| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Sorisky, R Magun, A M Gagno. Adipose cell apoptosis: death in the energy depot. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 24 Suppl 4. 2001-03-15. PMID:11126237. |
apoptosis is critical for mammalian tissue homeostasis, and its disruption has been linked to a wide variety of disorders, including cancer, neurodegenerative disease, autoimmune disease and diabetes. |
2001-03-15 |
2023-08-12 |
Not clear |
| D Offen, H Elkon, E Melame. Apoptosis as a general cell death pathway in neurodegenerative diseases. Journal of neural transmission. Supplementum. issue 58. 2001-02-22. PMID:11128605. |
apoptosis as a general cell death pathway in neurodegenerative diseases. |
2001-02-22 |
2023-08-12 |
human |
| C Schaper, Y Zhu, M Kouklei, C Culmsee, J Krieglstei. Stimulation of 5-HT(1A) receptors reduces apoptosis after transient forebrain ischemia in the rat. Brain research. vol 883. issue 1. 2001-02-01. PMID:11063986. |
since there is increasing evidence that apoptosis is involved in neurodegenerative diseases and stroke, we investigated whether the 5-ht(1a) agonist bay x 3702 could protect neurons against apoptotic damage in a rat model of transient forebrain cerebral ischemia. |
2001-02-01 |
2023-08-12 |
rat |
| Y H Chung, C Shin, M J Kim, B Lee, K H Park, C I Ch. Immunocytochemical study on the distribution of p53 in the hippocampus and cerebellum of the aged rat. Brain research. vol 885. issue 1. 2001-01-25. PMID:11121541. |
recent studies suggest that p53-associated apoptosis may be a common mechanism of cell loss in several important neurodegenerative diseases. |
2001-01-25 |
2023-08-12 |
rat |
| P T Danie. Dissecting the pathways to death. Leukemia. vol 14. issue 12. 2001-01-25. PMID:11187890. |
therapeutic applications of apoptosis manipulation include (1) the inhibition of caspases in acute and chronic neurodegenerative diseases, ie stroke, alzheimer's or huntington's disease by drugs and (2) sensitization of cancer cells for drug/radiation-induced apoptosis by modulation of survival signals and viral transfer of apoptosis promoting genes. |
2001-01-25 |
2023-08-12 |
Not clear |
| M Naoi, W Maruyama, Y Akao, J Zhang, H Parve. Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons. Toxicology. vol 153. issue 1-3. 2001-01-03. PMID:11090952. |
these results are discussed in relation to the role of apoptosis in neurodegenerative diseases and the involvement of the endogenous toxin in the pathogenesis of parkinson's disease. |
2001-01-03 |
2023-08-12 |
human |
| H P Deigner, U Haberkorn, R Kinscher. Apoptosis modulators in the therapy of neurodegenerative diseases. Expert opinion on investigational drugs. vol 9. issue 4. 2000-12-14. PMID:11060707. |
apoptosis modulators in the therapy of neurodegenerative diseases. |
2000-12-14 |
2023-08-12 |
human |
| P Nicoter. Caspase requirement for neuronal apoptosis and neurodegeneration. IUBMB life. vol 49. issue 5. 2000-12-07. PMID:10902574. |
the possibility of inhibiting apoptosis as strategy to treat neurodegenerative disease is discussed in this review. |
2000-12-07 |
2023-08-12 |
Not clear |
| P C Kam, N I Ferc. Apoptosis: mechanisms and clinical implications. Anaesthesia. vol 55. issue 11. 2000-12-06. PMID:11069335. |
excessive apoptosis is associated with ischaemic heart disease, stroke, neurodegenerative disease, sepsis and multiple organ dysfunction syndrome. |
2000-12-06 |
2023-08-12 |
Not clear |
| Y Sagot, N Toni, D Perrelet, S Lurot, B King, H Rixner, L Mattenberger, P C Waldmeier, A C Kat. An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. British journal of pharmacology. vol 131. issue 4. 2000-12-05. PMID:11030721. |
apoptosis and mitochondrial dysfunction are thought to be involved in the aetiology of neurodegenerative diseases. |
2000-12-05 |
2023-08-12 |
mouse |
| S Martin, F Vallett. [Apoptosis and pathologies of the central nervous system]. Neuro-Chirurgie. vol 46. issue 4. 2000-11-30. PMID:11015674. |
in the past years, the involvement of apoptosis has been shown not only during the embryonic development of the nervous system, but also in neurodegenerative diseases. |
2000-11-30 |
2023-08-12 |
Not clear |
| J Yuan, B A Yankne. Apoptosis in the nervous system. Nature. vol 407. issue 6805. 2000-11-07. PMID:11048732. |
neuronal apoptosis sculpts the developing brain and has a potentially important role in neurodegenerative diseases. |
2000-11-07 |
2023-08-12 |
Not clear |
| J Ham, A Eilers, J Whitfield, S J Neame, B Sha. c-Jun and the transcriptional control of neuronal apoptosis. Biochemical pharmacology. vol 60. issue 8. 2000-10-31. PMID:11007936. |
there has been considerable interest in the molecular mechanisms of apoptosis in mammalian neurons because this form of neuronal cell death is important for the normal development of the nervous system and because inappropriate neuronal apoptosis may contribute to the pathology of human neurodegenerative diseases. |
2000-10-31 |
2023-08-12 |
mouse |
| A R Saha, N N Ninkina, D P Hanger, B H Anderton, A M Davies, V L Buchma. Induction of neuronal death by alpha-synuclein. The European journal of neuroscience. vol 12. issue 8. 2000-10-19. PMID:10971650. |
however, there is growing evidence that neuronal apoptosis in the absence of obvious pathological deposits could have a serious impact on the pathogenesis of neurodegenerative diseases. |
2000-10-19 |
2023-08-12 |
Not clear |
| V Máximo, M Sobrinho-Simõe. Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Virchows Archiv : an international journal of pathology. vol 437. issue 2. 2000-10-02. PMID:10993269. |
the molecular and enzymatic abnormalities of mitochondria in oxyphilic / oncocytic / hürthle cells and their respective tumours are reviewed in a series of sections: "mitochondria, ageing, neurodegenerative diseases and cancer", "mitochondrial abnormalities in hürthle cells and hürthle cells tumours", "mitochondrion-related alterations in tumours with and without hürthle cell/oncocytic features", "true and secondary oxyphilia", and "bcl-2 expression, apoptosis and necrosis in hürthle cell tumours and tumour-like lesions". |
2000-10-02 |
2023-08-12 |
Not clear |
| M Shimura, Y Osawa, A Yuo, K Hatake, F Takaku, Y Ishizak. Oxidative stress as a necessary factor in room temperature-induced apoptosis of HL-60 cells. Journal of leukocyte biology. vol 68. issue 1. 2000-08-17. PMID:10914494. |
taken together with the reports that some burkitt lymphoma cells showed apoptosis when exposed at low temperature followed by rewarming, and that hepatocytes or liver endothelial cells are susceptible to cold-induced apoptosis through the ros function, we propose that studying the mechanism of rt-induced apoptosis of hl-60 cells may provide a therapeutic strategy for pathological conditions involving ros, such as neurodegenerative diseases and ischemia. |
2000-08-17 |
2023-08-12 |
Not clear |
| S Afford, S Randhaw. Apoptosis. Molecular pathology : MP. vol 53. issue 2. 2000-07-19. PMID:10889903. |
in humans, dysregulation of apoptosis can result in inflammatory, malignant, autoimmune, and neurodegenerative diseases. |
2000-07-19 |
2023-08-12 |
Not clear |
| G S Robertson, S J Crocker, D W Nicholson, J B Schul. Neuroprotection by the inhibition of apoptosis. Brain pathology (Zurich, Switzerland). vol 10. issue 2. 2000-06-06. PMID:10764048. |
consistent with the proposal that apoptosis plays a central in role human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and alzheimer's disease. |
2000-06-06 |
2023-08-12 |
mouse |
| M S Beer, J A Stanton, K Salim, M Rigby, R P Heavens, D Smith, G Mcalliste. EDG receptors as a therapeutic target in the nervous system. Annals of the New York Academy of Sciences. vol 905. 2000-06-05. PMID:10818448. |
edg receptors located in brain neuronal cells might, for example, influence apoptosis and be involved in cell rescue following ischemic damage or during the early stages of progressive neurodegenerative diseases. |
2000-06-05 |
2023-08-12 |
Not clear |
| H W Ko, K S Han, E Y Kim, B R Ryu, W J Yoon, Y K Jung, S U Kim, B J Gwa. Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-d-aspartate-induced necrosis in mouse cortical neurons. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820206. |
we examined the possibility that p38 mitogen-activated protein kinase and caspase-3 would be activated for execution of apoptosis and excitotoxicity, the two major types of neuronal death underlying hypoxicischemic and neurodegenerative diseases. |
2000-06-02 |
2023-08-12 |
mouse |