| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryo Okuyama, Stephen Marshal. UDP-N-acetylglucosaminyl transferase (OGT) in brain tissue: temperature sensitivity and subcellular distribution of cytosolic and nuclear enzyme. Journal of neurochemistry. vol 86. issue 5. 2003-11-12. PMID:12911634. |
in brain tissue, udp-n-acetylglucosaminyl transferase (ogt) is known to catalyze the addition of a single n-acetylglucosamine moiety (glcnac) onto two proteins linked to the etiology of neurodegenerative disease--beta-amyloid associated protein and tau. |
2003-11-12 |
2023-08-12 |
Not clear |
| Olaf Goldbaum, Malte Oppermann, Melanie Handschuh, Deepa Dabir, Bin Zhang, Mark S Forman, John Q Trojanowski, Virginia M-Y Lee, Christiane Richter-Landsber. Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 26. 2003-11-12. PMID:14523089. |
hence, although tau hyperphosphorylation induced by protein phosphatase inhibition contributes to pathological aggregate formation, only hyperphosporylation of tau followed by proteasome inhibition leads to stable fibrillary deposits of tau similar to those observed in neurodegenerative diseases. |
2003-11-12 |
2023-08-12 |
human |
| M Riemenschneider, S Wagenpfeil, H Vanderstichele, M Otto, J Wiltfang, H Kretzschmar, E Vanmechelen, H Förstl, A Kur. Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias. Molecular psychiatry. vol 8. issue 3. 2003-11-04. PMID:12660807. |
since hyperphosphorylation of tau may specifically occur in neurodegenerative diseases associated with neurofibrillary changes, we hypothesized that the phospho-tau (p-tau)/total tau ratio in csf may be a useful marker to discriminate cjd from other neurodegenerative disorders. |
2003-11-04 |
2023-08-12 |
Not clear |
| Brian C Kraemer, Bin Zhang, James B Leverenz, James H Thomas, John Q Trojanowski, Gerard D Schellenber. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 17. 2003-10-29. PMID:12872001. |
aggregated tau is seen in numerous other neurodegenerative diseases, including alzheimer's disease (ad). |
2003-10-29 |
2023-08-12 |
human |
| Dulal Panda, Jonathan C Samuel, Michelle Massie, Stuart C Feinstein, Leslie Wilso. Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 16. 2003-10-03. PMID:12886013. |
differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease. |
2003-10-03 |
2023-08-12 |
Not clear |
| Dulal Panda, Jonathan C Samuel, Michelle Massie, Stuart C Feinstein, Leslie Wilso. Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 16. 2003-10-03. PMID:12886013. |
the microtubule (mt)-associated protein tau is important in neuronal development and in alzheimer's and other neurodegenerative diseases. |
2003-10-03 |
2023-08-12 |
Not clear |
| Victoria Makrides, Ting E Shen, Rajinder Bhatia, Bettye L Smith, Julian Thimm, Ratneshwar Lal, Stuart C Feinstei. Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12805366. |
the accumulation of abnormal tau filaments is a pathological hallmark of many neurodegenerative diseases. |
2003-10-02 |
2023-08-12 |
Not clear |
| Victoria Makrides, Ting E Shen, Rajinder Bhatia, Bettye L Smith, Julian Thimm, Ratneshwar Lal, Stuart C Feinstei. Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12805366. |
in 1998, genetic analyses revealed a direct linkage between structural and regulatory mutations in the tau gene and the neurodegenerative disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2003-10-02 |
2023-08-12 |
Not clear |
| April Case, Ross L Stei. Kinetic analysis of the action of tissue transglutaminase on peptide and protein substrates. Biochemistry. vol 42. issue 31. 2003-09-26. PMID:12899634. |
natural substrates for this enzyme include proteins (e.g., tau, alpha-synuclein, and huntingtin) whose tgase-promoted polymerization may be causative in neurodegenerative diseases. |
2003-09-26 |
2023-08-12 |
Not clear |
| Hanno M Rode. Prospect of therapeutic approaches to tauopathies. Journal of molecular neuroscience : MN. vol 20. issue 2. 2003-08-18. PMID:12794313. |
these enzymes are therapeutic targets for ad and other neurodegenerative diseases, which feature pathological tau structures in brain |
2003-08-18 |
2023-08-12 |
Not clear |
| R W Berry, A Abraha, S Lagalwar, N LaPointe, T C Gamblin, V L Cryns, L I Binde. Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment. Biochemistry. vol 42. issue 27. 2003-08-12. PMID:12846581. |
abnormal aggregation of the microtubule-associated protein, tau, occurs in many neurodegenerative diseases, making it important to understand the mechanisms of tau polymerization. |
2003-08-12 |
2023-08-12 |
Not clear |
| G Benitez-King, I Túnez, A Bellon, G G Ortíz, F Antón-Ta. Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821385. |
cytoskeleton in neurodegenerative diseases is characterized by hyperphosphorylated tau assembled in neurofibrillary tangles. |
2003-08-06 |
2023-08-12 |
Not clear |
| Wendy Noble, Vicki Olm, Kazuyuki Takata, Evelyn Casey, O Mary, Jordana Meyerson, Kate Gaynor, John LaFrancois, Lili Wang, Takayuki Kondo, Peter Davies, Mark Burns, Veeranna, Ralph Nixon, Dennis Dickson, Yasuji Matsuoka, Michael Ahlijanian, Lit-Fui Lau, Karen Duf. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. vol 38. issue 4. 2003-06-25. PMID:12765608. |
tau aggregation is a common feature of neurodegenerative diseases such as alzheimer's disease, and hyperphosphorylation of tau has been implicated as a fundamental pathogenic mechanism in this process. |
2003-06-25 |
2023-08-12 |
mouse |
| Benoit I Giasson, Mark S Forman, Makoto Higuchi, Lawrence I Golbe, Charles L Graves, Paul T Kotzbauer, John Q Trojanowski, Virginia M-Y Le. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science (New York, N.Y.). vol 300. issue 5619. 2003-05-23. PMID:12714745. |
alpha-synuclein (alpha-syn) and tau polymerize into amyloid fibrils and form intraneuronal filamentous inclusions characteristic of neurodegenerative diseases. |
2003-05-23 |
2023-08-12 |
mouse |
| Benoit I Giasson, Mark S Forman, Makoto Higuchi, Lawrence I Golbe, Charles L Graves, Paul T Kotzbauer, John Q Trojanowski, Virginia M-Y Le. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science (New York, N.Y.). vol 300. issue 5619. 2003-05-23. PMID:12714745. |
this suggests that interactions between alpha-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases. |
2003-05-23 |
2023-08-12 |
mouse |
| Barkur S Shastr. Neurodegenerative disorders of protein aggregation. Neurochemistry international. vol 43. issue 1. 2003-05-08. PMID:12605877. |
in recent years, it has become increasingly clear that many neurodegenerative diseases involve aggregation and deposition of misfolded proteins such as amyloid beta, tau, alpha-synuclein and polyglutamine containing proteins. |
2003-05-08 |
2023-08-12 |
Not clear |
| Gail V W Johnson, Craig D C Baile. Tau, where are we now? Journal of Alzheimer's disease : JAD. vol 4. issue 5. 2003-04-04. PMID:12446970. |
further there is an ever growing family of neurodegenerative diseases called "tauopathies" where tau pathology is the primary, defining characteristic with little or no abeta pathology. |
2003-04-04 |
2023-08-12 |
Not clear |
| Javier Díaz-Nido, Francisco Wandosell, Jesús Avil. Glycosaminoglycans and beta-amyloid, prion and tau peptides in neurodegenerative diseases. Peptides. vol 23. issue 7. 2003-04-03. PMID:12128089. |
glycosaminoglycans and beta-amyloid, prion and tau peptides in neurodegenerative diseases. |
2003-04-03 |
2023-08-12 |
Not clear |
| Henry G Tomasiewicz, Denise B Flaherty, J P Soria, John G Woo. Transgenic zebrafish model of neurodegeneration. Journal of neuroscience research. vol 70. issue 6. 2003-01-24. PMID:12444595. |
this has rekindled interest in the importance of tau in neurodegenerative diseases (cf. |
2003-01-24 |
2023-08-12 |
human |
| Henry G Tomasiewicz, Denise B Flaherty, J P Soria, John G Woo. Transgenic zebrafish model of neurodegeneration. Journal of neuroscience research. vol 70. issue 6. 2003-01-24. PMID:12444595. |
despite significant progress in the field of tau biology and neurodegenerative diseases, several important issues remain unresolved. |
2003-01-24 |
2023-08-12 |
human |