| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Porat, A Premkumar, R Simanto. Dopamine induces phenotypic differentiation or apoptosis in a dose-dependent fashion: involvement of the dopamine transporter and p53. Developmental neuroscience. vol 23. issue 6. 2002-04-12. PMID:11872944. |
these findings provide an insight into the role of dopamine, dopamine transporters and p53 in the differentiation and apoptosis of dopaminergic neurons, which will further our understanding of neuronal development and neurodegenerative diseases. |
2002-04-12 |
2023-08-12 |
human |
| Allen M Gown, Mark C Willingha. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 50. issue 4. 2002-04-09. PMID:11897797. |
apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative diseases, and development. |
2002-04-09 |
2023-08-12 |
Not clear |
| D Reverter, S Strobl, C Fernandez-Catalan, H Sorimachi, K Suzuki, W Bod. Structural basis for possible calcium-induced activation mechanisms of calpains. Biological chemistry. vol 382. issue 5. 2002-03-12. PMID:11517928. |
the calpains are believed to play important roles in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction, but have also been implicated in muscular dystrophy, ischemia, traumatic brain injury, neurodegenerative diseases, rheumatoid arthritis and cataract formation. |
2002-03-12 |
2023-08-12 |
human |
| Shigeko Uryu, Jun Harada, Marie Hisamoto, Tomiichiro Od. Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons. Brain research. vol 924. issue 2. 2002-03-05. PMID:11750908. |
both excitotoxicity and apoptosis contribute to neuronal loss in various neurodegenerative diseases such as alzheimer's disease as well as stroke, and a drug inhibiting both types of cell death may lead to practical treatment for these diseases. |
2002-03-05 |
2023-08-12 |
Not clear |
| Shigeko Uryu, Jun Harada, Marie Hisamoto, Tomiichiro Od. Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons. Brain research. vol 924. issue 2. 2002-03-05. PMID:11750908. |
in conclusion, although the mechanisms of troglitazone's neuroprotective effects are unknown, the post-treatment-neuroprotective effect and the dual-inhibitory-activity against both excitotoxicity and apoptosis may provide a novel therapy for various neurodegenerative diseases. |
2002-03-05 |
2023-08-12 |
Not clear |
| X H Liu, R J Collier, R J Youl. Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11574549. |
bcl-2 and bcl-xl prevent neuronal apoptosis during development, neurodegenerative disease, and trauma. |
2002-01-10 |
2023-08-12 |
rat |
| D Reverter, H Sorimachi, W Bod. The structure of calcium-free human m-calpain: implications for calcium activation and function. Trends in cardiovascular medicine. vol 11. issue 6. 2001-12-05. PMID:11673052. |
the calpains are believed to play important roles in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction, but are also implicated in muscular dystrophy, cardiac and cerebral ischemia, platelet aggregation, restenosis, neurodegenerative diseases, rheumatoid arthritis and cataract formation. |
2001-12-05 |
2023-08-12 |
human |
| Iu A Chelyshev, G V Cherepnev, K I Saĭtkulo. [Apoptosis in the nervous system]. Ontogenez. vol 32. issue 2. 2001-10-18. PMID:11544763. |
various disturbances in the control of apoptosis underlie various neurodegenerative diseases, the formation of malignant tumors, autoimmune disturbances, and developmental abnormalities. |
2001-10-18 |
2023-08-12 |
Not clear |
| b' R Neuwirtov\\xc3\\xa. [Will knowledge of the mechanisms of apoptosis lead to new therapeutic procedures?]. Casopis lekaru ceskych. vol 140. issue 15. 2001-10-18. PMID:11569166.' |
conversely a delay of premature apoptosis gives hope for hitherto untreatable neurodegenerative diseases, myelodysplastic syndromes, ischaemic events and some severe infections. |
2001-10-18 |
2023-08-12 |
human |
| S Sathasivam, P G Ince, P J Sha. Apoptosis in amyotrophic lateral sclerosis: a review of the evidence. Neuropathology and applied neurobiology. vol 27. issue 4. 2001-10-04. PMID:11532157. |
in a chronic neurodegenerative disease such as als, conclusive evidence of apoptosis is likely to be difficult to detect, given the rapidity of the apoptotic cell death process in relation to the relatively slow time course of the disease. |
2001-10-04 |
2023-08-12 |
human |
| E B Stuart, J M Thompson, R W Rhees, E D Lephar. Steroid hormone influence on brain calbindin-D(28K) in male prepubertal and ovariectomized rats. Brain research. Developmental brain research. vol 129. issue 2. 2001-09-27. PMID:11506857. |
calbindin-d(28k) (calb), a calcium-binding protein, is thought to buffer intracellular calcium levels in neurons playing several important roles during central nervous system development such as, protecting against apoptosis (programmed cell death), neurodegenerative diseases and influencing sexually dimorphic brain structures. |
2001-09-27 |
2023-08-12 |
rat |
| S Gökhan, M F Mehle. Basic and clinical neuroscience applications of embryonic stem cells. The Anatomical record. vol 265. issue 3. 2001-09-13. PMID:11458329. |
in addition, recent experimental observations suggest that neurodegenerative disease pathology may involve alterations in a range of progressive neural inductive and neurodevelopmental events through novel biological mechanisms that result in sublethal impairments in cellular homeostasis within evolving regional neuronal precursor populations containing the mutant proteins, culminating in increased vulnerability of their differentiated neuronal progeny to late-onset apoptosis. |
2001-09-13 |
2023-08-12 |
Not clear |
| I V Smirnova, B A Citron, P M Arnold, B W Festof. Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis. Journal of neurobiology. vol 48. issue 2. 2001-08-30. PMID:11438939. |
effects on neuronal rounding and apoptosis were also detected, suggesting therapeutic utility may result from interference with downstream components of thrombin signaling pathways in human motor neuron disorders, and possibly other neurodegenerative diseases. |
2001-08-30 |
2023-08-12 |
human |
| C Volbracht, M Leist, S A Kolb, P Nicoter. Apoptosis in caspase-inhibited neurons. Molecular medicine (Cambridge, Mass.). vol 7. issue 1. 2001-08-30. PMID:11474126. |
there is growing evidence of apoptosis in neurodegenerative disease. |
2001-08-30 |
2023-08-12 |
Not clear |
| K Dikranian, M J Ishimaru, T Tenkova, J Labruyere, Y Q Qin, C Ikonomidou, J W Olne. Apoptosis in the in vivo mammalian forebrain. Neurobiology of disease. vol 8. issue 3. 2001-08-16. PMID:11447994. |
whether the cell death process in neurodegenerative diseases meets ultrastructural criteria for apoptosis has been given very little consideration. |
2001-08-16 |
2023-08-12 |
human |
| N P Baja. Cyclin-dependent kinase-5 (CDK5) and amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. vol 1. issue 5. 2001-08-09. PMID:11464850. |
apoptosis has been implicated as the final common pathway of cell death in a number of neurodegenerative diseases including als. |
2001-08-09 |
2023-08-12 |
Not clear |
| M Mota, M Reeder, J Chernoff, C E Bazene. Evidence for a role of mixed lineage kinases in neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 14. 2001-07-26. PMID:11438570. |
mlk3 therefore could be an interesting therapeutic target in a number of neurodegenerative diseases involving neuronal apoptosis. |
2001-07-26 |
2023-08-12 |
Not clear |
| L J Marti. Neuronal cell death in nervous system development, disease, and injury (Review). International journal of molecular medicine. vol 7. issue 5. 2001-06-14. PMID:11295106. |
the re-emergence of apoptosis may contribute to the neuronal degeneration in chronic neurodegenerative disease, such as amyotrophic lateral sclerosis and alzheimer's disease, and in neurological injury such as cerebral ischemia and trauma. |
2001-06-14 |
2023-08-12 |
Not clear |
| W G Tatton, R M Chalmers-Redman, M Elstner, W Leesch, F B Jagodzinski, D P Stupak, M M Sugrue, N A Tatto. Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205159. |
pathologically, gapdh has been implicated in apoptosis, neurodegenerative disease, prostate cancer and viral pathogenesis (see sirover (1999) for a recent review of gapdh functions). |
2001-04-12 |
2023-08-12 |
Not clear |
| S Shimoham. Apoptosis in Alzheimer's disease--an update. Apoptosis : an international journal on programmed cell death. vol 5. issue 1. 2001-03-29. PMID:11227497. |
it is now generally accepted that massive neuronal death due to apoptosis is a commmon characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in ad. |
2001-03-29 |
2023-08-12 |
human |