| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
qiangji decoction alleviates neurodegenerative changes and hippocampal neuron apoptosis induced by d-galactose qiangji decoction (qjd), a classic formula, has been widely used to treat brain aging-related neurodegenerative diseases. |
2021-10-12 |
2023-08-13 |
mouse |
| Bhawna Pandey, Aditya Dev, Debamitra Chakravorty, Vishwambhar Vishnu Bhandare, Smarajit Polley, Siddhartha Roy, Gautam Bas. Insights on the disruption of the complex between human positive coactivator 4 and p53 by small molecules. Biochemical and biophysical research communications. vol 578. 2021-10-11. PMID:34534740. |
in certain neurodegenerative diseases pc4 assisted-p53-dependent apoptosis may play a central role. |
2021-10-11 |
2023-08-13 |
human |
| Fei Wang, Juan Li, Shengjie Fan, Zhigang Jin, Cheng Huan. Targeting stress granules: A novel therapeutic strategy for human diseases. Pharmacological research. vol 161. 2021-09-01. PMID:32814168. |
sgs participate in various biological functions including response to apoptosis, inflammation, immune modulation, and signalling pathways; moreover, sgs are involved in pathogenesis of neurodegenerative diseases, viral infection, aging, cancers and many other diseases. |
2021-09-01 |
2023-08-13 |
human |
| Haifan Gong, Julia Bandura, Guan-Lei Wang, Zhong-Ping Feng, Hong-Shuo Su. Xyloketal B: A marine compound with medicinal potential. Pharmacology & therapeutics. 2021-08-18. PMID:34375691. |
xyloketal b and its derivatives exhibit cytoprotective effects in cardiovascular and neurodegenerative diseases by reducing oxidative stress, regulating the apoptosis pathway, maintaining ionic balance, mitigating inflammatory responses, and preventing protein aggregation. |
2021-08-18 |
2023-08-13 |
Not clear |
| Zhonghao Su, Lanyue Sheng, Ping Yu, Na Ren, Yajuan Li, Zhenxia Qi. Regulation of microRNAs by IRE1α in apoptosis: implications for the pathomechanism of neurodegenerative diseases. The International journal of neuroscience. vol 130. issue 12. 2021-08-16. PMID:32070174. |
regulation of micrornas by ire1α in apoptosis: implications for the pathomechanism of neurodegenerative diseases. |
2021-08-16 |
2023-08-13 |
Not clear |
| Zhonghao Su, Lanyue Sheng, Ping Yu, Na Ren, Yajuan Li, Zhenxia Qi. Regulation of microRNAs by IRE1α in apoptosis: implications for the pathomechanism of neurodegenerative diseases. The International journal of neuroscience. vol 130. issue 12. 2021-08-16. PMID:32070174. |
this review provides an overview of recent progress in unfolded protein response (upr) during apoptosis induced by abnormal protein aggregation and emphasizes on the potential role of inositol requiring enzyme 1 alpha (ire1α)-micrornas (mirnas) mediated apoptosis in nds, which will provide new insights in the pathogenesis of neurodegenerative diseases and novel therapeutic targets for the treatment of nds. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yanting Shen, Jing Yue, Weiqing Xu, Shuping X. Recent progress of surface-enhanced Raman spectroscopy for subcellular compartment analysis. Theranostics. vol 11. issue 10. 2021-08-16. PMID:33754033. |
organelles are involved in many cell life activities, and their metabolic or functional disorders are closely related to apoptosis, neurodegenerative diseases, cardiovascular diseases, and the development and metastasis of cancers. |
2021-08-16 |
2023-08-13 |
Not clear |
| V L Shliapina, S V Yurtaeva, M P Rubtsova, O A Dontsov. At the Crossroads: Mechanisms of Apoptosis and Autophagy in Cell Life and Death. Acta naturae. vol 13. issue 2. 2021-08-12. PMID:34377561. |
the signaling pathways involved in the regulation of apoptosis and autophagy largely overlap, leading to both competition and unidirectional interaction, which is of particular interest in investigating them as potential targets for cancer, autoimmune, and neurodegenerative disease therapies. |
2021-08-12 |
2023-08-13 |
Not clear |
| Jianhua Su, Junhua Zhang, Rui Bao, Changbo Xia, Yu Zhang, Zhujun Zhu, Qi Lv, Yingjie Qi, Jianqin Xu. Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK/GSK-3β/PP2A pathway in Parkinson's disease. European journal of pharmacology. vol 907. 2021-08-03. PMID:34048739. |
adenosine 5'-monophosphate-activated protein kinase (ampk), glycogen synthase kinase 3 (gsk-3β) and protein phosphatase 2a (pp2a) are all key proteins that regulate mitochondrial metabolism and apoptosis, and they are involved in a variety of neurodegenerative diseases. |
2021-08-03 |
2023-08-13 |
mouse |
| Juepu Zhou, Yao Jin, Yuhong Lei, Tianyi Liu, Zheng Wan, Hao Meng, Honglei Wan. Ferroptosis Is Regulated by Mitochondria in Neurodegenerative Diseases. Neuro-degenerative diseases. vol 20. issue 1. 2021-08-02. PMID:32814328. |
previous research has revealed that many forms of cell death, such as apoptosis and necrosis, occur in neurodegenerative diseases. |
2021-08-02 |
2023-08-13 |
Not clear |
| Mei L. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis : an international journal on programmed cell death. vol 26. issue 5-6. 2021-07-27. PMID:33783663. |
the role of p53 up-regulated modulator of apoptosis (puma) in ovarian development, cardiovascular and neurodegenerative diseases. |
2021-07-27 |
2023-08-13 |
Not clear |
| Mei L. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis : an international journal on programmed cell death. vol 26. issue 5-6. 2021-07-27. PMID:33783663. |
it also induces excessive apoptosis in cardiovascular and/or neurodegenerative diseases. |
2021-07-27 |
2023-08-13 |
Not clear |
| Manas Ranjan Sahu, Amal Chandra Monda. The emerging role of Hippo signaling in neurodegeneration. Journal of neuroscience research. vol 98. issue 5. 2021-07-14. PMID:31705587. |
however, aberrant and unrestricted apoptosis can lead to a variety of degenerative conditions including neurodegenerative diseases. |
2021-07-14 |
2023-08-13 |
drosophila_melanogaster |
| Zhi-Tong Zhang, Guang-Xiao Huang, Wen-Jiao He, Wen-Ting Gu, Xue Wang, Zhi-Quan Chen, Fu-Jun Bi, Lu-Yong Zhang, Shu-Mei Wang, Dan Tan. Rapid screening of neuroprotective components from Huang-Lian-Jie-Du Decoction by living cell biospecific extraction coupled with HPLC-Q-Orbitrap-HRMS/MS analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1176. 2021-07-12. PMID:34052562. |
furthermore, three representative compounds named baicalin, wogonoside, and berberine were subsequently verified to exert cytoprotective effects on pc12 cells injured by hydrogen peroxide via inhibiting oxidative stress and cell apoptosis, indicating that these screened compounds may possess a potential for the treatment of neurodegenerative diseases and were responsible, in part at least, for the neuroprotective beneficial effects of hljdd. |
2021-07-12 |
2023-08-13 |
Not clear |
| Zahra Asefy, Sirus Hoseinnejhad, Zaker Cefero. Nanoparticles approaches in neurodegenerative diseases diagnosis and treatment. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 7. 2021-07-09. PMID:33846881. |
current neurodegenerative diseases treatment protocols only help to treat symptoms nevertheless with nanotechnology approaches, can regress nerve cells apoptosis, reduce inflammation, and improve brain drug delivery. |
2021-07-09 |
2023-08-13 |
Not clear |
| Wanqing Du, Xiangjun Di, Qian Peter S. Studying Mitochondrial Network Formation by In Vivo and In Vitro Reconstitution Assay. Methods in molecular biology (Clifton, N.J.). vol 2276. 2021-07-08. PMID:34060053. |
the disruption of the mitochondrial network affects mitochondrial functions, such as atp production, integration of metabolism, calcium homeostasis, and regulation of apoptosis, leading to the abnormal development and several human diseases including neurodegenerative disease. |
2021-07-08 |
2023-08-13 |
human |
| Jordane Preto, Isabelle Krim. The intrinsically disordered N-terminus of the voltage-dependent anion channel. PLoS computational biology. vol 17. issue 2. 2021-07-06. PMID:33577583. |
in addition, vdac plays a central role in the control of apoptosis and is therefore of great interest in both cancer and neurodegenerative diseases. |
2021-07-06 |
2023-08-13 |
Not clear |
| Jin-Ha Choi, Jeong-Woo Cho. Metal-Enhanced Fluorescence by Bifunctional Au Nanoparticles for Highly Sensitive and Simple Detection of Proteolytic Enzyme. Nano letters. vol 20. issue 10. 2021-06-24. PMID:32809833. |
although fluorescence-based analytical methods have been used in intracellular analyses, their sensitivity is low for the precise analysis of intracellular proteolytic enzymes to observe cell apoptosis related to cancer and neurodegenerative diseases. |
2021-06-24 |
2023-08-13 |
Not clear |
| Mitchell J Brun, Kefan Song, Byunguk Kang, Cooper Lueck, Weitong Chen, Kaitlyn Thatcher, Erhe Gao, Walter J Koch, Joy Lincoln, Sudarsan Rajan, Junghae Su. Constructing and evaluating caspase-activatable adeno-associated virus vector for gene delivery to the injured heart. Journal of controlled release : official journal of the Controlled Release Society. vol 328. 2021-06-17. PMID:33157191. |
here, we have designed a provector that is activated by cysteine aspartic proteases (caspases), which have roles in inflammation and apoptosis and thus are elevated at sites of diseases such as heart failure, neurodegenerative diseases, and ischemic stroke. |
2021-06-17 |
2023-08-13 |
Not clear |
| Shao-Peng Lin, Jiasong Hu, Jue-Xian Wei, Shan Ye, Jingyi Bu, Weiqiang Xu, Shishi Chen, Yi Wu, Guohao Wu, Lidong Zhu, Pei-Yi Lin, Xiao-Hui Che. Silencing of circFoxO3 Protects HT22 Cells from Glutamate-Induced Oxidative Injury via Regulating the Mitochondrial Apoptosis Pathway. Cellular and molecular neurobiology. vol 40. issue 7. 2021-06-11. PMID:32140899. |
collectively, our study demonstrates that endogenous circfoxo3 plays a key role in inducing apoptosis and neuronal cell death and may act as a novel therapeutic target for neurodegenerative diseases. |
2021-06-11 |
2023-08-13 |
human |