| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Hutton, J Lewis, D Dickson, S H Yen, E McGowa. Analysis of tauopathies with transgenic mice. Trends in molecular medicine. vol 7. issue 10. 2002-01-09. PMID:11597522. |
intraneuronal filamentous inclusions composed of the microtubule-associated protein tau are a feature of several neurodegenerative diseases (including alzheimer's disease) known as tauopathies. |
2002-01-09 |
2023-08-12 |
mouse |
| C Atzori, B Ghetti, R Piva, A N Srinivasan, P Zolo, M B Delisle, S S Mirra, A Mighel. Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. Journal of neuropathology and experimental neurology. vol 60. issue 12. 2001-12-31. PMID:11764091. |
as both kinases phosphorylate tau protein in vitro, we have investigated their immunohistochemical localization in a group of neurodegenerative diseases characterized by intracellular deposits of hyperphosphorylated tau. |
2001-12-31 |
2023-08-12 |
Not clear |
| R W Berry, B Quinn, N Johnson, E J Cochran, N Ghoshal, L I Binde. Pathological glial tau accumulations in neurodegenerative disease: review and case report. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578782. |
pathological glial tau accumulations in neurodegenerative disease: review and case report. |
2001-12-28 |
2023-08-12 |
Not clear |
| R W Berry, B Quinn, N Johnson, E J Cochran, N Ghoshal, L I Binde. Pathological glial tau accumulations in neurodegenerative disease: review and case report. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578782. |
abnormal deposits of tau protein accumulate in glia in many neurodegenerative diseases. |
2001-12-28 |
2023-08-12 |
Not clear |
| R W Berry, B Quinn, N Johnson, E J Cochran, N Ghoshal, L I Binde. Pathological glial tau accumulations in neurodegenerative disease: review and case report. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578782. |
the neurodegenerative diseases span the spectrum of relative neuronal and glial tau involvement, from disorders affecting only neuronal tau to those in which abnormal tau deposits are found only in glia. |
2001-12-28 |
2023-08-12 |
Not clear |
| M Goedert, M G Spillantin. Tau gene mutations and neurodegeneration. Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447840. |
filamentous tau protein deposits are also the defining neuropathological characteristic of other neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as pick's disease, progressive supranuclear palsy and corticobasal degeneration. |
2001-12-14 |
2023-08-12 |
Not clear |
| B M Riederer, C Mourton-Gilles, P Frey, A Delacourte, A Probs. Differential phosphorylation of tau proteins during kitten brain development and Alzheimer's disease. Journal of neurocytology. vol 30. issue 2. 2001-12-14. PMID:11577253. |
in either event, phosphorylation of tau may play a crucial role to modulate microtubule dynamics, contributing to increased microtubule instability and promoting growth of processes during neuronal development or changing dynamic properties of the cytoskeleton and contributing to the formation of pathological structures in neurodegenerative diseases. |
2001-12-14 |
2023-08-12 |
human |
| M P Sánchez, V Alvarez-Tallada, J Avil. [The microtubule-associated protein tau in neurodegenerative diseases. Tauopathies]. Revista de neurologia. vol 33. issue 2. 2001-12-10. PMID:11562878. |
[the microtubule-associated protein tau in neurodegenerative diseases. |
2001-12-10 |
2023-08-12 |
Not clear |
| M Goeder. The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases. Current opinion in genetics & development. vol 11. issue 3. 2001-11-01. PMID:11377973. |
the significance of tau and alpha-synuclein inclusions in neurodegenerative diseases. |
2001-11-01 |
2023-08-12 |
Not clear |
| M Goeder. The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases. Current opinion in genetics & development. vol 11. issue 3. 2001-11-01. PMID:11377973. |
intracellular filamentous inclusions made of either the microtubule-associated protein tau or the protein alpha-synuclein define the majority of cases of neurodegenerative disease. |
2001-11-01 |
2023-08-12 |
Not clear |
| V M Lee, M Goedert, J Q Trojanowsk. Neurodegenerative tauopathies. Annual review of neuroscience. vol 24. 2001-09-13. PMID:11520930. |
because multiple tau gene mutations are pathogenic for ftdp-17 and tau polymorphisms appear to be genetic risk factors for sporadic progressive supranuclear palsy and corticobasal degeneration, tau abnormalities are linked directly to the etiology and pathogenesis of neurodegenerative disease. |
2001-09-13 |
2023-08-12 |
Not clear |
| J Göt. Tau and transgenic animal models. Brain research. Brain research reviews. vol 35. issue 3. 2001-08-30. PMID:11423157. |
tau filament formation, in the absence of abeta production, is also a feature of several additional neurodegenerative diseases including progressive supranuclear palsy, corticobasal degeneration, pick's disease, and frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2001-08-30 |
2023-08-12 |
mouse |
| T Ishihara, M Higuchi, B Zhang, Y Yoshiyama, M Hong, J Q Trojanowski, V M Le. Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487626. |
attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. |
2001-08-30 |
2023-08-12 |
mouse |
| T Arai, K Ikeda, H Akiyama, K Tsuchiya, S Yagishita, J Takamats. Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy. Neuroreport. vol 12. issue 5. 2001-08-09. PMID:11303763. |
corticobasal degeneration (cbd) and progressive supranuclear palsy (psp) are sporadic neurodegenerative diseases with intracytoplasmic aggregates of the microtubule-associated protein, tau, in neurons and glial cells. |
2001-08-09 |
2023-08-12 |
Not clear |
| C A McRae, G Diem, T G Yamazaki, A Mitek, Z K Wszole. Interest in genetic testing in pallido-ponto-nigral degeneration (PPND): a family with frontotemporal dementia with Parkinsonism linked to chromosome 17. European journal of neurology. vol 8. issue 2. 2001-08-02. PMID:11284997. |
the specific mutation on the tau gene responsible for a neurodegenerative disease known as pallido-ponto-nigral degeneration (ppnd) was recently located. |
2001-08-02 |
2023-08-12 |
Not clear |
| C W Wittmann, M F Wszolek, J M Shulman, P M Salvaterra, J Lewis, M Hutton, M B Fean. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science (New York, N.Y.). vol 293. issue 5530. 2001-08-02. PMID:11408621. |
we created a genetic model of tau-related neurodegenerative disease by expressing wild-type and mutant forms of human tau in the fruit fly drosophila melanogaster. |
2001-08-02 |
2023-08-12 |
human |
| M S Forman, V M Lee, J Q Trojanowsk. New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. Journal of chemical neuroanatomy. vol 20. issue 3-4. 2001-05-24. PMID:11207421. |
the discovery of multiple tau gene mutations that are pathogenic for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 in many kindreds, as well as the demonstration that tau polymorphisms are genetic risk factors for sporadic tauopathies, directly implicate tau abnormalities in the onset/progression of neurodegenerative disease. |
2001-05-24 |
2023-08-12 |
Not clear |
| C X Gong, T Lidsky, J Wegiel, I Grundke-Iqbal, K Iqba. Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. Brain research. Brain research protocols. vol 6. issue 3. 2001-05-24. PMID:11223412. |
the abnormal hyperphosphorylation of microtubule-associated protein tau and its aggregation into neurofibrillary tangles in selective neurons is one of the major brain pathologies of alzheimer's disease and several other related neurodegenerative diseases. |
2001-05-24 |
2023-08-12 |
human |
| A C Ludolph, A Sperfeld, B M Collatz, A Storc. [Tauopathies--a new class of neurodegenerative diseases]. Der Nervenarzt. vol 72. issue 2. 2001-05-03. PMID:11256158. |
the discovery of mutations in the tau gene causing a distinct neurodegenerative disease in humans has firmly established the importance of the tau gene for neurodegenerative processes, not only in tauopathies but also in other degenerative disorders with tau pathology, such as corticobasal degeneration, supranuclear progressive paralysis, amyotropic lateral sclerosis, parkinsonism-dementia complex of guam, and alzheimer's disease. |
2001-05-03 |
2023-08-12 |
Not clear |
| G Esposito, P Viglino, M Novak, A Cattane. The solution structure of the C-terminal segment of tau protein. Journal of peptide science : an official publication of the European Peptide Society. vol 6. issue 11. 2001-04-26. PMID:11147714. |
pathological changes in the microtubule associated protein tau, leading to tau-containing filamentous lesions, are a major hallmark common to many types of human neurodegenerative diseases, including alzheimer's disease (ad). |
2001-04-26 |
2023-08-12 |
human |