| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Ye, H C Meeker, P Kozlowski, R I Car. Increased c-Fos protein in the brains of scrapie-infected SAMP8, SAMR1, AKR and C57BL mice. Neuropathology and applied neurobiology. vol 28. issue 5. 2003-03-12. PMID:12366817. |
in many neurodegenerative diseases, activation of the p38 pathway and of the immediate-early gene termed c-fos appears to be required for the initiation of apoptosis. |
2003-03-12 |
2023-08-12 |
mouse |
| Nadia El-Guendy, Vivek M Rangneka. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Experimental cell research. vol 283. issue 1. 2003-03-12. PMID:12565819. |
apoptosis by par-4 in cancer and neurodegenerative diseases. |
2003-03-12 |
2023-08-12 |
Not clear |
| Nadia El-Guendy, Vivek M Rangneka. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Experimental cell research. vol 283. issue 1. 2003-03-12. PMID:12565819. |
cells that are resistant to apoptosis by par-4 alone, however, are greatly sensitized by par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, tumor necrosis factor, ionizing radiation, intracellular calcium elevation, or those involved in neurodegenerative diseases such as alzheimer's, parkinson's, huntington's, and stroke. |
2003-03-12 |
2023-08-12 |
Not clear |
| Nadia El-Guendy, Vivek M Rangneka. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Experimental cell research. vol 283. issue 1. 2003-03-12. PMID:12565819. |
the unique ability of par-4 to induce apoptosis in cancer cells but not normal cells and the ability of par-4 antisense or dominant-negative mutant to abrogate apoptosis in neurodegenerative disease paradigms makes it an appealing candidate for molecular therapy of cancer and neuronal diseases. |
2003-03-12 |
2023-08-12 |
Not clear |
| Manuel B Graeber, Linda B Mora. Mechanisms of cell death in neurodegenerative diseases: fashion, fiction, and facts. Brain pathology (Zurich, Switzerland). vol 12. issue 3. 2003-02-14. PMID:12146806. |
in addition, with the exception of developmental conditions, there is essentially no evidence of apoptosis fulfilling the criteria of its classical definition in any of the important human neurodegenerative diseases, including alzheimer's, parkinson's, huntington's, amyotrophic lateral sclerosis, and creutzfeldt-jakob disease. |
2003-02-14 |
2023-08-12 |
human |
| H Shimizu, M Ohgoh, Y Momose, Y Nishizawa, H Ogur. Massive cell death of cerebellar granule neurons accompanied with caspase-3-like protease activation and subsequent motor discoordination after intracerebroventricular injection of vincristine in mice. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401321. |
these vincristine-treated mice should be a useful in vivo model for examination of neuronal apoptosis, which might be involved in a variety of neurodegenerative diseases. |
2003-02-05 |
2023-08-12 |
mouse |
| Catherine M Cowan, A Jane Roskam. Apoptosis in the mature and developing olfactory neuroepithelium. Microscopy research and technique. vol 58. issue 3. 2003-01-29. PMID:12203699. |
neuronal apoptosis is important in the developmental sculpting of a normal nervous system and also in the loss of neurons caused by neurodegenerative disease, ischemia or trauma. |
2003-01-29 |
2023-08-12 |
Not clear |
| R Takahash. [Cell death protection by anti-apoptotic factor]. Rinsho shinkeigaku = Clinical neurology. vol 41. issue 12. 2002-11-08. PMID:12235797. |
regarding the involvement of apoptosis in neurodegenerative diseases, several lines of evidence indicated that caspases are involved in the pathogenesis of als and polyglutamine disease, suggesting the effectiveness of anti-apoptotic therapy for these diseases. |
2002-11-08 |
2023-08-12 |
human |
| Andrew J Danielsen, Nita J Maihl. The EGF/ErbB receptor family and apoptosis. Growth factors (Chur, Switzerland). vol 20. issue 1. 2002-10-28. PMID:11999214. |
the understanding of erbb receptor signaling as it relates to the avoidance of apoptosis had profound implications for the treatment of solid tumors originating in multiple tissues, as well as for the treatment of neurodegenerative disease. |
2002-10-28 |
2023-08-12 |
Not clear |
| Ricardo C Machado, Rodrigo N R Pereira, Mara S A Costa, Ricardo Guelerman P Ramo. "In vivo" toxicity of a truncated version of the Drosophila Rst-IrreC protein is dependent on the presence of a glutamine-rich region in its intracellular domain. Anais da Academia Brasileira de Ciencias. vol 74. issue 2. 2002-10-21. PMID:12098754. |
the results suggest the possibility that the opa-like domain and the carboxyl terminus act in concert to modulate rst-irrec function in apoptosis, and we discuss this implication in the context of the general mechanisms causing glutamine-rich neurodegenerative diseases in humans. |
2002-10-21 |
2023-08-12 |
drosophila_melanogaster |
| Kathleen A Gallo, Gary L Johnso. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nature reviews. Molecular cell biology. vol 3. issue 9. 2002-10-07. PMID:12209126. |
in mammalian cells, mlks are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases. |
2002-10-07 |
2023-08-12 |
caenorhabditis_elegans |
| Shuxian Hu, Wen S Sheng, James R Lokensgard, Phillip K Peterso. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology. vol 42. issue 6. 2002-09-25. PMID:12015209. |
apoptosis plays a critical role in normal brain development and in a number of neurodegenerative diseases. |
2002-09-25 |
2023-08-12 |
human |
| Daniel A Linseman, Maria L McClure, Ron J Bouchard, Tracey A Laessig, Ferogh A Ahmadi, Kim A Heidenreic. Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor I-dependent mechanism. The Journal of biological chemistry. vol 277. issue 27. 2002-08-27. PMID:11964396. |
neuronal apoptosis contributes to the progression of neurodegenerative disease. |
2002-08-27 |
2023-08-12 |
Not clear |
| J L Mazzola, M A Sirove. Reduction of glyceraldehyde-3-phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblasts. Journal of neurochemistry. vol 76. issue 2. 2002-08-15. PMID:11208907. |
new functions have been identified for glyceraldehyde-3-phosphate dehydrogenase (gapdh) including its role in neurodegenerative disease and in apoptosis. |
2002-08-15 |
2023-08-12 |
Not clear |
| Carol M Troy, Guy S Salvese. Caspases on the brain. Journal of neuroscience research. vol 69. issue 2. 2002-08-14. PMID:12111795. |
there is now evidence that the pathology of several neurodegenerative diseases is due to inappropriate apoptosis. |
2002-08-14 |
2023-08-12 |
Not clear |
| D Perrelet, A Ferri, P Liston, P Muzzin, R G Korneluk, A C Kat. IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo. Nature cell biology. vol 4. issue 2. 2002-08-08. PMID:11813002. |
during embryonic development, and in certain neurodegenerative diseases, neurons die by apoptosis. |
2002-08-08 |
2023-08-12 |
rat |
| [Alzheimer's disease in the year 2000]. Revista panamericana de salud publica = Pan American journal of public health. vol 10. issue 4. 2002-07-15. PMID:11715172. |
in research on the etiology of the disease, key areas of attention have included amyloid, presenilins, apolipoprotein e, and other genetic ties; apoptosis; and protein aggregation in other neurodegenerative disease. |
2002-07-15 |
2023-08-12 |
human |
| K Schindowski, S Leutner, S Kressmann, A Eckert, W E Mülle. Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761). Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 8-9. 2002-04-29. PMID:11716149. |
in addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis in neuronal tissue. |
2002-04-29 |
2023-08-12 |
mouse |
| Kawase, K Sunaga, S Tani, M Niwa, T Uemats. Trifluoromethyl ketone-based inhibitors of apoptosis in cerebellar granule neurons. Biological & pharmaceutical bulletin. vol 24. issue 11. 2002-04-23. PMID:11725976. |
among them, alpha-trifluoromethyl diketone (2) and benzyl trifluoromethyl ketone (11) were found to be apoptosis inhibitors which can prevent a neurodegenerative disease. |
2002-04-23 |
2023-08-12 |
Not clear |
| Sumeer Dhar, Rhonda L Bitting, Svetlana N Rylova, Paul J Jansen, Ellen Lockhart, Dwight D Koeberl, Andrea Amalfitano, Rose-Mary N Boustan. Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. Annals of neurology. vol 51. issue 4. 2002-04-18. PMID:11921051. |
flupirtine may be useful as a drug capable of halting the progression of neurodegenerative diseases caused by dysregulated apoptosis. |
2002-04-18 |
2023-08-12 |
human |