| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul T Kotzbauer, Benoit I Giasson, Alexxai V Kravitz, Lawrence I Golbe, Margery H Mark, John Q Trojanowski, Virginia M-Y Le. Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation. Experimental neurology. vol 187. issue 2. 2004-06-30. PMID:15144854. |
our data implicate fibrillization of alpha-syn and tau in the pathogenesis of pd, and suggest that distinct amyloidogenic proteins may cross-seed each other in neurodegenerative diseases. |
2004-06-30 |
2023-08-12 |
Not clear |
| Jonathan B Macknin, Makoto Higuchi, Virginia M-Y Lee, John Q Trojanowski, Richard L Dot. Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein. Brain research. vol 1000. issue 1-2. 2004-06-22. PMID:15053964. |
these data lend support to the notion that tau may be involved in the pathogenesis of the olfactory dysfunction of some neurodegenerative diseases. |
2004-06-22 |
2023-08-12 |
mouse |
| Markus Schubert, Dinesh Gautam, David Surjo, Kojihiko Ueki, Stephanie Baudler, Dominic Schubert, Tatsuya Kondo, Jens Alber, Norbert Galldiks, Eckehardt Küstermann, Saskia Arndt, Andreas H Jacobs, Wilhelm Krone, C Ronald Kahn, Jens C Brünin. Role for neuronal insulin resistance in neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 9. 2004-06-17. PMID:14981233. |
in intact animals, this loss results in markedly reduced phosphorylation of akt and gsk3 beta, leading to substantially increased phosphorylation of the microtubule-associated protein tau, a hallmark of neurodegenerative diseases. |
2004-06-17 |
2023-08-12 |
mouse |
| Susanna Schraen-Maschke, Claire-Marie Dhaenens, André Delacourte, Bernard Sablonnièr. Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiology of disease. vol 15. issue 3. 2004-05-27. PMID:15056452. |
microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. |
2004-05-27 |
2023-08-12 |
human |
| Susanna Schraen-Maschke, Claire-Marie Dhaenens, André Delacourte, Bernard Sablonnièr. Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiology of disease. vol 15. issue 3. 2004-05-27. PMID:15056452. |
as tau pathology represents a primary pathogenic event in various neurodegenerative diseases, the hypothesis that tau genotype could influence the development of these diseases was tested by several groups. |
2004-05-27 |
2023-08-12 |
human |
| Susanna Schraen-Maschke, Claire-Marie Dhaenens, André Delacourte, Bernard Sablonnièr. Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiology of disease. vol 15. issue 3. 2004-05-27. PMID:15056452. |
this review summarizes advances in the molecular genetics of the tau gene, as well as recent studies addressing the disease incidence of novel tau polymorphisms in different neurodegenerative diseases. |
2004-05-27 |
2023-08-12 |
human |
| Susanna Schraen-Maschke, Claire-Marie Dhaenens, André Delacourte, Bernard Sablonnièr. Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiology of disease. vol 15. issue 3. 2004-05-27. PMID:15056452. |
hopefully, the identification of several genetic defects of the tau gene will be helpful in improving our understanding of the role of tau protein in the pathogenesis of various neurodegenerative diseases. |
2004-05-27 |
2023-08-12 |
human |
| T Chris Gamblin, Robert W Berry, Lester I Binde. Modeling tau polymerization in vitro: a review and synthesis. Biochemistry. vol 42. issue 51. 2004-05-04. PMID:14690409. |
the major antigenic component of neurofibrillary pathology in a large number of neurodegenerative diseases consists of the microtubule-associated protein tau. |
2004-05-04 |
2023-08-12 |
Not clear |
| Virginia M-Y Lee, Benoit I Giasson, John Q Trojanowsk. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends in neurosciences. vol 27. issue 3. 2004-05-03. PMID:15036877. |
more than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. |
2004-05-03 |
2023-08-12 |
Not clear |
| Isao Nishimura, Yufeng Yang, Bingwei L. PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. Cell. vol 116. issue 5. 2004-04-13. PMID:15006350. |
multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including alzheimer's disease (ad). |
2004-04-13 |
2023-08-12 |
drosophila_melanogaster |
| J-J Hauw, C Hausser-Hauw, C Duyckaert. [Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge]. Revue neurologique. vol 159. issue 11 Suppl. 2004-04-02. PMID:14646802. |
abnormalities of tau and alpha-synuclein have been described in a variety of neurodegenerative diseases often associated with sleep disorders. |
2004-04-02 |
2023-08-12 |
human |
| Tetsuaki Arai, Kenji Ikeda, Haruhiko Akiyama, Takashi Nonaka, Masato Hasegawa, Koichi Ishiguro, Shuji Iritani, Kuniaki Tsuchiya, Eizo Iseki, Saburo Yagishita, Tatsuro Oda, Akihide Mochizuk. Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration. Annals of neurology. vol 55. issue 1. 2004-03-12. PMID:14705114. |
progressive supranuclear palsy (psp) and corticobasal degeneration (cbd) are neurodegenerative diseases that are characterized by intracytoplasmic aggregates of hyperphosphorylated tau with four microtubule-binding repeats. |
2004-03-12 |
2023-08-12 |
Not clear |
| Chul-Woong Chung, Yeon-Mi Hong, Sungmin Song, Ha-Na Woo, Yun-Hee Choi, Troy Rohn, Yong-Keun Jun. Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678771. |
abnormal tau protein is known to be closely associated with several neurodegenerative diseases. |
2004-03-05 |
2023-08-12 |
Not clear |
| Deepa V Dabir, John Q Trojanowski, Christiane Richter-Landsberg, Virginia M-Y Lee, Mark S Forma. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American journal of pathology. vol 164. issue 1. 2004-02-27. PMID:14695329. |
although the pathogenesis of tauopathies remains primarily unknown, molecular chaperones such as heat-shock proteins (hsps) are implicated in these tau disorders as well as other neurodegenerative diseases characterized by the accumulation of insoluble protein aggregates such as alpha-synuclein in parkinson's disease and polyglutamine in huntington's disease. |
2004-02-27 |
2023-08-12 |
Not clear |
| Deepa V Dabir, John Q Trojanowski, Christiane Richter-Landsberg, Virginia M-Y Lee, Mark S Forma. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American journal of pathology. vol 164. issue 1. 2004-02-27. PMID:14695329. |
thus, increased alphab-crystallin expression in glial tau inclusions may represent a response by glia to the accumulation of misfolded or aggregated tau protein that is linked to the pathogenesis of the glial pathology and distinct from mechanisms underlying neuronal tau pathology in neurodegenerative disease. |
2004-02-27 |
2023-08-12 |
Not clear |
| Despina Yancopoulou, Maria Grazia Spillantin. Tau protein in familial and sporadic diseases. Neuromolecular medicine. vol 4. issue 1-2. 2004-01-21. PMID:14528051. |
filamentous deposits made of the microtubule-associated protein tau constitute a major defining characteristic of several neurodegenerative diseases known as tauopathies. |
2004-01-21 |
2023-08-12 |
Not clear |
| Daniel H Geschwin. Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg? Neuron. vol 40. issue 3. 2004-01-05. PMID:14642270. |
pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. |
2004-01-05 |
2023-08-12 |
human |
| Daniel H Geschwin. Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg? Neuron. vol 40. issue 3. 2004-01-05. PMID:14642270. |
now, several animal models and data from human patients provide converging evidence that aberrant tau phosphorylation can cause a neurodegenerative phenotype similar to that seen in human neurodegenerative diseases. |
2004-01-05 |
2023-08-12 |
human |
| Yasumasa Yoshiyama, Bin Zhang, Jennifer Bruce, John Q Trojanowski, Virginia M-Y Le. Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 33. 2003-12-11. PMID:14627651. |
several human neurodegenerative diseases are associated with abnormal accumulations of aggregated tau proteins and glial degeneration in astrocytes, but the mechanism whereby tau proteins cause astrocytic degeneration is unclear. |
2003-12-11 |
2023-08-12 |
human |
| Esther M Ingram, Maria G Spillantin. Tau gene mutations: dissecting the pathogenesis of FTDP-17. Trends in molecular medicine. vol 8. issue 12. 2003-11-17. PMID:12470988. |
abnormal filamentous tau deposits constitute a major defining characteristic of several neurodegenerative diseases, including alzheimer's disease. |
2003-11-17 |
2023-08-12 |
Not clear |