| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Henry G Tomasiewicz, Denise B Flaherty, J P Soria, John G Woo. Transgenic zebrafish model of neurodegeneration. Journal of neuroscience research. vol 70. issue 6. 2003-01-24. PMID:12444595. |
the early functional consequences of tau alterations in living neurons is incompletely understood, and it is not clear how tau in neurodegenerative diseases becomes redistributed from its normal concentration in neuronal axons to pathological inclusions in neuronal soma known as neurofibrillary tangles (nft). |
2003-01-24 |
2023-08-12 |
human |
| Maho Morishima-Kawashima, Yasuo Ihar. Alzheimer's disease: beta-Amyloid protein and tau. Journal of neuroscience research. vol 70. issue 3. 2002-12-13. PMID:12391602. |
whereas a beta deposition is relatively specific for ad, tau deposition is observed in various neurodegenerative diseases and is assumed to be intimately associated with neuronal loss. |
2002-12-13 |
2023-08-12 |
Not clear |
| Masashi Takanashi, Hideo Mori, Kunimasa Arima, Yoshikuni Mizuno, Nobutaka Hattor. Expression patterns of tau mRNA isoforms correlate with susceptible lesions in progressive supranuclear palsy and corticobasal degeneration. Brain research. Molecular brain research. vol 104. issue 2. 2002-12-04. PMID:12225876. |
deposition of hyperphosphorylated tau (p-tau) has been observed in several neurodegenerative diseases. |
2002-12-04 |
2023-08-12 |
Not clear |
| Della C David, Robert Layfield, Louise Serpell, Yolanda Narain, Michel Goedert, Maria Grazia Spillantin. Proteasomal degradation of tau protein. Journal of neurochemistry. vol 83. issue 1. 2002-10-28. PMID:12358741. |
filamentous inclusions composed of the microtubule-associated protein tau are a defining characteristic of a large number of neurodegenerative diseases. |
2002-10-28 |
2023-08-12 |
Not clear |
| Emil Adamec, Panaiyur Mohan, Jean P Vonsattel, Ralph A Nixo. Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta neuropathologica. vol 104. issue 1. 2002-09-13. PMID:12070670. |
overall, these results provide evidence of the important role of the calpain proteolytic system in the pathogenesis of neurodegenerative diseases with tau neurofibrillary pathology. |
2002-09-13 |
2023-08-12 |
Not clear |
| Sonia M Rosso, John C van Swiete. New developments in frontotemporal dementia and parkinsonism linked to chromosome 17. Current opinion in neurology. vol 15. issue 4. 2002-09-13. PMID:12151838. |
the identification of tau mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) has revealed invaluable information regarding the role of the tau protein in neurodegenerative disease. |
2002-09-13 |
2023-08-12 |
Not clear |
| Lit-Fui Lau, Joel B Schachter, Patricia A Seymour, Mark A Sanne. Tau protein phosphorylation as a therapeutic target in Alzheimer's disease. Current topics in medicinal chemistry. vol 2. issue 4. 2002-09-12. PMID:11966463. |
this review summarizes recent data and prevailing views on the roles of protein kinases and phosphatases in the regulation of tau phosphorylation in vitro and in vivo, taking into account data from human neurodegenerative diseases and from transgenic rodent models. |
2002-09-12 |
2023-08-12 |
human |
| Yves Christe. [Proteins and mutations: a new vision (molecular) of neurodegenerative diseases]. Journal de la Societe de biologie. vol 196. issue 1. 2002-08-23. PMID:12134639. |
it now appears that numerous neurodegenerative diseases of the central nervous system correspond to the aggregation of specific proteins: beta-amyloid in alzheimer disease, tau protein in alzheimer disease, fronto-temporal dementia, progressive supranuclear palsy and corticobasal degeneration, alpha-synuclein in parkinson disease and lewy body dementia, prp protein in prion diseases, sod in amyotrophic lateral sclerosis, polyglutamine expansions in huntington's disease and other diseases, etc. |
2002-08-23 |
2023-08-12 |
mouse |
| John Q Trojanowski, Virginia M Y Le. The role of tau in Alzheimer's disease. The Medical clinics of North America. vol 86. issue 3. 2002-08-22. PMID:12168561. |
despite earlier uncertainties about the role of tau pathology in ad, the discovery of multiple mutations in the tau gene that lead to the abnormal aggregation of tau and the onset/progression of ftdp-17 demonstrates that tau dysfunction is sufficient to produce neurodegenerative disease. |
2002-08-22 |
2023-08-12 |
human |
| Jared Goldstine, David B Seligson, Pouneh Beizai, Hajime Miyata, Harry V Vinter. Tissue microarrays in the study of non-neoplastic disease of the nervous system. Journal of neuropathology and experimental neurology. vol 61. issue 8. 2002-08-14. PMID:12152780. |
tau, abeta, alpha-synuclein) in multiple regions of large numbers of brain specimens (from patients with neurodegenerative diseases) can be efficiently examined using tma technology. |
2002-08-14 |
2023-08-12 |
Not clear |
| Mark S Forman, M Luise Schmidt, Sanjay Kasturi, Daniel P Perl, Virginia M-Y Lee, John Q Trojanowsk. Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. The American journal of pathology. vol 160. issue 5. 2002-06-04. PMID:12000724. |
a variety of neurodegenerative diseases with tau pathology including als/pdc also have alpha-synuclein positive pathology, primarily in the amygdala. |
2002-06-04 |
2023-08-12 |
Not clear |
| Valérie Buée-Scherrer, Michel Goeder. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells. FEBS letters. vol 515. issue 1-3. 2002-05-10. PMID:11943212. |
tau is a microtubule-associated protein that is abnormally hyperphosphorylated in the filamentous lesions that define a number of neurodegenerative diseases collectively referred to as tauopathies. |
2002-05-10 |
2023-08-12 |
Not clear |
| Janet Hoenicka, Montserrat Arrasate, Justo Garcia de Yebenes, Jesús Avil. A two-hybrid screening of human Tau protein: interactions with Alu-derived domain. Neuroreport. vol 13. issue 3. 2002-05-02. PMID:11930135. |
the microtubule associated protein tau has been implicated in several neurodegenerative diseases, grouped as tauopathies. |
2002-05-02 |
2023-08-12 |
human |
| James A Richardson, Dennis K Burn. Mouse models of Alzheimer's disease: a quest for plaques and tangles. ILAR journal. vol 43. issue 2. 2002-04-16. PMID:11917160. |
many genetically altered mice have been designed to help understand the role of specific gene mutations in the pathogenesis of alzheimer's disease (ad) based on the realization that specific mutations in the genes for amyloid precursor protein--the presenilins and tau--are associated with early-onset familial ad or, in the case of tau mutations, other neurodegenerative diseases with neurofibrillary tangles. |
2002-04-16 |
2023-08-12 |
mouse |
| M Goedert, M G Spillantini, L C Serpell, J Berriman, M J Smith, R Jakes, R A Crowthe. From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 356. issue 1406. 2002-03-20. PMID:11260802. |
from genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases. |
2002-03-20 |
2023-08-12 |
human |
| G Heidary, M E Fortin. Identification and characterization of the Drosophila tau homolog. Mechanisms of development. vol 108. issue 1-2. 2002-03-05. PMID:11578871. |
the identification of mutations in the tau locus in patients with familial frontotemporal dementia and parkinsonism linked to chromosome 17 has demonstrated that mutations in tau are sufficient to cause neurodegenerative disease (poorkaj et al., ann. |
2002-03-05 |
2023-08-12 |
human |
| Andreas Bitsch, Claudia Horn, Yvonne Kemmling, Maria Seipelt, Uwe Hellenbrand, Michael Stiefel, Barbara Ciesielczyk, Lukas Cepek, Erik Bahn, Peter Ratzka, Hilmar Prange, Markus Ott. Serum tau protein level as a marker of axonal damage in acute ischemic stroke. European neurology. vol 47. issue 1. 2002-03-05. PMID:11803192. |
tau protein, which derives predominantly from neurons and axons, is elevated in the cerebrospinal fluid of patients with neurodegenerative disease. |
2002-03-05 |
2023-08-12 |
Not clear |
| K Tanemura, T Akagi, M Murayama, N Kikuchi, O Murayama, T Hashikawa, Y Yoshiike, J M Park, K Matsuda, S Nakao, X Sun, S Sato, H Yamaguchi, A Takashim. Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiology of disease. vol 8. issue 6. 2002-02-21. PMID:11741399. |
the aggregation of tau in these transgenic mice satisfies all histological criteria used to identify nfts common to human neurodegenerative diseases. |
2002-02-21 |
2023-08-12 |
mouse |
| Christopher D Syme, Ewan W Blanch, Carl Holt, Ross Jakes, Michel Goedert, Lutz Hecht, Laurence D Barro. A Raman optical activity study of rheomorphism in caseins, synucleins and tau. New insight into the structure and behaviour of natively unfolded proteins. European journal of biochemistry. vol 269. issue 1. 2002-02-21. PMID:11784308. |
the casein milk proteins and the brain proteins alpha-synuclein and tau have been described as natively unfolded with random coil structures, which, in the case of alpha-synuclein and tau, have a propensity to form the fibrils found in a number of neurodegenerative diseases. |
2002-02-21 |
2023-08-12 |
human |
| Kentaro Tanemura, Miyuki Murayama, Takumi Akagi, Tsutomu Hashikawa, Takashi Tominaga, Michinori Ichikawa, Haruyasu Yamaguchi, Akihiko Takashim. Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756496. |
v337m tg mice revealed tau aggregations in the hippocampus, which fulfills the histological criteria for nfts in human neurodegenerative diseases. |
2002-02-04 |
2023-08-12 |
mouse |