| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F G Blankenberg, J F Tait, H W Straus. Apoptotic cell death: its implications for imaging in the next millennium. European journal of nuclear medicine. vol 27. issue 3. 2000-05-18. PMID:10774891. |
thereafter an outline is provided of the role of apoptosis in the pathophysiology of clinical disorders including stroke, neurodegenerative diseases, pulmonary inflammatory diseases, myocardial ischemia and inflammation, myelodysplastic disorders, organ transplantation, and oncology, in which imaging may play a critical role in diagnosis and patient management. |
2000-05-18 |
2023-08-12 |
human |
| C L Wellington, M R Hayde. Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches. Clinical genetics. vol 57. issue 1. 2000-04-28. PMID:10733228. |
unregulated apoptosis underlies many pathological conditions, including neurodegenerative diseases. |
2000-04-28 |
2023-08-12 |
Not clear |
| L F Jarskog, J H Gilmor. Developmental expression of Bcl-2 protein in human cortex. Brain research. Developmental brain research. vol 119. issue 2. 2000-04-11. PMID:10675772. |
apoptosis is essential for normal human neurodevelopment and is increasingly recognized for its role in various neurodegenerative diseases such as alzheimer's and parkinson's diseases. |
2000-04-11 |
2023-08-12 |
human |
| G W Glazner, M P Mattso. Differential effects of BDNF, ADNF9, and TNFalpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity. Experimental neurology. vol 161. issue 2. 2000-03-29. PMID:10686066. |
calcium influx through n-methyl-d-aspartate (nmda) receptors can result in neuronal apoptosis or necrosis and may play a pivotal role in neuronal death in many different neurodegenerative diseases. |
2000-03-29 |
2023-08-12 |
Not clear |
| H R Warne. Apoptosis: a two-edged sword in aging. Anticancer research. vol 19. issue 4B. 2000-02-15. PMID:10652562. |
of particular importance are the roles of apoptosis in reducing cancer incidence, and in promoting neurodegenerative disease. |
2000-02-15 |
2023-08-12 |
Not clear |
| F Terro, F Esclaire, C Yardin, J Hugo. N-methyl-D-aspartate receptor blockade enhances neuronal apoptosis induced by serum deprivation. Neuroscience letters. vol 278. issue 3. 2000-02-15. PMID:10653015. |
neuronal apoptosis a hallmark of brain development could also be involved in neurodegenerative diseases. |
2000-02-15 |
2023-08-12 |
rat |
| J V Leonard, A H Schapir. Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects. Lancet (London, England). vol 355. issue 9201. 2000-02-15. PMID:10665569. |
the mitochondrion's role in apoptosis and its contribution to the pathogenesis of neurodegenerative diseases are also covered. |
2000-02-15 |
2023-08-12 |
Not clear |
| N Canu, C Barbato, M T Ciotti, A Serafino, L Dus, P Calissan. Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632588. |
the finding that the proteasomes are early involved in apoptosis and that ubiquitinated proteins accumulate during this process prospect granule neurons as a model system aimed at correlating these events with neurodegenerative diseases. |
2000-02-09 |
2023-08-12 |
Not clear |
| P S Sastry, K S Ra. Apoptosis and the nervous system. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617101. |
apoptosis is now recognized as a normal feature in the development of the nervous system and may also play a role in neurodegenerative diseases and aging. |
2000-01-18 |
2023-08-12 |
Not clear |
| J Y Follézou, J Emerit, F Bricair. [Neuro-degenerative diseases: role of reactive oxygen species and of apoptosis]. Presse medicale (Paris, France : 1983). vol 28. issue 30. 1999-11-09. PMID:10544701. |
neuron death: major progress in our understanding of the pathophysiology of neurodegenerative diseases has greatly benefited from the convergence between work devoted to reactive oxygen species (including nitric oxide) and programmed cell death, or apoptosis, and exitotoxicity. |
1999-11-09 |
2023-08-12 |
mouse |
| J Y Follézou, J Emerit, F Bricair. [Neuro-degenerative diseases: role of reactive oxygen species and of apoptosis]. Presse medicale (Paris, France : 1983). vol 28. issue 30. 1999-11-09. PMID:10544701. |
other chronic conditions: based on evidence from the mouse model, apoptosis, excitotoxicity and oxygenated free radicals could play a causal role in other neurodegenerative diseases including hiv-related encephalopathy, parkinsonís disease and alzheimerís disease. |
1999-11-09 |
2023-08-12 |
mouse |
| A M Gleckman, Z Jiang, Y Liu, T W Smit. Neuronal and glial DNA fragmentation in Pick's disease. Acta neuropathologica. vol 98. issue 1. 1999-09-24. PMID:10412801. |
evidence from other neurodegenerative diseases has suggested that dna damage and apoptosis may play a major role in cellular degeneration and death. |
1999-09-24 |
2023-08-12 |
Not clear |
| M A Sirove. New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase. Biochimica et biophysica acta. vol 1432. issue 2. 1999-08-20. PMID:10407139. |
furthermore, other investigations suggest that gapdh is involved in apoptosis, age-related neurodegenerative disease, prostate cancer and viral pathogenesis. |
1999-08-20 |
2023-08-12 |
Not clear |
| P P Michel, N Lambeng, M Ruber. Neuropharmacologic aspects of apoptosis: significance for neurodegenerative diseases. Clinical neuropharmacology. vol 22. issue 3. 1999-07-21. PMID:10367178. |
neuropharmacologic aspects of apoptosis: significance for neurodegenerative diseases. |
1999-07-21 |
2023-08-12 |
Not clear |
| R Seidl, S Fang-Kircher, B Bidmon, N Cairns, G Lube. Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027687. |
upregulation of p53 and apo-1/fas (cd95) precedes apoptosis in many cell types, and a potential role for these molecules has already been demonstrated in alzheimer's disease (ad) and several other neurodegenerative diseases. |
1999-06-18 |
2023-08-12 |
Not clear |
| P Klevenyi, O Andreassen, R J Ferrante, J R Schleicher, R M Friedlander, M F Bea. Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport. vol 10. issue 3. 1999-06-10. PMID:10208603. |
increasing evidence implicates apoptosis as a major mechanism of cell death in neurodegenerative diseases. |
1999-06-10 |
2023-08-12 |
mouse |
| R M Friedlander, J Yua. ICE, neuronal apoptosis and neurodegeneration. Cell death and differentiation. vol 5. issue 10. 1999-05-06. PMID:10203693. |
understanding the basic mechanisms mediating cell death in neurodegenerative disease may lead to the development of novel approaches for the treatment of diseases featuring apoptosis. |
1999-05-06 |
2023-08-12 |
Not clear |
| M Grilli, M Mem. Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. Cell death and differentiation. vol 6. issue 1. 1999-04-29. PMID:10200544. |
apoptosis is now recognized as an important component in many progressive and acute neurodegenerative diseases. |
1999-04-29 |
2023-08-12 |
Not clear |
| M Grilli, M Mem. Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. Cell death and differentiation. vol 6. issue 1. 1999-04-29. PMID:10200544. |
identification of such mechanisms could be relevant for understanding the apoptosis associated with various neurodegenerative diseases as well as for developing novel strategies of pharmacological intervention. |
1999-04-29 |
2023-08-12 |
Not clear |
| D L Gelowitz, I A Paterso. Neuronal sparing and behavioral effects of the antiapoptotic drug, (-)deprenyl, following kainic acid administration. Pharmacology, biochemistry, and behavior. vol 62. issue 2. 1999-04-26. PMID:9972692. |
given deprenyl's antiapoptotic actions, it is proposed that (-)deprenyl may be beneficial in the treatment of a variety of neurodegenerative diseases where evidence of apoptosis exists, such as parkinson's and alzheimer's disease, by slowing the disease process itself. |
1999-04-26 |
2023-08-12 |
human |