis, and diabetes mellitus. Cell biology international. vol 45. issue 5. 2021-11-08. PMID:33438267. |
tripartite motif-containing (trim) family proteins are the richest subfamily of really interesting new gene e3 ubiquitin ligases, which play a critical role not only in many biological processes, including proliferation, apoptosis, pyroptosis, innate immunity, and autophagy, but also many diseases like cancer, diabetes mellitus, and neurodegenerative disease. |
2021-11-08 |
2023-08-13 |
Not clear |
| Rizwana Qadri, Vinay Goyal, Madhuri Behari, Arulselvi Subramanian, Sudip Kumar Datta, Asok Kumar Mukhopadhya. Alteration of Mitochondrial Function in Oxidative Stress in Parkinsonian Neurodegeneration: A Cross-Sectional Study. Annals of Indian Academy of Neurology. vol 24. issue 4. 2021-11-05. PMID:34728942. |
mitochondrial dysfunction initiates neuronal apoptosis thereby leading to neurodegenerative diseases including parkinson's disease (pd). |
2021-11-05 |
2023-08-13 |
Not clear |
| Wenli Dai, Jin Cheng, Xi Leng, Xiaoqing Hu, Yingfang A. The potential role of necroptosis in clinical diseases (Review). International journal of molecular medicine. vol 47. issue 5. 2021-11-03. PMID:33786617. |
as an important type of programmed cell death in addition to apoptosis, necroptosis occurs in a variety of pathophysiological processes, including infections, liver diseases, kidney injury, neurodegenerative diseases, cardiovascular diseases, and human tumors. |
2021-11-03 |
2023-08-13 |
human |
| Gülgün Teze. Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects. Cells. vol 10. issue 6. 2021-10-29. PMID:34199494. |
glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal ganglion cell (rgc) somas, degeneration of axons, and loss of synapses at dendrites and axon terminals. |
2021-10-29 |
2023-08-13 |
Not clear |
| John Sieh Dumbuya, Lu Chen, Jang-Yen Wu, Bin Wan. The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status. Journal of neuroinflammation. vol 18. issue 1. 2021-10-27. PMID:33612099. |
extensive studies both in vivo and ex vivo have shown the neuroprotective effect of g-csf in neurodegenerative diseases and neonatal brain damage via inhibition of apoptosis and inflammation. |
2021-10-27 |
2023-08-13 |
Not clear |
| Daniel L Morris, Nico Tjandr. Inducible fold-switching as a mechanism to fibrillate pro-apoptotic BCL-2 proteins. Biopolymers. vol 112. issue 10. 2021-10-26. PMID:33764501. |
neurodegenerative diseases often are associated with cellular dysregulation that results in premature cell death or apoptosis. |
2021-10-26 |
2023-08-13 |
Not clear |
| Qi Wu, Zhi-Han Tang, Juan Peng, Ling Liao, Li-Hong Pan, Chun-Yan Wu, Zhi-Sheng Jiang, Gui-Xue Wang, Lu-Shan Li. The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer's disease progression (Review). Biomedical reports. vol 2. issue 2. 2021-10-21. PMID:24649090. |
neuronal apoptosis is crucial in neurodegenerative diseases. |
2021-10-21 |
2023-08-12 |
human |
| Qi Wu, Zhi-Han Tang, Juan Peng, Ling Liao, Li-Hong Pan, Chun-Yan Wu, Zhi-Sheng Jiang, Gui-Xue Wang, Lu-Shan Li. The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer's disease progression (Review). Biomedical reports. vol 2. issue 2. 2021-10-21. PMID:24649090. |
human and animal studies demonstrated that a high concentration of oxidized ldl (ox-ldl) in the brain, which is associated with hyperlipidemia, is one of the key apoptosis inducers in neurodegenerative diseases. |
2021-10-21 |
2023-08-12 |
human |
| Qi Wu, Zhi-Han Tang, Juan Peng, Ling Liao, Li-Hong Pan, Chun-Yan Wu, Zhi-Sheng Jiang, Gui-Xue Wang, Lu-Shan Li. The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer's disease progression (Review). Biomedical reports. vol 2. issue 2. 2021-10-21. PMID:24649090. |
aβ is another key apoptosis inducer in neurodegenerative diseases. |
2021-10-21 |
2023-08-12 |
human |
| Altmash Khan, Gifty Kuriachan, Radhakrishnan Mahalakshm. Cellular Interactome of Mitochondrial Voltage-Dependent Anion Channels: Oligomerization and Channel (Mis)Regulation. ACS chemical neuroscience. vol 12. issue 19. 2021-10-21. PMID:34503333. |
however, research findings in the past decade have revealed the multifaceted regulatory roles of vdacs, from governing cellular physiology and mitochondria-mediated apoptosis to directly regulating debilitating cancers and neurodegenerative diseases. |
2021-10-21 |
2023-08-13 |
human |
| Srikanth Ranganathan, Robert Bowse. p53 and Cell Cycle Proteins Participate in Spinal Motor Neuron Cell Death in ALS. The open pathology journal. vol 4. 2021-10-20. PMID:21572928. |
apoptosis has been implicated in many neurodegenerative diseases, including amyotrophic lateral sclerosis (als). |
2021-10-20 |
2023-08-12 |
human |
| Chong Xu, Sujuan Chen, Ming Xu, Xiaoling Chen, Xiaoxue Wang, Hai Zhang, Xiaoqing Dong, Ruijie Zhang, Xin Chen, Wei Gao, Shile Huang, Long Che. Cadmium Impairs Autophagy Leading to Apoptosis by Ca Neurochemical research. vol 46. issue 8. 2021-10-18. PMID:34021889. |
cadmium impairs autophagy leading to apoptosis by ca autophagy, a process for self-degradation of intracellular components and dysfunctional organelles, is closely related with neurodegenerative diseases. |
2021-10-18 |
2023-08-13 |
Not clear |
| Łucja Justyna Walczak-Nowicka, Mariola Herbe. Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis. International journal of molecular sciences. vol 22. issue 17. 2021-10-18. PMID:34502198. |
acetylcholinesterase (ache) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. |
2021-10-18 |
2023-08-13 |
Not clear |